PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12578834-5 2003 The relevance of HO-1 in NGF-induced ROS reduction was further demonstrated by the evidence that cells treated with the HO-1 inhibitor tin-protoporphyrin or infected with a retroviral expression vector for antisense HO-1 exhibited enhanced ROS release in response to 6-OHDA, despite the presence of the neurotrophin. tin protoporphyrin IX 135-153 heme oxygenase 1 Rattus norvegicus 120-124 16198371-5 2005 This angiogenic response was repressed by tin-protoporphyrin IX (SnPP), an HO-1 inhibitor, along with downregulation of VEGF expression. tin protoporphyrin IX 42-63 heme oxygenase 1 Rattus norvegicus 75-79 12819870-2 2003 We investigated the protective role of HO-1, induced by tin-protoporphyrin IX (SnPP), in attenuating liver transplantation injury. tin protoporphyrin IX 56-77 heme oxygenase 1 Rattus norvegicus 39-43 15543205-4 2005 Therapeutic administration of the HO-1 inhibitor tin protoporphyrin IX was able to control the symptoms of arthritis. tin protoporphyrin IX 49-70 heme oxygenase 1 Rattus norvegicus 34-38 15226216-5 2004 Cotreatment of cells with tin protoporphyrin IX, a HO inhibitor, significantly reversed the suppressive effect of HO-1. tin protoporphyrin IX 26-47 heme oxygenase 1 Rattus norvegicus 114-118 14662543-10 2003 Blockade of HO in vivo with tin protoporphyrin IX abolished the sex differences caused by diverse HO1 expression. tin protoporphyrin IX 28-49 heme oxygenase 1 Rattus norvegicus 98-101 12919086-5 2003 However, inhibition of HO-1 with tin protoporphyrin reversed cytoprotective/antiapoptotic effects of IL-13. tin protoporphyrin IX 33-51 heme oxygenase 1 Rattus norvegicus 23-27 12121889-6 2002 These effects were abolished by the heme-oxygenase-1 (HO-1) inhibitor tin protoporphyrin (Sn-PP). tin protoporphyrin IX 70-88 heme oxygenase 1 Rattus norvegicus 36-52 12121889-6 2002 These effects were abolished by the heme-oxygenase-1 (HO-1) inhibitor tin protoporphyrin (Sn-PP). tin protoporphyrin IX 70-88 heme oxygenase 1 Rattus norvegicus 54-58 11981758-6 2002 HO-1 was specifically induced and inhibited by cobalt protoporphyrin and tin protoporphyrin, respectively. tin protoporphyrin IX 73-91 heme oxygenase 1 Rattus norvegicus 0-4 12133272-7 2002 These beneficial effects were abrogated after adjunctive treatment with tin protoporphyrin (SnPP), an HO-1 antagonist. tin protoporphyrin IX 72-90 heme oxygenase 1 Rattus norvegicus 102-106 11223432-3 2001 Rats were subjected to left carotid artery (LCA) balloon injury following pre-treatment with either vehicle, the HO-1 inducer hemin (50 mg/kg, SC), or concomitant treatment with hemin and the HO-1 inhibitor tin-protoporphyrin IX (SnPP-IX; 50 micromol/kg, IP). tin protoporphyrin IX 207-228 heme oxygenase 1 Rattus norvegicus 192-196 11723024-6 2001 In a separate group of animals, concomitant treatment of Ad-HO-1 with the HO-1 inhibitor tin protoporphyrin completely restored each morphometric parameter to control levels. tin protoporphyrin IX 89-107 heme oxygenase 1 Rattus norvegicus 60-64 11723024-6 2001 In a separate group of animals, concomitant treatment of Ad-HO-1 with the HO-1 inhibitor tin protoporphyrin completely restored each morphometric parameter to control levels. tin protoporphyrin IX 89-107 heme oxygenase 1 Rattus norvegicus 74-78 11734449-6 2001 These effects of Hb were reduced by the HO-1 inhibitor tin-protoporphyrin (Sn-PP 20 micromol/kg), while Sn-PP had no effect in the absence of Hb. tin