PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2548622-6 1989 Thrombin-induced platelet aggregation was only partial in the absence of external calcium, even if excess magnesium was present in the media, while the aggregation response became complete if external calcium was repleted. Magnesium 106-115 coagulation factor II, thrombin Homo sapiens 0-8 3411442-5 1988 In response to a lower concentration of thrombin, calcium and magnesium were released to a greater extent than was serotonin. Magnesium 62-71 coagulation factor II, thrombin Homo sapiens 40-48 13911732-3 1961 (b) Thrombin with calcium or magnesium causes rapid platelet agglutination. Magnesium 29-38 coagulation factor II, thrombin Homo sapiens 4-12 3578772-2 1987 The technique is used to determine the binding constants of magnesium to human prothrombin. Magnesium 60-69 coagulation factor II, thrombin Homo sapiens 79-90 812783-0 1975 Thrombin-induced calcium and magnesium platelet release and clot retraction. Magnesium 29-38 coagulation factor II, thrombin Homo sapiens 0-8 2982391-2 1985 In the present report, the aggregation response to a variety of inducers of platelet aggregation, the content of the dense granule constituents ATP, ADP, serotonin and calcium, the secretion of ATP, ADP, and calcium induced by thrombin, the total content of magnesium, the incorporation of 14C-adenine in the cytoplasmic pool of adenine nucleotides, as well as the content of intracellular cyclic-AMP, have been quantitated in six patients with CHS. Magnesium 258-267 coagulation factor II, thrombin Homo sapiens 227-235 6401213-1 1983 The secretion of the dense granule constituents ATP, ADP, calcium, pyrophosphate (PPi), and orthophosphate (Pi), and the release of magnesium induced by thrombin and the divalent cation ionophore A23187 have been quantitated directly in gel-filtered platelets from patients with storage pool deficiency (SPD). Magnesium 132-141 coagulation factor II, thrombin Homo sapiens 153-161 6401213-4 1983 The contents of magnesium were normal in all patients, and approximately 12% of platelet magnesium was liberated by thrombin in both SPD and normal platelets. Magnesium 89-98 coagulation factor II, thrombin Homo sapiens 116-124 718849-1 1978 Circular dichroism experiments indicate that prothrombin fragment 1 undergoes essentially the same secondary structural change whether in the presence of Ca(2+), Mg(2+), or Mn(2+). Magnesium 162-164 coagulation factor II, thrombin Homo sapiens 45-56 327607-8 1977 Responses to collagen or thrombin were greater in a modified medium containing magnesium but no calcium; in this medium, aggregation caused by ADP or polylysine was followed by the release of granule contents whereas these agents caused aggregation without release in a medium with both calcium and magnesium. Magnesium 79-88 coagulation factor II, thrombin Homo sapiens 25-33 327607-8 1977 Responses to collagen or thrombin were greater in a modified medium containing magnesium but no calcium; in this medium, aggregation caused by ADP or polylysine was followed by the release of granule contents whereas these agents caused aggregation without release in a medium with both calcium and magnesium. Magnesium 299-308 coagulation factor II, thrombin Homo sapiens 25-33 14405485-1 1960 Previous observations on the effect of oral magnesium and peptone on thrombin generation time are examined. Magnesium 44-53 coagulation factor II, thrombin Homo sapiens 69-77 14405485-6 1960 Amounts of magnesium of the same order as those acting on intravenous injection can produce a shift of thrombin generation time in vitro. Magnesium 11-20 coagulation factor II, thrombin Homo sapiens 103-111 24814970-1 2014 INTRODUCTION: Conventional Vacutainer Sodium Citrate blood collection tubes contain a relatively high concentration of contaminating magnesium ions, which may result in shortening of the prothrombin time (PT) and the International Normalized Ratio (INR). Magnesium 134-143 coagulation factor II, thrombin Homo sapiens 188-199 23266689-0 2013 Acidosis, magnesium and acetylsalicylic acid: effects on thrombin. Magnesium 10-19 coagulation factor II, thrombin Homo sapiens 57-65 12633766-3 2003 Results Using D-BUT-CHT-lys-pNA as a plasmin-specific substrate, we show that incubation of plasma with fructose, glyceraldehyde or MG but not glucose decreases plasminogen activity reaching more than 40% in 16 h. A parallel dose-dependent decrease in heparin activation of AT III by up to a 50% was demonstrated using SAR-PRO-ARG-pNA as a specific thrombin substrate. Magnesium 132-134 coagulation factor II, thrombin Homo sapiens 349-357 21080035-3 2011 Human prothrombin was cleaved with cathepsin G in the absence of calcium and magnesium ions. Magnesium 77-86 coagulation factor II, thrombin Homo sapiens 6-17 11341499-0 2001 Prothrombin time ratio is reduced by magnesium contamination in evacuated blood collection tubes. Magnesium 37-46 coagulation factor II, thrombin Homo sapiens 0-11 11341499-4 2001 It was shown that magnesium added to citrated plasma shortened the prothrombin time of both coumarin and normal plasma. Magnesium 18-27 coagulation factor II, thrombin Homo sapiens 67-78 1799661-3 1991 20 mM magnesium shortened the lag phase prior to turbidity development and increased the fibre mass/length ratio (0.28 to 1.23 x 10(13) Da/cm) in a purified fibrin-thrombin system. Magnesium 6-15 coagulation factor II, thrombin Homo sapiens 164-172 11341499-5 2001 The effect of magnesium was relatively greater on coumarin than on normal plasma resulting in reduced prothrombin time ratio. Magnesium 14-23 coagulation factor II, thrombin Homo sapiens 102-113 7540318-0 1995 [Changes of cytoplasmic calcium and magnesium concentration and calcium distribution in human platelets caused by thrombin]. Magnesium 36-45 coagulation factor II, thrombin Homo sapiens 114-122 1418832-1 1992 A dose-dependent effect of magnesium on the inhibition of platelet aggregation and release of ATP from dense granules was observed in human platelets (in whole blood, platelet-rich plasma, or washed platelets) against various aggregation agents (ADP, U46619, collagen, or thrombin). Magnesium 27-36 coagulation factor II, thrombin Homo sapiens 272-280 1418832-5 1992 Thrombin-stimulated influx of Ca ions decreased from 194 +/- 30 nmol/L to 156 +/- 21 nmol/L in the presence of 5 mmol/L Mg and to 111 +/- 16 nmol/L in 10 mmol/L Mg. Magnesium 120-122 coagulation factor II, thrombin Homo sapiens 0-8 1418832-5 1992 Thrombin-stimulated influx of Ca ions decreased from 194 +/- 30 nmol/L to 156 +/- 21 nmol/L in the presence of 5 mmol/L Mg and to 111 +/- 16 nmol/L in 10 mmol/L Mg. Magnesium 161-163 coagulation factor II, thrombin Homo sapiens 0-8 1799661-4 1991 In plasma clotted with thrombin, 20 mM magnesium increased fibre mass/length ratios from 0.60 to 1.65 x 10(13) Da/cm. Magnesium 39-48 coagulation factor II, thrombin Homo sapiens 23-31 34784661-3 2021 The players involved in magnesium reabsorption include proteins with diverse functions including tight junction proteins, cation and anion channels, sodium chloride cotransporter, calcium-sensing receptor, epidermal growth factor, cyclin M2, sodium potassium adenosine triphosphatase subunits, transcription factors, a serine protease, and proteins involved in mitochondrial function. Magnesium 24-33 coagulation factor II, thrombin Homo sapiens 319-334