PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2265738-0 1990 Impaired insulin-mediated erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose diposal in aged non-diabetic obese patients. Magnesium 38-47 insulin Homo sapiens 9-16 2037862-3 1991 Insulin was positively correlated with serum glucose, body mass index (BMI), skinfold thickness, waist/hip ratio and sucrose intake, and negatively correlated with heavy physical activity score, treadmill exercise duration, and magnesium intake (each p less than 0.01). Magnesium 228-237 insulin Homo sapiens 0-7 1844554-3 1991 The clinical consequences of magnesium deficiency include impairment of insulin secretion, insulin resistance and increased macrovascular risk. Magnesium 29-38 insulin Homo sapiens 72-79 2253826-2 1990 The relationship between insulin and magnesium has been recently studied. Magnesium 37-46 insulin Homo sapiens 25-32 2253826-3 1990 In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself has been demonstrated to be an important regulatory factor of intracellular magnesium accumulation. Magnesium 37-46 insulin Homo sapiens 88-95 2253826-3 1990 In particular it has been shown that magnesium plays the role of a second messenger for insulin action; on the other hand, insulin itself has been demonstrated to be an important regulatory factor of intracellular magnesium accumulation. Magnesium 214-223 insulin Homo sapiens 123-130 2253826-4 1990 Conditions associated with insulin resistance, such as hypertension or aging, are also associated with low intracellular magnesium contents. Magnesium 121-130 insulin Homo sapiens 27-34 2253826-5 1990 In diabetes mellitus, it is suggested that low intracellular magnesium levels result from both increased urinary losses and insulin resistance. Magnesium 61-70 insulin Homo sapiens 124-131 2253826-7 1990 A reduced intracellular magnesium content might contribute to the impaired insulin response and action which occurs in Type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 24-33 insulin Homo sapiens 75-82 2253826-8 1990 Chronic magnesium supplementation can contribute to an improvement in both islet Beta-cell response and insulin action in non-insulin-dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 104-111 2253826-8 1990 Chronic magnesium supplementation can contribute to an improvement in both islet Beta-cell response and insulin action in non-insulin-dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 126-133 2265738-2 1990 In vitro incubation in the presence of 100 mU/l insulin significantly increased magnesium erythrocyte levels in both groups of subjects. Magnesium 80-89 insulin Homo sapiens 48-55 2265738-5 1990 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in obese patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 40-47 2265738-5 1990 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in obese patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 80-87 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 47-56 insulin Homo sapiens 121-128 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 47-56 insulin Homo sapiens 211-218 2265738-6 1990 In obese patients, net increase in erythrocyte magnesium levels (calculated as the difference between basal and 100 mU/l insulin-induced erythrocyte magnesium levels) was negatively correlated with basal plasma insulin levels (r = 0.79 p less than 0.01), and with body mass index (r = 0.81 p less than 0.01) while it was positively correlated with the glucose disappearance rate after glucose load (r = 0.67 p less than 0.05) and glucose metabolic clearance rate (r = 0.71 p less than 0.01). Magnesium 149-158 insulin Homo sapiens 121-128 2265738-7 1990 These results demonstrate that insulin-induced erythrocyte magnesium accumulation is impaired in patients with obesity and that such defect is correlated to impaired -- mediated glucosal disposal in the patients. Magnesium 59-68 insulin Homo sapiens 31-38 2190608-6 1990 We hypothesize that hypertension and peripheral insulin resistance may be different clinical expressions of a common abnormal intracellular ionic environment, characterized at least in part by suppressed levels of intracellular free magnesium. Magnesium 233-242 insulin Homo sapiens 48-55 2184947-5 1990 The enhancing effects of insulin on the STA2-induced contractions were affected by extracellular glucose or magnesium ion concentrations. Magnesium 108-117 insulin Homo sapiens 25-32 2184947-6 1990 The enhancing effects of insulin were observed only at the glucose concentrations of 100-300 mg/dl and magnesium concentrations of 0.5-1.5 mM. Magnesium 103-112 insulin Homo sapiens 25-32 34348722-12 2021 OGTT showed that her glucose metabolism and insulin resistance much improved after potassium and magnesium supplemental therapy. Magnesium 97-106 insulin Homo sapiens 44-51 34444908-6 2021 Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested. Magnesium 84-93 insulin Homo sapiens 147-154 34836329-7 2021 Furthermore, Mg supplementation demonstrated an improvement in insulin sensitivity markers. Magnesium 13-15 insulin Homo sapiens 63-70 34836329-9 2021 Moreover, our work indicates that Mg supplementation may improve insulin-sensitivity parameters in those at high risk of diabetes. Magnesium 34-36 insulin Homo sapiens 65-72 34836340-7 2021 Dapagliflozin treatment improved insulin resistance by decreasing glucose and insulin levels, increased serum magnesium levels, and reduced urinary magnesium excretion. Magnesium 110-119 insulin Homo sapiens 33-40 34836340-7 2021 Dapagliflozin treatment improved insulin resistance by decreasing glucose and insulin levels, increased serum magnesium levels, and reduced urinary magnesium excretion. Magnesium 148-157 insulin Homo sapiens 33-40 34537919-2 2021 In particular, magnesium (Mg) is an extensively studied mineral that has been shown to function in the management of hyperglycemia and insulin resistance (IR) action. Magnesium 15-24 insulin Homo sapiens 135-142 34537919-2 2021 In particular, magnesium (Mg) is an extensively studied mineral that has been shown to function in the management of hyperglycemia and insulin resistance (IR) action. Magnesium 26-28 insulin Homo sapiens 135-142 34248844-0 2021 Associations of Serum Magnesium With Insulin Resistance and Testosterone in Women With Polycystic Ovary Syndrome. Magnesium 22-31 insulin Homo sapiens 37-44 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Magnesium 39-48 insulin Homo sapiens 298-305 34248844-1 2021 Objective: This article aimed to investigate whether serum magnesium is associated with insulin resistance index and testosterone level in women with polycystic ovary syndrome (PCOS). Magnesium 59-68 insulin Homo sapiens 88-95 34248844-7 2021 Multiple linear regression showed serum magnesium was independently negatively associated with insulin, glucose, HOMA-IR, testosterone and positively associated with QUICKI (P for trend <0.05) after adjusting confounding