PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33710861-10 2021 Moreover, we show that the effect of Olmesartan against cell senescence and deacetylation of p53 was abolished by inhibition of SIRT1, either by using nicotinamide or by transfection with SIRT1 siRNA. Niacinamide 151-163 sirtuin 1 Homo sapiens 128-133 32296111-0 2020 s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide. Niacinamide 169-181 sirtuin 1 Homo sapiens 8-13 33738067-1 2021 SIRT1, a member of the sirtuin family, catalyzes the deacetylation of proteins with the transformation of NAD+ into nicotinamide and 2"-O-acetyl-ADP-ribose. Niacinamide 116-128 sirtuin 1 Homo sapiens 0-5 33610183-11 2021 The addition of nicotinamide, a Sirt1 inhibitor, downregulated SOX9 and attenuated the therapeutic effects of SMN on IL-1beta-stimulated chondrocytes. Niacinamide 16-28 sirtuin 1 Homo sapiens 32-37 33613450-13 2020 However, SIRT1 inhibitor nicotinamide (NAM) and AMPK inhibitor Compound C blocked the beneficial effect of 17beta-E2. Niacinamide 25-37 sirtuin 1 Homo sapiens 9-14 33613450-13 2020 However, SIRT1 inhibitor nicotinamide (NAM) and AMPK inhibitor Compound C blocked the beneficial effect of 17beta-E2. Niacinamide 39-42 sirtuin 1 Homo sapiens 9-14 32894639-5 2021 SIRT1 agonist resveratrol was observed to modulate the activity of antioxidant enzymes by negatively regulating the expression of nuclear factor-kappaB (NF-kappaB) in alcohol-aflatoxin B1-induced HCC, thereby suggesting a cross-talk between antioxidant enzymes SIRT1 and NF-kappaB during the development and progression of HCC and its therapeutics by resveratrol and nicotinamide. Niacinamide 367-379 sirtuin 1 Homo sapiens 0-5 33319867-5 2020 Treatment with NAD + precursor nicotinamide increases the intracellular NAD + level and re-balances the NAD + /NADH ratio, with enhanced Sirt-1 activity in hMSCs at high passage, partially restores mitochondrial fitness and rejuvenates senescent hMSCs. Niacinamide 31-43 sirtuin 1 Homo sapiens 137-143 33670751-0 2021 Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition. Niacinamide 44-56 sirtuin 1 Homo sapiens 35-40 32572902-5 2020 We induced nucleus pulposus (NP) cell degeneration by IL-1beta and mediated cellular Sirt1 expression through the Sirt1 activator resveratrol (Res) or inhibitor Nicotinamide (Nico). Niacinamide 161-173 sirtuin 1 Homo sapiens 85-90 32531731-9 2020 These data suggest that H4KAC16 binding to SIRT1 may coordinate an unusual conformational readjustment of nicotinamide ring at site-b and reposition of HIS363 to facilitate SIRT1-dependent deacetylase activity. Niacinamide 106-118 sirtuin 1 Homo sapiens 43-48 32733649-6 2020 CAV-1 down-regulation was triggered by Micro-RNA 204-5p (miR204-5p) up-regulation and could be significantly blocked by pre-treatment with both Sirt-1/Sirt-3 specific siRNA and SIRT-1/SIRT-3 enzyme inhibitors, EX-527 and nicotinamide. Niacinamide 221-233 sirtuin 1 Homo sapiens 144-150 32733649-6 2020 CAV-1 down-regulation was triggered by Micro-RNA 204-5p (miR204-5p) up-regulation and could be significantly blocked by pre-treatment with both Sirt-1/Sirt-3 specific siRNA and SIRT-1/SIRT-3 enzyme inhibitors, EX-527 and nicotinamide. Niacinamide 221-233 sirtuin 1 Homo sapiens 177-183 32572902-5 2020 We induced nucleus pulposus (NP) cell degeneration by IL-1beta and mediated cellular Sirt1 expression through the Sirt1 activator resveratrol (Res) or inhibitor Nicotinamide (Nico). Niacinamide 161-165 sirtuin 1 Homo sapiens 85-90 32572902-12 2020 On the contrary, Sirt1 downregulation by Nico aggravated the phosphorylation of c-Fos/c-Jun and MCP-1 expression. Niacinamide 41-45 sirtuin 1 Homo sapiens 17-22 32469848-0 2020 Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor gamma Coactivator 1alpha (PGC-1alpha)/Hypoxia-Inducible Factor-2alpha (HIF2alpha) Signaling Pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 62-71 32469848-0 2020 Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor gamma Coactivator 1alpha (PGC-1alpha)/Hypoxia-Inducible Factor-2alpha (HIF2alpha) Signaling Pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 73-78 32469848-9 2020 Nicotinamide significantly inhibited the SIRT1/PGC-1alpha/HIF2alpha signaling pathway mRNAs compared to that of the CT group (p<0.05). Niacinamide 0-12 sirtuin 1 Homo sapiens 41-46 32469848-10 2020 Nicotinamide remarkably reduced mitochondrial regulatory factors SIRT1/PGC-1alpha expression compared to that in the CT group (p<0.05). Niacinamide 0-12 sirtuin 1 Homo sapiens 65-70 32469848-12 2020 Moreover, all of the above nicotinamide-induced effects, including glycolytic activity, apoptosis, and expression of SIRT1/PGC-1alpha/HIF2alpha, were changed in a dose-dependent manner. Niacinamide 27-39 sirtuin 1 Homo sapiens 117-122 32469848-13 2020 CONCLUSIONS Nicotinamide can inhibit glycolysis of HL-60 cells by inhibiting the mitochondrial regulatory factor SIRT1/PGC-1alpha and suppressing transcription factor HIF2alpha. Niacinamide 12-24 sirtuin 1 Homo sapiens 113-118 31614144-4 2019 NAD+ biosynthesis via nicotinamide phosphoribosyltransferase (NAMPT) modulates Sirtuin 1 activity. Niacinamide 22-34 sirtuin 1 Homo sapiens 79-88 32340156-9 2020 Treatment with a SIRT1 inhibitor, nicotinamide (NAM), paralleled lactate effects, promoting cell aggressiveness. Niacinamide 34-46 sirtuin 1 Homo sapiens 17-22 32340156-9 2020 Treatment with a SIRT1 inhibitor, nicotinamide (NAM), paralleled lactate effects, promoting cell aggressiveness. Niacinamide 48-51 sirtuin 1 Homo sapiens 17-22 31407410-0 2020 Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1. Niacinamide 0-12 sirtuin 1 Homo sapiens 110-115 31407410-2 2020 Nicotinamide (NAM) is the principal NAD+ precursor and a noncompetitive inhibitor of SIRT1. Niacinamide 0-12 sirtuin 1 Homo sapiens 85-90 31407410-3 2020 In our study, we showed that NAM enhanced the sensitivity of chronic myeloid leukemia (CML) to doxorubicin (DOX) via SIRT1. Niacinamide 29-32 sirtuin 1 Homo sapiens 117-122 31407410-5 2020 Exogenous NAM efficiently repressed the deacetylation activity of SIRT1 and induced the apoptosis of DOX-resistant K562 cells (K562R) in a dose-dependent manner. Niacinamide 10-13 sirtuin 1 Homo sapiens 66-71 31769563-0 2020 Nicotinamide-induced silencing of SIRT1 by miR-22-3p increases periodontal ligament stem cell proliferation and differentiation. Niacinamide 0-12 sirtuin 1 Homo sapiens 34-39 31753397-9 2020 Furthermore, we found that SIRT1 inhibition by nicotinamide completely counteracted the protective effect of DECM on chondrocytes in the presence of IL-1beta or TNF-alpha, indicating that the SIRT1 signaling pathway was involved in the DECM-mediated enhancement of anti-inflammatory properties of chondrocytes. Niacinamide 47-59 sirtuin 1 Homo sapiens 27-32 31753397-9 2020 Furthermore, we found that SIRT1 inhibition by nicotinamide completely counteracted the protective effect of DECM on chondrocytes in the presence of IL-1beta or TNF-alpha, indicating that the SIRT1 signaling pathway was involved in the DECM-mediated enhancement of anti-inflammatory properties of chondrocytes. Niacinamide 47-59 sirtuin 1 Homo sapiens 192-197 30548678-6 2019 SIRT1 inhibitor (nicotinamide) decreased SIRT1, reduced the effects of miRNA-141 on nerve cell apoptosis in vitro model of epilepsy through SIRT1/p53. Niacinamide 17-29 sirtuin 1 Homo sapiens 0-5 31638409-7 2019 The effects of resveratrol were abrogated after co-treatment with the SIRT1 inhibitor nicotinamide and the AMPK inhibitor compound C. In conclusion, resveratrol was able to reverse high-glucose-induced inflammation "metabolic memory" of HRVECs by activation