PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32851964-11	2021	CONCLUSION: Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead structure for design potent alpha-glucosidase inhibitors for treatment of type 2 diabetes.	coumarin	41-49	sucrase-isomaltase	Homo sapiens	127-144	
32926336-10	2021	The obtained result might suggest the potential of new coumarin (1) as a new type of natural PTP1B and alpha-glucosidase inhibitor for further research and development of antidiabetic and obese agents.Graphic abstract.	coumarin	55-63	sucrase-isomaltase	Homo sapiens	103-120	
32851964-0	2021	Novel coumarin containing dithiocarbamate derivatives as potent alpha-glucosidase inhibitors for management of type 2 diabetes.	coumarin	6-14	sucrase-isomaltase	Homo sapiens	64-81	
32851964-3	2021	OBJECTIVE: In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized and evaluated against alpha-glucosidase in vitro and in silico.	coumarin	32-40	sucrase-isomaltase	Homo sapiens	124-141	
31972390-0	2020	Synthesis and biological evaluation of coumarin derivatives as alpha-glucosidase inhibitors.	coumarin	39-47	sucrase-isomaltase	Homo sapiens	63-80	
33376861-0	2020	Discovery of Novel Coumarin Analogs against the alpha-Glucosidase Protein Target of Diabetes Mellitus: Pharmacophore-Based QSAR, Docking, and Molecular Dynamics Simulation Studies.	coumarin	19-27	sucrase-isomaltase	Homo sapiens	48-65	
31972390-1	2020	In this study, two series of coumarin derivatives 5a~i and 6a~i were synthesized, and their inhibitory activity against alpha-glucosidase was determined.	coumarin	29-37	sucrase-isomaltase	Homo sapiens	120-137	
21899493-1	2012	In the present investigation, a QSAR analysis on structurally diverse alpha-glucosidase inhibitors (andrographolide, chromenone, triazole derivatives) was performed and the developed models were validated by various validation methods (LMO, LOO, LSO, bootstrapping, Y-randomization and test set).	coumarin	117-127	sucrase-isomaltase	Homo sapiens	70-87	
31553294-0	2020	Coumarin-based Scaffold as alpha-glucosidase Inhibitory Activity: Implication for Development of Potent Antidiabetic Agents.	coumarin	0-8	sucrase-isomaltase	Homo sapiens	27-44	
31553294-6	2020	Among them, coumarin scaffold has attracted great attention, which can be isolated from various natural products and/or synthesized for the development of novel alpha-glucosidase inhibitors.	coumarin	12-20	sucrase-isomaltase	Homo sapiens	161-178	
31553294-7	2020	Therefore, this review describes the applications of coumarin-containing derivatives based on published reports as alpha-glucosidase inhibitors and will be useful for innovative approaches in the search for novel coumarin-based antidiabetic drugs with less toxicity and more potency.	coumarin	53-61	sucrase-isomaltase	Homo sapiens	115-132	
31553294-7	2020	Therefore, this review describes the applications of coumarin-containing derivatives based on published reports as alpha-glucosidase inhibitors and will be useful for innovative approaches in the search for novel coumarin-based antidiabetic drugs with less toxicity and more potency.	coumarin	213-221	sucrase-isomaltase	Homo sapiens	115-132	
29676183-0	2018	Synthesis & alpha-glucosidase inhibitory & glucose consumption-promoting activities of flavonoid-coumarin hybrids.	coumarin	105-113	sucrase-isomaltase	Homo sapiens	16-33	
29477126-0	2018	Synthesis, alpha-glucosidase inhibition and molecular docking study of coumarin based derivatives.	coumarin	71-79	sucrase-isomaltase	Homo sapiens	11-28	
26964016-0	2016	Design, synthesis and biological evaluation of novel coumarin thiazole derivatives as alpha-glucosidase inhibitors.	coumarin	53-61	sucrase-isomaltase	Homo sapiens	86-103	
22313292-0	2011	Analysis of the alpha-glucosidase inhibitory activity of chromenone derivatives based on their molecular features: a computational study.	coumarin	57-67	sucrase-isomaltase	Homo sapiens	16-33