PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32377712-9	2020	It was identified that the induction of phosphorylated AMPK by Rb1 markedly increased endothelial nitric oxide synthase expression and nitric oxide production, and suppressed PAI-1 expression, which were abrogated in HUVECs pretreated with compound C. Further experiments demonstrated that nicotinamide, a SIRT1 inhibitor, downregulated the phosphorylation of AMPK and reduced the protective effects of Rb1 against H2O2-induced endothelial aging.	Niacinamide	290-302	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	55-59	
35301252-7	2022	Ferulic acid also enhances the activation of AMP-activated kinase (AMPK) by increasing expression and activity of its activating kinase LKB1-whereas AMPK in turn amplifies Sirt1 activity by promoting induction of nicotinamide phosphoribosyltranferase, rate-limiting for generation of Sirt1"s obligate substrate NAD+.	Niacinamide	213-225	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	149-153	
21945934-9	2011	Additionally, the ability of Leptin to reduce tau phosphorylation and beta-amyloid production was sensitive to the AMPK and sirtuin inhibitors, compound C and nicotinamide, respectively.	Niacinamide	159-171	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	115-119