of the SIRT1/AMPK/NF-kappaB pathway. Niacinamide 86-98 sirtuin 1 Homo sapiens 70-75 31638409-7 2019 The effects of resveratrol were abrogated after co-treatment with the SIRT1 inhibitor nicotinamide and the AMPK inhibitor compound C. In conclusion, resveratrol was able to reverse high-glucose-induced inflammation "metabolic memory" of HRVECs by activation of the SIRT1/AMPK/NF-kappaB pathway. Niacinamide 86-98 sirtuin 1 Homo sapiens 265-270 31491460-13 2019 Interestingly, autophagy markers were down regulated in MCF7 cells upon treatment with nicotinamide, an inhibitor of SIRT1 activity and dorsomorphin, a phospho-AMPK inhibitor when treated separately under nitrosative stress. Niacinamide 87-99 sirtuin 1 Homo sapiens 117-122 31993545-2 2019 It has been known that nicotinamide inhibits the enzymatic activity of SIRT1, an NAD+-dependent deacetylase. Niacinamide 23-35 sirtuin 1 Homo sapiens 71-76 31146723-10 2019 Nicotinamide (NAM) and AS1842856 were used to inhibit activities of SIRT1 and FOXO1, respectively. Niacinamide 0-12 sirtuin 1 Homo sapiens 68-73 31553614-4 2019 In this investigation, we have made an attempt to unravel the unbinding pathways of nicotinamide from SIRT1, SIRT2, and SIRT3 (SIRT1-3) using Random Acceleration Molecular Dynamics (RAMD) Simulations, and we have successfully identified various unbinding channels. Niacinamide 84-96 sirtuin 1 Homo sapiens 102-107 30789361-8 2019 This process was inhibited by nicotinamide, an inhibitor of Sirt1. Niacinamide 30-42 sirtuin 1 Homo sapiens 60-65 30548678-6 2019 SIRT1 inhibitor (nicotinamide) decreased SIRT1, reduced the effects of miRNA-141 on nerve cell apoptosis in vitro model of epilepsy through SIRT1/p53. Niacinamide 17-29 sirtuin 1 Homo sapiens 41-46 30548678-6 2019 SIRT1 inhibitor (nicotinamide) decreased SIRT1, reduced the effects of miRNA-141 on nerve cell apoptosis in vitro model of epilepsy through SIRT1/p53. Niacinamide 17-29 sirtuin 1 Homo sapiens 41-46 30648523-11 2019 Mechanistically, nicotinamide translocated SIRT1 from the cell nucleus to cytoplasm, dissociated the connection between SIRT1 and Akt, and consequently decreased expressions of SIRT1, and P-Akt, thereby inhibiting the growth of MCF7/ADR cells. Niacinamide 17-29 sirtuin 1 Homo sapiens 43-48 30648523-0 2019 Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 90-95 30648523-11 2019 Mechanistically, nicotinamide translocated SIRT1 from the cell nucleus to cytoplasm, dissociated the connection between SIRT1 and Akt, and consequently decreased expressions of SIRT1, and P-Akt, thereby inhibiting the growth of MCF7/ADR cells. Niacinamide 17-29 sirtuin 1 Homo sapiens 120-125 30648523-11 2019 Mechanistically, nicotinamide translocated SIRT1 from the cell nucleus to cytoplasm, dissociated the connection between SIRT1 and Akt, and consequently decreased expressions of SIRT1, and P-Akt, thereby inhibiting the growth of MCF7/ADR cells. Niacinamide 17-29 sirtuin 1 Homo sapiens 120-125 30648523-12 2019 CONCLUSIONS: Our results suggested that the value of nicotinamide is a potential therapeutic agent for breast cancer treatment through downregulating SIRT1/Akt pathway, leading to the valid management of breast cancer patients. Niacinamide 53-65 sirtuin 1 Homo sapiens 150-155 30464525-13 2018 Moreover, inhibiting autophagy by autophagy inhibitor 3-methyladenine or SIRT1 inhibitor nicotinamide significantly suppressed proliferation while promoted apoptosis compared with the resveratrol 200 muM group, suggesting that resveratrol-induced autophagy might act as a protective mechanism to promote NSCLC cell survival and inhibiting autophagy can enhance the anti-tumor effect of resveratrol. Niacinamide 89-101 sirtuin 1 Homo sapiens 73-78 29380418-8 2018 Activation of SIRT1 by resveratrol rescued the effect of H2 O2 on early-differentiated BM-MSCs and inhibition of SIRT1 by nicotinamide intensified the effect of H2 O2 on late-differentiated BM-MSCs, indicating that the SIRT1-mediated pathway was actively involved in MSC osteogenesis and antioxidant mechanisms. Niacinamide 122-134 sirtuin 1 Homo sapiens 113-118 30203236-10 2018 The involvement of DHP-8 in SIRT1 activation was further verified by co-treatment of nicotinamide with DHP-8 in both A375 and HepG2 cells. Niacinamide 85-97 sirtuin 1 Homo sapiens 28-33 30116472-7 2018 Inhibition of SIRT1 by nicotinamide reversed the antioxidant effect of KGN on BM-MSCs and suppressed osteogenic differentiation. Niacinamide 23-35 sirtuin 1 Homo sapiens 14-19 30105071-8 2018 When coincubated with 20 mM nicotinamide, the results with SA-beta-gal-positive cells and the expression of SIRT1, E2F1, p53, and p21 were contrary to that obtained with only TFs pretreatment. Niacinamide 28-40 sirtuin 1 Homo sapiens 108-113 29380418-8 2018 Activation of SIRT1 by resveratrol rescued the effect of H2 O2 on early-differentiated BM-MSCs and inhibition of SIRT1 by nicotinamide intensified the effect of H2 O2 on late-differentiated BM-MSCs, indicating that the SIRT1-mediated pathway was actively involved in MSC osteogenesis and antioxidant mechanisms. Niacinamide 122-134 sirtuin 1 Homo sapiens 113-118 28107614-11 2018 The underlying molecular mechanisms involved the silent information regulator type 1 (SIRT1)-dependent signalling pathway, confirmed by the fact that the SIRT1 inhibitor nicotinamide counteracted the DECM-mediated anti-senescent effect. Niacinamide 170-182 sirtuin 1 Homo sapiens 49-84 29844677-5 2018 Finally, nicotinamide"s potential mechanisms of action are discussed, including the general maintenance of cellular energy levels and the more specific inhibition of molecules such as the nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin 1 (SIRT1). Niacinamide 9-21 sirtuin 1 Homo sapiens 245-254 29844677-5 2018 Finally, nicotinamide"s potential mechanisms of action are discussed, including the general maintenance of cellular energy levels and the more specific inhibition of molecules such as the nicotinamide adenine dinucleotide-dependent deacetylase, sirtuin 1 (SIRT1). Niacinamide 9-21 sirtuin 1 Homo sapiens 256-261 28750181-6 2018 Treatment with resveratrol (RSV), a SIRT1 agonist, or overexpression of SIRT1 also promoted the expression Cyr61 in human dermal fibroblasts, whereas the inhibition of SIRT1 activity by nicotinamide or knockdown of SIRT1 decreased the level of Cyr61, as well as TGF-beta or RSV-induced Cyr61 expression. Niacinamide 186-198 sirtuin 1 Homo sapiens 72-77 29805651-6 2018 In addition, nicotinamide treatment significantly suppressed the expression of SIRT1 even in PC-3 cells transfected with adeno-associated virus-NNMT. Niacinamide 13-25 sirtuin 1 Homo sapiens 79-84 28750181-6 2018 Treatment with resveratrol (RSV), a SIRT1 agonist, or overexpression of SIRT1 also promoted the expression Cyr61 in human dermal fibroblasts, whereas the inhibition of SIRT1 activity by nicotinamide or knockdown of SIRT1 decreased the level of Cyr61, as well as TGF-beta or RSV-induced Cyr61 expression. Niacinamide 186-198 sirtuin 1 Homo sapiens 72-77 28750181-6 2018 Treatment with resveratrol (RSV), a SIRT1 agonist, or overexpression of SIRT1 also promoted the expression Cyr61 in human dermal fibroblasts, whereas the inhibition of SIRT1 activity by nicotinamide or knockdown of SIRT1 decreased the level of Cyr61, as well as TGF-beta or RSV-induced Cyr61 expression. Niacinamide 186-198 sirtuin 1 Homo sapiens 72-77 28107614-11 2018 The underlying molecular mechanisms involved the silent information regulator type 1 (SIRT1)-dependent signalling pathway, confirmed by the fact that the SIRT1 inhibitor nicotinamide counteracted the DECM-mediated anti-senescent