PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11698172-5 2001 The MC-induced ECOD and EROD activities were also dose-dependently inhibited by alpha-naphothflavone, which was given to the cells during the incubation with CYP 1A1 inducers. Methylcholanthrene 4-6 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 158-165 10859152-7 2000 In three independent experiments, a 48-h exposure to 3-methylcholanthrene, omeprazole, and lansoprazole significantly induced CYP1A1 expression in comparison to untreated cultures (P <.05). Methylcholanthrene 53-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-132 11513080-6 2001 Expression of CYP 1A1 and 1A2 messenger ribonucleic acid by the cells was induced by treatment with benz[a]pyrene, 3-methylcholanthrene, and benz[a]anthracene. Methylcholanthrene 115-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-21 11324719-4 2001 CYP1A1 mRNA level is induced 1) in HepG2 and HT29-D4 cells by 3-methylcholanthrene 2) only in HepG2 after treatment by serum. Methylcholanthrene 62-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 11231298-5 2001 Methylcholanthrene induced an increase in CYP1A1/2 enzyme activity (eightfold), phenobarbital induced CYP2B6 activity (1.7-fold), and dexamethasone induced CYP3A4 activity (fivefold). Methylcholanthrene 0-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 9454825-5 1998 When hepatocytes were treated with inducers, marked increases in the specific activities of CYP1A1/2 by 3-methylcholanthrene and CYP3A4 by rifampicin were observed, and these inductive effects were greatly reduced in the presence of HGF. Methylcholanthrene 104-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 92-98 10631103-4 2000 After treatment of CaCo-2 cells with fetal bovine serum, CYP1A1 mRNA level increased to the same extent as that observed after 3-methylcholanthrene induction. Methylcholanthrene 127-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 10445394-1 1999 Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1-inducer from Ah receptor-ligands, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. Methylcholanthrene 183-203 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 9784250-1 1998 Benzimidazole compounds, such as omeprazole and thiabendazole, are a different type of CYP1A1 inducer from Ah receptor-ligands, such as TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and 3-methylcholanthrene. Methylcholanthrene 183-203 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 10799337-7 2000 Surprisingly, in corresponding experiments using 3-methylcholanthrene (3-MC) as a CYP1A1 inducer, DFB was less effective. Methylcholanthrene 49-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 10799337-7 2000 Surprisingly, in corresponding experiments using 3-methylcholanthrene (3-MC) as a CYP1A1 inducer, DFB was less effective. Methylcholanthrene 71-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 20654500-4 1999 CYP 1A1/1A2 protein was not detected, neither in G nor in C HepG2 cells but was strongly induced by 3-methylcholanthrene (3-MC) treatment. Methylcholanthrene 100-120 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-7 20654500-4 1999 CYP 1A1/1A2 protein was not detected, neither in G nor in C HepG2 cells but was strongly induced by 3-methylcholanthrene (3-MC) treatment. Methylcholanthrene 122-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-7 9860486-6 1998 Known prototype inducers such as beta-naphthoflavone and 3-methylcholanthrene exhibited the highest inducing potency quantified with an Imax value (maximal induction of cytochrome P450 1A1 mRNA synthesis) of 5.48 and 10.7 x 10(6) mRNA molecules per 150 ng of total RNA, respectively. Methylcholanthrene 57-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-188 9783729-7 1998 CYP1A1 and CYP1B1, additional CYP1 enzymes regulated by the aryl hydrocarbon receptor (AHR), also were inducible by TCDD and MC in LS180 cells; their concentration-dependent induction was highly correlated with induction of CYP1A2 at mRNA, protein, and catalytic levels. Methylcholanthrene 125-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 9783729-7 1998 CYP1A1 and CYP1B1, additional CYP1 enzymes regulated by the aryl hydrocarbon receptor (AHR), also were inducible by TCDD and MC in LS180 cells; their concentration-dependent induction was highly correlated with induction of CYP1A2 at mRNA, protein, and catalytic levels. Methylcholanthrene 125-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 9731718-4 1998 AHH inducibility (3-methylcholanthrene-induced/non-induced AHH activity) showed a very wide interindividual variation as well as non-induced AHH activity. Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-3 9731718-4 1998 AHH inducibility (3-methylcholanthrene-induced/non-induced AHH activity) showed a very wide interindividual variation as well as non-induced AHH activity. Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-62 9731718-4 1998 AHH inducibility (3-methylcholanthrene-induced/non-induced AHH activity) showed a very wide interindividual variation as well as non-induced AHH activity. Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-62 9388470-0 1997 Upstream stimulatory factor 1 (USF1) suppresses induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) in HepG2 cells. Methylcholanthrene 76-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 61-67 9388470-0 1997 Upstream stimulatory factor 1 (USF1) suppresses induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) in HepG2 cells. Methylcholanthrene 98-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 61-67 9388470-7 1997 Furthermore, the S1 nuclease protection assay showed that the induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) was depressed by the transfection of USF1-SR alpha into HepG2 cells. Methylcholanthrene 90-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 9388470-7 1997 Furthermore, the S1 nuclease protection assay showed that the induction of CYP1A1 mRNA by 3-methylcholanthrene (MC) was depressed by the transfection of USF1-SR alpha into HepG2 cells. Methylcholanthrene 112-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 9219504-9 1997 Further, MCF-7/0 and MCF-7/OAP cells treated with 3-methylcholanthrene, but not those treated with catechol, transiently expressed elevated levels of cytochrome P450 1A1 and were transiently more sensitive to ellipticine. Methylcholanthrene 50-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 150-169 20654333-0 1997 Comparative study of CYP1A1 induction by 3-methylcholanthrene in various human hepatic and epidermal cell types. Methylcholanthrene 41-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 20654333-3 1997 In these cell types, the effects of 3-methylcholanthrene (3-MC) were analysed on CYP1A1 gene expression, a crucial CYP subfamily in the activation of chemical carcinogens. Methylcholanthrene 36-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 20654333-3 1997 In these cell types, the effects of 3-methylcholanthrene (3-MC) were analysed on CYP1A1 gene expression, a crucial CYP subfamily in the activation of chemical carcinogens. Methylcholanthrene 58-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 20654333-8 1997 This study also demonstrated that 3-MC is capable of significantly inducing CYP1A1 in HaCaT cells (17-fold over control), as in human hepatocytes (six- to 18-fold) and HepG2 (fourfold). Methylcholanthrene 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-82 11360624-1 1997 With specific designed primers, CYP2B6 and CYP1A1 cDNA were generated by reverse transcription-polymerase chain reaction(RT-PCR) technique performed on total RNAs isolated from human liver and 3-methylcholanthrene(3-MC) induced human amnion FL cells. Methylcholanthrene 193-213 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 7808430-5 1994 TGF-beta 1 proved to be the most effective cytokine, because 72 hr of treatment with 2 ng/ml TGF-beta 1 produced nearly 100% inhibition of 3-MC- and benzo(a)pyrene-induced CYP1A1 and CYP1A2 mRNAs and EROD activity. Methylcholanthrene 139-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-3 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-55 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-55 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 40-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-3 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 40-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-55 8609043-2 1996 AHH inducibility (3-methylcholanthrene (MC)-induced AHH activity/non-induced AHH activity) was correlated with the MspI polymorphism (P < 0.0001) and age class (P = 0.015), whereas no correlation was found for the Ile-Val polymorphism (P = 0.509). Methylcholanthrene 40-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-55 7662117-2 1995 Hepatocytes from all 15 individuals tested responded to treatment with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with induction of CYP1A1 mRNA. Methylcholanthrene 71-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 161-167 7662117-2 1995 Hepatocytes from all 15 individuals tested responded to treatment with 3-methylcholanthrene (MC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with induction of CYP1A1 mRNA. Methylcholanthrene 93-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 161-167 7756127-3 1995 This study has shown that the expression of CYP1A1 and UGT is concomitantly induced by 3-methylcholanthrene, dimethylbenz[a]anthracene, and RA, and that of NADPH reductase is only enhanced by phenobarbital and RA. Methylcholanthrene 87-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 7756127-5 1995 Using the reverse transcriptase-polymerase chain reaction, we have demonstrated that the effects of 3-methylcholanthrene, dimethylbenz[a]anthracene and RA on CYP1A1 expression correlate with an increase of CYP1A1 mRNA level. Methylcholanthrene 100-120 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 158-164 7756127-5 1995 Using the reverse transcriptase-polymerase chain reaction, we have demonstrated that the effects of 3-methylcholanthrene, dimethylbenz[a]anthracene and RA on CYP1A1 expression correlate with an increase of CYP1A1 mRNA level. Methylcholanthrene 100-120 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 206-212 7734403-4 1995 The RNA for CYP 1A1 was dramatically and completely induced within 2 hours after exposure of immortalized granulosa cells to 3-methyl-cholanthrene (3MC) and expression could be inhibited with 10 microM phorbol myristate acetate. Methylcholanthrene 125-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-19 7734403-4 1995 The RNA for CYP 1A1 was dramatically and completely induced within 2 hours after exposure of immortalized granulosa cells to 3-methyl-cholanthrene (3MC) and expression could be inhibited with 10 microM phorbol myristate acetate. Methylcholanthrene 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-19 8161348-2 1994 Treatment of cells with IL-6 decreased the level of 3-methylcholanthrene-induced CYPIA1 protein and its mRNA. Methylcholanthrene 52-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 8380963-4 1993 3-Methylcholanthrene, beta-naphthoflavone, and benz[alpha]anthracene were strong inducers of CYP1A1, benzo[alpha]pyrene induced CYP1A1 activity