PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2913311-5 1989 The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). Ethyl 4-nitrophenyl methylphosphonate 254-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Ethyl 4-nitrophenyl methylphosphonate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Ethyl 4-nitrophenyl methylphosphonate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203