PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7903279-4	1993	Nicotinamide and 3-AB dose-dependently inhibited the induction of ICAM-1 expression by IFN-gamma or PHA on thyroid cells.	Niacinamide	0-12	interferon gamma	Homo sapiens	87-96	
11914744-11	2002	CONCLUSION/INTERPRETATION: IFN gamma and TNFalpha synergistically induced MHC class II expression on insulinoma cells through the induction of CIITA; nicotinamide reduced the expression of cytokine-induced MHC class II expression on insulinoma cells through its effect on CIITA expression; and the preventive effect of nicotimamide on Type I (insulin-dependent) diabetes mellitus is probably due to its effect of MHC class II expression rather than that on islet cell apoptosis.	Niacinamide	150-162	interferon gamma	Homo sapiens	27-36	
20495288-0	2010	Interferon-gamma elevates nicotinamide N-methyltransferase activity and nicotinamide level in human glioma cells.	Niacinamide	26-38	interferon gamma	Homo sapiens	0-16	
20495288-5	2010	To clarify the mechanisms by which IFN-gamma increases 1-methylnicotinamide levels in these cells, we measured NNMT activity and the levels of NNMT expression, nicotinamide and nicotinamide adenine dinucleotide (NAD(+)) in the presence and absence of IFN-gamma.	Niacinamide	63-75	interferon gamma	Homo sapiens	35-44	
20495288-8	2010	Conversely, IFN-gamma significantly increased NNMT activity and the nicotinamide cellular concentration, while leaving NNMT expression and the NAD(+) cellular concentration unchanged.	Niacinamide	68-80	interferon gamma	Homo sapiens	12-21	
20495288-9	2010	Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se.	Niacinamide	39-51	interferon gamma	Homo sapiens	69-78	
20495288-9	2010	Therefore, the increase in the 1-methylnicotinamide level found when IFN-gamma is present in culture may be a consequence of increases in both the nicotinamide concentration and NNMT activity, whereas, 1-methylnicotinamide did not influence nicotinamide levels, NAD(+) levels, or cell viability per se.	Niacinamide	147-159	interferon gamma	Homo sapiens	69-78	
16704296-0	2006	Nicotinamide reduces high secretion of IFN-gamma in high-risk relatives even though it does not prevent type 1 diabetes.	Niacinamide	0-12	interferon gamma	Homo sapiens	39-48	
16704296-9	2006	Nicotinamide caused decreased spontaneous (p = 0.05) and in vitro autoantigen-induced IFN-gamma secretion (p < 0.05) and may play a role in immune regulation, even though it has not been shown to prevent T1D.	Niacinamide	0-12	interferon gamma	Homo sapiens	86-95	
1532770-0	1992	Nicotinamide and 3-aminobenzamide inhibit recombinant human interferon-gamma-induced HLA-DR antigen expression, but not HLA-A, B, C antigen expression, on cultured human thyroid cells.	Niacinamide	0-12	interferon gamma	Homo sapiens	60-76	
1532770-1	1992	OBJECTIVE: We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves" disease.	Niacinamide	51-63	interferon gamma	Homo sapiens	146-162	
1347751-0	1992	Inhibitory effects of nicotinamide on recombinant human interferon-gamma-induced intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigen expression on cultured human endothelial cells.	Niacinamide	22-34	interferon gamma	Homo sapiens	56-72	
1347751-2	1992	In the present study, we investigated the effect of nicotinamide, an inhibitor of poly(ADP ribose) synthetase, on interferon-gamma (IFN gamma)-induced ICAM-1 and HLA-DR antigen expression on the surface of cultured human umbilical vein endothelial cells, assessed by flow cytometry, and EC proliferation by counting cell numbers and [3H]thymidine incorporation assays.	Niacinamide	52-64	interferon gamma	Homo sapiens	114-130	
1834724-1	1991	We investigated the effects of nicotinamide and 3-aminobenzamide, known as inhibitors of poly (ADP-ribose) synthetase, on the expression of interferon- gamma (IFN-gamma)-induced class I and II major histocompatibility complex (MHC) molecules on the surface of cultured human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF).	Niacinamide	31-43	interferon gamma	Homo sapiens	159-168	
1834724-5	1991	Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression.	Niacinamide	0-12	interferon gamma	Homo sapiens	97-107	
1834724-5	1991	Nicotinamide and 3-aminobenzamide in the concentration greater than or equal to 1 mM reduced the IFN- gamma -induced expression of HLA-DR and HLA-DP on both HUVEC and HDF, whereas neither agent in the concentration of up to 10 mM affected the IFN- gamma -induced increase in HLA-A,B,C molecule expression.	Niacinamide	0-12	interferon gamma	Homo sapiens	243-253	
2503544-7	1989	Inhibition by IFN-gamma (100-300 U/ml after 5-6 d) was, however, completely prevented by addition of two inhibitors of adenosine diphosphate-ribosyl transferase (ADP-RT), 3-aminobenzamide or nicotinamide.	Niacinamide	191-203	interferon gamma	Homo sapiens	14-23