PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32141296-3	2020	Herein, we demonstrate that we can obtain accurate structural and absolute binding free energies of Co2+ and Ni2+ to the enzyme glyoxalase I using an optimized 12-6-4 (m12-6-4) potential.	Nickel(2+)	109-113	glyoxalase I	Homo sapiens	128-140	
18533363-3	2008	Detailed studies have determined that the glyoxalase I from Escherichia coli, Neisseria meningitidis and Yersinia pestis are maximally activated by Ni2+ and Co2+, and are inactive with Zn2+, a situation quite different from the human glyoxalase I enzyme, which is activated by Zn2+.	Nickel(2+)	148-152	glyoxalase I	Homo sapiens	42-54	
18533363-4	2008	Recent studies on the Pseudomonas aeruginosa genome have led to the characterization of three different glyoxalase I enzymes, two of which follow a Ni2+/Co2+ activation profile and the third exhibits a human-like preference for Zn2+.	Nickel(2+)	148-152	glyoxalase I	Homo sapiens	104-116	
21310258-3	2011	Detailed studies have determined that a number of bacterial Glyoxalase I enzymes are maximally activated by Ni(2+) and Co(2+) ions, but are inactive in the presence of Zn(2+).	Nickel(2+)	108-114	glyoxalase I	Homo sapiens	60-72	
28034013-5	2018	We have shown that the enzyme possesses glyoxalase I activity in the presence of Zn2+, Mg2+, Ni2+, and Co2+, in this order of preference.	Nickel(2+)	93-97	glyoxalase I	Homo sapiens	40-52	
28358304-6	2017	Plants possess both Ni2+- and Zn2+-dependent forms of GLYI, and studies on plant glyoxalases reveal the various unique features of these enzymes distinguishing them from prokaryotic and other eukaryotic glyoxalases.	Nickel(2+)	20-24	glyoxalase I	Homo sapiens	54-58	
24646264-1	2014	A number of bacterial glyoxalase I enzymes are maximally activated by Ni2+ and Co2+ ions, but are inactive in the presence of Zn2+, yet these enzymes will also bind this metal ion.	Nickel(2+)	70-74	glyoxalase I	Homo sapiens	22-34	
24220130-2	2013	The first enzyme of this pathway, glyoxalase I (GlxI), uses methylglyoxal as a substrate and requires either Ni(II)/Co(II) or Zn(II) for activity.	Nickel(2+)	109-115	glyoxalase I	Homo sapiens	34-46