only weakly, while benzo[e]pyrene and phenobarbital were essentially inactive as inducers. Methylcholanthrene 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-99 8380963-4 1993 3-Methylcholanthrene, beta-naphthoflavone, and benz[alpha]anthracene were strong inducers of CYP1A1, benzo[alpha]pyrene induced CYP1A1 activity only weakly, while benzo[e]pyrene and phenobarbital were essentially inactive as inducers. Methylcholanthrene 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 2747632-8 1989 In comparison, when a DNA fragment that contained a copy of the human Cyp1A1 xenobiotic-responsive element was analyzed for enhancer activity, 3-methylcholanthrene initiated chloramphenicol acetyltransferase activity in both HepG2 cells and MCF-7 cells. Methylcholanthrene 143-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 1282830-1 1992 Three cDNAs coding for monkey cytochrome P-450 (P450) 2C, 2E and 3A (MKmp13, MKj1 and MKnf2, respectively) were isolated from a lambda gt11 cDNA library of a liver from a 3-methylcholanthrene (3MC)-treated crab-eating monkey, using cDNA fragments for human P450 2C, 2E and 3A as respective probes. Methylcholanthrene 171-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-67 1282830-1 1992 Three cDNAs coding for monkey cytochrome P-450 (P450) 2C, 2E and 3A (MKmp13, MKj1 and MKnf2, respectively) were isolated from a lambda gt11 cDNA library of a liver from a 3-methylcholanthrene (3MC)-treated crab-eating monkey, using cDNA fragments for human P450 2C, 2E and 3A as respective probes. Methylcholanthrene 193-196 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-67 1761516-6 1991 A fusion gene which was constructed by ligating the upstream region of the human P-450c gene to the chloramphenicol acetyltransferase (CAT) gene expressed the CAT activity in response to the inducer, methylcholanthrene, when transfected into Hepa-1 cells. Methylcholanthrene 200-218 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 3839750-4 1985 Translation in vitro of 3-methylcholanthrene-induced mRNA, selected with the human P1-450 genomic clone, detect a protein with Mr 52000, which is immunoprecipitable by the anti-(mouse P1-450) antibody. Methylcholanthrene 24-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 3839750-4 1985 Translation in vitro of 3-methylcholanthrene-induced mRNA, selected with the human P1-450 genomic clone, detect a protein with Mr 52000, which is immunoprecipitable by the anti-(mouse P1-450) antibody. Methylcholanthrene 24-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 184-190 3839750-5 1985 The isolated human P1-450 genomic clone hybridizes to 3-methylcholanthrene-induced mRNA from monkey liver, benzanthracene and 3-methylcholanthrene-treated human mammary tumor cells (MCF-7), but not to isosafrole-treated human cells. Methylcholanthrene 54-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-25 3839750-5 1985 The isolated human P1-450 genomic clone hybridizes to 3-methylcholanthrene-induced mRNA from monkey liver, benzanthracene and 3-methylcholanthrene-treated human mammary tumor cells (MCF-7), but not to isosafrole-treated human cells. Methylcholanthrene 126-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 19-25 32730838-6 2020 3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1. Methylcholanthrene 0-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 32730838-7 2020 The potent aryl hydrocarbon receptor antagonist GNF351 significantly suppressed the 3-MC- and VPA-mediated upregulation of CYP1B1 and CYP1A1. Methylcholanthrene 84-88 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 134-140 32730838-8 2020 In addition, VPA potentiated the induction of CYP1B1 and CYP1A1 by 3-MC, B[a]A, and B[a]P, although the augmentation of CYP1A1 was more remarkable than that of CYP1B1. Methylcholanthrene 67-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 32730838-11 2020 Therefore, the effects of trichostatin A, a representative HDAC inhibitor, on CYP1 induction by 3-MC were examined. Methylcholanthrene 96-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-82 32730838-12 2020 Trichostatin A enhanced the 3-MC-mediated upregulation of CYP1A1 but not CYP1B1. Methylcholanthrene 28-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 31776611-9 2020 However, both 3-MC and TCDD potently induced CYP1A1 gene expression and modestly increased CYP1A1 enzyme activity in human islets after 48 h. The induction of CYP1A1 in human islets by TCDD was prevented by cotreatment with a cytokine mixture. Methylcholanthrene 14-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 31776611-9 2020 However, both 3-MC and TCDD potently induced CYP1A1 gene expression and modestly increased CYP1A1 enzyme activity in human islets after 48 h. The induction of CYP1A1 in human islets by TCDD was prevented by cotreatment with a cytokine mixture. Methylcholanthrene 14-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 31776611-9 2020 However, both 3-MC and TCDD potently induced CYP1A1 gene expression and modestly increased CYP1A1 enzyme activity in human islets after 48 h. The induction of CYP1A1 in human islets by TCDD was prevented by cotreatment with a cytokine mixture. Methylcholanthrene 14-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Methylcholanthrene 111-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 29980579-5 2018 CYP1A1 mRNA levels were determined after treatment with varying concentrations of 3-methylcholanthrene (3MC). Methylcholanthrene 82-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29980579-5 2018 CYP1A1 mRNA levels were determined after treatment with varying concentrations of 3-methylcholanthrene (3MC). Methylcholanthrene 104-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29980579-7 2018 LCLs with the AA genotype displayed significantly higher AHR-XRE binding and CYP1A1 mRNA expression after 3MC treatment than did those with the GG genotype. Methylcholanthrene 106-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-83 29980579-9 2018 In conclusion, we have demonstrated that the rs2470893 SNP, which maps 196 bp from a CYP1A1 promoter XRE, is associated with variations in 3MC-dependent AHR binding and CYP1A1 expression. Methylcholanthrene 139-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 28384415-5 2017 MC strongly induced CYP1A1 mRNA levels and markedly downregulated CYP2C8 mRNA levels in HepaRG cells. Methylcholanthrene 0-2 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Methylcholanthrene 133-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 26296470-0 2015 Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1alpha. Methylcholanthrene 38-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 26296470-7 2015 CAPE-mediated HIF-1alpha reduced 3-MC-inducible CYP1A1 protein expression. Methylcholanthrene 33-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 26296470-8 2015 Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1alpha induction. Methylcholanthrene 31-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 26970402-6 2016 Three of the 12mer peptides (namely 11-3, 1-7, and 7-3) suppressed the 3MC-induced, CYP1A1-dependent EROD activity and the ROS production caused by benzo[a]pyrene. Methylcholanthrene 71-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 26296470-2 2015 In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. Methylcholanthrene 50-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 26296470-2 2015 In this study, we examined the effects of CAPE on 3-methylcholanthrene (3-MC)-induced CYP1A1 expression and activities. Methylcholanthrene 72-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 26296470-4 2015 Moreover, CAPE inhibited 3-MC-induced CYP1A1 activity, mRNA expression, protein level, and promoter activity. Methylcholanthrene 25-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-44 22673034-5 2012 The levels of CYP1A1, CYP1A2, and UGT1A1 mRNA expression were increased by omeprazole and 3-methylcholanthrene. Methylcholanthrene 90-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 24663500-3 2014 The expression and activity of CYP1A1, 2B6 and 2E1 were carried out in the cells exposed to CYP inducers viz., 3-methylcholanthrene (3-MC), cyclophosphamide (CPA), ethanol and known neurotoxicant- monocrotophos (MCP), a widely used organophosphorous pesticide. Methylcholanthrene 111-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 24663500-3 2014 The expression and activity of CYP1A1, 2B6 and 2E1 were carried out in the cells exposed to CYP inducers viz., 3-methylcholanthrene (3-MC), cyclophosphamide (CPA), ethanol and known neurotoxicant- monocrotophos (MCP), a widely used organophosphorous pesticide. Methylcholanthrene 133-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 24091107-3 2013 We found that dexamethasone dose- and time-dependently suppresses CYP1A1 transactivation in gene reporter assays, CYP1A1 mRNA induction, and upregulation of 7-ethoxyresorufin-O-deethylase (EROD) activity by 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in JEG-3 cells. Methylcholanthrene 207-227 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 24091107-3 2013 We found that dexamethasone dose- and time-dependently suppresses CYP1A1 transactivation in gene reporter assays, CYP1A1 mRNA induction, and upregulation of 7-ethoxyresorufin-O-deethylase (EROD) activity by 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in JEG-3 cells. Methylcholanthrene 229-231 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 24091107-4 2013 Co-transfection of JEG-3 cells with glucocorticoid receptor (GR) expression construct and treatment with dexamethasone abolished the effect of MC on CYP1A1 promoter construct in transient transfection gene reporter assays. Methylcholanthrene 143-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 23603339-4 2013 In primary human hepatocytes, DHEA diminished the increase in CYP1A activities (7-ethoxyresorufin O-dealkylation and phenacetin O-dealkylation) and in CYP1A2 mRNA level induced by 3-methylcholanthrene, but did not alter the amount of CYP1A1 and CYP1B1 mRNA. Methylcholanthrene 180-200 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 234-240 25112181-6 2014 In studying the concentration dependent effects of the environmental toxicant 3-methylcholanthrene (3MC) on the activation of cytochrome P450 1A1 (Cyp 1A1) enzyme in H4IIE rat hepatoma cells, statistical variation of the Cyp 1A1 response was significantly lower (C.V. = 5 %) when using the developed mixture generator compared to that using the conventional gradient generator (C.V. = 12 %). Methylcholanthrene 78-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-145 25112181-6 2014 In studying the concentration dependent effects of the environmental toxicant 3-methylcholanthrene (3MC) on the activation of cytochrome P450 1A1 (Cyp 1A1) enzyme in H4IIE rat hepatoma cells, statistical variation of the Cyp 1A1 response was significantly lower (C.V. = 5 %) when using the developed mixture generator compared to that using the conventional gradient generator (C.V. = 12 %). Methylcholanthrene 78-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-154 25112181-6 2014 In studying the concentration dependent effects of the environmental toxicant 3-methylcholanthrene (3MC) on the activation of cytochrome P450 1A1 (Cyp 1A1) enzyme in