effect. Niacinamide 170-182 sirtuin 1 Homo sapiens 86-91 28107614-11 2018 The underlying molecular mechanisms involved the silent information regulator type 1 (SIRT1)-dependent signalling pathway, confirmed by the fact that the SIRT1 inhibitor nicotinamide counteracted the DECM-mediated anti-senescent effect. Niacinamide 170-182 sirtuin 1 Homo sapiens 154-159 28608449-6 2017 The inhibition of resveratrol was inversed partially by sirtuin 1 (SIRT1) inhibitors (Nicotinamide, 1-10 mM) (p<0.05). Niacinamide 86-98 sirtuin 1 Homo sapiens 56-65 29251317-11 2018 Moreover, combined treatment with the SIRT-1 inhibitor nicotinamide and EPS was able to significantly enhance the induction of necrosis and reduction in cell viability of 786-O cells noted following treatment with EPS alone. Niacinamide 55-67 sirtuin 1 Homo sapiens 38-44 29118980-6 2017 Inversely, SIRT1 inhibitors nicotinamide and sirtinol suppressed methylation and increased acetylation of pronuclear H3K9. Niacinamide 28-40 sirtuin 1 Homo sapiens 11-16 28608449-6 2017 The inhibition of resveratrol was inversed partially by sirtuin 1 (SIRT1) inhibitors (Nicotinamide, 1-10 mM) (p<0.05). Niacinamide 86-98 sirtuin 1 Homo sapiens 67-72 28627707-10 2017 Furthermore, it was revealed that TFPS additionally protected fibroblasts via the upregulation of SIRT1 expression, and this was abrogated by the SIRT1 inhibitor niacinamide. Niacinamide 162-173 sirtuin 1 Homo sapiens 98-103 28417163-0 2017 Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Niacinamide 0-12 sirtuin 1 Homo sapiens 32-37 28627707-10 2017 Furthermore, it was revealed that TFPS additionally protected fibroblasts via the upregulation of SIRT1 expression, and this was abrogated by the SIRT1 inhibitor niacinamide. Niacinamide 162-173 sirtuin 1 Homo sapiens 146-151 28736426-0 2017 Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and Mitophagy. Niacinamide 69-81 sirtuin 1 Homo sapiens 109-114 28139552-15 2017 Furthermore, the anti-aging effects of allicin were abolished by the Sirt1 inhibitor nicotinamide (NAM). Niacinamide 85-97 sirtuin 1 Homo sapiens 69-74 28693188-5 2017 The effects of the activator of SIRT1, SRT1720, and the inhibitor of SIRT1, nicotinamide, were also analyzed. Niacinamide 76-88 sirtuin 1 Homo sapiens 69-74 28473059-5 2017 We previously reported that nicotinamide endowed hepatocytes resistance to palmitate-induced ER stress via up-regulating SIRT1, with cAMP/PKA/CREB pathway activation being a fundamental mechanism. Niacinamide 28-40 sirtuin 1 Homo sapiens 121-126 28473059-10 2017 Furthermore, we showed that SIRT1 inhibition blunted autophagy induction in response to nicotinamide supplementation and similarly abrogated the anti-lipotoxic effect conferred by nicotinamide supplementation. Niacinamide 88-100 sirtuin 1 Homo sapiens 28-33 28473059-10 2017 Furthermore, we showed that SIRT1 inhibition blunted autophagy induction in response to nicotinamide supplementation and similarly abrogated the anti-lipotoxic effect conferred by nicotinamide supplementation. Niacinamide 180-192 sirtuin 1 Homo sapiens 28-33 28351214-6 2017 After nicotinamide (5 mM) mediated inhibition of SIRT1, levels of TLE1, HES1, and MASH1 were examined; TLE1 was significantly upregulated and MASH1 was downregulated. Niacinamide 6-18 sirtuin 1 Homo sapiens 49-54 28000862-8 2017 By contrast, inhibition of SIRT1 by nicotinamide had the opposite effects that enhance cell ROS production. Niacinamide 36-48 sirtuin 1 Homo sapiens 27-32 27414406-2 2016 However, nicotinamide (NAM), a fundamental micronutrient that is important in energy metabolism, has been shown to regulate adipogenesis through inhibition of SIRT1. Niacinamide 9-21 sirtuin 1 Homo sapiens 159-164 27608947-1 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for a number of enzymes and regulatory proteins involved in a variety of cellular processes, including deacetylation enzyme SIRT1 which modulates several tumor suppressors such as p53 and FOXO. Niacinamide 0-12 sirtuin 1 Homo sapiens 258-263 27608947-1 2016 Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD(+), essential for a number of enzymes and regulatory proteins involved in a variety of cellular processes, including deacetylation enzyme SIRT1 which modulates several tumor suppressors such as p53 and FOXO. Niacinamide 100-112 sirtuin 1 Homo sapiens 258-263 27708228-7 2016 Furthermore, treatment of KSHV-transformed cells with a SIRT1 inhibitor, nicotinamide (NAM), had the same effect as SIRT1 knockdown and knockout. Niacinamide 73-85 sirtuin 1 Homo sapiens 56-61 26055227-11 2016 Finally, SIRT1 inhibitor nicotinamide blocked MK-801 injury effects and suppressed miR-134 expression. Niacinamide 25-37 sirtuin 1 Homo sapiens 9-14 27023330-6 2016 Like SIRT1, the nicotinamide inhibition of SIRT5 double mutant (Y102A/R105I) exhibited the mixed non-competitive behavior. Niacinamide 16-28 sirtuin 1 Homo sapiens 5-10 27050994-10 2016 Together, these results suggest that the SIRT1 activator and inhibitor compounds, resveratrol and nicotinamide, function at high efficiency in adjusting cell proliferation, and that SIRT1 is a powerful regulator of osteoblastic differentiation of PDLSCs and SCAPs. Niacinamide 98-110 sirtuin 1 Homo sapiens 41-46 26194321-7 2015 Pretreatment with nicotinamide (NAM), a sirtuin 1 (SIRT1) inhibitor, inhibited the reduction in senescence associated with donepezil. Niacinamide 18-30 sirtuin 1 Homo sapiens 40-49 26660162-0 2016 The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo. Niacinamide 21-33 sirtuin 1 Homo sapiens 4-9 26660162-2 2016 However, the potential antiviral effects of nicotinamide, a SIRT1 inhibitor, have not yet been explored. Niacinamide 44-56 sirtuin 1 Homo sapiens 60-65 26330291-7 2015 We found that FK866 induced cell senescence and diminished cellular NAD(+) levels and SIRT1 activity (detected by acetylation of p53), and these effects were dramatically antagonized by co-treatment with nicotinic acid, nicotinamide, or NAD(+). Niacinamide 220-232 sirtuin 1 Homo sapiens 86-91 26483208-7 2016 Furthermore, the increased level of SIRT1 induced by TVN was inhibited by nicotinamide and siRNA-medicated SIRT1 silencing (si-SIRT1), thereby confirming the significant role of SIRT1 in these events. Niacinamide 74-86 sirtuin 1 Homo sapiens 36-41 26723256-4 2016 The results showed that treatment with either SIRT1 siRNA or SIRT1 inhibitor nicotinamide (NAM) increased Dil-labelled-ox-LDL (Dil-ox-LDL) accumulation in HUVECs, and the SIRT1 inducer resveratrol (RSV) decreased it. Niacinamide 77-89 sirtuin 1 Homo sapiens 61-66 26723256-4 2016 The results showed that treatment with either SIRT1 siRNA or SIRT1 inhibitor nicotinamide (NAM) increased Dil-labelled-ox-LDL (Dil-ox-LDL) accumulation in HUVECs, and the SIRT1 inducer resveratrol (RSV) decreased it. Niacinamide 77-89 sirtuin 1 Homo sapiens 61-66 27512785-7 2015 One of the exciting findings is that targeting Sirt1, a class III HDAC, with nicotinamide (vitamin B3) delays renal cyst growth and preserves renal function in three Pkd1 knockout animal models. Niacinamide 77-89 sirtuin 1 Homo sapiens 47-52 27512785-7 2015 One of the exciting findings is that targeting Sirt1, a class III HDAC, with nicotinamide (vitamin B3) delays renal cyst growth and preserves renal function in three Pkd1 knockout animal models. Niacinamide 91-101 sirtuin 1 Homo sapiens 47-52 26352206-0 2015 Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation. Niacinamide 0-12 sirtuin 1 Homo sapiens 104-109 26194321-7 2015 Pretreatment with nicotinamide (NAM), a sirtuin 1 (SIRT1) inhibitor, inhibited the reduction in senescence associated with donepezil. Niacinamide 