PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27671300-4	2017	The apoptotic potential of the coumarin compounds was evaluated against UACC-62 cell by assessing membrane change, mitochondria membrane potential, pro-apoptotic changes were investigated using the AnnexinV-PI staining, JC-1, caspase-3 enzyme kits respectively on flow cytometer.	coumarin	31-39	caspase 3	Homo sapiens	226-235	
26640551-8	2015	These results suggest that the rapid in vivo activation of C-3 is induced by 7-HC, the most relevant biotransformation product of coumarin in humans.	coumarin	130-138	caspase 3	Homo sapiens	59-62	
30826588-5	2019	The coumarin platinum(IV) complex could effectively induce apoptosis of SKOV-3 cells through up-regulating the expression of caspase3 and caspase9.	coumarin	4-12	caspase 3	Homo sapiens	125-133	
30155071-2	2016	Herein, we report a self-validated fluorescent probe which is composed of a coumarin fluorophore as the energy donor and a fluorogen with aggregation-induced emission characteristics (AIEgen) as the energy quencher linked through a caspase-3 specific peptide substrate.	coumarin	76-84	caspase 3	Homo sapiens	232-241	
18210747-0	2007	Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation.	coumarin	0-8	caspase 3	Homo sapiens	113-122	
18210747-6	2007	Coumarin decreased the mitochondrial membrane potential and promoted the release of cytochrome c and the activation of caspase-3 before leading to apoptosis.	coumarin	0-8	caspase 3	Homo sapiens	119-128