PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34153849-2	2021	METHODS: Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and employed as a carrier for the delivery of glucose oxidase (GOx) and doxorubicin (Dox) (COF/GOx/Dox) for the therapy of MDR lung cancers.	cupric ion	30-34	hydroxyacid oxidase 1	Homo sapiens	188-191	
34153849-0	2021	Glucose oxidase loaded Cu2+ based metal-organic framework for glutathione depletion/reactive oxygen species elevation enhanced chemotherapy.	cupric ion	23-27	hydroxyacid oxidase 1	Homo sapiens	0-15	
34153849-2	2021	METHODS: Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and employed as a carrier for the delivery of glucose oxidase (GOx) and doxorubicin (Dox) (COF/GOx/Dox) for the therapy of MDR lung cancers.	cupric ion	30-34	hydroxyacid oxidase 1	Homo sapiens	139-154	
34153849-2	2021	METHODS: Here in our study, a Cu2+ based metal-organic framework (COF) was firstly developed and employed as a carrier for the delivery of glucose oxidase (GOx) and doxorubicin (Dox) (COF/GOx/Dox) for the therapy of MDR lung cancers.	cupric ion	30-34	hydroxyacid oxidase 1	Homo sapiens	156-159	
35076646-4	2022	GOx catalyzes conversion of glucose into H2O2, and the Cu2+ ions then convert H2O2 into  OH to kill bacteria, thereby showing a domino effect.	cupric ion	55-59	hydroxyacid oxidase 1	Homo sapiens	0-3	
32156109-3	2020	In the preparation processes, the glucose oxidase (GOx) hybrid nanoflowers were first synthesized via a self-assembly mechanism, and then, glucoamylase (GA) was adsorbed on the surface of GOx hybrid nanoflowers through the interaction of Cu2+ and amino acids of GA.	cupric ion	238-242	hydroxyacid oxidase 1	Homo sapiens	34-49	
32156109-3	2020	In the preparation processes, the glucose oxidase (GOx) hybrid nanoflowers were first synthesized via a self-assembly mechanism, and then, glucoamylase (GA) was adsorbed on the surface of GOx hybrid nanoflowers through the interaction of Cu2+ and amino acids of GA.	cupric ion	238-242	hydroxyacid oxidase 1	Homo sapiens	51-54	
32156109-3	2020	In the preparation processes, the glucose oxidase (GOx) hybrid nanoflowers were first synthesized via a self-assembly mechanism, and then, glucoamylase (GA) was adsorbed on the surface of GOx hybrid nanoflowers through the interaction of Cu2+ and amino acids of GA.	cupric ion	238-242	hydroxyacid oxidase 1	Homo sapiens	188-191	
25863343-4	2015	First, GOx, as a molecular recognition element, catalyzes the oxidation of glucose forming H2O2; then PLDz recognizes the produced H2O2 as a secondary signal and performs a self-cleavage reaction promoted by Mn(2+), Co(2+) and Cu(2+).	cupric ion	227-233	hydroxyacid oxidase 1	Homo sapiens	7-10	
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	cupric ion	239-243	hydroxyacid oxidase 1	Homo sapiens	90-93	
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	cupric ion	239-243	hydroxyacid oxidase 1	Homo sapiens	216-231	
31423772-2	2019	In this work, a bifunctional hybrid enzyme-catalytic metal organic framework reactor (GAA@GOx@Cu-MOF) with a flower-shaped globular structure was innovatively prepared via self-assembling of alpha-glucosidase (GAA), glucose oxidase (GOx), Cu2+, and 4,4"-bipyridine.	cupric ion	239-243	hydroxyacid oxidase 1	Homo sapiens	233-236	
30677737-1	2019	We develop a glucose oxidase (GOx)-mediated strategy for detecting glucose based on oxidized 3,3",5,5"-tetramethylbenzidine (oxTMB), which is generated from Cu2+-catalyzed 3,3",5,5"-tetramethylbenzidine (TMB)-H2O2 reaction, as colorimetric readout.	cupric ion	157-161	hydroxyacid oxidase 1	Homo sapiens	13-28	
30677737-1	2019	We develop a glucose oxidase (GOx)-mediated strategy for detecting glucose based on oxidized 3,3",5,5"-tetramethylbenzidine (oxTMB), which is generated from Cu2+-catalyzed 3,3",5,5"-tetramethylbenzidine (TMB)-H2O2 reaction, as colorimetric readout.	cupric ion	157-161	hydroxyacid oxidase 1	Homo sapiens	30-33	
22634106-3	2012	In addition, an online enzyme inhibition study was performed on the immobilized GOx microreactor with metal ions Ag+ and Cu2+ used as model inhibitors.	cupric ion	121-125	hydroxyacid oxidase 1	Homo sapiens	80-83	
21627304-3	2011	Although EDTA is not redox-active, it is detected by the activation of a Cu(2+)-inhibited GOx bioanode in either a typical amperometric sensor (using a standard three-electrode setup) or in a self-powered sensor where the GOx bioanode is coupled to a platinum cathode.	cupric ion	73-79	hydroxyacid oxidase 1	Homo sapiens	90-93	
21627304-3	2011	Although EDTA is not redox-active, it is detected by the activation of a Cu(2+)-inhibited GOx bioanode in either a typical amperometric sensor (using a standard three-electrode setup) or in a self-powered sensor where the GOx bioanode is coupled to a platinum cathode.	cupric ion	73-79	hydroxyacid oxidase 1	Homo sapiens	222-225