PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32192153-2 2020 EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols. diols 84-89 epoxide hydrolase 2 Homo sapiens 0-5 32182938-3 2020 Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion of epoxides derived from long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA), into their corresponding diols. diols 313-318 epoxide hydrolase 2 Homo sapiens 81-106 32182938-3 2020 Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion of epoxides derived from long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA), into their corresponding diols. diols 313-318 epoxide hydrolase 2 Homo sapiens 108-111 29960002-1 2018 CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). diols 150-155 epoxide hydrolase 2 Homo sapiens 159-184 32176647-3 2020 Oxylipins generated from the cytochrome P450 pathway are enzymatically converted to diols by soluble epoxide hydrolase (sEH); sEH products have been associated with small vessel ischemic disease. diols 84-89 epoxide hydrolase 2 Homo sapiens 93-118 32176647-3 2020 Oxylipins generated from the cytochrome P450 pathway are enzymatically converted to diols by soluble epoxide hydrolase (sEH); sEH products have been associated with small vessel ischemic disease. diols 84-89 epoxide hydrolase 2 Homo sapiens 120-123 32176647-3 2020 Oxylipins generated from the cytochrome P450 pathway are enzymatically converted to diols by soluble epoxide hydrolase (sEH); sEH products have been associated with small vessel ischemic disease. diols 84-89 epoxide hydrolase 2 Homo sapiens 126-129 29960002-1 2018 CYP epoxygenases metabolize arachidonic acid into four regioisomers of epoxyeicosatrienoic acids (EETs) which are hydrolysed into their corresponding diols by soluble epoxide hydrolase (sEH). diols 150-155 epoxide hydrolase 2 Homo sapiens 186-189 30031209-3 2018 EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to form corresponding diols, thereby reducing their biological activity. diols 77-82 epoxide hydrolase 2 Homo sapiens 23-48 30031209-3 2018 EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to form corresponding diols, thereby reducing their biological activity. diols 77-82 epoxide hydrolase 2 Homo sapiens 50-53 26621325-2 2016 Epoxyeicosatrienoic acids can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH). diols 67-72 epoxide hydrolase 2 Homo sapiens 87-112 26621325-2 2016 Epoxyeicosatrienoic acids can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH). diols 67-72 epoxide hydrolase 2 Homo sapiens 114-117 25824304-3 2016 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. diols 238-243 epoxide hydrolase 2 Homo sapiens 8-27 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. diols 225-230 epoxide hydrolase 2 Homo sapiens 155-180 27079253-3 2016 Epoxyecosatrienoic acids (EETs), the products of arachidonic acid metabolism mediated by cytochrome P450 (CYP) 2J, 2C and other isoforms, are regulated by soluble epoxide hydrolase (sEH)-catalyzed conversion into less active diols. diols 225-230 epoxide hydrolase 2 Homo sapiens 182-185 25824304-3 2016 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. diols 238-243 epoxide hydrolase 2 Homo sapiens 29-34 25824304-3 2016 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. diols 238-243 epoxide hydrolase 2 Homo sapiens 119-144 25824304-3 2016 Because epoxide hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN. diols 238-243 epoxide hydrolase 2 Homo sapiens 146-149 26453326-2 2015 Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. diols 64-69 epoxide hydrolase 2 Homo sapiens 0-25 26453326-2 2015 Soluble epoxide hydrolase (sEH) metabolizes EETs to less active diols, thus diminishing their biological activity. diols 64-69 epoxide hydrolase 2 Homo sapiens 27-30 25330284-6 2015 The omega3-epoxides, like the EETs, are metabolized by the soluble epoxide hydrolase (sEH) to corresponding diols, and epoxide hydrolase inhibition increases epoxide levels and demonstrates anti-hypertensive as well as anti-inflammatory effects. diols 108-113 epoxide hydrolase 2 Homo sapiens 59-84 25330284-6 2015 The omega3-epoxides, like the EETs, are metabolized by the soluble epoxide hydrolase (sEH) to corresponding diols, and epoxide hydrolase inhibition increases epoxide levels and demonstrates anti-hypertensive as well as anti-inflammatory effects. diols 108-113 epoxide hydrolase 2 Homo sapiens 86-89 25173047-2 2014 EETs are hydrolyzed to less biologically active diols by soluble epoxide hydrolase (encoded for by EPHX2). diols 48-53 epoxide hydrolase 2 Homo