PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12899610-0 2003 Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Niacinamide 19-31 sirtuin 1 Mus musculus 0-4 12899610-1 2003 Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes. Niacinamide 83-95 sirtuin 1 Mus musculus 107-111 12899610-2 2003 The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene expression by forming deacetylated proteins, nicotinamide and 2"-O-acetyl-ADPR. Niacinamide 124-136 sirtuin 1 Mus musculus 4-8 12899610-5 2003 Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha). Niacinamide 0-12 sirtuin 1 Mus musculus 135-144 12899610-11 2003 Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate. Niacinamide 0-12 sirtuin 1 Mus musculus 56-60 12899610-11 2003 Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate. Niacinamide 0-12 sirtuin 1 Mus musculus 123-127 33269751-7 2021 Intraperitoneal injection of the sirtuin 1 inhibitor nicotinamide (500 muM/d) for 7 successive days after astaxanthin intervention inhibited these phenomena. Niacinamide 53-65 sirtuin 1 Mus musculus 33-42 34363387-6 2021 In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred. Niacinamide 57-69 sirtuin 1 Mus musculus 24-29 34363387-6 2021 In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred. Niacinamide 71-74 sirtuin 1 Mus musculus 24-29 31710686-8 2020 Mechanistically, both niacin and nicotinamide supplementation increased nicotinamide adenine dinucleotide (NAD+) levels and NAD+-dependent Sirt1 activity, which were reduced in AAA tissues. Niacinamide 33-45 sirtuin 1 Mus musculus 139-144 33889076-3 2021 SIRT1 protein levels are enhanced by the conversion of nicotinamide to N1-methylnicotinamide (MNAM), independent of its mRNA levels. Niacinamide 55-67 sirtuin 1 Mus musculus 0-5 32987101-8 2020 After the application of nicotinamide (NAM, SIRT1 inhibitor), the positive effects of exercise were remarkably suppressed. Niacinamide 25-37 sirtuin 1 Mus musculus 44-49 31710686-9 2020 Furthermore, pharmacological inhibition of Sirt1 abrogated the protective effect of nicotinamide against AAA formation. Niacinamide 84-96 sirtuin 1 Mus musculus 43-48 33068868-8 2020 More importantly, the SIRT1 inhibitor nicotinamide prevented these puerarin-induced cardioprotective effects and regulation of the SIRT1/NF-kappaB pathway, as well as the NLRP3 inflammasome activation. Niacinamide 38-50 sirtuin 1 Mus musculus 22-27 33068868-8 2020 More importantly, the SIRT1 inhibitor nicotinamide prevented these puerarin-induced cardioprotective effects and regulation of the SIRT1/NF-kappaB pathway, as well as the NLRP3 inflammasome activation. Niacinamide 38-50 sirtuin 1 Mus musculus 131-136 31497199-8 2019 Remarkably, administration of nicotinamide (NAM), a recognized inhibitor of SIRT1 to mice 24 h after IR promotes the survival of Lgr5+ taste bud stem cells, resulting in alleviated tongue mucositis. Niacinamide 30-42 sirtuin 1 Mus musculus 76-81 33228716-2 2020 Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor of SIRT1. Niacinamide 0-12 sirtuin 1 Mus musculus 82-87 33228716-2 2020 Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor of SIRT1. Niacinamide 14-17 sirtuin 1 Mus musculus 82-87 33228716-2 2020 Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor of SIRT1. Niacinamide 30-40 sirtuin 1 Mus musculus 82-87 33072538-5 2020 The ability of (+) - catechin as an activator of sirtuin-1 was assessed by administration of (+) - catechin with the presence of a specific inhibitor of sirtuin-1, nicotinamide. Niacinamide 164-176 sirtuin 1 Mus musculus 49-58 32296111-6 2020 Furthermore, we report that HBEGF neutralization antibody, Sirt1 knockdown, and a classic SIRT1 inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model. Niacinamide 106-118 sirtuin 1 Mus musculus 90-95 31497199-7 2019 Results showed that SIRT1 inhibitors (nicotinamide, EX527, salermide and sirtinol), but not SIRT2 inhibitors, significantly improve taste bud organoid survival after IR. Niacinamide 38-50 sirtuin 1 Mus musculus 20-25 31859031-0 2020 Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7. Niacinamide 0-12 sirtuin 1 Mus musculus 31-36 30877853-7 2019 Moreover, pharmacologic molecules including nicotinamide and EX-527 attenuate SirT1 activity; purported activators of SirT1, the polyphenol S17834, the polyphenol resveratrol, or the non-polyphenolic Sirtris compound SRT1720, failed to activate endogenous SirT1 significantly. Niacinamide 44-56 sirtuin 1 Mus musculus 78-83 31020545-7 2019 All of the above camptothecin-induced alterations were attenuated by the SIRT1-specific inhibitor nicotinamide and/or 6-[4-(2-piperidin-1-ylethoxy) phenyl]-3-pyridin-4-ylpyrazolo [1,5-a]pyrimidin (compound C). Niacinamide 98-110 sirtuin 1 Mus musculus 73-78 30877853-7 2019 Moreover, pharmacologic molecules including nicotinamide and EX-527 attenuate SirT1 activity; purported activators of SirT1, the polyphenol S17834, the polyphenol resveratrol, or the non-polyphenolic Sirtris compound SRT1720, failed to activate endogenous SirT1 significantly. Niacinamide 44-56 sirtuin 1 Mus musculus 118-123 30877853-7 2019 Moreover, pharmacologic molecules including nicotinamide and EX-527 attenuate SirT1 activity; purported activators of SirT1, the polyphenol S17834, the polyphenol resveratrol, or the non-polyphenolic Sirtris compound SRT1720, failed to activate endogenous SirT1 significantly. Niacinamide 44-56 sirtuin 1 Mus musculus 118-123 30836727-4 2019 Methods and Results: Treatment with the SIRT1 inhibitors, nicotinamide and splitomicin, during the hematopoietic differentiation of ES cells enhanced the production of hematopoietic progenitors and slightly up-regulated erythroid and myeloid specific gene expression. Niacinamide 58-70 sirtuin 1 Mus musculus 40-45 30318050-9 2018 We also demonstrated that nicotinamide, a Sirt1 inhibitor, blocks the effect of overexpression of Sirt1 in MSCs on osteogenesis and osteogenic cell senescence. Niacinamide 26-38 sirtuin 1 Mus musculus 42-47 31016257-5 2019 We have previously reported that nicotinamide, a Sirt1 inhibitor, treatment delayed the development and decreased the expression of aca at 4 h after starvation. Niacinamide 33-45 sirtuin 1 Mus musculus 49-54 30483782-0 2019 Nicotinamide induces liver regeneration and improves liver function by activating SIRT1. Niacinamide 0-12 sirtuin 1 Mus musculus 82-87 29424794-8 2019 Sirt1 blocker nicotinamide and Nrf2 siRNA restrained the levels of GRP78, CHOP, Bax, and active caspase 3. Niacinamide 14-26 sirtuin 1 Mus musculus 0-5 30318050-9 2018 We also demonstrated that nicotinamide, a Sirt1 inhibitor, blocks the effect of overexpression of Sirt1 in MSCs on osteogenesis and osteogenic cell senescence. Niacinamide 26-38 sirtuin 1 Mus musculus 98-103 29996125-2 2018 METHODS: Tert-butylhydroquinone (t-BHQ) and small interfering RNAs (siRNAs) were used to regulate Nrf2 expression, while nicotinamide and siRNAs were used to regulate sirtuin 1 (Sirt1) activity and expression, respectively. Niacinamide 121-133 sirtuin 1 Mus musculus 167-176 29574225-8 2018 In addition, suppression of SIRT1 by Nicotinamide or abrogation of AMPK by Compound C eliminated the inhibitory effects of dioscin on lipid metabolism. Niacinamide 37-49 sirtuin 1 Mus musculus 28-33 28816006-10 2018 Finally, the CD38 deficiency-mediated activations of Sirt1 signalling were up-regulated or down-regulated by resveratrol and nicotinamide, respectively. Niacinamide 125-137 sirtuin 1 Mus musculus 53-58 27542907-4 2016 Nicotinamide 5mM (a concentration commonly used to inhibit SIRT1), increased TSC2 acetylation in its N-terminal domain, and concomitantly with an augment in its ubiquitination protein status, leading to mTORC1 activation and cell proliferation. Niacinamide 0-12 sirtuin 1 Mus musculus 59-64 28973641-6 2017 The critical role of Sirt1 in this process was validated by using Sirt1 overexpression, resveratrol (a pharmacologic activator of Sirt1), nicotinamide (a Sirt1 inhibitor) and siSirt1. Niacinamide 138-150 sirtuin 1 Mus musculus 21-26 27824104-7 2016 Supplementation with fat or ketone bodies