covariates. Magnesium 40-49 insulin Homo sapiens 95-102 34248844-9 2021 Conclusion: The current findings suggest that lower serum magnesium was associated with aggravated insulin resistance and higher testosterone levels among women with PCOS. Magnesium 58-67 insulin Homo sapiens 99-106 34092248-11 2021 Moreover, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C and insulin, and HOMA-IR. Magnesium 33-42 insulin Homo sapiens 137-144 35565766-18 2022 Lower serum magnesium concentration was associated with a higher risk of insulin resistance and diabetes. Magnesium 12-21 insulin Homo sapiens 73-80 35565760-0 2022 Nuclear Magnetic Resonance-Measured Ionized Magnesium Is Inversely Associated with Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study. Magnesium 44-53 insulin Homo sapiens 106-113 35565766-0 2022 Association of Serum Magnesium with Insulin Resistance and Type 2 Diabetes among Adults in China. Magnesium 21-30 insulin Homo sapiens 36-43 35565766-1 2022 Magnesium is an essential mineral for the human body and a cofactor or activator for more than 300 enzymatic reactions, including blood glucose control and insulin release. Magnesium 0-9 insulin Homo sapiens 156-163 35565766-4 2022 Evidence shows that magnesium is a predictor of insulin resistance and diabetes. Magnesium 20-29 insulin Homo sapiens 48-55 35565766-6 2022 We study the correlation of serum magnesium levels with insulin resistance and Type 2 diabetes. Magnesium 34-43 insulin Homo sapiens 56-63 35565766-14 2022 After adjusting for relevant covariates, the third quintile of serum magnesium (0.89-0.93 mmol/L) was correlated with 29% lower risk of incident insulin resistance (hazard ratio = 0.71, 95% CI 0.58, 0.86) and with a lower risk of Type 2 diabetes. Magnesium 69-78 insulin Homo sapiens 145-152 35440685-6 2022 Hierarchical multiple regression of serum magnesium with insulin resistance was adjusted for diabetes and potential magnesium confounders. Magnesium 42-51 insulin Homo sapiens 57-64 35440685-10 2022 The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Magnesium 29-38 insulin Homo sapiens 189-196 35440685-10 2022 The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia. Magnesium 29-38 insulin Homo sapiens 220-227 35443355-5 2022 Also, Magnesium is required for insulin secretion and for proper insulin functioning via tyrosine kinase activity at the receptor level. Magnesium 6-15 insulin Homo sapiens 32-39 35443355-5 2022 Also, Magnesium is required for insulin secretion and for proper insulin functioning via tyrosine kinase activity at the receptor level. Magnesium 6-15 insulin Homo sapiens 65-72 2662695-0 1989 Dietary magnesium supplements improve B-cell response to glucose and arginine in elderly non-insulin dependent diabetic subjects. Magnesium 8-17 insulin Homo sapiens 93-100 2662695-6 1989 Dietary magnesium supplementation vs placebo produced a slight but significant decrease in basal plasma glucose (8.6 +/- 0.3 vs 8.0 +/- 0.1 mmol/l, p less than 0.05) and an increase in acute insulin response after iv glucose (3.7 +/- 2.3 vs - 14.7 +/- 0.9 pmol.l 1. Magnesium 8-17 insulin Homo sapiens 191-198 2662695-10 1989 Net increase in acute insulin response after iv glucose and after iv arginine was significantly correlated to the net increase in erythrocyte magnesium content after dietary magnesium supplementation. Magnesium 142-151 insulin Homo sapiens 22-29 2662695-10 1989 Net increase in acute insulin response after iv glucose and after iv arginine was significantly correlated to the net increase in erythrocyte magnesium content after dietary magnesium supplementation. Magnesium 174-183 insulin Homo sapiens 22-29 2662695-11 1989 We conclude that magnesium administration may be a useful adjuvant to the classic hypoglycemic agents in the treatment of non-insulin-dependent diabetic subjects. Magnesium 17-26 insulin Homo sapiens 126-133 2542339-3 1989 The polylysine-dependent insulin stimulation of protein kinase activity required the presence of both magnesium and manganese but at relatively low divalent metal ion concentrations (0.1 mM) compared to the typical 2-10 mM Mg/Mn used in the standard in vitro kinase assays. Magnesium 102-111 insulin Homo sapiens 25-32 2651054-0 1989 Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects. Magnesium 48-57 insulin Homo sapiens 9-16 2540806-3 1989 In the absence of insulin, a noncovalent association of the alpha beta heterodimeric insulin receptor complex into an alpha 2 beta 2 heterotetrameric state required the continuous presence of both a divalent metal ion (Mn or Mg) and an adenine nucleotide (ATP, ADP, or AMPPCP). Magnesium 225-227 insulin Homo sapiens 85-92 3071486-0 1988 Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in type 2 (non-insulin-dependent) diabetic patients. Magnesium 37-46 insulin Homo sapiens 9-16 3071486-0 1988 Impaired insulin-induced erythrocyte magnesium accumulation is correlated to impaired insulin-mediated glucose disposal in type 2 (non-insulin-dependent) diabetic patients. Magnesium 37-46 insulin Homo sapiens 86-93 3071486-3 1988 In vitro incubation in the presence of 100 mU/l insulin significantly increased magnesium erythrocyte levels in both control subjects (p less than 0.001) and patients with diabetes (p less than 0.001). Magnesium 80-89 insulin Homo sapiens 48-55 3071486-4 1988 However, even in the presence of 100 mU/l insulin, the erythrocyte magnesium content of patients with Type 2 diabetes was lower than that of control subjects. Magnesium 67-76 insulin Homo sapiens 42-49 3071486-6 1988 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in Type 2 diabetic patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 40-47 3071486-6 1988 Such reduction of the maximal effect of insulin suggests that the impairment of insulin-induced erythrocyte magnesium accumulation observed in Type 2 diabetic patients results essentially from a post-receptor defect. Magnesium 108-117 insulin Homo sapiens 80-87 3241201-0 1988 Intracellular free magnesium in hypertension: relation to peripheral insulin resistance. Magnesium 19-28 insulin Homo sapiens 69-76 3241201-5 1988 Thus, suppressed intracellular Mg is linked to hypertension and to decreased tissue insulin sensitivity, and is not consequent to the hyperinsulinaemia itself. Magnesium 31-33 insulin Homo sapiens 84-91 3451413-2 1987 In all diabetics taken as a whole and in insulin dependent and non-insulin dependent diabetics considered separately, plasma magnesium concentrations were lower compared to healthy controls but these differences were not statistically significant. Magnesium 125-134 insulin Homo sapiens 41-48 3075149-3 1988 Insulin without affecting the filtration rate of creatinine and the urine flow rate resulted in significant increases in urinary calcium (3.56 +/- 0.80 vs. 7.48 +/- 0.80 mumol/min/1.73 m2) and magnesium (2.44 +/- 0.41 vs. 4.29 +/- 0.5 mumol/min/1.73 m2) and a fall in potassium excretion (53.25 +/- 13.17 vs. 23.71 +/- 4.21 