PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9157990-1	1997	The anticancer oxazaphosphorine prodrugs cyclophosphamide and ifosfamide are activated in human liver by a 4-hydroxylation reaction catalyzed by multiple cytochrome P450 (CYP) enzymes.	oxazaphosphorine	15-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	154-169	
10348794-1	1999	The contributions of specific human liver cytochrome P-450 (CYP) enzymes to the activation, via 4-hydroxylation, of the oxazaphosphorine anticancer prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) were investigated.	oxazaphosphorine	120-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	42-58	
10348794-1	1999	The contributions of specific human liver cytochrome P-450 (CYP) enzymes to the activation, via 4-hydroxylation, of the oxazaphosphorine anticancer prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) were investigated.	oxazaphosphorine	120-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	60-63	
9157990-8	1997	These studies: (a) demonstrate an underlying metabolic basis for the clinically important oxazaphosphorine autoinduction pharmacokinetics seen with these drugs in cancer patients; and (b) identify rifampin and other CYP inducers as potentially useful for increasing the rates of cyclophosphamide 4-hydroxylation and ifosfamide 4-hydroxylation in human liver in a manner that could favorably impact the clinical pharmacokinetics of these anticancer prodrugs.	oxazaphosphorine	90-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	216-219	
9157990-1	1997	The anticancer oxazaphosphorine prodrugs cyclophosphamide and ifosfamide are activated in human liver by a 4-hydroxylation reaction catalyzed by multiple cytochrome P450 (CYP) enzymes.	oxazaphosphorine	15-31	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	171-174