PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11371572-2	2001	Cobalamin (vitamin B(12)) is structurally similar to heme and is a cofactor for methionine synthase, a key enzyme in folate metabolism.	Niacinamide	11-20	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	80-99	
10444343-4	1999	The observation that homocysteine and vitamin B(12) levels are independent predictors of NTD risk suggested that methionine synthase could be a candidate gene for NTDs.	Niacinamide	38-47	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	113-132	
10520212-2	1999	Methionine synthase is a vitamin B(12)-dependent enzyme that catalyses the remethylation of homocysteine to methionine.	Niacinamide	25-34	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19	
20876572-1	2010	Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT).	Niacinamide	0-9	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	82-101	
25535791-1	2014	Mutations in human LMBRD1 and ABCD4 prevent lysosomal export of vitamin B(12) to the cytoplasm, impairing the vitamin B(12)-dependent enzymes methionine synthase and methylmalonyl-CoA mutase.	Niacinamide	110-119	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	142-161	
23141461-1	2012	Inborn errors of vitamin B(12) (cobalamin) metabolism are characterized by decreased production of active cobalamin cofactors and subsequent deficiencies in the activities of methionine synthase and methylmalonyl-CoA mutase.	Niacinamide	17-26	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	175-194	
19298066-1	2009	The one-electron-reduced form of vitamin B(12), cob(II)alamin (Co(2+)Cbl), is found in several essential human enzymes, including the cobalamin-dependent methionine synthase (MetH).	Niacinamide	33-42	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	134-173	
18606554-1	2008	Derivatives of vitamin B(12) (cobalamin, Cbl) are required for activity of the mitochondrial enzyme L-methylmalonyl-CoA mutase and the cytoplasmic enzyme methionine synthase in human cells.	Niacinamide	15-24	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	154-173	
15782407-2	2005	Vitamin B(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in folate metabolism.	Niacinamide	0-9	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	53-72	
14654360-1	2003	Methionine synthase and methylmalonyl-CoA mutase (mutase) are the only two known vitamin B(12) (B(12)) dependent enzymes in humans.	Niacinamide	81-90	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19	
20808328-1	2010	BACKGROUND/OBJECTIVES: Methionine synthase catalyzes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate and homocysteine (Hcy) to methionine using vitamin B(12) as a cofactor.	Niacinamide	159-168	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	23-42	
18844488-2	2008	Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body.	Niacinamide	28-37	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19	
18844488-2	2008	Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body.	Niacinamide	28-37	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	21-23	
18844488-4	2008	The influence of a common genetic polymorphism 2756A>G of the MS gene (MTR) on plasma tHcy, folate and vitamin B(12) levels and its relation to the risk of myocardial infarction (MI) in a Tunisian case-control study was investigated.	Niacinamide	106-115	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	65-67	
17087642-2	2006	The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine.	Niacinamide	156-165	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-23