mumol/min/1.73 m2). Magnesium 193-202 insulin Homo sapiens 0-7 3054347-0 1988 Oral administration of magnesium hydroxide to subjects with insulin-dependent diabetes mellitus: effects on magnesium and potassium levels and on insulin requirements. Magnesium 23-32 insulin Homo sapiens 60-67 3315399-0 1987 Impaired insulin-mediated erythrocyte magnesium accumulation in essential hypertension. Magnesium 38-47 insulin Homo sapiens 9-16 3315399-2 1987 This study was designed to investigate variations in erythrocyte magnesium in the presence of insulin (0.1 unit/l) in hypertensive subjects. Magnesium 65-74 insulin Homo sapiens 94-101 3601271-1 1987 Insulin-dependent diabetic pregnant women are at risk for magnesium deficiency, predominantly because of increased urinary magnesium losses. Magnesium 58-67 insulin Homo sapiens 0-7 3601271-1 1987 Insulin-dependent diabetic pregnant women are at risk for magnesium deficiency, predominantly because of increased urinary magnesium losses. Magnesium 123-132 insulin Homo sapiens 0-7 3601271-3 1987 We tested the hypothesis that adverse fetal outcome (fetal loss before 20 weeks" gestation and/or congenital major malformations) is related to magnesium status (as assessed by determining serum magnesium levels) in insulin-dependent diabetic pregnant women, even after sonographic documentation of fetal viability. Magnesium 144-153 insulin Homo sapiens 216-223 3601271-3 1987 We tested the hypothesis that adverse fetal outcome (fetal loss before 20 weeks" gestation and/or congenital major malformations) is related to magnesium status (as assessed by determining serum magnesium levels) in insulin-dependent diabetic pregnant women, even after sonographic documentation of fetal viability. Magnesium 195-204 insulin Homo sapiens 216-223 3601271-8 1987 We speculate that decreased magnesium status may contribute to the high spontaneous abortion and malformation rate in insulin-dependent diabetic pregnant women. Magnesium 28-37 insulin Homo sapiens 118-125 3094377-5 1986 PDH activity assayed with high magnesium and calcium concentrations was significantly stimulated by insulin in adipocytes from control, but not obese or NIDDM subjects. Magnesium 31-40 insulin Homo sapiens 100-107 3539681-0 1986 Insulin induces opposite changes in plasma and erythrocyte magnesium concentrations in normal man. Magnesium 59-68 insulin Homo sapiens 0-7 3539681-5 1986 In contrast, erythrocyte magnesium levels were significantly increased (p less than 0.01) by insulin (100 mU/l), an effect entirely abolished by ouabain (5 X 10(-4) mol/l). Magnesium 25-34 insulin Homo sapiens 93-100 3539681-6 1986 These results suggest that insulin induces a shift of magnesium from the plasma to the erythrocytes both in vivo and in vitro. Magnesium 54-63 insulin Homo sapiens 27-34 3719968-0 1986 Stepwise regression equations relating plasma or erythrocyte magnesium and other variables in insulin-dependent and non-insulin-dependent diabetics. Magnesium 61-70 insulin Homo sapiens 94-101 3886415-1 1985 UNLABELLED: In order to investigate the influence of insulin secretion on serum magnesium concentrations 33 insulin-dependent diabetics and 10 control subjects were studied. Magnesium 80-89 insulin Homo sapiens 53-60 3912195-0 1985 On the insulin effect on the magnesium homeostasis. Magnesium 29-38 insulin Homo sapiens 7-14 3912195-2 1985 insulin per kg body mass is followed by a decline of the plasma magnesium levels of about 15 to 20 percent of the basal levels. Magnesium 64-73 insulin Homo sapiens 0-7 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 67-76 insulin Homo sapiens 113-120 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 67-76 insulin Homo sapiens 179-186 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 187-196 insulin Homo sapiens 113-120 3912195-3 1985 This effect is explained as a result of transport of extracellular magnesium into the intracellular space of the insulin-dependent tissues, and is discussed on the basis of known insulin-magnesium interactions at the receptor level. Magnesium 187-196 insulin Homo sapiens 179-186 3914811-5 1985 Besides the probable importance of a nearly normalized glucose metabolism in IDDM patients during pregnancy, it is postulated that the altered pattern of plasma proteins in diabetes and pregnancy, and possibly also exogenous insulin may influence the serum concentrations of zinc and magnesium seen at the end of pregnancy. Magnesium 284-293 insulin Homo sapiens 225-232 6423182-2 1984 Plasma concentrations of magnesium were lowest in the insulin treated group (mean 0.84 (SEM 0.01) mmol/1; 2.0 (0.02) mg/100 ml), intermediate in the non-diabetics (mean 0.89 (SEM 0.01) mmol/1; 2.2 (0.02) mg/100 ml), and highest in the non-insulin-treated diabetics (mean 0.95 (SEM 0.02) mmol/1; 2.3 (0.05) mg/100 ml). Magnesium 25-34 insulin Homo sapiens 54-61 6384712-3 1984 With 50 microM Mg++ in the medium, insulin selectively stimulated the phosphorylation of a 47kD phosphoprotein, Protein F1. Magnesium 15-19 insulin Homo sapiens 35-42 6384712-6 1984 At 1 mM Mg++, insulin selectively decreased the phosphorylation of the alpha-subunit of pyruvate dehydrogenase. Magnesium 8-12 insulin Homo sapiens 14-21 6423182-2 1984 Plasma concentrations of magnesium were lowest in the insulin treated group (mean 0.84 (SEM 0.01) mmol/1; 2.0 (0.02) mg/100 ml), intermediate in the non-diabetics (mean 0.89 (SEM 0.01) mmol/1; 2.2 (0.02) mg/100 ml), and highest in the non-insulin-treated diabetics (mean 0.95 (SEM 0.02) mmol/1; 2.3 (0.05) mg/100 ml). Magnesium 25-34 insulin Homo sapiens 239-246 6423182-3 1984 In all diabetics plasma magnesium concentrations were inversely related to plasma glucose values (rs = -0.33; p less than 0.01) and in non-insulin-treated patients to plasma insulin concentrations (rs = -0.28; p less than 0.05), the former confirming previous observations. Magnesium 24-33 insulin Homo sapiens 174-181 6423182-5 1984 This direct relation of plasma magnesium concentration with glucose disposal was unexplained by its influence on insulin secretion but was related to insulin sensitivity; hence magnesium may be an important determinant of insulin sensitivity in maturity onset diabetes. Magnesium 31-40 insulin Homo sapiens 150-157 6423182-5 1984 This direct relation of plasma magnesium concentration with glucose disposal was unexplained by its influence on insulin secretion but was related to insulin sensitivity; hence magnesium may be an important determinant of insulin sensitivity in maturity onset diabetes. Magnesium 31-40 insulin Homo sapiens 150-157 720767-1 1978 The serum magnesium concentration was measured in 71 insulin-treated diabetic outpatients who had had the disease for 10 to 20 years. Magnesium 10-19 insulin Homo sapiens 53-60 658615-9 1978 Both calcium and magnesium enhanced 125I-insulin binding by 100 per cent but had no synergistic effect when mixed in a 1:1 molar ratio. Magnesium 17-26 insulin Homo sapiens 41-48 855379-4 