PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1716990-1 1991 The binding of the lignans, enterolactone, enterodiol, nordihydroguaiaretic acid (NDGA), and the isoflavonic phytoestrogen equol, to human and rat alpha-fetoprotein (AFP) was studied. Masoprocol 82-86 alpha-fetoprotein Rattus norvegicus 147-164 1716990-2 1991 They had differential inhibitory effects (NDGA greater than equol greater than enterolactone greater than enterodiol) on the binding of estrone and estradiol to rat AFP and the binding of unsaturated fatty acid to both rat and human AFP. Masoprocol 42-46 alpha-fetoprotein Rattus norvegicus 165-168 1716990-6 1991 NDGA also competitively inhibited estrone binding at low NDGA concentrations (increased Kd), but high concentrations induced conformational changes in rat AFP, as both Kd and the number of binding sites (n) were altered. Masoprocol 0-4 alpha-fetoprotein Rattus norvegicus 155-158