PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18426907-5 2008 NS binds to the central acidic domain of MDM2 and inhibits MDM2-mediated p53 ubiquitylation and degradation. ns 0-2 MDM2 proto-oncogene Homo sapiens 41-45 21132010-4 2011 We found that GNL3L binds MDM2 in vivo and displays the same function as NS in stabilizing MDM2 protein and preventing its ubiquitylation. ns 73-75 MDM2 proto-oncogene Homo sapiens 91-95 18426907-5 2008 NS binds to the central acidic domain of MDM2 and inhibits MDM2-mediated p53 ubiquitylation and degradation. ns 0-2 MDM2 proto-oncogene Homo sapiens 59-63 18426907-9 2008 These results suggest that a p53-dependent cell cycle checkpoint monitors changes of cellular NS levels via the impediment of MDM2 function. ns 94-96 MDM2 proto-oncogene Homo sapiens 126-130 26835157-7 2015 To determine how p53 shapes the response of cells to NS depletion at the molecular level, we showed that p53 turns on the expression of reprimo and MDM2 in NS-deficient MEF cells. ns 53-55 MDM2 proto-oncogene Homo sapiens 148-152