1977 After treatment with insulin, most of these serum levels approached the normal, except for serum potassium and magnesium. Magnesium 111-120 insulin Homo sapiens 21-28 991619-0 1976 Changes in plasma and urine magnesium following subcutaneous insulin. Magnesium 28-37 insulin Homo sapiens 61-68 800645-0 1976 [Effect of magnesium on insulin secretion and on the CO2 production from glucose]. Magnesium 11-20 insulin Homo sapiens 24-31 5434-9 1976 Divalent cations (calcium and magnesium) appear to stabilize the insulin-receptor interaction, since higher degrees of receptor occupancy were required to achieve a given rate of dissociation of 125I-insulin. Magnesium 30-39 insulin Homo sapiens 65-72 991619-1 1976 In 7 of 13 patients given subcutaneous insulin as part of the assessment of their endocrinological status, serum magnesium levels fell below the lower limit of the normal range for the laboratory 1 to 2 hours after insulin administration. Magnesium 113-122 insulin Homo sapiens 39-46 991619-1 1976 In 7 of 13 patients given subcutaneous insulin as part of the assessment of their endocrinological status, serum magnesium levels fell below the lower limit of the normal range for the laboratory 1 to 2 hours after insulin administration. Magnesium 113-122 insulin Homo sapiens 215-222 991619-3 1976 During the 2 1/2 hour period following insulin therapy there was renal conservation of magnesium ion. Magnesium 87-96 insulin Homo sapiens 39-46 1230136-3 1975 The insulin-like effect of lithium on carbohydrate metabolism and correlated ions (phosphates, calcium, magnesium, potassium) at cell membrane level is then discussed. Magnesium 104-113 insulin Homo sapiens 4-11 13954055-0 1963 Effect of insulin on short-circuit current across isolated frog skin in the presence of calcium and magnesium. Magnesium 100-109 insulin Homo sapiens 10-17 4277727-0 1974 The stimulation of adipocyte plasma membrane magnesium ion-stimulated adenosine triphosphatase by insulin and concanavalin A. Magnesium 45-54 insulin Homo sapiens 98-105 4376898-0 1974 Magnesium, a second messenger for insulin: ion translocation coupled to transport activity. Magnesium 0-9 insulin Homo sapiens 34-41 5712938-0 1968 Potentation of the hypoglicemic action of insulin by calcium and magnesium. Magnesium 65-74 insulin Homo sapiens 42-49 14447735-0 1960 Effect of insulin and glucose on tissue magnesium. Magnesium 40-49 insulin Homo sapiens 10-17 14896546-0 1951 [Effect of sodium succinate on the magnesium inhibition of post-insulin gastric hypersecretion]. Magnesium 35-44 insulin Homo sapiens 64-71 13250792-0 1955 [Variations of plasma sodium, potassium and magnesium under the effect of insulin]. Magnesium 44-53 insulin Homo sapiens 74-81 33719988-1 2021 OBJECTIVE: We investigated the association of dietary magnesium intake with insulin resistance and markers of endothelial function among Iranian women. Magnesium 54-63 insulin Homo sapiens 76-83 33736626-3 2021 Since previous studies suggested that calcium (Ca) to magnesium (Mg) ratio intake is associated with some chronic diseases including dyslipidemia and insulin resistance, we designed this study to find any possible association between this ratio and NAFLD development. Magnesium 65-67 insulin Homo sapiens 150-157 33719988-12 2021 CONCLUSIONS: Higher dietary magnesium intake was associated with better insulin sensitivity in Iranian females. Magnesium 28-37 insulin Homo sapiens 72-79 33994484-2 2021 This work was aimed to estimate insulin resistance (IR) effect on some markers and trace elements (Selenium, Zinc, Magnesium) levels for early predicting of DN in T2DM patients. Magnesium 115-124 insulin Homo sapiens 32-39 33487252-10 2021 Our meta-analysis indicated that the co-supplementation with magnesium and vitamin E resulted in a significant decrease in FPG, Insulin, HOMA-IR, TG, TC, and LDL-C in comparison with placebo. Magnesium 61-70 insulin Homo sapiens 128-135 33487252-13 2021 CONCLUSIONS: Our meta-analysis indicated that the co-supplementation with magnesium and vitamin E resulted in a significant decrease in FPG, Insulin, HOMA-IR, TG, LDL-C. Magnesium 74-83 insulin Homo sapiens 141-148 33727515-3 2021 Lower intake of Mg and low-serum Mg concentrations are associated with metabolic syndrome, insulin resistance, and Type-2 diabetes. Magnesium 16-18 insulin Homo sapiens 91-98 33727515-3 2021 Lower intake of Mg and low-serum Mg concentrations are associated with metabolic syndrome, insulin resistance, and Type-2 diabetes. Magnesium 33-35 insulin Homo sapiens 91-98 32812214-8 2020 Male gender, a greater number of MetS components, and lower magnesium were predictors of higher homeostatic model assessment for insulin resistance (HOMA-IR). Magnesium 60-69 insulin Homo sapiens 129-136 32095867-9 2020 Consistently, Mg intake was inversely associated with the levels of BMI, triceps skinfold, suprailiac skinfold, subscapular skinfold, fasting insulin, and C-reactive protein. Magnesium 14-16 insulin Homo sapiens 142-149 32406532-7 2020 Magnesium levels were inversely associated with >15 mg/dL increased glucose concentrations between T2 and T1 (HR 0.373, 95% CI 0.154-0.903, P=0.029) after adjustment for pre-existing diabetes, insulin resistance markers, calcineurin inhibitors (cyclosporine/tacrolimus), prednisone doses, and magnesium supplementation. Magnesium 0-9 insulin Homo sapiens 193-200 33532626-10 2021 This aligned with recent investigations of the inverse causal association of Mg intake with insulin resistance and with decreased inflammation. Magnesium 77-79 insulin Homo sapiens 92-99 32466773-4 2020 RESULTS: Magnesium and zinc significantly decreased fasting plasma glucose (FPG) (beta - 9.44 mg/dL, 95% CI, - 18.30, - 0.57; P = 0.03) and insulin levels (beta - 1.37 muIU/mL, 95% CI, - 2.57, - 0.18; P = 0.02). Magnesium 9-18 insulin Homo sapiens 140-147 32765033-0 2020 Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population. Magnesium 75-84 insulin Homo sapiens 8-15 32765033-1 2020 Purpose: High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). Magnesium 22-31 insulin Homo sapiens 50-57 32765033-9 2020 The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. Magnesium 94-103 insulin Homo sapiens 44-51 32654500-7 2021 Magnesium supplementation resulted in a great reduction in BMI [Weighted Mean Difference (WMD): -0.21 kg/m2, 95% CI: -0.41, -0.001, P = 0.048, I 2 = 89.5%, n = 22], which was mainly driven by the effect among those with magnesium deficiency, insulin resistance related disorders, and obesity at baseline. Magnesium 0-9 insulin Homo sapiens 242-249 31713111-5 2020 Imbalances in Mg2+ status, more frequently hypomagnesemia, inhibit glucose transporter type 4 translocation, increase insulin resistance, affect lipid metabolism, induce oxidative stress, and impair the antioxidant system of endothelial cells, In these ways, hypomagnesemia contributes to the initiation and progression of DM and its macrovascular and microvascular