PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 180977-3 1976 Poly(ADP-ribose) polymerase is inhibited by ATP, thymidine, nicotinamide, theophylline, 3-isobutyl-1-methylxanthine and caffeine and stimulated by actinomycin D. Niacinamide 60-72 poly (ADP-ribose) polymerase 1 Rattus norvegicus 0-27 33428094-9 2021 Nicotinamide treatment suppressed oxidative stress and apoptosis by supporting antioxidant capacity and increased PPARgamma through SIRT1 activation, causing PARP1 to decrease. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 158-163 4325158-0 1971 Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5"-methyl nicotinamide. Niacinamide 97-109 poly (ADP-ribose) polymerase 1 Rattus norvegicus 43-69 32422328-11 2020 Bile duct ligated (BDL) rats were treated with nicotinamide (NA) as a PARP-1 inhibitor. Niacinamide 47-59 poly (ADP-ribose) polymerase 1 Rattus norvegicus 70-76 32631099-3 2021 The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract. Niacinamide 120-132 poly (ADP-ribose) polymerase 1 Rattus norvegicus 76-80 21399558-5 2011 Here, we tested the hypothesis that NO dysregulation in intestinal epithelial cells during NEC leads to marked PARP-1 expression and that administration of a PARP-1 inhibitor (nicotinamide) attenuates intestinal injury in a newborn rat model of NEC. Niacinamide 176-188 poly (ADP-ribose) polymerase 1 Rattus norvegicus 158-164 28844085-8 2018 Nicotinamide, a PARP-1 inhibitor, protects against the metabolic cascade elicited by the primary stage, avoiding NAD+ exhaustion and the energetic crisis. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 16-22 24723845-7 2014 Nicotinamide has been proposed as a suitable PARP-1 inhibitor. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 45-51 24723845-11 2014 Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 142-148 24723845-11 2014 Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles. Niacinamide 274-286 poly (ADP-ribose) polymerase 1 Rattus norvegicus 142-148 24151909-0 2014 Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Abeta(1-42)-induced rat model of Alzheimer"s disease. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 78-84 24151909-3 2014 In this study we searched the effects of nicotinamide (NA), endogenous PARP-1 inhibitor, on oxidative stress, apoptosis, and the regulation of PARP-1 and nuclear factor kappa B (NF-kappaB) in amyloid beta peptide (1-42) (Abeta(1-42))-induced neurodegeneration. Niacinamide 41-53 poly (ADP-ribose) polymerase 1 Rattus norvegicus 71-77 24151909-3 2014 In this study we searched the effects of nicotinamide (NA), endogenous PARP-1 inhibitor, on oxidative stress, apoptosis, and the regulation of PARP-1 and nuclear factor kappa B (NF-kappaB) in amyloid beta peptide (1-42) (Abeta(1-42))-induced neurodegeneration. Niacinamide 41-53 poly (ADP-ribose) polymerase 1 Rattus norvegicus 143-149 30054774-0 2018 Nicotinamide reverses behavioral impairments and provides neuroprotection in 3-nitropropionic acid induced animal model ofHuntington"s disease: implication of oxidative stress- poly(ADP- ribose) polymerase pathway. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 177-205 28844085-11 2018 Here, we discuss evidence showing that (i) inhibition of PARP-1 overactivation by nicotinamide and (ii) inhibition of extrasynaptic NMDA receptor overactivation by memantine can prevent the short- and long-term consequences of PA. Niacinamide 82-94 poly (ADP-ribose) polymerase 1 Rattus norvegicus 57-63 25835215-7 2015 A single dose of the PARP-1 inhibitor nicotinamide (0.8 mmol/kg, i.p. Niacinamide 38-50 poly (ADP-ribose) polymerase 1 Rattus norvegicus 21-27 25835215-9 2015 The present study demonstrates that PA leads to PARP-1 overactivation, increasing the expression of pro-inflammatory cytokines and cell death in mesencephalon, effects prevented by systemic neonatal nicotinamide administration, supporting the idea that PARP-1 inhibition represents a therapeutic target against the effects of PA. Niacinamide 199-211 poly (ADP-ribose) polymerase 1 Rattus norvegicus 48-54 25835215-9 2015 The present study demonstrates that PA leads to PARP-1 overactivation, increasing the expression of pro-inflammatory cytokines and cell death in mesencephalon, effects prevented by systemic neonatal nicotinamide administration, supporting the idea that PARP-1 inhibition represents a therapeutic target against the effects of PA. Niacinamide 199-211 poly (ADP-ribose) polymerase 1 Rattus norvegicus 253-259 25287541-6 2015 It is proposed that PARP-1 inhibition also down-regulates the expression of pro-inflammatory