PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2775885-0 1989 Strain- and organ-dependent differences in induction of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene. Methylcholanthrene 97-117 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 56-84 109558-0 1979 Parameters influencing quantitation of 3-methylcholanthrene-induced aryl hydrocarbon hydroxylase activity in cultured human lymphocytes. Methylcholanthrene 39-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 68-96 3599463-1 1987 To investigate life environmental factors which affect aryl hydrocarbon hydroxylase (AHH) activity, basal and 3-methylcholanthrene(3-MC)-induced AHH activities were determined by the formation of 3-hydroxybenzo(a)pyrene in cultured lymphocytes obtained from 111 healthy male subjects who lived in Fukuoka Prefecture, Japan. Methylcholanthrene 110-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 85-88 3599463-1 1987 To investigate life environmental factors which affect aryl hydrocarbon hydroxylase (AHH) activity, basal and 3-methylcholanthrene(3-MC)-induced AHH activities were determined by the formation of 3-hydroxybenzo(a)pyrene in cultured lymphocytes obtained from 111 healthy male subjects who lived in Fukuoka Prefecture, Japan. Methylcholanthrene 110-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 145-148 3599463-1 1987 To investigate life environmental factors which affect aryl hydrocarbon hydroxylase (AHH) activity, basal and 3-methylcholanthrene(3-MC)-induced AHH activities were determined by the formation of 3-hydroxybenzo(a)pyrene in cultured lymphocytes obtained from 111 healthy male subjects who lived in Fukuoka Prefecture, Japan. Methylcholanthrene 131-135 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 85-88 3599463-1 1987 To investigate life environmental factors which affect aryl hydrocarbon hydroxylase (AHH) activity, basal and 3-methylcholanthrene(3-MC)-induced AHH activities were determined by the formation of 3-hydroxybenzo(a)pyrene in cultured lymphocytes obtained from 111 healthy male subjects who lived in Fukuoka Prefecture, Japan. Methylcholanthrene 131-135 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 145-148 4720873-0 1973 Evidence of a genetic relationship between susceptibility to 3-methyl-cholanthrene-induced subcutaneous tumors and inducibility of aryl hydrocarbon hydroxylase. Methylcholanthrene 61-82 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 131-159 870187-3 1977 AHH inducibility was determined by comparing lymphocytes from the same person cultured with and without the inducer 3-methylcholanthrene. Methylcholanthrene 116-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-3 63323-1 1976 Interindividual and intraindividual variations in aryl hydrocarbon hydroxylase (AHH) induction by 3-methylcholanthrene were studied in cultured lymphocytes from normal adult volunteers. Methylcholanthrene 98-118 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 50-78 63323-1 1976 Interindividual and intraindividual variations in aryl hydrocarbon hydroxylase (AHH) induction by 3-methylcholanthrene were studied in cultured lymphocytes from normal adult volunteers. Methylcholanthrene 98-118 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 80-83 63323-5 1976 Fetal calf serum may contain inducers of AHH activity that vary with the particular lot of serum, thereby rendering the apparent induction ratio an imprecise indicator of genetic susceptibility to induction by 3-methylcholanthrene. Methylcholanthrene 210-230 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-44 63323-6 1976 The index of heritability for AHH fold inducibility in twins studied with different lots of fetal calf serum (0.80) or with a single lot of fetal calf serum (0.77) suggests nonetheless that genetic rather than environmental factors are mainly responsible for interindividual variations in AHH inducibility by 3-methylcholanthrene in human lymphocytes. Methylcholanthrene 309-329 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-33 907723-0 1977 3-Methylcholanthrene inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes depends upon the extent of blast transformation. Methylcholanthrene 2-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 37-65 32730838-6 2020 3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1. Methylcholanthrene 0-20 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 132-138 