complications. Magnesium 14-17 insulin Homo sapiens 118-125 31713111-6 2020 In this review, we summarize recent advances in knowledge of the mechanisms whereby Mg2+ regulates insulin secretion and sensitivity. Magnesium 84-87 insulin Homo sapiens 99-106 29788815-0 2020 Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial. Magnesium 10-19 insulin Homo sapiens 36-43 29788815-2 2020 In this study, effects of magnesium loading dose on insulin resistance (IR) indices were evaluated in critically ill patients without diabetes having SIH. Magnesium 26-35 insulin Homo sapiens 52-59 32466773-8 2020 CONCLUSIONS: In patients with T2DM and CHD, the 12-week intake of magnesium plus zinc had beneficial effects on FPG, HDL-cholesterol, CRP, insulin, total nitrite, TAC levels, and BDI and BAI score. Magnesium 66-75 insulin Homo sapiens 139-146 31696157-2 2019 Hypomagnesemia may worsen insulin resistance (IR) due to the role magnesium (Mg) plays in glucose metabolism. Magnesium 66-75 insulin Homo sapiens 26-33 32365559-1 2020 Magnesium (Mg2+) levels are associated with insulin resistance, hypertension, atherosclerosis, and type 2 diabetes (T2DM). Magnesium 0-9 insulin Homo sapiens 44-51 32185236-8 2020 Compared with placebo, omega-3, magnesium, vitamin D, zinc, and probiotics were more beneficial for improving FPG, serum insulin, and HOMA-IR. Magnesium 32-41 insulin Homo sapiens 121-128 32185236-10 2020 Magnesium supplementation was more beneficial for decreasing serum insulin compared with probiotics (-5.10 muIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 muIU/mL, 95% CI: -9.32 to -0.88) and placebo (-7.80 . Magnesium 0-9 insulin Homo sapiens 67-74 32185236-12 2020 Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. Magnesium 0-9 insulin Homo sapiens 59-66 30941676-12 2020 A negative correlation also existed between Mg levels and TAC in non-insulin-resistant PCOS patients (r = - 0.407, p = 0.04). Magnesium 44-46 insulin Homo sapiens 69-76 30941676-13 2020 According to the results, copper and magnesium seem to contribute to oxidative stress and insulin resistance in PCOS patients. Magnesium 37-46 insulin Homo sapiens 90-97 30835085-0 2020 Oral Magnesium Supplementation Improved Lipid Profile but Increased Insulin Resistance in Patients with Diabetic Nephropathy: a Double-Blind Randomized Controlled Clinical Trial. Magnesium 5-14 insulin Homo sapiens 68-75 30835085-2 2020 We aimed to determine whether magnesium supplementation improves renal function, insulin resistance, and metabolic profiles in patients with diabetic nephropathy. Magnesium 30-39 insulin Homo sapiens 81-88 30835085-10 2020 Although the supplementation did not influence glycemic indices, patients in the magnesium group had greater insulin resistance compared with the placebo group after intervention (0.3 +- 2.3 muIU/mL vs. - 0.04 +- 2.05, P = 0.04). Magnesium 81-90 insulin Homo sapiens 109-116 30835085-14 2020 Oral magnesium supplementation slightly improved microalbuminuria but resulted in increased insulin resistance in patients with diabetic nephropathy. Magnesium 5-14 insulin Homo sapiens 92-99 30332968-0 2020 Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population. Magnesium 21-30 insulin Homo sapiens 36-43 30332968-3 2020 The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults. Magnesium 72-81 insulin Homo sapiens 94-101 30332968-4 2020 OBJECTIVE: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Magnesium 75-84 insulin Homo sapiens 111-118 30332968-4 2020 OBJECTIVE: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Magnesium 75-84 insulin Homo sapiens 158-165 30332968-4 2020 OBJECTIVE: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Magnesium 75-84 insulin Homo sapiens 158-165 30332968-4 2020 OBJECTIVE: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance. Magnesium 75-84 insulin Homo sapiens 158-165 30332968-7 2020 RESULTS: Serum magnesium was found to be negatively correlated with fasting blood sugar (FBS), insulin level and HOMA-IR. Magnesium 15-24 insulin Homo sapiens 95-102 30332968-9 2020 CONCLUSION: As per findings it was concluded that serum magnesium was found to have significant negative correlation with fasting blood sugar (FBS), insulin and HOMA-IR, thus hypomagnesaemia can be suggested to be one of the important predictor of type 2 diabetes mellitus. Magnesium 56-65 insulin Homo sapiens 149-156 31696157-2 2019 Hypomagnesemia may worsen insulin resistance (IR) due to the role magnesium (Mg) plays in glucose metabolism. Magnesium 77-79 insulin Homo sapiens 26-33 30889804-0 2019 Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling. Magnesium 11-20 insulin Homo sapiens 49-56 30446179-8 2019 Alterations in metabolic pathways associated with the sensitivity of sodium, potassium, magnesium and calcium may lead to obesity, hypertension, and insulin resistance. Magnesium 88-97 insulin Homo sapiens 149-156 30950934-8 2019 Oxidative stress in Mg-free-treated treated neurons underwent AZGP1 knock-down, AZGP1 overexpression, or insulin treatment was determined. Magnesium 20-22 insulin Homo sapiens 105-112 31086781-2 2019 In our previous study, significant evidence was provided for the contribution of oral Mg supplement that could improve insulin sensitivity and body weight in animal trials. Magnesium 86-88 insulin Homo sapiens 119-126 31024716-0 2019 Low intakes of dietary fiber and magnesium are associated with insulin resistance and hyperandrogenism in polycystic ovary syndrome: A cohort study. Magnesium 33-42 insulin Homo sapiens 63-70 32091026-6 2019 After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 microg/g of magnesium in the nails (p = 0.020). Magnesium 175-184 insulin Homo sapiens 70-77 30626750-1 2019 In heart failure and type 2 diabetes mellitus (DM), the majority of patients have hypomagnesemia, and magnesium (Mg) supplementation has improved cardiac function and insulin resistance. Magnesium 102-111 insulin Homo sapiens 167-174 30626750-1 2019 In heart failure and type 2 diabetes mellitus (DM), the majority of patients have hypomagnesemia, and magnesium (Mg) supplementation has improved cardiac function and insulin resistance. Magnesium 113-115 insulin Homo sapiens 167-174 30815575-2 2019 Magnesium has received considerable attention for its potential role in improving insulin sensitivity and preventing diabetes and its cardiovascular complications. Magnesium 0-9 insulin Homo sapiens 82-89 31695237-6 2019 After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 microg/g of magnesium in the nails (p = 0.020). Magnesium 175-184 insulin Homo sapiens 70-77 29740897-3 2018 In humans, multiple studies have demonstrated the beneficial effect of magnesium supplementation on insulin sensitivity. Magnesium 71-80 insulin Homo sapiens 100-107 30295109-0 2018 Effect of Magnesium Loading Dose on Insulin Resistance in Patients With Stress-Induced Hyperglycemia: A Randomized Clinical Trial. Magnesium 10-19 insulin Homo sapiens 36-43 29607802-2 