PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15749705-10 2005 Without resveratrol, the coumarin of p53-AMC peptide is solvent-exposed and makes no significant contacts with SIRT1. coumarin 25-33 tumor protein p53 Homo sapiens 37-40 32578917-0 2020 A synthetic coumarin derivative (4-flourophenylacetamide-acetyl coumarin) impedes cell cycle at G0/G1 stage, induces apoptosis, and inhibits metastasis via ROS-mediated p53 and AKT signaling pathways in A549 cells. coumarin 12-20 tumor protein p53 Homo sapiens 169-172 14634213-4 2003 We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis. coumarin 49-57 tumor protein p53 Homo sapiens 177-180 14634213-4 2003 We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis. coumarin 49-57 tumor protein p53 Homo sapiens 217-220 31923958-2 2020 To this end, we constructed a novel UV-light cross-linked and pH de-cross-linked coumarin-decorated cationic copolymer functionalized mesoporous silica nanoparticles (MSN) for co-delivery of chemotherapeutic agent 5-FU and tumor suppresser p53 gene. coumarin 81-89 tumor protein p53 Homo sapiens 240-243 28349922-0 2017 Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications. coumarin 0-8 tumor protein p53 Homo sapiens 86-89