18-30 sirtuin 1 Homo sapiens 51-56 25751058-5 2015 Inhibitor treatment combined with genetic deletion showed that the effects of the pan-sirtuin inhibitor nicotinamide are primarily mediated by SIRT1 inhibition. Niacinamide 104-116 sirtuin 1 Homo sapiens 143-148 25472572-8 2015 Additionally, the protective effects of ICA were abrogated in the presence of SIRT1 inhibitor nicotinamide. Niacinamide 94-106 sirtuin 1 Homo sapiens 78-83 25815111-5 2015 Modulation of the cellular activity of SIRT1 can involve oversight by nicotinamide/nicotinic acid mononucleotide adenylyltransferase, mammalian forkhead transcription factors, mechanistic of rapamycin pathways, and cysteine-rich protein 61, connective tissue growth factor, and nephroblastoma over-expressed gene family members that can impact cytoprotective outcomes. Niacinamide 70-82 sirtuin 1 Homo sapiens 39-44 24845634-14 2014 The roles of SIRT1 in protecting cells in response to Fol were further confirmed by applications of SIRT1 activator (resveratrol) and inhibitors (nicotinamide and sirtinol), and through SIRT1 overexpression and knockdown. Niacinamide 146-158 sirtuin 1 Homo sapiens 13-18 25004063-10 2014 Nicotinamide, an SIRT1 inhibitor, reduced the SIRT1-mediated suppression of HMGB1 translocation and aggravated cecal ligation and puncture-induced liver damage. Niacinamide 0-12 sirtuin 1 Homo sapiens 17-22 25004063-10 2014 Nicotinamide, an SIRT1 inhibitor, reduced the SIRT1-mediated suppression of HMGB1 translocation and aggravated cecal ligation and puncture-induced liver damage. Niacinamide 0-12 sirtuin 1 Homo sapiens 46-51 25004411-5 2014 Nicotinamide is a known inhibitor for sirtuins, and it was found to be less potent inhibitor for SIRT6 than it is for SIRT1. Niacinamide 0-12 sirtuin 1 Homo sapiens 118-123 24446069-9 2014 Inhibition of SIRT1 by nicotinamide and siRNA significantly increased the expression of ER stress marker genes in cells treated with both PA and exendin-4. Niacinamide 23-35 sirtuin 1 Homo sapiens 14-19 24729176-0 2014 Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells. Niacinamide 24-36 sirtuin 1 Homo sapiens 86-91 24729176-2 2014 The premature senescence-like phenotype HUVECs (the fourth passage) was induced by treatment with nicotinamide (NAM, an inhibitor of SIRT1, 5 mmol/L, 12 h). Niacinamide 98-110 sirtuin 1 Homo sapiens 133-138 24880902-6 2014 We propose that binding of the inhibitors repels the entering of the nicotinamide moiety of NAD(+) to the C pocket, prevents its transformation to the productive conformation and therefore inhibits the deacetylation catalyzed by SIRT1. Niacinamide 69-81 sirtuin 1 Homo sapiens 229-234 25349818-9 2014 A number of molecular links, including nicotinamide adenine dinucleotide, nicotinamide, biotin, and related metabolites, are suggested to be the most important conduits mediating caloric restriction-induced Sir2/SIRT1 activation and lifespan extension. Niacinamide 39-51 sirtuin 1 Homo sapiens 212-217 25057854-4 2014 Luteolin and epigallocatechin gallate, but not quercetin, increased sirtuin 1 abundance, and their regulation of glucose consumption was also attenuated by co-treatment with sirtuin 1 inhibitor nicotinamide. Niacinamide 194-206 sirtuin 1 Homo sapiens 68-77 25057854-4 2014 Luteolin and epigallocatechin gallate, but not quercetin, increased sirtuin 1 abundance, and their regulation of glucose consumption was also attenuated by co-treatment with sirtuin 1 inhibitor nicotinamide. Niacinamide 194-206 sirtuin 1 Homo sapiens 174-183 25057854-5 2014 Quercetin, luteolin, and epigallocatechin gallate suppressed nuclear factor-kappaB activation by inhibition of p65 phosphorylation with beneficial regulation of adipokine expression, whereas these actions were diminished by coincubation with compound C. The sirtuin 1 inhibitor nicotinamide attenuated the effects of luteolin and EGCG on p65 phosphorylation and adipokine expression without any influence on the activity of quercetin. Niacinamide 278-290 sirtuin 1 Homo sapiens 258-267 24022598-6 2014 Furthermore, SIRT1 inhibitors sirtinol/nicotinamide (NAM) or SIRT1 knockdown could attenuate the effect of fenofibrate on CD40 expression in endothelial cells. Niacinamide 39-51 sirtuin 1 Homo sapiens 13-18 24557422-13 2014 Sirtuin 1 small interfering RNA knockdown experiments confirmed that carnosic acid increased sirtuin 1-mediated repression of p66shc in HepG2 cells and that the protective effect of carnosic acid against hypoxia/reoxygenation injury was inhibited by the sirtuin 1 inhibitor nicotinamide. Niacinamide 274-286 sirtuin 1 Homo sapiens 93-102 24040102-5 2013 The antimycin A-induced increase in ROS levels and apoptosis was enhanced by SIRT1 inhibitors nicotinamide and splitomicin, whereas it was suppressed by a SIRT1 activator, resveratrol, and a SIRT1 cofactor, NAD+. Niacinamide 94-106 sirtuin 1 Homo sapiens 77-82 24127549-11 2013 Remarkably, inhibition of sirtuin 1 with nicotinamide, increased H2A.Z levels, whereas activation of sirtuin 1 by resveratrol led to an abrupt decrease in H2A.Z. Niacinamide 41-53 sirtuin 1 Homo sapiens 26-35 24137378-0 2013 Nicotinamide-mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis. Niacinamide 0-12 sirtuin 1 Homo sapiens 36-41 23977047-8 2013 This repression was relieved by mutation of only the NBRE-A element and by nicotinamide [an inhibitor of class III histone deacetylases (HDACs), such as SIRT1], but not by trichostatin A (an inhibitor of class I and II HDACs). Niacinamide 75-87 sirtuin 1 Homo sapiens 153-158 23603572-6 2013 Moreover, SIRT1 inhibitors sirtinol/nicotinamide (NAM) or knockdown of SIRT1 could attenuate the effect of fenofibrate on TNF-alpha-induced CD40 expression in adipocytes. Niacinamide 36-48 sirtuin 1 Homo sapiens 10-15 23922917-8 2013 Drugs that target the SIRT1 pathway, resveratrol and nicotinamide, modulate T3 response at dual TRbeta1/SIRT1 target genes. Niacinamide 53-65 sirtuin 1 Homo sapiens 22-27 23922917-8 2013 Drugs that target the SIRT1 pathway, resveratrol and nicotinamide, modulate T3 response at dual TRbeta1/SIRT1 target genes. Niacinamide 53-65 sirtuin 1 Homo sapiens 104-109 23652462-13 2013 The SIRT1 inhibitor, nicotinamide, was found to eliminate the effects of SRT1720. Niacinamide 21-33 sirtuin 1 Homo sapiens 4-9 23588928-4 2013 Pretreatment with nicotinamide (NAM), a sirtuin 1 (SIRT1) inhibitor, inhibited the reduction in senescence associated with H2S. Niacinamide 18-30 sirtuin 1 Homo sapiens 40-49 23479127-7 2013 In contrast, inhibition of SIRT1 by sirtinol/nicotinamide or knockdown of SIRT1 enhanced apoptosis of VAFs. Niacinamide 45-57 sirtuin 1 Homo sapiens 27-32 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 31-61 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 63-68 23022493-5 2013 Nicotinamide , an inhibitor of silent information regulator 1 (SIRT1), prevented RSV-induced elevation of FOXO3a and MsrA expression, indicating that the effect of RSV was mediated by a SIRT1-dependent pathway. Niacinamide 0-12 sirtuin 1 Homo sapiens 186-191 23588928-4 2013 Pretreatment with nicotinamide (NAM), a sirtuin 1 (SIRT1) inhibitor, inhibited the reduction in senescence associated with H2S. Niacinamide 18-30 sirtuin 1 Homo sapiens 51-56 23313797-7 2013 The effects of Res were blocked by the 5"-adenosine monophosphate-activated protein kinase inhibitor Compound C and the sirtuin 1 inhibitor nicotinamide. Niacinamide 140-152 sirtuin 1 Homo sapiens 120-129 23363613-9 2013 In contrast, inhibition of SIRT1 by nicotinamide had the opposite effects enhancing cell apoptosis and ROS production. Niacinamide 36-48 sirtuin 1 Homo sapiens 27-32 23561972-0 