PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33376011-1	2021	Two new series of 1,3,4-oxadiazole and coumarin derivatives based on pyrimidine-5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 inhibitory activity.	coumarin	39-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161	
22252110-1	2012	A cubic cage complex assembled from twelve bis-bidentate ligands and eight Co(II) ions provides a cavity that selectively recognises and binds coumarin in MeCN solution.	coumarin	143-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-81	
31210111-0	2019	Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents.	coumarin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59	
28720504-0	2017	Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.	coumarin	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79	
26462142-0	2015	New Coumarin Derivatives as Potent Selective COX-2 Inhibitors: Synthesis, Anti-Inflammatory, QSAR, and Molecular Modeling Studies.	coumarin	4-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50	
26462142-1	2015	Two new series of coumarin derivatives incorporating thiazoline and thiazolidinone moieties were designed, synthesized, and investigated in vivo for their anti-inflammatory activities using the carrageenan-induced rat paw edema model and in vitro for their inhibitory activities against the human cyclooxygenase (COX)-1 and COX-2 isoforms.	coumarin	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	324-329	
21296065-9	2011	In this last category, we identified a structural family of coumarin-derived compounds (imperatorin, osthol and prenyletin), along with deracoxib, a drug in veterinary use for its COX2 inhibitory properties.	coumarin	60-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-184