PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7698507-1 1995 Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide. Niacinamide 97-109 interleukin 1 beta Rattus norvegicus 0-18 9275497-0 1996 [The protective effect of nicotinamide on interleukin-1 beta induced damage to rat islets of Langerhans and its mechanism]. Niacinamide 26-38 interleukin 1 beta Rattus norvegicus 42-60 7487987-0 1995 Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 56-65 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Niacinamide 76-88 interleukin 1 beta Rattus norvegicus 160-178 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Niacinamide 76-88 interleukin 1 beta Rattus norvegicus 412-430 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Niacinamide 19-31 interleukin 1 beta Rattus norvegicus 49-67 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Niacinamide 19-31 interleukin 1 beta Rattus norvegicus 142-160 7698507-9 1995 Addition of nicotinamide and L-arginine depletion reduced the upregulation of 16 and 20 IL-1 beta-induced proteins, respectively. Niacinamide 12-24 interleukin 1 beta Rattus norvegicus 88-97 9202213-9 1997 It has been previously reported that nicotinamide prevents IL-1beta-induced IRF-1 expression in rat pancreatic islets. Niacinamide 37-49 interleukin 1 beta Rattus norvegicus 59-67 8895350-2 1996 NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. Niacinamide 0-3 interleukin 1 beta Rattus norvegicus 39-68 7720637-0 1995 Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta. Niacinamide 21-33 interleukin 1 beta Rattus norvegicus 147-165 7720637-2 1995 This study aimed to examine the consequence of exposing isolated rat pancreatic islets to various concentrations of NIC (0, 0.5, 1.0, 5.0, 10, and 25 mM) over a prolonged period (6 days) in tissue culture and also to assess the efficacy of NIC to counteract interleukin-1 beta (IL-1; 25 U/ml)-induced beta-cell dysfunction. Niacinamide 116-119 interleukin 1 beta Rattus norvegicus 258-276 7698507-5 1995 Nicotinamide, while in itself inactive, inhibited IL-1 beta-induced NO production in a time- and dose-dependent manner. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 50-59 7958397-9 1994 The nuclear effects of IL-1 beta were modified by nicotinamide (10 mM), an inhibitor of poly(ADP-ribose) synthetase. Niacinamide 50-62 interleukin 1 beta Rattus norvegicus 23-32 7691579-8 1993 Thus, 10 mM nicotinamide decreased rIL-1 beta-induced nitrite formation by 30%, 20 mM by 60%, and 50 mM by 90%. Niacinamide 12-24 interleukin 1 beta Rattus norvegicus 35-45 7507826-7 1994 Nicotinamide and thymidine prevented the IL-1 beta-induced loss of cell viability and suppression of NAD, but had no effect on sustaining insulin secretion. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 41-50 7691579-9 1993 The highest concentration of nicotinamide also prevented rIL-1 beta-induced iNOS mRNA, an effect associated with inhibition of total protein biosynthesis. Niacinamide 29-41 interleukin 1 beta Rattus norvegicus 57-67 16165703-12 2005 Moreover, in TGFbeta-activated cells, nicotinamide reduces expression of pro-inflammatory and pro-fibrotic cytokines TGFbeta2, IL-1beta, TNFalpha and macrophage chemotactic protein-1. Niacinamide 38-50 interleukin 1 beta Rattus norvegicus 127-135 1531861-0 1992 Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose-induced insulin release in pancreatic islets. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 36-54 1531861-2 1992 We studied the effect of nicotinamide, an inhibitor of poly[adenosine diphosphate (ADP)-ribose] synthetase and a free-radical scavenger, on this IL-1 beta-induced inhibition using rat pancreatic islets. Niacinamide 25-37 interleukin 1 beta Rattus norvegicus 145-154 1531861-8 1992 When islets were simultaneously exposed to IL-1 beta and increasing concentrations of nicotinamide, a dose-dependent recovery of glucose-induced insulin secretion was observed, with the maximum effect at 25 mmol/L nicotinamide (1,007 +/- 123, P less than .001). Niacinamide 214-226 interleukin 1 beta Rattus norvegicus 43-52