H4IIE rat hepatoma cells, statistical variation of the Cyp 1A1 response was significantly lower (C.V. = 5 %) when using the developed mixture generator compared to that using the conventional gradient generator (C.V. = 12 %). Methylcholanthrene 100-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-145 25112181-6 2014 In studying the concentration dependent effects of the environmental toxicant 3-methylcholanthrene (3MC) on the activation of cytochrome P450 1A1 (Cyp 1A1) enzyme in H4IIE rat hepatoma cells, statistical variation of the Cyp 1A1 response was significantly lower (C.V. = 5 %) when using the developed mixture generator compared to that using the conventional gradient generator (C.V. = 12 %). Methylcholanthrene 100-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 147-154 23846855-4 2013 In concurrence with in silico data, MC exposure significantly up regulates the expression and activity of AHR, CYP1A1 and glutathione S-transferase P1-1 (GSTP1-1) and down regulates the expression of CREB, AMPA and NMDA receptors in hUCBSC-derived neuronal cells at various maturity (0, 2, 4, 8 days of differentiation). Methylcholanthrene 36-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 20051482-7 2010 In conclusion, the results of this study support the hypothesis that MC causes persistent induction of CYP1A1 in human hepatoma cells by mechanisms entailing sustained transcriptional activation of the CYP1A1 promoter via AHR-independent mechanisms. Methylcholanthrene 69-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 103-109 20732958-0 2010 Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. Methylcholanthrene 225-245 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 20732958-2 2010 In this study, we tested the hypothesis that hepatic CYP1A2 differentially regulates mouse hepatic and pulmonary CYP1A1 expression and suppresses transcriptional activation of human CYP1A1 (hCYP1A1) promoter in response to 3-methylcholanthrene (MC) in vivo. Methylcholanthrene 223-243 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 182-188 20732958-2 2010 In this study, we tested the hypothesis that hepatic CYP1A2 differentially regulates mouse hepatic and pulmonary CYP1A1 expression and suppresses transcriptional activation of human CYP1A1 (hCYP1A1) promoter in response to 3-methylcholanthrene (MC) in vivo. Methylcholanthrene 223-243 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 190-197 20732958-2 2010 In this study, we tested the hypothesis that hepatic CYP1A2 differentially regulates mouse hepatic and pulmonary CYP1A1 expression and suppresses transcriptional activation of human CYP1A1 (hCYP1A1) promoter in response to 3-methylcholanthrene (MC) in vivo. Methylcholanthrene 245-247 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 182-188 20732958-2 2010 In this study, we tested the hypothesis that hepatic CYP1A2 differentially regulates mouse hepatic and pulmonary CYP1A1 expression and suppresses transcriptional activation of human CYP1A1 (hCYP1A1) promoter in response to 3-methylcholanthrene (MC) in vivo. Methylcholanthrene 245-247 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 190-197 20732958-7 2010 It is noteworthy that MC caused significant augmentation of human CYP1A1 promoter activation in transgenic mice expressing the hCYP1A1 and the reporter luciferase gene on a Cyp1a2-null background, compared with transgenic mice on the WT background. Methylcholanthrene 22-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 20732958-7 2010 It is noteworthy that MC caused significant augmentation of human CYP1A1 promoter activation in transgenic mice expressing the hCYP1A1 and the reporter luciferase gene on a Cyp1a2-null background, compared with transgenic mice on the WT background. Methylcholanthrene 22-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-134 20732958-8 2010 In contrast, the mouse endogenous hepatic, but not pulmonary, persistent CYP1A1 expression was repressed by MC in the hCYP1A1-Cyp1a2-null mice. Methylcholanthrene 108-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-125 20350595-7 2010 Though the basal expression of CYPs in particular was low in EpiDerm, significant induction of CYP1A1/1B1 activity was observed following treatment with 3-methylcholanthrene. Methylcholanthrene 153-173 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-105 20051482-2 2010 In this investigation, we tested the hypothesis that MC elicits persistent induction of CYP1A1 expression in human hepatoma cells (HepG2) and that this phenomenon is mediated by sustained transcriptional activation of the CYP1A1 promoter. Methylcholanthrene 53-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 20051482-2 2010 In this investigation, we tested the hypothesis that MC elicits persistent induction of CYP1A1 expression in human hepatoma cells (HepG2) and that this phenomenon is mediated by sustained transcriptional activation of the CYP1A1 promoter. Methylcholanthrene 53-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 222-228 20051482-3 2010 Treatment of HepG2 cells with MC resulted in marked induction (8-20-fold) of ethoxyresorufin O-de-ethylase activities, CYP1A1 apoprotein contents, and mRNA levels, which persisted for up to 96 h. MC also caused sustained transcriptional activation of the human CYP1A1 promoter for up to 96 h, as inferred from transient transfection experiments. Methylcholanthrene 30-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 20051482-3 2010 Treatment of HepG2 cells with MC resulted in marked induction (8-20-fold) of ethoxyresorufin O-de-ethylase activities, CYP1A1 apoprotein contents, and mRNA levels, which persisted for