2013 Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways. Niacinamide 0-12 sirtuin 1 Homo sapiens 115-120 23561972-1 2013 BACKGROUND: Nicotinamide (NAM), the precursor for the synthesis of NAD(+) and also an inhibitor of SIRT1, has been discovered to inhibit some types of cancer. Niacinamide 12-24 sirtuin 1 Homo sapiens 99-104 22537175-9 2013 Similarly, inhibition of SIRT1 enzymatic activity with nicotinamide brought about G1 arrest and apoptosis in a dose-related fashion. Niacinamide 55-67 sirtuin 1 Homo sapiens 25-30 23135526-4 2013 Enzyme-linked immunosorbent assay-based angiogenesis arrays were used to assess the potential of an SIRT1 inhibitor, nicotinamide, to reduce secretion of 10 unique proangiogenic cytokines from retinal pigment epithelial cells. Niacinamide 117-129 sirtuin 1 Homo sapiens 100-105 23137540-6 2012 Conversely, suppression of SIRT1 activity with nicotinamide inhibited the effect of resveratrol on JNK phosphorylation, leading to restoration of resistance to oxidation-induced apoptosis. Niacinamide 47-59 sirtuin 1 Homo sapiens 27-32 23092114-5 2013 EXPERT OPINION: Nicotinamide, erythropoietin, and the downstream pathways of SIRT1, mTOR, forkhead transcription factors, and wingless signaling offer exciting prospects for novel directions of drug discovery for the treatment of metabolic disorders. Niacinamide 16-28 sirtuin 1 Homo sapiens 77-82 22465780-3 2012 Here we present evidence that the metabolite nicotinamide, an inhibitor of SIRT1, PARP-1 and mono(ADP-ribosyl) transferases, blocks the ability of dexamethasone to induce the acute response of the circadian clock gene, mper1, while it concomitantly reduces the levels of histone H3 trimethylation of lysine 4 (H3K4me3) in the mper1 promoter. Niacinamide 45-57 sirtuin 1 Homo sapiens 75-80 22717288-7 2012 Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of CD40 induced by TNF-alpha in 3T3-L1 adipocytes, whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-alpha-induced expression of CD40. Niacinamide 196-208 sirtuin 1 Homo sapiens 18-23 22717288-7 2012 Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of CD40 induced by TNF-alpha in 3T3-L1 adipocytes, whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-alpha-induced expression of CD40. Niacinamide 196-208 sirtuin 1 Homo sapiens 27-32 22717288-7 2012 Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of CD40 induced by TNF-alpha in 3T3-L1 adipocytes, whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-alpha-induced expression of CD40. Niacinamide 196-208 sirtuin 1 Homo sapiens 27-32 22717288-7 2012 Overexpression of SIRT1 or SIRT1 activation by resveratrol obviously attenuated the expression of CD40 induced by TNF-alpha in 3T3-L1 adipocytes, whereas knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol significantly enhanced TNF-alpha-induced expression of CD40. Niacinamide 196-208 sirtuin 1 Homo sapiens 27-32 22717288-8 2012 Furthermore, overexpression of SIRT1 or SIRT1 activation by resveratrol diminished TNF-alpha-induced acetylation of NF-kappaBp65, while knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol augmented TNF-alpha-induced acetylation of NF-kappaBp65 in 3T3-L1 adipocytes. Niacinamide 178-190 sirtuin 1 Homo sapiens 31-36 22717288-8 2012 Furthermore, overexpression of SIRT1 or SIRT1 activation by resveratrol diminished TNF-alpha-induced acetylation of NF-kappaBp65, while knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol augmented TNF-alpha-induced acetylation of NF-kappaBp65 in 3T3-L1 adipocytes. Niacinamide 178-190 sirtuin 1 Homo sapiens 40-45 22717288-8 2012 Furthermore, overexpression of SIRT1 or SIRT1 activation by resveratrol diminished TNF-alpha-induced acetylation of NF-kappaBp65, while knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol augmented TNF-alpha-induced acetylation of NF-kappaBp65 in 3T3-L1 adipocytes. Niacinamide 178-190 sirtuin 1 Homo sapiens 40-45 22717288-8 2012 Furthermore, overexpression of SIRT1 or SIRT1 activation by resveratrol diminished TNF-alpha-induced acetylation of NF-kappaBp65, while knockdown of SIRT1 or SIRT1 inhibition by nicotinamide and sirtinol augmented TNF-alpha-induced acetylation of NF-kappaBp65 in 3T3-L1 adipocytes. Niacinamide 178-190 sirtuin 1 Homo sapiens 40-45 22780949-4 2012 A SIRT1 activator resveratrol elevated E-cadherin expression in a dose dependent manner, while SIRT1 repressors nicotinamide and sirtinol exhibited a dose dependent reduction of E-cadherin expression. Niacinamide 112-124 sirtuin 1 Homo sapiens 95-100 22385246-6 2012 Blockade of SIRT1 activity by the SIRT1 inhibitors sirtinol and nicotinamide and down-regulation of SIRT1 expression by SIRT1 siRNA reduced the stimulatory effects of MS on defensins and TLRs, but increased its effects on cytokines and chemokines. Niacinamide 64-76 sirtuin 1 Homo sapiens 12-17 22689577-7 2012 In contrast, Sirt-1 activator resveratrol inhibited interleukin-1beta (IL-1beta)- and nicotinamide-induced NF-kappaB activation and p65 acetylation and suppressed the activation of IkappaB-alpha kinase. Niacinamide 86-98 sirtuin 1 Homo sapiens 13-19 22562294-5 2012 Reduction of SIRT1 with siRNA or suppression of SIRT1 activity with nicotinamide upregulated beta-catenin protein levels. Niacinamide 80-92 sirtuin 1 Homo sapiens 60-65 22493485-0 2012 Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. Niacinamide 0-12 sirtuin 1 Homo sapiens 75-80 22493485-3 2012 Here, we present evidence to show that the effect of nicotinamide is mediated through an increase of the [NAD(+)]/[NADH] ratio and the activation of SIRT1, an NAD(+)-dependent deacetylase that plays a role in autophagy flux. Niacinamide 53-65 sirtuin 1 Homo sapiens 149-154 22385246-6 2012 Blockade of SIRT1 activity by the SIRT1 inhibitors sirtinol and nicotinamide and down-regulation of SIRT1 expression by SIRT1 siRNA reduced the stimulatory effects of MS on defensins and TLRs, but increased its effects on cytokines and chemokines. Niacinamide 64-76 sirtuin 1 Homo sapiens 34-39 22385246-6 2012 Blockade of SIRT1 activity by the SIRT1 inhibitors sirtinol and nicotinamide and down-regulation of SIRT1 expression by SIRT1 siRNA reduced the stimulatory effects of MS on defensins and TLRs, but increased its effects on cytokines and chemokines. Niacinamide 64-76 sirtuin 1 Homo sapiens 34-39 22385246-6 2012 Blockade of SIRT1 activity by the SIRT1 inhibitors sirtinol and nicotinamide and down-regulation of SIRT1 expression by SIRT1 siRNA reduced the stimulatory effects of MS on defensins and TLRs, but increased its effects on cytokines and chemokines. Niacinamide 64-76 sirtuin 1 Homo sapiens 34-39 22198152-0 2012 Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Niacinamide 0-12 sirtuin 1 Homo sapiens 16-21 22204321-5 2012 For examples, the key NAD(+)-dependent enzymes SIRT1 and SIRT2 have been indicated to strongly affect the pathological changes of PD and AD; PARP-1 inhibition can profoundly reduce the brain injury in the animal models of multiple neurological diseases; and administration of either NAD(+) or nicotinamide can also decrease ischemic brain damage. Niacinamide 293-305 sirtuin 1 Homo sapiens 47-52 21745208-8 2011 In contrast, inhibition of SIRT1 using sirtinol, nicotinamide and gene silencing by RNA interference suppressed mineralization and the expression of osteoblast marker mRNAs. Niacinamide 49-61 sirtuin 1 Homo sapiens 27-32 23155420-5 2012 Inhibition of SIRT1 amounts or activity using siRNA, sirtinol, nicotinamide, or etomoxir attenuated the amount of TG loss, while SIRT1 activator SRT1720 increased the TG loss. Niacinamide 63-75 sirtuin 1 Homo sapiens 14-19 22302044-4 