cytokines.Nicotinamide is a suitable PARP-1 inhibitor, whose effects have been studied in an experimental model of global perinatal asphyxia in rats, inducing the insult by immersing rat foetuses into a water bath for various periods of time. Niacinamide 103-115 poly (ADP-ribose) polymerase 1 Rattus norvegicus 20-26 25287541-6 2015 It is proposed that PARP-1 inhibition also down-regulates the expression of pro-inflammatory cytokines.Nicotinamide is a suitable PARP-1 inhibitor, whose effects have been studied in an experimental model of global perinatal asphyxia in rats, inducing the insult by immersing rat foetuses into a water bath for various periods of time. Niacinamide 103-115 poly (ADP-ribose) polymerase 1 Rattus norvegicus 130-136 25287541-8 2015 Systemic administration of nicotinamide 1 h after the insult inhibited PARP-1 overactivity in peripheral and brain tissue, preventing several of the long-term consequences elicited by perinatal asphyxia, supporting the idea that it constitutes a lead for exploring compounds with similar or better pharmacological profiles. Niacinamide 27-39 poly (ADP-ribose) polymerase 1 Rattus norvegicus 71-77 22311271-0 2012 Further studies on the hypothesis of PARP-1 inhibition as a strategy for lessening the long-term effects produced by perinatal asphyxia: effects of nicotinamide and theophylline on PARP-1 activity in brain and peripheral tissue : nicotinamide and theophylline on PARP-1 activity. Niacinamide 230-242 poly (ADP-ribose) polymerase 1 Rattus norvegicus 37-43 22311271-11 2012 Only nicotinamide produced a consistent decrease in PARP-1 activity in brain and heart, whether assayed in control or asphyxia-exposed pups. Niacinamide 5-17 poly (ADP-ribose) polymerase 1 Rattus norvegicus 52-58 15564335-4 2005 In parallel with the activation of PARP, cellular ATP concentrations fall at high H2O2 doses and the PARP inhibitors, 3-aminobenzamide and nicotinamide (NIC) partially prevent this fall. Niacinamide 153-156 poly (ADP-ribose) polymerase 1 Rattus norvegicus 101-105 22164206-5 2011 Post-treatment of developing rats with nicotinamide suppressed thiotepa-induced upregulation of Bax, reduced cytochrome-c release into the cytosol and reduced expression of activated caspase-3 and cleavage of PARP-1. Niacinamide 39-51 poly (ADP-ribose) polymerase 1 Rattus norvegicus 209-215 17021258-3 2007 Nicotinamide (vitamin B3) is a weak PARP inhibitor, antioxidant, and calcium modulator and can improve energy status and inhibit cell death in ischemic tissues. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 36-40 17021258-3 2007 Nicotinamide (vitamin B3) is a weak PARP inhibitor, antioxidant, and calcium modulator and can improve energy status and inhibit cell death in ischemic tissues. Niacinamide 14-24 poly (ADP-ribose) polymerase 1 Rattus norvegicus 36-40 16168987-0 2006 Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly (ADP-ribose) polymerase activity and Jun N-terminal kinase/activator protein-1 pathway inhibition. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 96-124 18019406-11 2007 CONCLUSION: The PARP inhibitors nicotinamide and 3-aminobenzamide accelerated MNU-induced cataractogenesis. Niacinamide 32-44 poly (ADP-ribose) polymerase 1 Rattus norvegicus 16-20 17051386-13 2007 Nicotinamide can help to restore NADH/NAD+ depletion, but also to inhibit PARP-1 overactivation, a mechanism of action that has attracted attention, representing a novel target for neuroprotection following insults involving energy failure. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 74-80 15564335-4 2005 In parallel with the activation of PARP, cellular ATP concentrations fall at high H2O2 doses and the PARP inhibitors, 3-aminobenzamide and nicotinamide (NIC) partially prevent this fall. Niacinamide 139-151 poly (ADP-ribose) polymerase 1 Rattus norvegicus 35-39 15564335-4 2005 In parallel with the activation of PARP, cellular ATP concentrations fall at high H2O2 doses and the PARP inhibitors, 3-aminobenzamide and nicotinamide (NIC) partially prevent this fall. Niacinamide 153-156 poly (ADP-ribose) polymerase 1 Rattus norvegicus 35-39 15564335-5 2005 Using NIC to inhibit PARP activity, we show that treatment of cells with NIC before the addition of H2O2 (0.5-1 mm), results in rapid cell death (90 min). Niacinamide 6-9 poly (ADP-ribose) polymerase 1 Rattus norvegicus 21-25 15564335-5 2005 Using NIC to inhibit PARP activity, we show that treatment of cells with NIC before the addition of H2O2 (0.5-1 mm), results in rapid cell death (90 min). Niacinamide 73-76 poly (ADP-ribose) polymerase 1 Rattus norvegicus 21-25 9705078-0 1998 Nicotinamide-induced apoptosis in insulin producing cells is associated with cleavage of poly(ADP-ribose) polymerase. