PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27347731-0 2016 Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. coumarin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 27230386-0 2016 Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer"s disease using multifunctional tacrine-coumarin hybrid molecules. coumarin 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 28570763-0 2017 Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties. coumarin 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 28570763-3 2017 With the aim of discovering novel AChE dual binders with improved drug-likeness, homo- and heterodimers containing 2H-chromen-2-one building blocks were developed. coumarin 115-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27214510-3 2016 The SAR study demonstrated that the introduction of benzyloxy moiety on the 7-position of coumarin scaffold can improve the anti-AChE activity. coumarin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 24321276-3 2014 Herein is presented the results of selective screening assays of a coumarin derivatives library using BChE and AChE covalently immobilized onto silica fused capillaries (ICERs, 15 cm x 0.1 mm ID). coumarin 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 26440714-3 2015 Coumarin linked thiourea derivatives were designed, synthesized and evaluated biologically in order to determine their inhibitory activity against acetylcholinesterases (AChE) and butyrylcholinesterases (BChE). coumarin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24321276-5 2014 Two out of 20 coumarin derivatives could be highlighted: compound 17 is more active toward BChE (IC50=109 +- 21 muM) and 19 showed activity against both enzymes (BChE IC50=128 +- 28 muM and hu-AChE IC50=144 +- 40 muM). coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. coumarin 182-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 24591157-0 2013 Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors. coumarin 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 24591157-4 2013 Docking experiments of the designed coumarin-piperazine derivatives were carried out in order to compare the theoretical and experimental binding affinities toward hAChE, to delineate the inhibitory mechanism. coumarin 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-169 22257528-3 2012 The scientists have attempted to explore the coumarin template for synthesizing novel AChE inhibitors with additional pharmacological activities including decrease in beta-amyloid (Abeta) deposition and beta-secretase inhibition that are also important for AD management. coumarin 45-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 22257528-5 2012 The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD. coumarin 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 21217689-6 2011 We also developed a direct screen for protection of acetylcholinesterase from inactivation by nerve agents and used it to isolate variants that degrade the toxic isomer of the coumarin analog and cyclosarin itself with k(cat)/K(M) ~ 10(7) M(-1) min(-1). coumarin 176-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 18778776-0 2008 Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. coumarin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 167-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 167-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18778776-5 2008 The follow-up analysis using kinetic studies demonstrated that coumarin 106 displays mixed-type AChE inhibition with a pIC(50)=4.97+/-0.09 and K(i)=2.36+/-0.17 microM. coumarin 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 18778776-9 2008 This is the first report where AChE inhibitory activity has been associated with coumarin 106, and proof has been given of its convenience as a lead molecule. coumarin 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 34740688-0 2021 Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer"s agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly. coumarin 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 34558680-3 2022 Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34361702-4 2021 Most of the 3-(7-phenyl-3,5-dioxohepta-1,6-dien-1-yl)coumarin derivatives 11-18 resulted in moderated inhibitors of hMAO isoforms and AChE and BuChE activity. coumarin 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 35195417-1 2022 Bioisosteric H/F or CH2OH/CF2H replacement was introduced in coumarin derivatives previously characterized as dual AChE-MAO B inhibitors to probe the effects on both inhibitory potency and drug-likeness. coumarin 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 35300078-0 2022 Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 25088549-0 2014 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Abeta aggregation, and beta-secretase. coumarin 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 25088549-3 2014 In present study, a series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as potent dual-site AChE inhibitors. coumarin 44-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23988412-1 2013 Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. coumarin 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 23140986-0 2012 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. coumarin 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). coumarin 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). coumarin 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 20677317-0 2010 Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. coumarin 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). coumarin 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). coumarin 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 17998161-0 2008 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. coumarin 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-49 16182411-1 2005 Three series of functionalized coumarin compounds were designed and prepared as cholinesterase (AChE and BuChE) inhibitors. coumarin 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 35408542-5 2022 In this work, 21 novel hybrids of BMT and coumarin were synthesized and evaluated for their inhibitory activity on AChE. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. coumarin 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 32781220-0 2020 New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation. coumarin 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 32364046-5 2021 Galbanic acid as a natural compound with a sesquiterpene coumarin scaffold is a weak inhibitor of AChE. coumarin 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. coumarin 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 32643792-3 2020 The new coumarin-1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1,104.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. coumarin 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 31479975-0 2019 Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives. coumarin 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31125474-1 2019 Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 31125474-1 2019 Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 29663860-0 2019 Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. coumarin 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. coumarin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. coumarin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 30008113-4 2018 In this context, we designed and performed molecular recognitions studies of coumarin-based inhibitors towards AChE. coumarin 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29934672-0 2018 Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. coumarin 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 30515636-3 2018 Coumarin based conjugates have been described as potential AChE, BuChE, MAO and beta-amyloid inhibitors. coumarin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29934672-3 2018 Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE. coumarin 52-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29934672-9 2018 Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease. coumarin 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 29390885-3 2018 The aim of the current study was to design multi-targeted directed lead structures based on the coumarin scaffold with inhibitory properties at two key enzymes in disease relevant systems, i.e. acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). coumarin 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 29390885-3 2018 The aim of the current study was to design multi-targeted directed lead structures based on the coumarin scaffold with inhibitory properties at two key enzymes in disease relevant systems, i.e. acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). coumarin 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220