PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17999461-0	2007	Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1.	coumarin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	35-67	
17999461-3	2007	We identify new coumarin-based competitive inhibitors of NQO1, one of which is nanomolar.	coumarin	16-24	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61	
17669387-1	2007	OBJECTIVES: In a preliminary study, NAD(P)H:quinone oxidoreductase 1 (NQO1) was found to be highly expressed in cultured human aortic smooth muscle cells (HASMC) and dicumarol, a NQO1 inhibitor and a coumarin-derived natural anticoagulant, suppressed tumor necrosis factor (TNF)-alpha-induced HASMC migration.	coumarin	200-208	NAD(P)H quinone dehydrogenase 1	Homo sapiens	36-68	
17669387-1	2007	OBJECTIVES: In a preliminary study, NAD(P)H:quinone oxidoreductase 1 (NQO1) was found to be highly expressed in cultured human aortic smooth muscle cells (HASMC) and dicumarol, a NQO1 inhibitor and a coumarin-derived natural anticoagulant, suppressed tumor necrosis factor (TNF)-alpha-induced HASMC migration.	coumarin	200-208	NAD(P)H quinone dehydrogenase 1	Homo sapiens	70-74	
3932474-5	1985	The coumarin-sensitive DT-diaphorase (EC.1.6.99.2) in human liver appears to play a relatively minor role in the dehydrogenase pathway.	coumarin	4-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	23-36	
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	coumarin	49-57	NAD(P)H quinone dehydrogenase 1	Homo sapiens	84-88	
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	coumarin	49-57	NAD(P)H quinone dehydrogenase 1	Homo sapiens	141-145	
3089219-4	1986	DT-Diaphorase has been used to test a lapachol affinity chromatography column designed for purification of another coumarin anticoagulant and lapachol sensitive enzyme, vitamin K epoxide reductase.	coumarin	115-123	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13	
20599803-4	2010	Coumarin-based compounds that are more potent than dicoumarol as inhibitors of recombinant human NQO1 have been identified (Nolan et al., J Med Chem 2009;52:7142-56) The purpose of the work reported here is to demonstrate the functional activity of these agents for inhibiting NQO1 in cells.	coumarin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	97-101	
32812103-4	2020	Additionally, coumarin-pi promoted nuclear factor erythroid 2-related factor 2 (Nrf2) expression and upregulated the protein expression of antioxidantenzymes, including heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidase (NQO1), glutamyl cysteine ligase catalytic subunit (GCLC), and glutamate-cysteine ligase regulatory subunit (GCLM).	coumarin	14-22	NAD(P)H quinone dehydrogenase 1	Homo sapiens	220-224	
32254473-6	2018	DT-diaphorase can annihilate the effect of PET and restore the fluorescence of coumarin.	coumarin	79-87	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13	
20970406-4	2011	Coumarin-based compounds that are more potent than dicoumarol as inhibitors of NQO1 in cells have been identified (Nolan et al., Biochem Pharmacol 2010;80:977-81).	coumarin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	79-83	
30584780-7	2019	The mechanisms and kinetics of enzyme inhibition of coumarin, aesculetin, umbelliferone, and scopoletin using the cell lysates as a source of NQO1 enzyme best fit with an uncompetitive inhibition model.	coumarin	52-60	NAD(P)H quinone dehydrogenase 1	Homo sapiens	142-146	
29325897-3	2018	In this study we have designed, produced and tested a fluorogenic coumarin conjugate which selectively releases highly fluorescent 4-methylumbelliferone (4-MU) in the presence of NQO1.	coumarin	66-74	NAD(P)H quinone dehydrogenase 1	Homo sapiens	179-183	
20599803-4	2010	Coumarin-based compounds that are more potent than dicoumarol as inhibitors of recombinant human NQO1 have been identified (Nolan et al., J Med Chem 2009;52:7142-56) The purpose of the work reported here is to demonstrate the functional activity of these agents for inhibiting NQO1 in cells.	coumarin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	277-281	
19877692-0	2009	Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).	coumarin	39-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	68-101	
19877692-0	2009	Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1).	coumarin	39-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	103-107