but not glucose, or intraperitoneal administration of nicotinamide, restored the locomotor rhythmicity and circadian expression of SIRT1 and clock genes, as well as reducing neurodegeneration. Niacinamide 96-108 sirtuin 1 Mus musculus 173-178 27567590-1 2016 Nicotinamide (NAM), or vitamin B3, is an essential coenzyme for ATP synthesis and an inhibitor of sirtuin 1. Niacinamide 0-12 sirtuin 1 Mus musculus 98-107 27748907-4 2016 Emodin and or the sirtuin 1 (Sirt1) inhibitor, nicotinamide, were used to treat the modeled animals. Niacinamide 47-59 sirtuin 1 Mus musculus 29-34 27567590-1 2016 Nicotinamide (NAM), or vitamin B3, is an essential coenzyme for ATP synthesis and an inhibitor of sirtuin 1. Niacinamide 23-33 sirtuin 1 Mus musculus 98-107 26924896-10 2016 The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide. Niacinamide 176-188 sirtuin 1 Mus musculus 155-164 26974211-4 2016 Increased frequency of spindle defects and disturbed distribution of mitochondria were also observed in MII oocytes aged in vitro after treatment with Nicotinamide (NAM), indicating that inhibition of SIRT1, 2, 3 may accelerate postovulatory oocyte aging. Niacinamide 151-163 sirtuin 1 Mus musculus 201-206 24246675-2 2013 Recent studies have shown that Sirt1 deacetylase, a putative protector of beta-cells, is inhibited by nicotinamide. Niacinamide 102-114 sirtuin 1 Mus musculus 31-36 25727991-10 2015 Additionally, SIRT1 antagonist nicotinamide (NAM) attenuated the inhibitory effects of AngsiRNA both on LPS-induced NF-kBp65 expression and IL6 expression. Niacinamide 31-43 sirtuin 1 Mus musculus 14-19 24480879-5 2014 SIRT1 inhibitor nicotinamide (NAM) or SIRT1 small interfering RNAs suppressed the lamellipodium extension by serum or platelet-derived growth factor (PDGF). Niacinamide 16-28 sirtuin 1 Mus musculus 0-5 25967595-6 2015 In cells treated with nicotinamide, SIRT1 deacetylase inhibitor, PAFR internalization by resveratrol or reSIRT1 was inhibited, demonstrating that deacetylation of SIRT1 is an important step in SIRT1-induced PAFR down-regulation. Niacinamide 22-34 sirtuin 1 Mus musculus 106-111 25967595-6 2015 In cells treated with nicotinamide, SIRT1 deacetylase inhibitor, PAFR internalization by resveratrol or reSIRT1 was inhibited, demonstrating that deacetylation of SIRT1 is an important step in SIRT1-induced PAFR down-regulation. Niacinamide 22-34 sirtuin 1 Mus musculus 106-111 24824780-9 2015 Treatment of cells with the SIRT1 inhibitor Nicotinamide reverses MCC-induced deacetylation of beta-cat K49. Niacinamide 44-56 sirtuin 1 Mus musculus 28-33 25614777-9 2014 Moreover, estrogen receptor inhibitor ICI 182,780 and SIRT1 inhibitor niacinamide could block SIRT1"s protective effect. Niacinamide 70-81 sirtuin 1 Mus musculus 54-59 25614777-9 2014 Moreover, estrogen receptor inhibitor ICI 182,780 and SIRT1 inhibitor niacinamide could block SIRT1"s protective effect. Niacinamide 70-81 sirtuin 1 Mus musculus 94-99 23096014-4 2012 We previously showed these mechanisms are also involved in Zn(2+) neurotoxicity and are attenuated by nicotinamide- or pyruvate-induced restoration of NAD(+) concentrations, Zn(2+) restriction, or inhibition of Sir2 proteins. Niacinamide 102-114 sirtuin 1 Mus musculus 211-215 22934562-5 2013 Sirt1 inhibitor nicotinamide (NAM) was administrated to investigate the role of Sirt1 in hepatocyte damage, leukocyte infiltration, and proinflammatory cytokine production. Niacinamide 16-28 sirtuin 1 Mus musculus 0-5 23735732-9 2013 Furthermore, the protective effect of resveratrol was correlated with SIRT1, because application of SIRT1 inhibitor nicotinamide strikingly weakened the protective effect of resveratrol. Niacinamide 116-128 sirtuin 1 Mus musculus 70-75 23735732-9 2013 Furthermore, the protective effect of resveratrol was correlated with SIRT1, because application of SIRT1 inhibitor nicotinamide strikingly weakened the protective effect of resveratrol. Niacinamide 116-128 sirtuin 1 Mus musculus 100-105 23525928-6 2013 Treatment with resveratrol promoted the protein