PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15153782-9	2004	Results showed that vitamin B(3) reduced cell injury, caspase-3 cleavage and nuclear condensation (DAPI staining) in neuronal cells under H/R.	Niacinamide	20-29	caspase 3	Rattus norvegicus	54-63	
16165703-8	2005	RESULTS: Nicotinamide inhibits hepatic stellate cell proliferation and induces apoptosis with caspase-3 activation.	Niacinamide	9-21	caspase 3	Rattus norvegicus	94-103	
35612786-8	2022	This resulted in reduced cytochrome c levels in neuronal culture and reduced hippocampal neurodegeneration (reduced caspase-3/NeuN+ co-labeled neurons) following nicotinamide treatment in BPA-treated group.	Niacinamide	162-174	caspase 3	Rattus norvegicus	116-125	
10994860-8	2000	Although not dependent upon pHi, neuroprotection by nicotinamide was linked to the modulation of two independent components of neuronal PCD through the regulation of caspase 1 and caspase 3-like activities and the DNA repair enzyme poly(ADP-ribose) polymerase.	Niacinamide	52-64	caspase 3	Rattus norvegicus	180-189	
26884920-6	2015	Administrate of nicotinamide suppressed the activation of NF-kappaB and caspase-3, reduced the protein expression of Bax, and promoted Bcl-2 protein expression in rats.	Niacinamide	16-28	caspase 3	Rattus norvegicus	72-81	
22164206-5	2011	Post-treatment of developing rats with nicotinamide suppressed thiotepa-induced upregulation of Bax, reduced cytochrome-c release into the cytosol and reduced expression of activated caspase-3 and cleavage of PARP-1.	Niacinamide	39-51	caspase 3	Rattus norvegicus	183-192	
22160932-5	2012	One single dose of 1 mg/g nicotinamide was administered to a developing rat and was found to inhibit ketamine-induced neuroapoptosis by downregulating Bax, inhibiting cytochrome c release from mitochondria into cytosol, and inhibiting the expression of activated caspase-3.	Niacinamide	26-38	caspase 3	Rattus norvegicus	263-272	
19415680-6	2009	Sirtuin inhibitor, nicotinamide (20 mM) attenuated resveratrol"s inhibitory effect on cell apoptosis and caspase-3 activity.	Niacinamide	19-31	caspase 3	Rattus norvegicus	105-114	
16533659-10	2006	Nicotinamide reduced the increase in caspase-3 activity caused by hypoxic ischemia (P < 0.01).	Niacinamide	0-12	caspase 3	Rattus norvegicus	37-46	
16533659-11	2006	Nicotinamide reduces brain injury in the neonatal rat, possibly by reducing oxidative stress and caspase-3 activity.	Niacinamide	0-12	caspase 3	Rattus norvegicus	97-106