PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8291131-1	1993	Natural porphyrin (hemin and its synthetic analogue--tetraphenylporphyrin with iron TPP-Fe3+) has been studied for its effect on activity of monooxygenase responses and cytochrome P-450 content against a background of introduction of four-chlorine carbon in the in vitro experiments.	Hemin	19-24	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	169-185	
15451555-2	2004	Inhibitory effects of hemin on the cytochrome P450 (CYP)-catalyzed reactions of human liver microsomes and reconstituted systems containing purified CYP and NADPH-cytochrome P450 reductase (NPR) were seen.	Hemin	22-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	52-55	
15451555-3	2004	Hemin non-specifically inhibited all of the microsomal CYP activities examined.	Hemin	0-5	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	55-58	
15451555-6	2004	Spectrally detectable CYP was destroyed in human liver microsomes and in a reconstituted system in the presence of hemin and an NADPH-generating system.	Hemin	115-120	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-25	
15451555-7	2004	We propose that the antimutagenic effect of hemin might be due to inhibition of CYP and NPR enzymes involved in the bioactivation of mutagens.	Hemin	44-49	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	80-83	
15451555-0	2004	Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin.	Hemin	72-77	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-48	
15451555-2	2004	Inhibitory effects of hemin on the cytochrome P450 (CYP)-catalyzed reactions of human liver microsomes and reconstituted systems containing purified CYP and NADPH-cytochrome P450 reductase (NPR) were seen.	Hemin	22-27	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	35-50	
8291131-2	1993	The reducing effect of hemin and TPP-Fe3+ on cytochrome P-450 and dependent enzymes: N-demethylase, n-hydroxylase and benz(a)pyrene hydroxylase has been noticed; the synthetic analogue of heme was more efficient.	Hemin	23-28	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	45-61	
208787-0	1978	A model of cytochrome P-450; optical and EPR properties of a thiol-containing peptide-hemin system and its activity of aniline hydroxylation.	Hemin	86-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	11-27	
2298305-2	1990	The apoenzyme thus produced could be reconstituted to catalytically active cytochrome P-450 by incubation with hemin, the reconstitution efficiency being 50% for the soluble enzyme and 80% for the liposome-bound enzyme.	Hemin	111-116	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-91	
880239-10	1977	Apo-(cytochrome P-450) is capable of binding to the endoplasmic reticulum in a form and at a site, which can be reconstituted with haemin to yield the functional protein.	Hemin	131-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	5-21