PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21131399-7	2011	Nicotinamide proapoptotic effect was associated with enhanced caspase-3 activity.	Niacinamide	0-12	caspase 3	Mus musculus	62-71	
29424794-8	2019	Sirt1 blocker nicotinamide and Nrf2 siRNA restrained the levels of GRP78, CHOP, Bax, and active caspase 3.	Niacinamide	14-26	caspase 3	Mus musculus	96-105	
29327278-0	2018	Nicotinamide Inhibits Ethanol-Induced Caspase-3 and PARP-1 Over-activation and Subsequent Neurodegeneration in the Developing Mouse Cerebellum.	Niacinamide	0-12	caspase 3	Mus musculus	38-47	
29327278-7	2018	Interestingly, treatment with nicotinamide, immediately or 2 h after ethanol exposure, diminished caspase-3 and PARP-1 over-activation and reduced ethanol-induced neurodegeneration.	Niacinamide	30-42	caspase 3	Mus musculus	98-107	
29327278-9	2018	Our results showed that nicotinamide reduces ethanol-induced neuronal cell death and inhibits both caspase-3 and PARP-1 alcohol-induced activation in the developing cerebellum, suggesting that nicotinamide might be a promising and safe neuroprotective agent for treating FASD and other neurodegenerative disorders in the developing brain that shares similar cell death pathways.	Niacinamide	24-36	caspase 3	Mus musculus	99-108	
29327278-9	2018	Our results showed that nicotinamide reduces ethanol-induced neuronal cell death and inhibits both caspase-3 and PARP-1 alcohol-induced activation in the developing cerebellum, suggesting that nicotinamide might be a promising and safe neuroprotective agent for treating FASD and other neurodegenerative disorders in the developing brain that shares similar cell death pathways.	Niacinamide	193-205	caspase 3	Mus musculus	99-108	
23403179-13	2013	Caspase-3 activity was significantly increased in PARP-1 knockout females compared to males and wild-type females, this was reversed with nicotinamide.	Niacinamide	138-150	caspase 3	Mus musculus	0-9	
16478293-6	2006	The effects of nicotinamide on ethanol-induced activation of caspase-3 and release of cytochrome-c from the mitochondria were analyzed by Western blot (n = 4-7/group).	Niacinamide	15-27	caspase 3	Mus musculus	61-70	
16478293-9	2006	Nicotinamide reduced the activation of caspase-3 (85.14 +/- 4.1%) and the release of cytochrome-c (80.78 +/- 4.39%) in postnatal mouse forebrain, too.	Niacinamide	0-12	caspase 3	Mus musculus	39-48