32730838-7 2020 The potent aryl hydrocarbon receptor antagonist GNF351 significantly suppressed the 3-MC- and VPA-mediated upregulation of CYP1B1 and CYP1A1. Methylcholanthrene 84-88 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-129 32730838-8 2020 In addition, VPA potentiated the induction of CYP1B1 and CYP1A1 by 3-MC, B[a]A, and B[a]P, although the augmentation of CYP1A1 was more remarkable than that of CYP1B1. Methylcholanthrene 67-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 46-52 31370872-1 2019 BACKGROUND: The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants as well as in the estrogen biosynthesis and metabolism. Methylcholanthrene 36-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 174-180 31370872-1 2019 BACKGROUND: The chemical carcinogen 3-methylcholanthrene (3MC) binds to the aryl hydrocarbon receptor (AHR) that regulates the expression of cytochrome P450 (CYP) enzymes as CYP1B1, which is involved in the oncogenic activation of environmental pollutants as well as in the estrogen biosynthesis and metabolism. Methylcholanthrene 58-61 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 174-180 29039776-7 2017 Results of microarray and subsequent PCR analysis did reveal that estrogen metabolizing and synthesizing enzymes, such as CYP1B1 and aromatase, were increased by 3-MC in hFOB and osteosarcoma cell line, MG-63. Methylcholanthrene 162-166 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 122-128 15746899-3 2004 Complementary DNA of cytochrome CYP1B1 was isolated from carp (Cyprinus carpio) liver 24 h after the injection of 3-methylcholanthrene (3-MC). Methylcholanthrene 114-134 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 32-38 23603339-4 2013 In primary human hepatocytes, DHEA diminished the increase in CYP1A activities (7-ethoxyresorufin O-dealkylation and phenacetin O-dealkylation) and in CYP1A2 mRNA level induced by 3-methylcholanthrene, but did not alter the amount of CYP1A1 and CYP1B1 mRNA. Methylcholanthrene 180-200 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 245-251 19270430-3 2009 In this study, we investigated the mechanism for the repression of 3-methylcholanthrene (3MC)-induced transcription of AhR-regulated genes, CYP1A1, CYP1A2, CYP1B1, and AhR repressor (AhRR), by 5alpha-dihydroteststerone (DHT) in LNCaP and T47D cells, which are androgen receptor (AR)- and AhR-positive. Methylcholanthrene 67-87 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 156-162 19270430-3 2009 In this study, we investigated the mechanism for the repression of 3-methylcholanthrene (3MC)-induced transcription of AhR-regulated genes, CYP1A1, CYP1A2, CYP1B1, and AhR repressor (AhRR), by 5alpha-dihydroteststerone (DHT) in LNCaP and T47D cells, which are androgen receptor (AR)- and AhR-positive. Methylcholanthrene 89-92 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 156-162 15746899-3 2004 Complementary DNA of cytochrome CYP1B1 was isolated from carp (Cyprinus carpio) liver 24 h after the injection of 3-methylcholanthrene (3-MC). Methylcholanthrene 136-140 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 32-38 15746899-10 2004 Carp treated with 3-MC showed expression of CYP1B1 in liver, intestine and gills with distinct induction except for the gills that showed marked constitutive expression. Methylcholanthrene 18-22 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 15750580-8 2004 Despite the structural similarity of CYP1B2 with CYP1B1, which showed induced expression in 3-MC-treated liver, intestine, and gills with marked constitutive expression in gills, CYP1B2 revealed induced expression in gills but not in liver or intestine, and no detectable constitutive expression in the tissues studied. Methylcholanthrene 92-96 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 49-55 11502733-8 2001 Treatment of CL5 cells with 10 microM 3-methylcholanthrene for 24 h induced monooxygenase activity and P450s 1A1 and 1B1 proteins and mRNA levels. Methylcholanthrene 38-58 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 103-120 9783729-7 1998 CYP1A1 and CYP1B1, additional CYP1 enzymes regulated by the aryl hydrocarbon receptor (AHR), also were inducible by TCDD and MC in LS180 cells; their concentration-dependent induction was highly correlated with induction of CYP1A2 at mRNA, protein, and catalytic levels. Methylcholanthrene 125-127 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17