PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28760336-8 2017 Oral magnesium supplementation also reduced blood pressure in uremic rats, and in vitro medium magnesium decreased BMP-2 and p65-NF-kappaB in TNF-alpha-treated human umbilical vein endothelial cells. Magnesium 95-104 tumor necrosis factor Rattus norvegicus 142-151 14704297-17 2004 These data demonstrated that a Mg intake of 10% of NR in rats causes bone loss that may be secondary to the increased release of substance P and TNF-alpha. Magnesium 31-33 tumor necrosis factor Rattus norvegicus 145-154 16601920-14 2006 Relative to the control, immunohistochemical staining intensity of the neurotransmitter substance P and of the cytokines TNFalpha and IL-1beta was increased in cells of the bone microenvironment in the Mg depletion group, suggesting that inflammatory cytokines may contribute to bone loss. Magnesium 202-204 tumor necrosis factor Rattus norvegicus 121-129 15923157-17 2005 These data demonstrate that Mg intake of 25% NR in the rat causes lower bone mass which may be related to increased release of substance P and TNFalpha. Magnesium 28-30 tumor necrosis factor Rattus norvegicus 143-151 12635865-0 2002 Effects of a low extracellular magnesium concentration and endotoxin on IL-1beta and TNF-alpha release from, and mRNA levels in, isolated rat alveolar macrophages. Magnesium 31-40 tumor necrosis factor Rattus norvegicus 85-94 13679239-6 2003 Endotoxemia for 6 h was associated with elevated serum interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels, and strong TNF receptor mRNA expression in the abdominal aortas, which were significantly greater in the Mg-deficient rats. Magnesium 229-231 tumor necrosis factor Rattus norvegicus 82-115 13679239-7 2003 Treatment of the thoracic aortas, isolated from control and Mg-deficient rats before endotoxic challenge, with IL-1beta or TNF-alpha for 6 h in vitro caused hyporeactivity to PE, but its severity did not differ significantly between the two groups. Magnesium 60-62 tumor necrosis factor Rattus norvegicus 123-132 13679239-8 2003 These results suggest that high serum IL-1beta and TNF-alpha levels, and increased TNF receptor production in the vascular tissue, contribute to vascular hyporeactivity to PE in endotoxemia, and to its enhancement in Mg-deficient rats, via NO/cGMP signaling. Magnesium 217-219 tumor necrosis factor Rattus norvegicus 51-60 33870500-9 2021 In vitro, in VSMCs cultured in a pro-inflammatory high phosphate medium, incubation with Mg 1.6 mM inhibited the increase in the production of ROS, the rise in the expression of TNF-alpha, IL-1beta, IL-6 and IL-8 and the activation of NF-kappaB signalling that was observed in cells incubated with a normal (0.8 mM) Mg. Magnesium 89-91 tumor necrosis factor Rattus norvegicus 178-187 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 tumor necrosis factor Rattus norvegicus 186-213 1384353-1 1992 During the progression of Mg deficiency in a rodent model, we have observed dramatic increases in serum levels of inflammatory cytokines [interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] after 3 wk on a Mg-deficient diet. Magnesium 26-28 tumor necrosis factor Rattus norvegicus 215-224 34774073-0 2021 Correction to: Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-alpha/NF-kappaB signaling in female rats. Magnesium 32-41 tumor necrosis factor Rattus norvegicus 197-206 11346186-4 2001 Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. Magnesium 108-110 tumor necrosis factor Rattus norvegicus 38-46 9989243-0 1999 Enhanced tumor necrosis factor-alpha production following endotoxin challenge in rats is an early event during magnesium deficiency. Magnesium 111-120 tumor necrosis factor Rattus norvegicus 9-36 9989243-7 1999 A significant increase in TNF alpha plasma level was observed in Mg-deficient rats compared to rats fed the control diet. Magnesium 65-67 tumor necrosis factor Rattus norvegicus 26-35 9989243-8 1999 Mg-deficient rats that received magnesium replacement therapy before endotoxin challenge had significantly lower TNF alpha plasma values than those receiving saline before endotoxin. Magnesium 0-2 tumor necrosis factor Rattus norvegicus 113-122 9989243-8 1999 Mg-deficient rats that received magnesium replacement therapy before endotoxin challenge had significantly lower TNF alpha plasma values than those receiving saline before endotoxin. Magnesium 32-41 tumor necrosis factor Rattus norvegicus 113-122 8177242-0 1993 Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency. Magnesium 60-69 tumor necrosis factor Rattus norvegicus 14-41 8177242-2 1993 After two weeks on a Mg-deficient diet, rats show an increase in circulating levels of tumor necrosis factor-alpha and interleukin 1. Magnesium 21-23 tumor necrosis factor Rattus norvegicus 87-114 8460675-2 1993 In another group of Mg-deficient animals chloroquine treatment diminished significantly the levels of circulating cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) and also resulted in a major decrease in myocardial lesions. Magnesium 20-22 tumor necrosis factor Rattus norvegicus 159-186 32241292-0 2020 Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-alpha/NF-kappaB signaling in female rats. Magnesium 17-26 tumor necrosis factor Rattus norvegicus 182-191 32241292-18 2020 CONCLUSIONS: Normalization of magnesium deficiency by L-TAMS attenuated mechanical allodynia, depressive-like behaviors, and STMD in the CYP-induced cystitis model via inhibition of TNF-alpha/NF-kappaV signaling and normalization of NR2B expression. Magnesium 30-39 tumor necrosis factor Rattus norvegicus 182-191 32045781-11 2020 TNFalpha expression and oxidative injury were decreased in bone marrow in Mg/VC/combination group. Magnesium 74-76 tumor necrosis factor Rattus norvegicus 0-8 32659877-9 2020 However, MG supplements decreased TNF - alpha, IL - 17, IL - 6, and DKK - 1 serum levels and increased obestatin, and sclerostin serum levels. Magnesium 9-11 tumor necrosis factor Rattus norvegicus 34-45 33268963-10 2020 RESULTS: The serum interleukin-10, tumor necrosis factor alpha, and creatinine levels were higher in the MG than in the SOG. Magnesium 105-107 tumor necrosis factor Rattus norvegicus 35-62