2012 It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Niacinamide 206-218 sirtuin 1 Homo sapiens 66-71 22302044-4 2012 It was found that the administration with resveratrol, a putative SirT1 activator, enhanced the resistance of HepG2 cells against radiation-induced DNA damage of MN formation under hypoxia condition; while nicotinamide, a well-known SirT1 inhibitor, sensitized this radiation damage. Niacinamide 206-218 sirtuin 1 Homo sapiens 233-238 22302044-7 2012 In contrast, nicotinamide attenuated c-Myc protein degradation induced by radiation under hypoxia through inhibition of SirT1 deacetylase activity. Niacinamide 13-25 sirtuin 1 Homo sapiens 120-125 23024800-5 2012 Nicotinamide, an inhibitor of SIRT1, was also evaluated for its effects on liver tumorigenesis. Niacinamide 0-12 sirtuin 1 Homo sapiens 30-35 22539994-8 2012 The modulatory effects of resveratrol on nicotinamide-induced expression of PPAR-gamma and its cofactor NCoR were found to be mediated, at least in part, by Sirt-1/Runx2 association and deacetylation of Runx2. Niacinamide 41-53 sirtuin 1 Homo sapiens 157-163 22539994-9 2012 Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. Niacinamide 172-184 sirtuin 1 Homo sapiens 22-28 22539994-9 2012 Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. Niacinamide 172-184 sirtuin 1 Homo sapiens 97-103 22539994-9 2012 Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. Niacinamide 172-184 sirtuin 1 Homo sapiens 97-103 22539994-9 2012 Finally, knockdown of Sirt-1 by using antisense oligonucleotides downregulated the expression of Sirt-1 protein and abolished the inhibitory effects of resveratrol, namely nicotinamide-induced Sirt-1 suppression and Runx2 acetylation, suggesting that the acetylated content of Runx2 is related to downregulated Sirt-1 expression. Niacinamide 172-184 sirtuin 1 Homo sapiens 97-103 21947960-6 2011 Further, inactivation of endogenic Sirt1 by nicotinamide markedly increased chemo-sensitivity in cisplatin resistant sub-cell line Tca8113/CDDP. Niacinamide 44-56 sirtuin 1 Homo sapiens 35-40 21289058-8 2011 Accordingly, we find that SIRT1 inhibition by nicotinamide limits proliferation, notably by increasing endogenous FOXL2 amount/activity. Niacinamide 46-58 sirtuin 1 Homo sapiens 26-31 21565980-4 2011 In this study, we showed that CLL cells express high levels of functional SIRT1, which is inhibited by exogenous nicotinamide. Niacinamide 113-125 sirtuin 1 Homo sapiens 74-79 21565980-8 2011 When leukemic cells are simultaneously exposed to nicotinamide and etoposide, we observe a significant increase in miR-34a levels with a concomitant inhibition of SIRT1. Niacinamide 50-62 sirtuin 1 Homo sapiens 163-168 21565980-11 2011 We therefore concluded that nicotinamide has the dual property of inhibiting SIRT1 through a noncompetitive enzymatic block (p53 independent) and at the same time through miR-34a induction (p53 dependent). Niacinamide 28-40 sirtuin 1 Homo sapiens 77-82 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Niacinamide 65-77 sirtuin 1 Homo sapiens 112-121 21892612-9 2011 Mercaptosuccinate, a glutathione peroxidase (GPx-1) inhibitor or nicotinamide, a silent information regulator 2/sirtuin 1 (SIRT1) inhibitor could attenuate the antiapoptotic action of RSV on PMVECs; and RSV treatment upregulated GPx-1 and SIRT1 expression in PMVECs. Niacinamide 65-77 sirtuin 1 Homo sapiens 123-128 20972827-8 2011 Exposure to the SIRT1 inhibitors nicotinamide and sirtinol altered neither cell viability nor the fraction of apoptotic cells. Niacinamide 33-45 sirtuin 1 Homo sapiens 16-21 21196497-5 2011 The SIRT1-selective inhibitors EX-527 and nicotinamide stimulated Nrf2-dependent gene transcription, whereas resveratrol, a putative activator of SIRT1, was inhibitory, mimicking the effect of SIRT1. Niacinamide 42-54 sirtuin 1 Homo sapiens 4-9 21118843-6 2011 SIRT1 activator resveratrol decreased, whereas endogenous SIRT1 inhibitor nicotinamide increased Nox1 expression in A7r5 VSMCs. Niacinamide 74-86 sirtuin 1 Homo sapiens 58-63 21144831-4 2011 A specific inhibitor of Sirt1, nicotinamide, dramatically increased motoneuron formation. Niacinamide 31-43 sirtuin 1 Homo sapiens 24-29 20506278-3 2010 Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the conversion of nicotinamide into NAD(+), which is crucial for SIRT1 activation. Niacinamide 94-106 sirtuin 1 Homo sapiens 141-146 19828042-8 2009 Similar effect was obtained with the Sirt1-inhibitor nicotinamide. Niacinamide 53-65 sirtuin 1 Homo sapiens 37-42 20171273-5 2010 By the use of either small interfering RNAs to target SIRT1 or the SIRT1 inhibitor nicotinamide we found that Nox1-dependent inhibition of p53 transcriptional activity was SIRT1-dependent. Niacinamide 83-95 sirtuin 1 Homo sapiens 67-72 20171273-5 2010 By the use of either small interfering RNAs to target SIRT1 or the SIRT1 inhibitor nicotinamide we found that Nox1-dependent inhibition of p53 transcriptional activity was SIRT1-dependent. Niacinamide 83-95 sirtuin 1 Homo sapiens 67-72 19682970-4 2009 By this assay, we found that nicotinamide, Cu(2+), and Zn(2+) antagonize the activity of SIRT1. Niacinamide 29-41 sirtuin 1 Homo sapiens 89-94 19720090-6 2009 SIRT1 activator resveratrol reversed Tat-mediated reduction in AMPK activation and downstream ACC activation; while SIRT1 inhibitor nicotinamide or knockdown of SIRT1 by siRNA potentiated Tat-mediated reduction in AMPK activation and downstream ACC activation. Niacinamide 132-144 sirtuin 1 Homo sapiens 116-121 19720090-6 2009 SIRT1 activator resveratrol reversed Tat-mediated reduction in AMPK activation and downstream ACC activation; while SIRT1 inhibitor nicotinamide or knockdown of SIRT1 by siRNA potentiated Tat-mediated reduction in AMPK activation and downstream ACC activation. Niacinamide 132-144 sirtuin 1 Homo sapiens 116-121 20169165-5 2010 The SIRT1 activator resveratrol reduces, whereas SIRT1 inhibitor nicotinamide enhances mTOR activity in a SIRT1 dependent manner. Niacinamide 65-77 sirtuin 1 Homo sapiens 49-54 20169165-5 2010 The SIRT1 activator resveratrol reduces, whereas SIRT1 inhibitor nicotinamide enhances mTOR activity in a SIRT1 dependent manner. Niacinamide 65-77 sirtuin 1 Homo sapiens 49-54 19934257-7 2010 Activation of SIRT1 with resveratrol promotes binding of APE1 to the BER protein X-ray cross-complementing-1 (XRCC1), while inhibition of SIRT1 with nicotinamide (NAM) decreases this interaction. Niacinamide 149-161 sirtuin 1 Homo sapiens 138-143 18681908-7 2009 SIRT1 activator, resveratrol, which has been considered as an important antioxidant, protects against UV- and H(2)O(2)-induced cell death, whereas SIRT inhibitors such as sirtinol and nicotinamide enhance cell death. Niacinamide 184-196 sirtuin 1 Homo sapiens 0-5 18681908-8 2009 Activation of SIRT1 negatively regulates UV- and H(2)O(2)-induced p53 acetylation, because nicotinamide and sirtinol as well as SIRT1 siRNA enhance UV- and H(2)O(2)-induced p53 acetylation, whereas SIRT1 activator resveratrol inhibits it. Niacinamide 91-103 sirtuin 1 Homo sapiens 14-19 19010791-10 2009 The regulatory relationship between FOXL2 and SIRT1 prompted us the test action of nicotinamide, an inhibitor of sirtuins, on FoxL2 expression/activity. Niacinamide 83-95 sirtuin 1 Homo sapiens 46-51 19303434-9 2009 The protective ability of RV against DOX was abolished when Sirt1 was inhibited by nicotinamide. Niacinamide 83-95 sirtuin 1 Homo sapiens 60-65 19302375-3 2009 Nicotinamide phosphoribosyltransferase (Nampt), also known as PBEF and visfatin, is rate-limiting for NAD+ salvage from nicotinamide and confers resistance to oxidative stress