2018 Mg intake is linked to a reduced risk of metabolic syndrome and insulin resistance; people with NAFLD or alcoholic liver disease are at high risk of Mg deficiency. Magnesium 0-2 insulin Homo sapiens 64-71 29758962-1 2018 BACKGROUND: Magnesium ion, as important cation in the human body, involved in various enzymatic reactions, glucose transport and insulin release. Magnesium 12-21 insulin Homo sapiens 129-136 29793663-4 2018 Magnesium is the second most abundant intracellular cation in the human body and plays an important role in insulin and adenosine triphosphate metabolism. Magnesium 0-9 insulin Homo sapiens 108-115 29793667-1 2018 Experimental and clinical studies have demonstrated that magnesium deficiency leads to hypertension, insulin resistance, and endothelial dysfunction, and is associated with an increased risk of cardiovascular events. Magnesium 57-66 insulin Homo sapiens 101-108 29360367-4 2018 In contrast, at close to neutral pH, when all the carboxylate groups are deprotonated and negatively charged, the charge-neutralizing effect of magnesium, calcium, and zinc, in particular, on the electrophoretic mobility of insulin is significant. Magnesium 144-153 insulin Homo sapiens 224-231 29256406-0 2017 Magnesium supplementation affects gene expression related to insulin and lipid in patients with gestational diabetes. Magnesium 0-9 insulin Homo sapiens 61-68 29263344-2 2017 Meanwhile, low magnesium status is linked to both chronic inflammation and insulin resistance. Magnesium 15-24 insulin Homo sapiens 75-82 29137465-7 2017 CONCLUSION: Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 12 weeks among patients with PCOS had beneficial effects on insulin metabolism and markers of cardio-metabolic risk. Magnesium 65-74 insulin Homo sapiens 181-188 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Magnesium 57-59 insulin Homo sapiens 64-71 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Magnesium 57-59 insulin Homo sapiens 64-71 28554793-7 2017 In case of a comparison together with Ca(II)-insulin and Mg(II)-insulin, the formation equilibrium constants (Kf1) are in order of Ca(II)-insulin>Mg(II)-insulin>Na(I)-insulin>K(I)-insulin in water. Magnesium 57-59 insulin Homo sapiens 64-71 28724644-0 2017 The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. Magnesium 14-23 insulin Homo sapiens 78-85 28724644-6 2017 Magnesium supplementation resulted in a mean reduction of 4.18 mm Hg in SBP and 2.27 mm Hg in DBP.Conclusion: The pooled results suggest that magnesium supplementation significantly lowers BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases. Magnesium 0-9 insulin Homo sapiens 212-219 28748724-7 2017 Insulin administration is associated with a reduction in serum potassium, magnesium and phosphorus concentration, along with reduced renal magnesium excretion. Magnesium 74-83 insulin Homo sapiens 0-7 28748724-7 2017 Insulin administration is associated with a reduction in serum potassium, magnesium and phosphorus concentration, along with reduced renal magnesium excretion. Magnesium 139-148 insulin Homo sapiens 0-7 28724644-6 2017 Magnesium supplementation resulted in a mean reduction of 4.18 mm Hg in SBP and 2.27 mm Hg in DBP.Conclusion: The pooled results suggest that magnesium supplementation significantly lowers BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases. Magnesium 142-151 insulin Homo sapiens 212-219 28848225-0 2017 Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial. Magnesium 10-19 insulin Homo sapiens 35-42 29256406-2 2017 The aim of this study was to evaluate the effects of magnesium supplementation on gene expression related to insulin and lipid metabolism in women with gestational diabetes (GDM) who were not on oral hypoglycemic agents. Magnesium 53-62 insulin Homo sapiens 109-116 28526383-0 2017 Effect of magnesium supplementation on insulin resistance in humans: A systematic review. Magnesium 10-19 insulin Homo sapiens 39-46 28526383-2 2017 Magnesium, in particular, is an extensively studied mineral that has been shown to function in the management of hyperglycemia, hyperinsulinemia, and insulin resistance (IR) action. Magnesium 0-9 insulin Homo sapiens 133-140 28224192-5 2017 Additionally, we quantified the effect of insulin resistance in the association between serum magnesium levels and diabetes risk. Magnesium 94-103 insulin Homo sapiens 42-49 28224192-12 2017 We found that 29.1% of the effect of serum magnesium levels on diabetes was mediated through insulin resistance, whereas for prediabetes 13.4% was mediated through insulin resistance. Magnesium 43-52 insulin Homo sapiens 93-100 28224192-15 2017 Both findings support a potential causal role of magnesium in the development of diabetes, where the hypothesised pathway is partly mediated through insulin resistance. Magnesium 49-58 insulin Homo sapiens 149-156 26689794-1 2017 PURPOSE: Several experimental studies showed that magnesium intake improved insulin resistance and glucose uptake in diabetes patients. Magnesium 50-59 insulin Homo sapiens 76-83 28380029-9 2017 Insulin resistance decreased with the increase of dietary Se intake in females but not in males after controlling for age, total calorie intake, physical activity level, serum calcium, serum magnesium, and body fat percentage (p < 0.01). Magnesium 191-200 insulin Homo sapiens 0-7 28304338-0 2017 Serum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance. Magnesium 6-15 insulin Homo sapiens 115-122 28178182-3 2017 In addition, magnesium supplementation was shown to improve blood pressure control, insulin sensitivity, and endothelial function. Magnesium 13-22 insulin Homo sapiens 84-91 27546733-1 2017 BACKGROUND: Insulin may influence magnesium homeostasis through multiple mechanisms. Magnesium 34-43 insulin Homo sapiens 12-19 27546733-3 2017 We investigated the impact of hyperinsulinemia on magnesium handling in participants with a wide range of insulin sensitivity. Magnesium 50-59 insulin Homo sapiens 35-42 27546733-12 2017 The magnitude of magnesium shift into the intracellular compartment in response to insulin does not correlate with that of insulin-stimulated glucose entry into cells. Magnesium 17-26 insulin Homo sapiens 83-90 27702717-1 2016 BACKGROUND AND OBJECTIVES: Peroral supplementation with trivalent-chromium (Cr) or magnesium (Mg) has been shown to improve insulin resistance (IR). Magnesium 83-92 insulin Homo sapiens 124-131 28239181-0 2017 High Dietary Magnesium Intake is Significantly and Independently Associated with Higher Insulin Sensitivity in a Mexican-Mestizo Population: A Brief Cross-Sectional Report. Magnesium 13-22 insulin Homo sapiens 88-95 28239181-1 2017 BACKGROUND: Magnesium acts as a cofactor in many intracellular reactions including phosphorylation of the insulin receptor; therefore, its imbalance can potentially cause insulin resistance. Magnesium 12-21 insulin Homo sapiens 106-113 28239181-3 2017 OBJECTIVE: