PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10220355-4 1999 In this paper, we report that several divalent metal cations, such as Mn2+, Co2+, Ni2+, and Zn2+ bind to the second Mg2+-binding site of Csk with up to 13200-fold higher affinity than Mg2+. Manganese(2+) 70-74 C-terminal Src kinase Homo sapiens 137-140 10220355-6 1999 Substitution by these divalent metal cations resulted in varied levels of Csk activity, with Mn2+ even more effective than Mg2+. Manganese(2+) 93-97 C-terminal Src kinase Homo sapiens 74-77