up to 96 h. MC also caused sustained transcriptional activation of the human CYP1A1 promoter for up to 96 h, as inferred from transient transfection experiments. Methylcholanthrene 30-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 261-267 21666223-4 2011 In this article, we show that only CYP1A1 messenger RNA (mRNA), but not CYP1A2, CYP1B1, UGT1A1, BCRP, AHR, ARNT, and AHRR mRNAs, is significantly induced in human term placental trophoblast cultures after exposure to prototype AHR ligands/activators 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, omeprazole, and beta-naphthoflavone. Methylcholanthrene 287-307 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 20051482-7 2010 In conclusion, the results of this study support the hypothesis that MC causes persistent induction of CYP1A1 in human hepatoma cells by mechanisms entailing sustained transcriptional activation of the CYP1A1 promoter via AHR-independent mechanisms. Methylcholanthrene 69-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 202-208 20067464-2 2010 The results from real time RT-PCR analysis demonstrated that Nic could induce CYP1 mRNAs and enhance the MC-mediated induction of the CYP1 mRNAs. Methylcholanthrene 105-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 134-138 20067464-6 2010 The present findings demonstrate that Nic can enhance the MC-mediated induction of CYP1s, especially CYP1A1, and the formation of MC-DNA adduct in HepG2 cells. Methylcholanthrene 58-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 101-107 19465936-4 2009 The AhR agonist, 3-methylcholanthrene, induced AhR nuclear translocation and upregulated mRNA levels of the AhR target gene, cytochrome P450 1A1 (CYP1A1). Methylcholanthrene 17-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 125-144 19465936-4 2009 The AhR agonist, 3-methylcholanthrene, induced AhR nuclear translocation and upregulated mRNA levels of the AhR target gene, cytochrome P450 1A1 (CYP1A1). Methylcholanthrene 17-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-152 18559486-9 2008 Stimulation with 3-methylcholanthrene and rifampicin markedly increased CYP1A1/2 or CYP3A4 activities, which could be selectively inhibited by nifedipine, verapamil, ketoconazole, and quercetin. Methylcholanthrene 17-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-78 19336894-3 2009 CYP1A1 and CYP3A8 mRNAs were significantly induced by 3-methylcholanthrene and rifampicin, respectively. Methylcholanthrene 54-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 19270430-3 2009 In this study, we investigated the mechanism for the repression of 3-methylcholanthrene (3MC)-induced transcription of AhR-regulated genes, CYP1A1, CYP1A2, CYP1B1, and AhR repressor (AhRR), by 5alpha-dihydroteststerone (DHT) in LNCaP and T47D cells, which are androgen receptor (AR)- and AhR-positive. Methylcholanthrene 67-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 19270430-3 2009 In this study, we investigated the mechanism for the repression of 3-methylcholanthrene (3MC)-induced transcription of AhR-regulated genes, CYP1A1, CYP1A2, CYP1B1, and AhR repressor (AhRR), by 5alpha-dihydroteststerone (DHT) in LNCaP and T47D cells, which are androgen receptor (AR)- and AhR-positive. Methylcholanthrene 89-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 19280519-5 2009 Additionally, treatment of the Huh7 cells with 3-methylcholanthrene induced cytochrome P450 (CYP) 1A1 expression. Methylcholanthrene 47-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 76-101 18502397-10 2008 The present results suggest that omeprazole as well as BNF and 3MC activates both human CYP1A1 and CYP1A2 expression through the common regulatory region despite that omeprazole may involve a different cellular signal(s) from BNF and 3MC. Methylcholanthrene 63-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 18502397-7 2008 Reporter assays with deletion constructs have demonstrated that the omeprazole-induced expression of both CYP1A1 and CYP1A2 is mediated via the common regulatory region containing multiple AHR-binding motifs (the nucleotides from -464 to -1829 of human CYP1A1), which is identical with the region for BNF and 3MC induction. Methylcholanthrene 309-312 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-112 18502397-10 2008 The present results suggest that omeprazole as well as BNF and 3MC activates both human CYP1A1 and CYP1A2 expression through the common regulatory region despite that omeprazole may involve a different cellular signal(s) from BNF and 3MC. Methylcholanthrene 234-237 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-94 16968971-6 2006 Exposure to the prototypical Cyp1A1 inducer, 3-methylcholanthrene, 3-MC, resulted in the translocation of SPT1 from a primarily cytoplasmic domain to sites of focal adhesion complexes. Methylcholanthrene 45-65 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 16868070-6 2006 Significant expression of CYP1A1/2 and 3A2 in the cells treated with Matrigel was induced by 3-MC and PCN, respectively. Methylcholanthrene 93-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 17276403-3 2007 MC bound covalently to plasmid DNA (50 micro g) containing human CYP1A1 promoter (pGL3-1A1), when incubated with wild-type (WT) liver microsomes (2 mg) and NAPPH 37 degrees C for 2h, giving rise to 9 adducts, as determined by (32)P-postlabeling. Methylcholanthrene 0-2 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 16968971-6 2006 Exposure to the prototypical Cyp1A1 inducer, 3-methylcholanthrene, 3-MC, resulted in the translocation of SPT1 from a primarily cytoplasmic domain to sites of focal adhesion complexes. Methylcholanthrene 