To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index. Magnesium 62-71 insulin Homo sapiens 83-90 28239181-3 2017 OBJECTIVE: To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index. Magnesium 62-71 insulin Homo sapiens 151-158 28239181-3 2017 OBJECTIVE: To study the association between the daily dietary magnesium intake and insulin resistance estimated by the homeostatic model assessment of insulin resistance and homeostatic model assessment 2, as well as insulin sensitivity estimated by the Matsuda index. Magnesium 62-71 insulin Homo sapiens 151-158 28239181-8 2017 RESULTS: The low dietary magnesium intake group (< 4.5 mg/kg/day) had a higher two-hour insulin concentration after an oral glucose tolerance test compared to those with high dietary magnesium (119.5 [73.0-190.6] vs. 63.5 [25.4-114.2]; p = 0.008), and insulin sensitivity assessed by the Matsuda index was higher in the high dietary magnesium intake group (4.3 +- 3.1 vs. 2.4 +- 1.5; p = 0.042). Magnesium 25-34 insulin Homo sapiens 91-98 28239181-9 2017 In multiple linear regression analysis a higher dietary magnesium intake was independently associated (beta = 4.93; p = 0.05) with a better insulin sensitivity estimated by the Matsuda index. Magnesium 56-65 insulin Homo sapiens 140-147 28239181-10 2017 CONCLUSIONS: Our results suggest that higher magnesium intake is independently associated with better insulin sensitivity in patients at risk for type 2 diabetes mellitus. Magnesium 45-54 insulin Homo sapiens 102-109 27702717-1 2016 BACKGROUND AND OBJECTIVES: Peroral supplementation with trivalent-chromium (Cr) or magnesium (Mg) has been shown to improve insulin resistance (IR). Magnesium 94-96 insulin Homo sapiens 124-131 26878772-2 2016 Brain food, e.g. L-tryptophan, antioxidative substances, B vitamins and magnesium are thought to be beneficial for obesity, inflammation and insulin resistance. Magnesium 72-81 insulin Homo sapiens 141-148 27530471-2 2016 Thus, we aimed to investigate the effect of oral Mg supplementation on glucose and insulin-sensitivity parameters in participants with diabetes or at high risk of diabetes compared with placebo. Magnesium 49-51 insulin Homo sapiens 83-90 28134397-2 2016 Low levels of magnesium have been associated with insulin resistance and type-2 diabetes mellitus, asthma, osteoporosis and chronic kidney disease (CKD). Magnesium 14-23 insulin Homo sapiens 50-57 27329332-0 2016 A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Magnesium 88-97 insulin Homo sapiens 117-124 27329332-1 2016 A systematic review and meta-analysis was conducted to evaluate the effect of oral magnesium supplementation on insulin sensitivity and glucose control in both diabetic and non-diabetic individuals. Magnesium 83-92 insulin Homo sapiens 112-119 27329332-2 2016 PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to November 25, 2015) to identify RCTs evaluating the effect of magnesium on insulin sensitivity and glucose control. Magnesium 162-171 insulin Homo sapiens 175-182 27910808-5 2016 Poor nutrition, gastrointestinal and renal diseases, insulin resistance and/or type 2 diabetes, alcoholism, stress, and certain medications may lead to magnesium deficiency. Magnesium 152-161 insulin Homo sapiens 53-60 27344112-15 2016 The low total serum magnesium in patient diagnosed having GDM compared to whom free of GDM and the importance of magnesium in the genesis of insulin resistance should encourage more large trial to explain the exact role of magnesium in the pathophysiology of GDM. Magnesium 113-122 insulin Homo sapiens 141-148 27344112-15 2016 The low total serum magnesium in patient diagnosed having GDM compared to whom free of GDM and the importance of magnesium in the genesis of insulin resistance should encourage more large trial to explain the exact role of magnesium in the pathophysiology of GDM. Magnesium 113-122 insulin Homo sapiens 141-148 27530471-9 2016 Mg supplementation appears to have a beneficial role and improves glucose parameters in people with diabetes and also improves insulin-sensitivity parameters in those at high risk of diabetes. Magnesium 0-2 insulin Homo sapiens 127-134 26096861-12 2016 Whether magnesium supplementation is suitable for improving insulin sensitivity and decreasing oxidative stress and inflammation will require confirmation through additional studies. Magnesium 8-17 insulin Homo sapiens 60-67 26355001-2 2015 OBJECTIVE: We investigated the effect of the insulin (INS)-signaling pathway (ISP) on the regulation of Mg(2+) efflux (Mg(2+)E) conducted by solute carrier family 41, member A1 (SLC41A1; activated by protein kinase A) in transgenic human embryonic kidney (HEK) 293 cells. Magnesium 104-106 insulin Homo sapiens 45-52 26417155-0 2015 Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. Magnesium 21-30 insulin Homo sapiens 47-54 26322160-3 2015 Insulin and glucose are important regulators of Mg metabolism. Magnesium 48-50 insulin Homo sapiens 0-7 26322160-4 2015 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 48-55 26322160-4 2015 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 64-71 26322160-5 2015 Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. Magnesium 22-24 insulin Homo sapiens 118-125 26404370-4 2015 Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Magnesium 10-19 insulin Homo sapiens 93-100 26404370-7 2015 Low levels of magnesium have been associated with a number of chronic diseases, such as Alzheimer"s disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (ADHD). Magnesium 14-23 insulin Homo sapiens 109-116 26417155-8 2015 An inverse, statistically significant correlation was found between serum magnesium and fasting insulin level. Magnesium 74-83 insulin Homo sapiens 96-103 26417155-12 2015 A strong association was also found between serum magnesium level and insulin sensitivity indices. Magnesium 50-59 insulin Homo sapiens 70-77 25929407-1 2015 INTRODUCTION: An appropriate magnesium intake has proved to have beneficial effects on bone health, reduce insulin resistance and prevent atherosclerosis. Magnesium 29-38 insulin Homo sapiens 107-114 26058915-14 2015 Following-up on functional studies of gene expression identified gene-environment interactions between progestin use and MUC1 and between insulin and TRPM6 on serum magnesium concentration in ARIC European-American participants. Magnesium 165-174 insulin Homo sapiens 138-145 25947295-0 2015 Lower serum magnesium concentration is associated with diabetes, insulin resistance, and obesity in South Asian and white Canadian women but not men. Magnesium 12-21 insulin Homo sapiens 65-72 25947295-7 2015 Use of diabetes medication and indicators of poorer glucose control, insulin resistance, and obesity were associated with lower serum Mg in women, but not in men. Magnesium 134-136 insulin Homo sapiens 69-76 26780281-11 2015 Chromium, vanadium, zinc, molybdenum and magnesium can enhance insulin activity while molybdenum, manganese and zinc stimulate lipogenesis. Magnesium 