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 89-116 12419488-4 2002 Nicotinamide is known to inhibit poly(ADP-ribose) polymerase at early time points, but was found to increase poly(ADP-ribose) polymerase activity at 24 h of reperfusion. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 33-60 12419488-4 2002 Nicotinamide is known to inhibit poly(ADP-ribose) polymerase at early time points, but was found to increase poly(ADP-ribose) polymerase activity at 24 h of reperfusion. Niacinamide 0-12 poly (ADP-ribose) polymerase 1 Rattus norvegicus 109-136 9705078-2 1998 The ADP-ribosylation activities of intact cells were decreased by incubation of RINm5F cells for 16 h with the PARP inhibitors nicotinamide (NA) (20-50 mM) or 3-aminobenzamide (3-ABA) (10 mM). Niacinamide 127-139 poly (ADP-ribose) polymerase 1 Rattus norvegicus 111-115 7763299-5 1995 The rate of NAD+ deletion induced by tert-butyl hydroperoxide (500 microM) and 2,3-dimethoxy-1,4-naphthoquinone (50 microM) was reduced by preincubating the hepatocytes for 1 hr with either 3-aminobenzamide (20 mM), nicotinamide (10 mM) or theophylline (7.5 mM), potent inhibitors of poly(ADP-ribose)polymerase. Niacinamide 216-228 poly (ADP-ribose) polymerase 1 Rattus norvegicus 284-310 8532139-5 1995 The NO effect was probably not due to mono-ADP-ribosylation of cellular proteins, since the ADP-ribosyltransferase (ADPRT) inhibitors nicotinamide (10 microM-10 microM) and luminol (1 microM-1mM) did not diminish the enhancement of transmitter release seen with NO. Niacinamide 134-146 poly (ADP-ribose) polymerase 1 Rattus norvegicus 92-114 8532139-5 1995 The NO effect was probably not due to mono-ADP-ribosylation of cellular proteins, since the ADP-ribosyltransferase (ADPRT) inhibitors nicotinamide (10 microM-10 microM) and luminol (1 microM-1mM) did not diminish the enhancement of transmitter release seen with NO. Niacinamide 134-146 poly (ADP-ribose) polymerase 1 Rattus norvegicus 116-121 7763299-9 1995 These results suggest that during oxidative stress, NAD+ is hydrolysed to nicotinamide, possibly by the activation of poly(ADP-ribose)polymerase and that the depletion of NAD+ is independent of the increase in NADP+. Niacinamide 74-86 poly (ADP-ribose) polymerase 1 Rattus norvegicus 118-144 8261576-1 1993 At a concentration of 2.5 mM, nicotinamide (NA), an inhibitor of poly(ADP-ribose) polymerase (PARP), significantly potentiated the cytotoxicity of cisplatin (DDP) in a DDP-resistant rat ovarian tumor cell line (O-342/DDP) in vitro, whereas the same treatment had no substantial effect on DDP"s cytotoxic activity against the DDP-sensitive parental line (O-342). Niacinamide 30-42 poly (ADP-ribose) polymerase 1 Rattus norvegicus 65-92 8261576-1 1993 At a concentration of 2.5 mM, nicotinamide (NA), an inhibitor of poly(ADP-ribose) polymerase (PARP), significantly potentiated the cytotoxicity of cisplatin (DDP) in a DDP-resistant rat ovarian tumor cell line (O-342/DDP) in vitro, whereas the same treatment had no substantial effect on DDP"s cytotoxic activity against the DDP-sensitive parental line (O-342). Niacinamide 30-42 poly (ADP-ribose) polymerase 1 Rattus norvegicus 94-98 16871361-1 2006 We have investigated the idea that nicotinamide, a non-selective inhibitor of the sentinel enzyme Poly(ADP-ribose) polymerase-I (PARP-1), provides neuroprotection against the long-term neurological changes induced by perinatal asphyxia. Niacinamide 35-47 poly (ADP-ribose) polymerase 1 Rattus norvegicus 129-135 35334819-9 2022 In Western blot analysis, the increased expression of cleaved PARP-1 in diabetes was attenuated by nicotinamide treatment at 12 weeks after induction of diabetes. Niacinamide 99-111 poly (ADP-ribose) polymerase 1 Rattus norvegicus 62-68 1544629-7 1992 Both nicotinamide and 5-aminobenzamide, which are inhibitors of poly (ADP-ribose) polymerase, prevented the decrease in NAD+ produced by 2-hr exposure of hepatocytes in culture to 100 mmol/L ethanol. Niacinamide 5-17 poly (ADP-ribose) polymerase 1 Rattus norvegicus 64-92 2150901-6 1990 Fractionation of chromatin by solutions of different ionic strength has confirmed that vitamin PP deficiency and NAD amount decrease in the liver are accompanied by a relative increase of the NAD-pyrophosphorylase and poly-ADP-ribose polymerase activities in the fraction extracted by the low ionic solution. Niacinamide 87-97 poly (ADP-ribose) polymerase 1 Rattus norvegicus 218-244