PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3500726-1 1987 The imidazole N-substituted antifungal agents ketoconazole, miconazole and clotrimazole have been shown to be potent inhibitors of oxidative metabolism by both a phenobarbital-induced cytochrome P-450 (P-450b) and a 3-methylcholanthrene-induced cytochrome P-448-protein (P-450c) in reconstituted systems. Methylcholanthrene 216-236 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 195-200 16135659-7 2005 All 23 single assays were validated by assessing the effects (induction or repression) of known inducers (ethanol, 3-methylcholanthrene, rifampicin, dexamethasone, phenobarbital) on P450 expression in human primary hepatocytes. Methylcholanthrene 115-135 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 182-186 8625481-4 1996 32P-Postlabeling assays showed that MCL-5 cells (genetically engineered to express five human cytochromes P450 and microsomal epoxide hydrolase) formed characteristic adduct spots with benz[a]pyrene, benzo[g]chrysene, 7,12-dimethylbenz[a]anthracene, benzidine, sterigmatocystin and 3-methylcholanthrene, whereas CCRF cells did not. Methylcholanthrene 282-302 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 106-143 11360624-1 1997 With specific designed primers, CYP2B6 and CYP1A1 cDNA were generated by reverse transcription-polymerase chain reaction(RT-PCR) technique performed on total RNAs isolated from human liver and 3-methylcholanthrene(3-MC) induced human amnion FL cells. Methylcholanthrene 193-213 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 32-38 11360624-1 1997 With specific designed primers, CYP2B6 and CYP1A1 cDNA were generated by reverse transcription-polymerase chain reaction(RT-PCR) technique performed on total RNAs isolated from human liver and 3-methylcholanthrene(3-MC) induced human amnion FL cells. Methylcholanthrene 214-218 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 32-38 8093105-3 1994 The purified 3-methylcholanthrene (3MC)-induced rat P450 forms, CYP1A1 and CYP1A2, and a possible variant form, CYP1A1*, showed substrate selectivities for propoxyresorufin, methoxyresorufin and ethoxyresorufin, respectively. Methylcholanthrene 13-33 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 52-56 8093105-3 1994 The purified 3-methylcholanthrene (3MC)-induced rat P450 forms, CYP1A1 and CYP1A2, and a possible variant form, CYP1A1*, showed substrate selectivities for propoxyresorufin, methoxyresorufin and ethoxyresorufin, respectively. Methylcholanthrene 35-38 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 52-56 2051622-0 1991 [Immunohistochemical Study of 3-methylcholanthrene inducible cytochrome P-450 in the stomach and liver--a guide of postoperative chemotherapy in gastric cancer]. Methylcholanthrene 30-50 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 72-77 2051622-1 1991 Immunohistochemical determination of 3-methylcholanthrene (MC) inducible cytochrome P-450 (MC-P-450) was investigated in rat and human tissue, and its clinical availability was discussed. Methylcholanthrene 37-57 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 91-99 2051622-1 1991 Immunohistochemical determination of 3-methylcholanthrene (MC) inducible cytochrome P-450 (MC-P-450) was investigated in rat and human tissue, and its clinical availability was discussed. Methylcholanthrene 59-61 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 91-99 2051622-2 1991 Induced by MC, MC-P-450 in rat liver and stomach was well stained immunohistochemically, showing clear contrast against control without induction. Methylcholanthrene 11-13 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-23 3050970-7 1988 These results demonstrate that maternal cigarette smoking induces in the trophoblastic layer of the placenta a cytochrome P-450 form which is detectable immunohistochemically with the monoclonal antibody to 3-methylcholanthrene-inducible P-450 in rat liver. Methylcholanthrene 207-227 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 122-127 118106-5 1979 Addition of phenobarbital or methylcholanthrene at day 5 in culture caused an increase in cytochromes P-450 and P-448, respectively, only in hepatocytes cultured on collagen membranes and confluent fibroblasts. Methylcholanthrene 29-47 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 102-117 25336106-6 2015 Among the cells tested, HepG2 cells were highly responsive to CYP inducers, such as 3-methylcholanthrene for CYP1A2 and phenobarbital for CYP2B6 and CYP3A4. Methylcholanthrene 84-104 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 138-144 3921402-7 1985 However, characteristic of P-450 forms, the synthesis of these proteins was suppressed by 3-methylcholanthrene treatment. Methylcholanthrene 90-110 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 27-32 6438379-1 1984 Cytochrome P-450-dependent oxidative cleavage of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) was investigated in a reconstituted system containing purified phenobarbital-inducible cytochrome P-450 (P-450(1)) or 3-methylcholanthrene-inducible cytochrome P-450 (P-448(1)). Methylcholanthrene 212-232 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 11-16 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Methylcholanthrene 111-131 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Methylcholanthrene 133-135 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 28384415-3 2017 MC suppresses mRNA levels for CYP2C8, an important human P450, in cultured human hepatocytes. Methylcholanthrene 0-2 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 57-61