protoporphyrin IX 55-73 heme oxygenase 1 Rattus norvegicus 40-44 11260115-4 2001 In a second group of animals, after heat-shock priming, the action of HSP-32 was inhibited by tin protoporphyrin IX. tin protoporphyrin IX 94-115 heme oxygenase 1 Rattus norvegicus 70-76 11260115-10 2001 Inhibition of HSP-32 by tin protoporphyrin IX completely abolished the priming-induced improvement in capillary perfusion, as indicated by the lack of increased capillary diameters and volumetric blood flow. tin protoporphyrin IX 24-45 heme oxygenase 1 Rattus norvegicus 14-20 11238670-5 2001 Under the same immunosuppressive regimen that allows mouse-to-rat cardiac transplants to survive long term (i.e., cobra venom factor plus cyclosporin A), inhibition of HO-1 activity by tin protoporphyrin, caused graft rejection in 3--7 days. tin protoporphyrin IX 185-203 heme oxygenase 1 Rattus norvegicus 168-172 11238670-7 2001 Under inhibition of HO-1 activity by tin protoporphyrin, exogenous CO suppressed graft rejection and restored long-term graft survival. tin protoporphyrin IX 37-55 heme oxygenase 1 Rattus norvegicus 20-24 9239406-10 1997 Treatment of sheared SMCs with the HO-1 inhibitor, tin protoporphyrin-IX, blocked the antiaggregatory effect of the cells, whereas the iNOS inhibitor, methyl--arginine, had no effect. tin protoporphyrin IX 51-72 heme oxygenase 1 Rattus norvegicus 35-39 10425182-7 1999 Local application of tin protoporphyrin, a HO inhibitor, blocked this effect, suggesting that induced HO-1 in the carotid artery was responsible for the inhibition of neointimal formation after balloon injury. tin protoporphyrin IX 21-39 heme oxygenase 1 Rattus norvegicus 102-106 10559009-7 1999 Incubation of platelets with PDGF-treated SMCs resulted in a significant increase in platelet cGMP concentration that was reversed by treatment of SMCs with the HO-1 inhibitor tin protoporphyrin-IX or by addition of the CO scavenger hemoglobin to platelets. tin protoporphyrin IX 176-197 heme oxygenase 1 Rattus norvegicus 161-165 33713981-4 2021 Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs. tin protoporphyrin IX 73-94 heme oxygenase 1 Rattus norvegicus 58-62 7589541-4 1995 Tin-protoporphyrin (SnPP) prevents protection, suggesting involvement of hsp32 (heme oxygenase) and/or guanylyl cyclase (GC). tin protoporphyrin IX 0-18 heme oxygenase 1 Rattus norvegicus 73-78 33713981-4 2021 Of note, Nrf2 transcription factor inhibitor brusatol and HO-1 inhibitor tin protoporphyrin IX (SnppIX) reversed BMSCs induced down-expression of NLRP3 and caspase-1 (p20), and inhibited the protective effects of BMSCs. tin protoporphyrin IX 96-102 heme oxygenase 1 Rattus norvegicus 58-62 29738777-0 2018 Heme oxygenase-1 inhibitor tin-protoporphyrin improves liver regeneration after partial hepatectomy. tin protoporphyrin IX 27-45 heme oxygenase 1 Rattus norvegicus 0-16 29738777-1 2018 AIMS: This study investigates the effects of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO-1 in the regulation of cellular growth. tin protoporphyrin IX 83-104 heme oxygenase 1 Rattus norvegicus 49-65 29738777-1 2018 AIMS: This study investigates the effects of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO-1 in the regulation of cellular growth. tin protoporphyrin IX 83-104 heme oxygenase 1 Rattus norvegicus 67-71 28589248-5 2017 Tin protoporphyrin (SnPP) is a HO-1 inhibitor. tin protoporphyrin IX 0-18 heme oxygenase 1 Rattus norvegicus 31-35 26193830-4 2015 MATERIALS AND METHODS: Adult male Sprague-Dawley