sapiens 99-104 22298653-2 2012 The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. diols 137-142 epoxide hydrolase 2 Homo sapiens 83-108 23701967-1 2013 Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. diols 83-88 epoxide hydrolase 2 Homo sapiens 10-35 23701967-1 2013 Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols through the addition of a water molecule. diols 83-88 epoxide hydrolase 2 Homo sapiens 37-40 22303912-2 2013 EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH). diols 67-72 epoxide hydrolase 2 Homo sapiens 76-101 22303912-2 2013 EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH). diols 67-72 epoxide hydrolase 2 Homo sapiens 103-106 22116511-8 2012 However, EETs are quickly degraded by the enzyme soluble epoxide hydrolase (sEH) to their less active diols, dihydroxyeicosatrienoic acids (DHETs). diols 102-107 epoxide hydrolase 2 Homo sapiens 49-74 22116511-8 2012 However, EETs are quickly degraded by the enzyme soluble epoxide hydrolase (sEH) to their less active diols, dihydroxyeicosatrienoic acids (DHETs). diols 102-107 epoxide hydrolase 2 Homo sapiens 76-79 22298653-2 2012 The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. diols 137-142 epoxide hydrolase 2 Homo sapiens 110-113 20339956-2 2010 Under physiological conditions, EETs are quickly converted by the soluble epoxide hydrolase (sEH) to diols which do not have the beneficiary roles. diols 101-106 epoxide hydrolase 2 Homo sapiens 93-96 21825980-4 2011 However, targeting the sEH which metabolizes fatty acid epoxides to their corresponding diols is a highly effective way of manipulating levels of these lipid mediators in vivo. diols 88-93 epoxide hydrolase 2 Homo sapiens 23-26 20531214-3 2010 One approach has been to prevent the conversion of EETs to their inactive diols by inhibiting the soluble epoxide hydrolase (sEH) enzyme. diols 74-79 epoxide hydrolase 2 Homo sapiens 98-123 20531214-3 2010 One approach has been to prevent the conversion of EETs to their inactive diols by inhibiting the soluble epoxide hydrolase (sEH) enzyme. diols 74-79 epoxide hydrolase 2 Homo sapiens 125-128 19794443-2 2009 These endogenous lipid mediators are broken down into diols by soluble epoxide hydrolase (sEH), and so inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs. diols 54-59 epoxide hydrolase 2 Homo sapiens 63-88 20425256-2 2010 Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols. diols 119-124 epoxide hydrolase 2 Homo sapiens 25-50 20425256-2 2010 Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols. diols 119-124 epoxide hydrolase 2 Homo sapiens 52-55 19794443-2 2009 These endogenous lipid mediators are broken down into diols by soluble epoxide hydrolase (sEH), and so inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs. diols 54-59 epoxide hydrolase 2 Homo sapiens 90-93 16961727-1 2006 Soluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water. diols 97-102 epoxide hydrolase 2 Homo sapiens 0-25 16961727-1 2006 Soluble epoxide hydrolase (sEH) is an enzyme responsible for the conversion of lipid epoxides to diols by the addition of water. diols 97-102 epoxide hydrolase 2 Homo sapiens 27-30 16961727-3 2006 Conversion of arachidonic acid epoxides to diols by sEH diminishes the beneficial cardiovascular properties of these epoxyeicosano-ids. diols 43-48 epoxide hydrolase 2 Homo sapiens 52-55 10775430-3 2000 The observed toxicity of ltx and iltx is, in fact, due to the metabolism of the epoxides to their corresponding diols by soluble epoxide hydrolase (sEH). diols 112-117 epoxide hydrolase 2 Homo sapiens 121-146 18221075-2 2006 Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols. diols 340-345 epoxide hydrolase 2 Homo sapiens 0-25 18221075-2 2006 Soluble epoxide hydrolase (sEH, formerly referred to as cytosolic epoxide hydrolase), which is widely distributed in mammalian tissues, is the primary enzyme responsible for the conversion of epoxyeicosatrienoic acids (EETs), the bioactive lipid mediators formed from arachidonic acid by cytochrome P450 epoxygenase, to their corresponding diols. diols 340-345 epoxide hydrolase 2 Homo sapiens 27-30 10775430-3 2000 The observed toxicity of ltx and iltx is, in fact, due to the metabolism of the epoxides to their corresponding diols by soluble epoxide hydrolase (sEH). diols 112-117 epoxide hydrolase 2 Homo sapiens 148-151 10775319-11 2000 These data support the hypothesis that long-chain epoxy fatty acid methyl esters are potential pro-toxins metabolized by sEH to more toxic diols. diols 139-144 epoxide hydrolase 2 Homo sapiens 121-124