via SIRT1. Niacinamide 120-132 sirtuin 1 Homo sapiens 180-185 18563176-6 2009 We experimentally assayed this prediction and found that the SIRT1 inhibitor nicotinamide inhibited expression of keratinocyte differentiation markers, whereas a SIRT1 activator, resveratrol, enhanced expression of keratinocyte differentiation markers. Niacinamide 77-89 sirtuin 1 Homo sapiens 61-66 18922599-6 2009 Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation. Niacinamide 178-190 sirtuin 1 Homo sapiens 77-82 18922599-6 2009 Using O2 levels as a platform to modulate basal Sirt1 protein, activation of Sirt1 activity with resveratrol in 20% O2 increased MPC proliferation while inhibition of Sirt1 with nicotinamide in 5% O2 lowered proliferation. Niacinamide 178-190 sirtuin 1 Homo sapiens 77-82 19075016-7 2009 Interestingly, our data demonstrated that SIRT1 inhibition via nicotinamide and sirtinol (at the activity level) as well as via short hairpin RNA-mediated RNA interference (at the genetic level) resulted in a significant inhibition in the growth and viability of human PCa cells while having no effect on normal prostate epithelial cells. Niacinamide 63-75 sirtuin 1 Homo sapiens 42-47 18230337-0 2008 p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells. Niacinamide 77-89 sirtuin 1 Homo sapiens 6-11 18230337-1 2008 Nicotinamide at mM concentration is a potent inhibitor of certain key molecules involved in cell survival, such as SIRT1 and PARP-1, and affects cell survival in various conditions in vivo and in vitro. Niacinamide 0-12 sirtuin 1 Homo sapiens 115-120 18230337-3 2008 In our study, the treatment of 10mM nicotinamide downregulated p21WAF1 expression in various human cells including p53-negative or SIRT1-knockdown cells indicating gene regulation not mediated by p53 or SIRT1. Niacinamide 36-48 sirtuin 1 Homo sapiens 131-136 18230337-3 2008 In our study, the treatment of 10mM nicotinamide downregulated p21WAF1 expression in various human cells including p53-negative or SIRT1-knockdown cells indicating gene regulation not mediated by p53 or SIRT1. Niacinamide 36-48 sirtuin 1 Homo sapiens 203-208 15150415-3 2004 To provide structural insights into the chemistry catalyzed by Sir2 proteins we report the high-resolution ternary structure of yeast Hst2 (homologue of Sir two 2) with an acetyllysine histone H4 peptide and a nonhydrolyzable NAD(+) analogue, carba-NAD(+), as well as an analogous ternary complex with a reaction intermediate analog formed immediately after nicotinamide hydrolysis, ADP-ribose. Niacinamide 358-370 sirtuin 1 Homo sapiens 63-67 17964266-5 2007 AROS activity was abrogated by the SIRT1 inhibitors splitomicin and nicotinamide and by SIRT1 small interfering RNA (siRNA). Niacinamide 68-80 sirtuin 1 Homo sapiens 35-40 17347648-4 2007 Moreover, expression of the acetyltransferase, GCN5, or the SIRT1 inhibitor, nicotinamide, induces PGC-1alpha acetylation and decreases expression of PGC-1alpha target genes in myotubes. Niacinamide 77-89 sirtuin 1 Homo sapiens 60-65 16815704-5 2006 Residues corresponding to the nicotinamide binding pocket of Sir2p are essential for Hst3p function, and H3 K56 deacetylation is inhibited by nicotinamide in vivo. Niacinamide 30-42 sirtuin 1 Homo sapiens 61-66 16815704-5 2006 Residues corresponding to the nicotinamide binding pocket of Sir2p are essential for Hst3p function, and H3 K56 deacetylation is inhibited by nicotinamide in vivo. Niacinamide 142-154 sirtuin 1 Homo sapiens 61-66 16783373-1 2006 Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Niacinamide 59-71 sirtuin 1 Homo sapiens 172-177 15716268-9 2005 This acetylation is augmented by treatment with the SIRT1 inhibitor nicotinamide or by expression of the transcriptional coactivator p300. Niacinamide 68-80 sirtuin 1 Homo sapiens 52-57 15780941-0 2005 Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Niacinamide 35-47 sirtuin 1 Homo sapiens 98-102 15780941-2 2005 Sir2 activity is regulated by nicotinamide, a noncompetitive inhibitor that promotes a base-exchange reaction at the expense of deacetylation. Niacinamide 30-42 sirtuin 1 Homo sapiens 0-4 15780941-3 2005 To elucidate the mechanism of nicotinamide inhibition, we determined ternary complex structures of Sir2 enzymes containing nicotinamide. Niacinamide 30-42 sirtuin 1 Homo sapiens 99-103 15780941-3 2005 To elucidate the mechanism of nicotinamide inhibition, we determined ternary complex structures of Sir2 enzymes containing nicotinamide. Niacinamide 123-135 sirtuin 1 Homo sapiens 99-103 15780941-6 2005 The characteristics of the altered specificity enzyme establish that Sir2 enzymes contain a single site that participates in catalysis and nicotinamide regulation and provides additional insights into the Sir2 catalytic mechanism. Niacinamide 139-151 sirtuin 1 Homo sapiens 69-73 15780941-6 2005 The characteristics of the altered specificity enzyme establish that Sir2 enzymes contain a single site that participates in catalysis and nicotinamide regulation and provides additional insights into the Sir2 catalytic mechanism. Niacinamide 139-151 sirtuin 1 Homo sapiens 205-209 15301953-5 2004 Using this method, the kinetics of the reaction of the cosubstrate nicotinamide adenine dinucleotide and the competitive inhibitor nicotinamide with SIRT1 and SIRT2 has been analyzed. Niacinamide 67-79 sirtuin 1 Homo sapiens 149-154 15150415-0 2004 Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Niacinamide 21-33 sirtuin 1 Homo sapiens 87-91 17901049-3 2007 Protein deacetylase activity of SirT1, the mammalian homologue of Sir2, was suppressed through either nicotinamide treatment or RNA interference in several cell lines, and these cells displayed impaired insulin responses. Niacinamide 102-114 sirtuin 1 Homo sapiens 32-37 17901049-3 2007 Protein deacetylase activity of SirT1, the mammalian homologue of Sir2, was suppressed through either nicotinamide treatment or RNA interference in several cell lines, and these cells displayed impaired insulin responses. Niacinamide 102-114 sirtuin 1 Homo sapiens 66-70 17620057-7 2007 The ability of SIRT1 to catalyse the deacetylation of Rb was dependent on NAD and was inhibited by the SIRT1 inhibitor nicotinamide. Niacinamide 119-131 sirtuin 1 Homo sapiens 15-20 17620057-7 2007 The ability of SIRT1 to catalyse the deacetylation of Rb was dependent on NAD and was inhibited by the SIRT1 inhibitor nicotinamide. Niacinamide 119-131 sirtuin 1 Homo sapiens 103-108 17620057-10 2007 Overexpression of SIRT1 in either confluent or etoposide-treated cells resulted in a significant reduction in Rb acetylation, which was restored with nicotinamide. Niacinamide 150-162 sirtuin 1 Homo sapiens 18-23 17620057-12 2007 This increase was augmented further when siRNA against SIRT1 was used in conjunction with nicotinamide. Niacinamide 90-102 sirtuin 1 Homo sapiens 55-60 16388603-3 2006 Sir2 proteins (sirtuins) catalyze the chemical conversion of NAD+ and acetylated lysine to nicotinamide, deacetylated lysine, and 2"-O-acetyl-ADP-ribose (OAADPr). Niacinamide 91-103 sirtuin 1 Homo sapiens 0-4 15639232-5 2005 BCL11A-mediated transcriptional repression, as well as deacetylation of histone H3/H4 in BCL11A-transfected cells, was partially reversed by nicotinamide, an inhibitor of class III histone deacetylases such as SIRT1. Niacinamide 141-153 sirtuin 1 Homo sapiens 210-215 15150415-4 2004 The ternary complex with carba-NAD(+) reveals that the nicotinamide group makes stabilizing interactions within a binding pocket harboring conserved Sir2 residues. Niacinamide 55-67 sirtuin 1 Homo sapiens 149-153 15150415-5 2004 Moreover, an asparagine residue, N116, strictly