67-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 16968971-8 2006 When compared to the wild type, cells transfected with recombinant SPT1-GFP vectors had significantly attenuated levels of 3-MC-induced Cyp1A1 mRNA, as determined by quantitative reverse transcription PCR. Methylcholanthrene 123-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 136-142 16968971-9 2006 Although all the Glioma cell lines exhibited mitogenic proliferative response in dose response assay with the potent Cyp1A1 inducers 3-MC, 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and benzo [k] fluoranthene, BKF, only the recombinant cell line designated - 75SPT1-GFP, which was transfected with a mutant deletion of SPT1, retained its proliferative capacity at the highest PAH doses used in this study. Methylcholanthrene 133-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 117-123 16393856-5 2005 PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. Methylcholanthrene 166-170 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 16137816-4 2005 The aim of this study was to evaluate, in a Caco-2 cell line, the effect of a coexposure to 3-methylcholanthrene (3MC, AhR ligand) and WY-14643 (WY, PPARalpha ligand) on CYP1A1 expression (enzymatic activity, mRNA level and promoter activity). Methylcholanthrene 92-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 170-176 16137816-5 2005 An additive effect on CYP1A1 expression was shown in cells coexposed with 3MC (0.1 or 1 microM) and a low WY concentration (30 microM) whereas a potentiating effect was observed after coexposure with 3MC (0.1 or 1 microM) and a high WY concentration (200 microM). Methylcholanthrene 74-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 16137816-7 2005 In conclusion, coexposure with 3MC and the PPARalpha agonist WY leads to an additive or potentiating effect on CYP1A1 inducibility, depending on the WY concentration. Methylcholanthrene 31-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 16202979-4 2005 Thus, the aim of this study was to clarify the role of CYP1A1 in the suppression of LXR-mediated signal transductions by 3-methlychoranthrene (MC), one of the PAHs. Methylcholanthrene 143-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 16202979-6 2005 The repression of LXR-mediated signal transductions by MC was restored by co-treatment of HepG2 cells with a CYP1A1 inhibitor, alpha-naphthoflavone, and by the transfection of short interference RNA for CYP1A1. Methylcholanthrene 55-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 16202979-6 2005 The repression of LXR-mediated signal transductions by MC was restored by co-treatment of HepG2 cells with a CYP1A1 inhibitor, alpha-naphthoflavone, and by the transfection of short interference RNA for CYP1A1. Methylcholanthrene 55-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 203-209 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Methylcholanthrene 94-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-42 16191477-3 2006 Typical inducers of the cytochrome P4501A1 (CYP1A1), such as TCDD, benzo(a)pyrene (B(a)P) and 3-methylcholanthrene, have a planar molecular structure in common and bind to the aryl hydrocarbon receptor (AhR). Methylcholanthrene 94-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 16393856-0 2005 CCAAT/enhancer binding protein activation by PD98059 contributes to the inhibition of AhR-mediated 3-methylcholanthrene induction of CYP1A1. Methylcholanthrene 99-119 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 16393856-5 2005 PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. Methylcholanthrene 18-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 16393856-5 2005 PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. Methylcholanthrene 18-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-152 16393856-5 2005 PD98059 inhibited 3-MC induction of CYP1A1 in cells stably transfected with a dominant negative mutant of MKK1, indicating that PD98059 represses CYP1A1 induction by 3-MC irrespective of its MKK1 inhibition. Methylcholanthrene 166-170 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-152 16393856-6 2005 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. Methylcholanthrene 187-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 16393856-6 2005 The role of C/EBP activation by PD98059 in repressing CYP1A1 induction was supported by the observation that a dominant-negative mutant C/EBP abolished the ability of PD98059 to suppress 3-MC induction of CYP1A1. Methylcholanthrene 187-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 205-211 15325265-2 2004 The effect of a coexposure with 3MC, a AhR ligand, and RA, a RAR ligand, which are, respectively, strong and weak CYP1A1 inducers, is poorly known. Methylcholanthrene 32-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-120 16167840-7 2005 In the hCYP1A1 and hCYP1A2 mice, 3-methylcholanthrene (3-MC) induced both human CYP1A1 and CYP1A2 protein in the liver. Methylcholanthrene 33-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 7-14 16167840-7 2005 In the hCYP1A1 and hCYP1A2 mice, 3-methylcholanthrene (3-MC) induced both human CYP1A1 and CYP1A2 protein in the liver. Methylcholanthrene 33-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 16167840-7 2005 In the hCYP1A1 and hCYP1A2 mice, 3-methylcholanthrene (3-MC) induced both human CYP1A1 and CYP1A2 protein in the liver. Methylcholanthrene 55-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 7-14 16167840-7 2005 In the hCYP1A1 and hCYP1A2 mice, 3-methylcholanthrene (3-MC) induced both human CYP1A1 and CYP1A2 protein in the liver. Methylcholanthrene 