rats were randomized to receive I/R, I/R plus cepharanthine, or I/R plus cepharanthine plus the HO-1 activity inhibitor tin protoporphyrin (SnPP; n = 12 in each group). tin protoporphyrin IX 169-187 heme oxygenase 1 Rattus norvegicus 145-149 28635609-6 2017 In order to elucidate the possible role of HO-1 in mediating the protective effects of ghrelin, tin protoporphyrin (SnPP) HO-1 blocker was administrated; it significantly attenuated the gastroprotective effect of ghrelin. tin protoporphyrin IX 96-114 heme oxygenase 1 Rattus norvegicus 122-126 25402296-11 2014 Heme oxygenase-1 was inhibited with tin protoporphyrin IX. tin protoporphyrin IX 36-57 heme oxygenase 1 Rattus norvegicus 0-16 25402296-17 2014 The inhibition of heme oxygenase-1 with tin protoporphyrin IX in rats or heme oxygenase-1-specific small interfering RNA in mice decreased ischemic preconditioning-induced autophagy and diminished the protective effects of ischemic preconditioning against ischemia/reperfusion injury. tin protoporphyrin IX 40-61 heme oxygenase 1 Rattus norvegicus 18-34 23333396-9 2013 Moreover, a selective HO-1 inhibitor, tin protoporphyrin IX (SnPP), significantly blocked the anti-ischemic effect of LMT-335. tin protoporphyrin IX 38-59 heme oxygenase 1 Rattus norvegicus 22-26 24337631-8 2014 Moreover, pretreatment of tin protoporphyrin IX (SnPP), a chemical inhibitor of HO-1, reversed the ability of isothamnetin to inhibit COX-2 expression. tin protoporphyrin IX 26-47 heme oxygenase 1 Rattus norvegicus 80-84 24434421-5 2014 These effects were abolished by pre-incubation of cells with concentrations of BTCC or PTCC that maximize HO-1 induction and were reversed by the inhibitor of heme oxygenase activity tin protoporphyrin IX (SnPPIX). tin protoporphyrin IX 206-212 heme oxygenase 1 Rattus norvegicus 106-110 21514603-7 2012 Inversely, the administration of tin protoporphyrin IX (SnPPN), a specific inhibitor of HO-1, completely abolished the therapeutic effects of octreotide, indicating that the favorable effects of octreotide against intestinal I/R injury is predominantly dependent on the early induction of HO-1. tin protoporphyrin IX 33-54 heme oxygenase 1 Rattus norvegicus 88-92 21514603-7 2012 Inversely, the administration of tin protoporphyrin IX (SnPPN), a specific inhibitor of HO-1, completely abolished the therapeutic effects of octreotide, indicating that the favorable effects of octreotide against intestinal I/R injury is predominantly dependent on the early induction of HO-1. tin protoporphyrin IX 33-54 heme oxygenase 1 Rattus norvegicus 289-293 22718607-7 2012 After the induction of HO-1 by hemin, gut barrier failure and apoptosis were abrogated in the immature gut, while the inhibition of HO-1 by tin protoporphyrin IX significantly aggravated gut injury. tin protoporphyrin IX 140-161 heme oxygenase 1 Rattus norvegicus 132-136 22461332-5 2012 The protection was abolished when the cultures were transfected with nuclear factor (erythroid-derived 2) like-2-shRNA or coincubated with tin protoporphyrin IX, a specific HO-1 inhibitor. tin protoporphyrin IX 139-160 heme oxygenase 1 Rattus norvegicus 173-177 21198546-5 2011 This protection was decreased by an inhibitor of HO-1 action, tin protoporphyrin. tin protoporphyrin IX 62-80 heme oxygenase 1 Rattus norvegicus 49-53 21075647-9 2011 These potential benefits of simvastatin were all abolished by co-application of tin protoporphyrin-IX (SnPP), a specific heme oxygenase-1 (HO-1) inhibitor. tin