PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30826588-5 2019 The coumarin platinum(IV) complex could effectively induce apoptosis of SKOV-3 cells through up-regulating the expression of caspase3 and caspase9. coumarin 4-12 caspase 3 Homo sapiens 125-133 26640551-8 2015 These results suggest that the rapid in vivo activation of C-3 is induced by 7-HC, the most relevant biotransformation product of coumarin in humans. coumarin 130-138 caspase 3 Homo sapiens 59-62 18210747-0 2007 Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and caspase-3 dependent mechanism and NF-kappaB down-regulation. coumarin 0-8 caspase 3 Homo sapiens 113-122 18210747-6 2007 Coumarin decreased the mitochondrial membrane potential and promoted the release of cytochrome c and the activation of caspase-3 before leading to apoptosis. coumarin 0-8 caspase 3 Homo sapiens 119-128 27671300-4 2017 The apoptotic potential of the coumarin compounds was evaluated against UACC-62 cell by assessing membrane change, mitochondria membrane potential, pro-apoptotic changes were investigated using the AnnexinV-PI staining, JC-1, caspase-3 enzyme kits respectively on flow cytometer. coumarin 31-39 caspase 3 Homo sapiens 226-235 30155071-2 2016 Herein, we report a self-validated fluorescent probe which is composed of a coumarin fluorophore as the energy donor and a fluorogen with aggregation-induced emission characteristics (AIEgen) as the energy quencher linked through a caspase-3 specific peptide substrate. coumarin 76-84 caspase 3 Homo sapiens 232-241