expression of SIRT1, but not PGC-1alpha; instead, resveratrol facilitated PGC-1alpha translocation from the cytoplasm to the nucleus and up-regulated NRF1 and TFAM, which were blocked by nicotinamide. Niacinamide 235-247 sirtuin 1 Mus musculus 62-67 23096014-6 2012 Zn(2+), streptozotocin, and cytokines caused NAD(+) loss and death in insulinoma cells and islets, which were attenuated by Zn(2+) restriction, pyruvate, nicotinamide, NAD(+), and inhibitors of Sir2 proteins. Niacinamide 154-166 sirtuin 1 Mus musculus 194-198 22339667-9 2012 The induced activation of GSK3 and p53, via the inhibition of proteins responsible for their inactivation (PKA via H-89 and SIRT-1 via nicotinamide, respectively), blocked the insulin"s effect on the epiblast.From our findings, we conclude that insulin increases epiblast cell number via the activation of PI3K, which ultimately inactivates GSK3 and p53. Niacinamide 135-147 sirtuin 1 Mus musculus 124-130 22992439-8 2012 Results indicated that the expression of sirt1, sirt5 and sirt6 was significant downregulated by nicotinamide treatment. Niacinamide 97-109 sirtuin 1 Mus musculus 41-46 22456698-8 2012 In cells treated with nicotinamide or transfected with SIRT1 siRNA, ALA-mediated AMPK/ACC phosphorylation, intracellular triacylglycerol accumulation and palmitate beta-oxidation were reduced, suggesting that SIRT1 is an upstream regulator of AMPK. Niacinamide 22-34 sirtuin 1 Mus musculus 209-214 21232033-10 2011 Suppression of SIRT1 function either by nicotinamide or siRNA decreased the level of SAP97 mRNA. Niacinamide 40-52 sirtuin 1 Mus musculus 15-20 22306819-3 2012 SIRT1 inhibitor, nicotinamide (NA), promoted and its activator, resveratrol, inhibited the differentiation of murine bone marrow c-Kit(high)Sca-1(+)Lineage(-) (KSL) cells during the culture system ex vivo. Niacinamide 17-29 sirtuin 1 Mus musculus 0-5 22269821-10 2012 The addition of nicotinamide (Nam) inhibited the deacetylation activity of SIRT1 on p53 and induced cell apoptosis in hybrid cells. Niacinamide 16-28 sirtuin 1 Mus musculus 75-80 22269821-10 2012 The addition of nicotinamide (Nam) inhibited the deacetylation activity of SIRT1 on p53 and induced cell apoptosis in hybrid cells. Niacinamide 30-33 sirtuin 1 Mus musculus 75-80 19539713-2 2009 We previously reported that nicotinamide, a SIRT1 inhibitor, regulates tyrosine hydroxylase (TH) expression in vitro. Niacinamide 28-40 sirtuin 1 Mus musculus 44-49 20736066-5 2011 We therefore examined the protective effects of nicotinamide (NAM), a well-characterized water-soluble B vitamin that is an inhibitor of sirtuin1/class III NAD(+)-dependent histone deacetylase (HDAC). Niacinamide 48-60 sirtuin 1 Mus musculus 137-145 20736066-5 2011 We therefore examined the protective effects of nicotinamide (NAM), a well-characterized water-soluble B vitamin that is an inhibitor of sirtuin1/class III NAD(+)-dependent histone deacetylase (HDAC). Niacinamide 62-65 sirtuin 1 Mus musculus 137-145 19288225-0 2009 Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Niacinamide 0-12 sirtuin 1 Mus musculus 124-129 19148549-1 2009 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of histone deacetylases (HDACs). Niacinamide 23-35 sirtuin 1 Mus musculus 0-9 19148549-1 2009 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of histone deacetylases (HDACs). Niacinamide 23-35 sirtuin 1 Mus musculus 11-16 19148549-1 2009 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of histone deacetylases (HDACs). Niacinamide 23-35 sirtuin 1 Mus musculus 108-138 19148549-1 2009 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the silent information regulator 2 (Sir2) family of histone deacetylases (HDACs). Niacinamide 23-35 sirtuin 1 Mus musculus 140-144 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. Niacinamide 82-94 sirtuin 1 Mus musculus 154-163 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. Niacinamide 82-94 sirtuin 1 Mus musculus 165-170 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. Niacinamide 82-94 sirtuin 1 Mus musculus 307-312