conserved within Sir2 proteins and shown to be essential for nicotinamide exchange, is in position to stabilize the oxocarbenium intermediate that has been proposed to proceed the hydrolysis of nicotinamide. Niacinamide 109-121 sirtuin 1 Homo sapiens 65-69 15150415-5 2004 Moreover, an asparagine residue, N116, strictly conserved within Sir2 proteins and shown to be essential for nicotinamide exchange, is in position to stabilize the oxocarbenium intermediate that has been proposed to proceed the hydrolysis of nicotinamide. Niacinamide 242-254 sirtuin 1 Homo sapiens 65-69 14727515-11 2003 Nicotinamide, splitomicin and sirtinol, potent inhibitors of Sir2 alpha, inhibited the growth of neurosphere. Niacinamide 0-12 sirtuin 1 Homo sapiens 61-65 15023335-5 2004 We propose a detailed structure-based mechanism for deacetylation and nicotinamide inhibition of Sir2 consistent with mutagenesis and enzymatic studies. Niacinamide 70-82 sirtuin 1 Homo sapiens 97-101 33802063-0 2021 Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca2. Niacinamide 0-12 sirtuin 1 Homo sapiens 93-98 12879452-3 2003 The decline of NAD(+) and the rise of nicotinamide may downregulate the activity of Sir2, the NAD(+)-dependent deacetylases, because deacetylation by Sir2 is dependent on high concentration of NAD(+) and inhibited by physiologic level of nicotinamide. Niacinamide 38-50 sirtuin 1 Homo sapiens 84-88 12879452-3 2003 The decline of NAD(+) and the rise of nicotinamide may downregulate the activity of Sir2, the NAD(+)-dependent deacetylases, because deacetylation by Sir2 is dependent on high concentration of NAD(+) and inhibited by physiologic level of nicotinamide. Niacinamide 38-50 sirtuin 1 Homo sapiens 150-154 12879452-3 2003 The decline of NAD(+) and the rise of nicotinamide may downregulate the activity of Sir2, the NAD(+)-dependent deacetylases, because deacetylation by Sir2 is dependent on high concentration of NAD(+) and inhibited by physiologic level of nicotinamide. Niacinamide 238-250 sirtuin 1 Homo sapiens 84-88 12879452-3 2003 The decline of NAD(+) and the rise of nicotinamide may downregulate the activity of Sir2, the NAD(+)-dependent deacetylases, because deacetylation by Sir2 is dependent on high concentration of NAD(+) and inhibited by physiologic level of nicotinamide. Niacinamide 238-250 sirtuin 1 Homo sapiens 150-154 12879452-5 2003 It is conceivable that poly(ADP-ribosyl)ation by PARP-1, which is induced by DNA damage, could modulate protein deacetylation by Sir2 via the NAD(+)/nicotinamide connection. Niacinamide 149-161 sirtuin 1 Homo sapiens 129-133 11672522-3 2001 Nicotinamide (Vitamin B3) inhibits an NAD-dependent p53 deacetylation induced by Sir2alpha, and also enhances the p53 acetylation levels in vivo. Niacinamide 0-12 sirtuin 1 Homo sapiens 81-90 11672522-3 2001 Nicotinamide (Vitamin B3) inhibits an NAD-dependent p53 deacetylation induced by Sir2alpha, and also enhances the p53 acetylation levels in vivo. Niacinamide 14-24 sirtuin 1 Homo sapiens 81-90 12736687-5 2003 We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Niacinamide 121-131 sirtuin 1 Homo sapiens 28-32 12736687-5 2003 We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Niacinamide 121-131 sirtuin 1 Homo sapiens 65-70 12736687-5 2003 We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Niacinamide 142-154 sirtuin 1 Homo sapiens 28-32 12736687-5 2003 We have recently shown that Sir2 and its closest human homologue SIRT1, a p53 deacetylase, are strongly inhibited by the vitamin B3 precursor nicotinamide. Niacinamide 142-154 sirtuin 1 Homo sapiens 65-70 12736687-8 2003 We provide evidence that nicotinamide depletion is sufficient to activate Sir2 and that this is the mechanism by which PNC1 regulates longevity. Niacinamide 25-37 sirtuin 1 Homo sapiens 74-78 12297502-0 2002 Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. Niacinamide 49-61 sirtuin 1 Homo sapiens 102-106 12297502-0 2002 Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. Niacinamide 49-61 sirtuin 1 Homo sapiens 117-122 12297502-3 2002 The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B(3). Niacinamide 80-92 sirtuin 1 Homo sapiens 4-8 12297502-3 2002 The Sir2 deacetylation reaction generates two products: O-acetyl-ADP-ribose and nicotinamide, a precursor of nicotinic acid and a form of niacin/vitamin B(3). Niacinamide 145-154 sirtuin 1 Homo sapiens 4-8 12297502-4 2002 We show here that nicotinamide strongly inhibits yeast silencing, increases rDNA recombination, and shortens replicative life span to that of a sir2 mutant. Niacinamide 18-30 sirtuin 1 Homo sapiens 144-148 12297502-5 2002 Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. Niacinamide 0-12 sirtuin 1 Homo sapiens 76-80 12297502-5 2002 Nicotinamide abolishes silencing and leads to an eventual delocalization of Sir2 even in G(1)-arrested cells, demonstrating that silent heterochromatin requires continual Sir2 activity. Niacinamide 0-12 sirtuin 1 Homo sapiens 171-175 12297502-6 2002 We show that physiological concentrations of nicotinamide noncompetitively inhibit both Sir2 and SIRT1 in vitro. Niacinamide 45-57 sirtuin 1 Homo sapiens 88-92 12297502-6 2002 We show that physiological concentrations of nicotinamide noncompetitively inhibit both Sir2 and SIRT1 in vitro. Niacinamide 45-57 sirtuin 1 Homo sapiens 97-102 12297502-9 2002 We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes. Niacinamide 32-44 sirtuin 1 Homo sapiens 88-92 33802063-2 2021 Previously, we showed that mitophagy is activated in human cells through SIRT1 activation upon treatment of nicotinamide (NAM). Niacinamide 108-120 sirtuin 1 Homo sapiens 73-78 33802063-2 2021 Previously, we showed that mitophagy is activated in human cells through SIRT1 activation upon treatment of nicotinamide (NAM). Niacinamide 122-125 sirtuin 1 Homo sapiens 73-78 35566069-1 2022 SIRT1, an NAD+-dependent deacetylase, catalyzes the deacetylation of proteins coupled with the breakdown of NAD+ into nicotinamide and 2"-O-acetyl-ADP-ribose (OAADPr). Niacinamide 118-130 sirtuin 1 Homo sapiens 0-5 35633910-8 2022 N-acetyl-L-cysteine was used to remove ROS, and the expression of Sirt1 was inhibited by nicotinamide. Niacinamide 89-101 sirtuin 1 Homo sapiens 66-71 34184746-7 2021 To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31. Niacinamide 208-220 sirtuin 1 Homo sapiens 66-75 34184746-7 2021 To further investigate its activity in tumorigenesis, deacetylase sirtuin 1 (Sirt1) was shown to interact with USP31 by co-immunoprecipitation and blocking the function of Sirt1 by knockdown or the inhibitor nicotinamide could increase the acetylation of USP31. Niacinamide 208-220 sirtuin 1 Homo sapiens 77-82 35301252-7 2022 Ferulic acid also enhances the activation of AMP-activated kinase (AMPK) by increasing expression and activity of its activating kinase LKB1-whereas AMPK in turn amplifies Sirt1 activity by promoting induction of nicotinamide phosphoribosyltranferase, rate-limiting for generation of Sirt1"s obligate substrate NAD+. Niacinamide 213-225 sirtuin 1 Homo sapiens 172-177 35251333-0 2022 Sirtuin 1 participates in intervertebral disc degeneration via the nicotinamide phosphoribosyl transferase/nicotinamide adenine dinucleotide/sirtuin 1 pathway responsible for regulating autophagy of nucleus pulposus cells. Niacinamide 67-79 sirtuin 1 Homo sapiens 0-9 35251333-0 2022 Sirtuin 1 participates in intervertebral disc degeneration via the nicotinamide phosphoribosyl transferase/nicotinamide adenine dinucleotide/sirtuin 1 pathway responsible for regulating autophagy of nucleus pulposus cells. Niacinamide 67-79 sirtuin 1 Homo sapiens 141-150