PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16199156-5	2005	As expected, the coumarin compounds potently inhibit LPS-induced TNFalpha production and ERK phosphorylation in THP-1 cells, with the most potent compound having an IC(50) of 90nM.	coumarin	17-25	tumor necrosis factor	Homo sapiens	65-73	
27491751-0	2016	Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation.	coumarin	17-25	tumor necrosis factor	Homo sapiens	76-79	
16199156-8	2005	Very interestingly, the identified coumarin derivatives are almost identical to a series of inhibitors recently reported that block LPS-induced TNFalpha production.	coumarin	35-43	tumor necrosis factor	Homo sapiens	144-152	
15698778-2	2005	We found that dihydroxy and diacetoxy derivatives of thiocoumarin were more potent in comparison to the corresponding coumarin derivatives in inhibiting TNF-alpha-induced expression of ICAM-1.	coumarin	57-65	tumor necrosis factor	Homo sapiens	153-162	
15109623-0	2004	Discovery and structure-activity relationship of coumarin derivatives as TNF-alpha inhibitors.	coumarin	49-57	tumor necrosis factor	Homo sapiens	73-82	
15109623-1	2004	The discovery and structure-activity relationship of a novel series of coumarin-based TNF-alpha inhibitors is described.	coumarin	71-79	tumor necrosis factor	Homo sapiens	86-95	
15109623-2	2004	Starting from the initial lead 1a, various derivatives were prepared surrounding the coumarin core structure to optimize the in vitro inhibitory activity of TNF-alpha production by human peripheral blood mononuclear cells (hPBMC), stimulated by bacterial lipopolysaccharide (LPS).	coumarin	85-93	tumor necrosis factor	Homo sapiens	157-166