protoporphyrin IX 80-101 heme oxygenase 1 Rattus norvegicus 121-137 21275512-10 2011 The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP). tin protoporphyrin IX 149-167 heme oxygenase 1 Rattus norvegicus 36-40 21275512-10 2011 The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP). tin protoporphyrin IX 149-167 heme oxygenase 1 Rattus norvegicus 79-83 21275512-10 2011 The protective effects of CoPP were HO-1 dependent because the upregulation of HO-1 and the RGC protection were both abolished by the HO-1 inhibitor tin protoporphyrin (SnPP). tin protoporphyrin IX 149-167 heme oxygenase 1 Rattus norvegicus 79-83 21075647-9 2011 These potential benefits of simvastatin were all abolished by co-application of tin protoporphyrin-IX (SnPP), a specific heme oxygenase-1 (HO-1) inhibitor. tin protoporphyrin IX 80-101 heme oxygenase 1 Rattus norvegicus 139-143 19646271-8 2009 Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor. tin protoporphyrin IX 246-250 heme oxygenase 1 Rattus norvegicus 38-43 20194885-9 2010 Conversely, we observed a significant reduction in the expression of vascular endothelial growth factor in nondiabetic and diabetic animals treated with tin protoporphyrin (SnPP, a heme oxygenase-1 enzyme inhibitor), even after Ad.Trx1 therapy. tin protoporphyrin IX 153-171 heme oxygenase 1 Rattus norvegicus 181-197 19520142-8 2009 In contrast, inhibition of HO activity by administration of tin protoporphyrin IX (SnPP, a specific inhibitor of HO) abolished the neuroprotective effects of HO-1 induction. tin protoporphyrin IX 60-81 heme oxygenase 1 Rattus norvegicus 158-162 19646271-8 2009 Systemic treatment of siRNA targeting rHO-1 reduced hepatic HO-1 expression and decreased the serum bilirubin levels in a time- and dose-dependent manner, and siRNA decreased the indirect bilirubin levels more effectively than Sn-protoporphyrin (SnPP), an HO-1 inhibitor. tin protoporphyrin IX 246-250 heme oxygenase 1 Rattus norvegicus 39-43 19372106-4 2009 One group of rats received ketamine (70 mg/kg ip) or saline concurrently with either the HO-1 inhibitor tin protoporphyrin IX (50 micromol/kg ip) or saline. tin protoporphyrin IX 104-125 heme oxygenase 1 Rattus norvegicus 89-93 19885007-7 2009 Aprotinin effects were reversed by pre-treatment with the HO-1 inhibitor, tin protoporphyrin IX (SnPPIX). tin protoporphyrin IX 74-95 heme oxygenase 1 Rattus norvegicus 58-62 19885007-7 2009 Aprotinin effects were reversed by pre-treatment with the HO-1 inhibitor, tin protoporphyrin IX (SnPPIX). tin protoporphyrin IX 97-103 heme oxygenase 1 Rattus norvegicus 58-62 18563666-5 2008 Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of ISL on PDGF-induced proliferation is mediated by HO-1. tin protoporphyrin IX 29-47 heme oxygenase 1 Rattus norvegicus 142-146 17292349-8 2007 In contrast, the HO-1 inhibitor, zinc protoporphyrin (50 micromol/kg/day, s.c) significantly increased the colonic damage and myeloperoxidase activity over 10 days, as did tin protoporphyrin (30 micromol/kg/day, s.c). tin protoporphyrin IX 172-190 heme oxygenase 1 Rattus norvegicus 17-21 17437850-9 2007 In addition, the protective effects of hemin were significantly offset by the heme oxygenase-1 inhibitor tin protoporphyrin. tin protoporphyrin IX 105-123 heme oxygenase 1 Rattus norvegicus 78-94 16982036-7 2006 Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of TMMC on PDGF-induced proliferation is mediated by HO-1. tin protoporphyrin IX 29-47 heme oxygenase 1 Rattus norvegicus 143-147