PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2548622-4	1989	Increased calcium influx could be evoked for several minutes after the addition of thrombin, it was selectively inhibited by Mg2+ (20 mM) and Ni2+ (1 mM) ions, by neomycin and by PCMB, a non-penetrating SH-group reagent.	Nickel(2+)	142-146	coagulation factor II, thrombin	Homo sapiens	83-91	
2705995-8	1989	Under conditions designed to prevent an increase in [Ca2+]i (presence of Ni2+ to prevent Ca2+ entry, and depletion of the intracellular Ca2+ stores), aggregation induced by thrombin resembles that by phorbol dibutyrate and is now inhibited completely by staurosporine.	Nickel(2+)	73-77	coagulation factor II, thrombin	Homo sapiens	173-181	
7723744-5	1995	Similarly, short term exposure to Ni2+ ions, which also prevent Ca2+ entry, inhibited thrombin-stimulated formation of inositol phosphates.	Nickel(2+)	34-38	coagulation factor II, thrombin	Homo sapiens	86-94	
15850220-2	2005	The effects of some BC (Ca2+, Fe2+, Zn2+, Cd2+, Co2+ and Ni2+) on thrombin-induced plasma clotting and clot lysis caused by streptokinase have been studied.	Nickel(2+)	57-61	coagulation factor II, thrombin	Homo sapiens	66-74	
15850220-6	2005	So, ions of Co2+, Cd2+, Zn2+ and Ni2+ but not Fe2+ significantly influence the dynamics of thrombin-induced clot formation and optical clot characteristics.	Nickel(2+)	33-37	coagulation factor II, thrombin	Homo sapiens	91-99	
8603105-4	1996	The platelet-evoked rises in [Ca2+]i in endothelial cells, similarly as the thrombin-evoked rises, were blocked by preincubation of HUVEC with the phospholipase C inhibitor U73122 or the Ca2+ influx blocker Ni2+.	Nickel(2+)	207-211	coagulation factor II, thrombin	Homo sapiens	76-84	
1310589-13	1992	Thrombin stimulated Mn2+ influx, which was blocked by Ni2+.	Nickel(2+)	54-58	coagulation factor II, thrombin	Homo sapiens	0-8	
8279529-0	1993	Ni2+ impairs thrombin-induced signal transduction by acting on the agonist and/or receptor in human platelets.	Nickel(2+)	0-4	coagulation factor II, thrombin	Homo sapiens	13-21