55-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 15860653-3 2005 The luciferase reporter assay using the CYP1A1 promoter reporter in HeLa cells treated with beta-naphthoflavone or 3-methylcholanthrene, which are known as typical agonists for AhR, showed that reporter activities of the K401R and N487D variants were reduced to 40 to 58% of those of wild-type (WT) but not of the other variants. Methylcholanthrene 115-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 15585370-0 2005 Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha. Methylcholanthrene 22-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 15325265-3 2004 We showed in Caco-2 cells that addition of RA significantly decreased 3MC-induced CYP1A1 expression by -55% for mRNA level and -30% for promoter and enzymatic activities. Methylcholanthrene 70-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 82-88 15325265-7 2004 This interaction explains the decrease of 3MC-induced CYP1A1 expression. Methylcholanthrene 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 15331414-9 2004 The mRNAs for hCYP3A4 and hCYP1A1/2 were induced in the liver in a CYP type-specific manner when the mice were treated with rifampicin and 3-methylcholanthrene, respectively. Methylcholanthrene 139-159 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-35 12941938-0 2003 Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation. Methylcholanthrene 18-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58 14993811-4 2004 MH7A cells express functional aryl hydrocarbon receptor (AhR) as shown by 3-MC-inducible CYP1A1 mRNA expression. Methylcholanthrene 74-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 14672759-7 2004 The induction of AhRR or CYP1A1 expression by 3-methylcholanthrene (3-MC) was observed in MNCs from adults but not from umbilical cord blood. Methylcholanthrene 46-66 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 14672759-7 2004 The induction of AhRR or CYP1A1 expression by 3-methylcholanthrene (3-MC) was observed in MNCs from adults but not from umbilical cord blood. Methylcholanthrene 68-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 12941938-4 2003 3-MC induced CYP1A1 in H4IIE cells in a time- and concentration-dependent manner. Methylcholanthrene 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 12941938-9 2003 Oltipraz (10 microM) significantly inhibited CYP1A1 and CYP1A1-luciferase gene induction by 3-MC with no increase in AhR DNA binding. Methylcholanthrene 92-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 12941938-9 2003 Oltipraz (10 microM) significantly inhibited CYP1A1 and CYP1A1-luciferase gene induction by 3-MC with no increase in AhR DNA binding. Methylcholanthrene 92-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 12941938-11 2003 Overexpression of dominant-negative mutant C/EBP significantly abolished the ability of oltipraz to suppress 3-MC-inducible CYP1A1 and the CYP1A1 reporter gene expression. Methylcholanthrene 109-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 124-130 12941938-12 2003 Consistently, C/EBPbeta overexpression blocked CYP1A1 reporter gene induction by 3-MC. Methylcholanthrene 81-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 47-53 12941938-13 2003 These results provide evidence that oltipraz suppresses 3-MC induction of CYP1A1 gene expression and that activation of C/EBPbeta by oltipraz contributes to suppression of 3-MC-inducible AhR-mediated CYP1A1 expression. Methylcholanthrene 56-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 74-80 12941938-13 2003 These results provide evidence that oltipraz suppresses 3-MC induction of CYP1A1 gene expression and that activation of C/EBPbeta by oltipraz contributes to suppression of 3-MC-inducible AhR-mediated CYP1A1 expression. Methylcholanthrene 172-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 200-206 12604190-5 2003 Somewhat at odds with the foregoing, transient exposure to 3-methylcholanthrene also induced increased levels of ALDH3A1 and CYP1A1 in cultured, essentially ER(-), human breast epithelial MCF-10A cells. Methylcholanthrene 59-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 125-131 12642474-7 2003 In addition, CYP1A1 protein was detected in microsomes from HepG2 cells pretreated with 3-methylcholanthrene but not with the vehicle. Methylcholanthrene 88-108 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 12237110-0 2002 Serum increases CYP1A1 induction by 3-methylcholanthrene. Methylcholanthrene 36-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 12490585-4 2003 As2O3 (2.5-5 microM) was demonstrated to markedly reduce induction of CYP1A1 mRNA and apoprotein levels and gene promotor activity in 3MC-treated Hep3B cells, whereas lower concentrations (0.25-1 microM) were ineffective. Methylcholanthrene 134-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 12237110-4 2002 In this work, we show evidence that the serum does not contain an AhR ligand and we evaluated the effect of a 3-methylcholanthrene (3-MC) and FBS cotreatment on CYP1A1 expression. Methylcholanthrene 110-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 161-167 12237110-4 2002 In this work, we show evidence that the serum does not contain an AhR ligand and we evaluated the effect of a 3-methylcholanthrene (3-MC) and FBS cotreatment on CYP1A1 expression. Methylcholanthrene 132-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 161-167 12237110-7 2002 FBS potentiation of CYP1A1 PAH-mediated induction was related to a significant increase of single strand breaks of DNA as compared to a single 3-MC treatment. Methylcholanthrene 143-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26