PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24658119-1	2014	We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase, Cdk2.	Methylcholanthrene	67-87	H3 histone pseudogene 16	Homo sapiens	175-178	
24535918-1	2014	We previously identified that activation of the aryl hydrocarbon receptor (AhR) by 3-methylcholanthrene (3MC) exerts antiproliferative and antimigratory effects on human umbilical vein endothelial cells (HUVECs) through the upregulation of p21/p27 transcription and RhoA activation.	Methylcholanthrene	83-103	H3 histone pseudogene 16	Homo sapiens	240-243	
24535918-1	2014	We previously identified that activation of the aryl hydrocarbon receptor (AhR) by 3-methylcholanthrene (3MC) exerts antiproliferative and antimigratory effects on human umbilical vein endothelial cells (HUVECs) through the upregulation of p21/p27 transcription and RhoA activation.	Methylcholanthrene	105-108	H3 histone pseudogene 16	Homo sapiens	240-243	
24535918-3	2014	Our results indicated that 3MC reduced the phosphorylation of p21/p27 through AhR/RhoA/PTEN-mediated PI3K/Akt inactivation, which reduced cytosolic p21/p27 retention, causing RhoA activation through positive feedback.	Methylcholanthrene	27-30	H3 histone pseudogene 16	Homo sapiens	62-65	
24535918-3	2014	Our results indicated that 3MC reduced the phosphorylation of p21/p27 through AhR/RhoA/PTEN-mediated PI3K/Akt inactivation, which reduced cytosolic p21/p27 retention, causing RhoA activation through positive feedback.	Methylcholanthrene	27-30	H3 histone pseudogene 16	Homo sapiens	148-151	
24535918-4	2014	Downregulation of p21/p27 by siRNA, and cytosolic p21/p27 by the nuclear export blocker leptomycin B, further reduced cell migration in the 3MC-treated cells.	Methylcholanthrene	140-143	H3 histone pseudogene 16	Homo sapiens	18-21	
24535918-4	2014	Downregulation of p21/p27 by siRNA, and cytosolic p21/p27 by the nuclear export blocker leptomycin B, further reduced cell migration in the 3MC-treated cells.	Methylcholanthrene	140-143	H3 histone pseudogene 16	Homo sapiens	50-53	
24658119-1	2014	We previously showed that treating vascular endothelial cells with 3-methylcholanthrene (3MC) caused cell-cycle arrest in the Go/G1 phase; this resulted from the induction of p21 and p27 and a decreased level and activity of the cyclin-dependent kinase, Cdk2.	Methylcholanthrene	89-92	H3 histone pseudogene 16	Homo sapiens	175-178	
16142311-8	2005	MC (68%, 100%) showed a higher frequency of expression of APC protein and p21 than NMC (19%, p<0.001; 45%, p<0.01).	Methylcholanthrene	0-2	H3 histone pseudogene 16	Homo sapiens	74-77	
18022818-0	2008	Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells.	Methylcholanthrene	49-69	H3 histone pseudogene 16	Homo sapiens	24-27	
18022818-2	2008	Herein, pretreatment of HUVECs with p21 or p27 small interfering (si)RNA reduced 3MC-induced elimination of [(3)H]thymidine incorporation, demonstrating their essential roles in the antiproliferation of HUVECs.	Methylcholanthrene	81-84	H3 histone pseudogene 16	Homo sapiens	36-39	
18022818-3	2008	The molecular mechanisms of p21 and p27 involved in the antiproliferative effects of 3MC were elucidated in this study.	Methylcholanthrene	85-88	H3 histone pseudogene 16	Homo sapiens	28-31	
18022818-5	2008	Interestingly, 3MC-mediated p21 and p27 inductions were eliminated by resveratrol, an AhR antagonist, suggesting their AhR dependency, further confirmed by AhR siRNA.	Methylcholanthrene	15-18	H3 histone pseudogene 16	Homo sapiens	28-31	
18022818-6	2008	Among the relevant pathways, p38MAPK activation sustained the levels of p21 and p27 induced by 3MC, which was eliminated by AhR antagonists and N-acetylcysteine (NAC), an antioxidant.	Methylcholanthrene	95-98	H3 histone pseudogene 16	Homo sapiens	72-75	
18022818-7	2008	3MC concentration-dependently enhanced not only the consensus dioxin-responsive element (DRE)-driven luciferase activity, but also the binding activity of the AhR to the putative DRE derived from the p21 and p27 promoters.	Methylcholanthrene	0-3	H3 histone pseudogene 16	Homo sapiens	200-203	
18022818-8	2008	A deletion of the DRE (-285/-270) in p21 (-2,300/+8) only partially alleviated the 3MC-induced luciferase activity unless NAC was added, suggesting that there may be a DRE-independent mechanism associated with oxidative stress.	Methylcholanthrene	83-86	H3 histone pseudogene 16	Homo sapiens	37-40	
18022818-10	2008	Our study demonstrated that both the functional DRE and the phosphorylation of p38MAPK are essential for the induction of p21 and p27, resulting in the antiproliferative action of 3MC in HUVECs.	Methylcholanthrene	180-183	H3 histone pseudogene 16	Homo sapiens	122-125