41-50 insulin Homo sapiens 63-70 25247020-1 2014 BACKGROUND: To evaluate the effect of magnesium (Mg) replacement on insulin resistance and cardiovascular risk factors in women with metabolic syndrome (MS) without diabetes. Magnesium 38-47 insulin Homo sapiens 68-75 25827151-4 2015 The pathophysiological mechanism comprises an increase in insulin levels, resulting in shifts of phosphate, potassium and magnesium into the intracellular environment, as well as fluid retention and relative deficiency of vitamin B1. Magnesium 122-131 insulin Homo sapiens 58-65 25247020-1 2014 BACKGROUND: To evaluate the effect of magnesium (Mg) replacement on insulin resistance and cardiovascular risk factors in women with metabolic syndrome (MS) without diabetes. Magnesium 49-51 insulin Homo sapiens 68-75 24984789-0 2014 Influence of magnesium on insulin resistance in obese women. Magnesium 13-22 insulin Homo sapiens 26-33 24641780-4 2014 Data from experimental and observational studies suggest that low levels of magnesium are associated with several factors, such as insulin resistance, diabetes, oxidative stress, hypertension, atherosclerosis, and inflammation which are implicated in the progression of chronic kidney disease. Magnesium 76-85 insulin Homo sapiens 131-138 24984789-1 2014 The present study evaluated the influence of magnesium on insulin resistance in obese women. Magnesium 45-54 insulin Homo sapiens 58-65 24984789-13 2014 The correlation between the erythrocyte magnesium concentration and the parameters of glycemic control suggests the influence of this mineral on the index of insulin resistance in obese women. Magnesium 40-49 insulin Homo sapiens 158-165 24909487-2 2014 Magnesium improves glycemic control in diabetics and insulin sensitivity in insulin resistant subjects. Magnesium 0-9 insulin Homo sapiens 76-83 24947193-2 2014 It is hypothesized that fluoroquinolones induce an intracellular magnesium deficit that can lead to insulin resistance. Magnesium 65-74 insulin Homo sapiens 100-107 24909487-3 2014 We aimed to assess the effectiveness of oral magnesium for improving glycemic control and insulin sensitivity at 3 months post-transplantation. Magnesium 45-54 insulin Homo sapiens 90-97 25560238-1 2014 Magnesium (Mg(2+)) deficiency is common in metabolic disorders such as obesity, type 2 diabetes, and insulin resistance. Magnesium 0-9 insulin Homo sapiens 101-108 24671621-9 2014 Our findings suggest that hair mineral concentrations, such as calcium, magnesium, zinc, sodium, and potassium concentrations, may play a role in the development of insulin resistance. Magnesium 72-81 insulin Homo sapiens 165-172 24089547-3 2014 In participants without incident diabetes, we examined magnesium intake in relation to 7-year changes in fasting and postload glucose and insulin, IR, and insulin sensitivity. Magnesium 55-64 insulin Homo sapiens 138-145 24089547-3 2014 In participants without incident diabetes, we examined magnesium intake in relation to 7-year changes in fasting and postload glucose and insulin, IR, and insulin sensitivity. Magnesium 55-64 insulin Homo sapiens 155-162 24503235-1 2014 Magnesium levels have been shown to be associated with elevated blood pressure (BP), endothelial dysfunction, insulin resistance, vascular calcification, inflammation, and atherosclerosis. Magnesium 0-9 insulin Homo sapiens 110-117 24392366-5 2013 In this study, we tried to find out the probable association of Vitamin D3, calcium and magnesium with reference to insulin resistance in type 2 diabetes mellitus (T2DM) cases. Magnesium 88-97 insulin Homo sapiens 116-123 25561119-2 2014 This study aims to determine a) the relationship between calcium, magnesium, cardiovascular disease (CVD) markers (e.g. lipids, lipoproteins, homocysteine) and insulin sensitivity/ resistance markers (e.g. glucose, insulin, HOMA) in cord serum; and b) to find out the possible influence of reduced or increased levels of serum calcium and magnesium on those markers. Magnesium 66-75 insulin Homo sapiens 160-167 25561119-2 2014 This study aims to determine a) the relationship between calcium, magnesium, cardiovascular disease (CVD) markers (e.g. lipids, lipoproteins, homocysteine) and insulin sensitivity/ resistance markers (e.g. glucose, insulin, HOMA) in cord serum; and b) to find out the possible influence of reduced or increased levels of serum calcium and magnesium on those markers. Magnesium 339-348 insulin Homo sapiens 160-167 25561119-10 2014 CONCLUSIONS: Calcium and magnesium levels appear related to CVD and insulin sensitivity/resistance markers at birth. Magnesium 25-34 insulin Homo sapiens 68-75 23758216-0 2013 Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. Magnesium 0-9 insulin Homo sapiens 75-82 23758216-9 2013 CONCLUSIONS: Our findings suggest that increased magnesium intake was a significant protective factor for the incidence of Type 2 diabetes in the general Japanese population, especially among subjects with insulin resistance, low-grade inflammation and a drinking habit. Magnesium 49-58 insulin Homo sapiens 206-213 25477716-11 2014 Determinants of insulin resistance were carbohydrates intake and circulating magnesium and adiponectin. Magnesium 77-86 insulin Homo sapiens 16-23 23343670-4 2013 In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. Magnesium 89-98 insulin Homo sapiens 140-147 23322284-2 2013 Pathophysiology in relation with the essential elements including copper, magnesium, zinc, manganese, chromium, and calcium has been reported in women with insulin resistance. Magnesium 74-83 insulin Homo sapiens 156-163 23322284-9 2013 However, the PCOS women with insulin resistance exhibited significantly lower serum levels of magnesium and chromium (p < 0.04), in addition to higher levels of zinc and copper (p < 0.04). Magnesium 94-103 insulin Homo sapiens 29-36 23322284-11 2013 In PCOS-associated insulin resistance, circulating serum magnesium (r = -0.31; p < 0.03) and chromium (r = -0.38; p < 0.006) status significantly correlated with fasting insulin levels. Magnesium 57-66 insulin Homo sapiens 19-26 23322284-11 2013 In PCOS-associated insulin resistance, circulating serum magnesium (r = -0.31; p < 0.03) and chromium (r = -0.38; p < 0.006) status significantly correlated with fasting insulin levels. Magnesium 57-66 insulin Homo sapiens 176-183 24084051-0 2013 Dietary magnesium intake improves insulin resistance among non-diabetic individuals with metabolic syndrome participating in a dietary trial. Magnesium 8-17 insulin Homo sapiens 34-41 24084051-1 2013 Many cross-sectional studies show an inverse association between dietary magnesium and insulin resistance, but few longitudinal studies examine the ability to meet the Recommended Dietary Allowance (RDA) for magnesium intake through food and its effect on insulin resistance among participants with metabolic syndrome (MetS). Magnesium 73-82 insulin Homo sapiens 87-94 24084051-8 2013 After multivariate adjustment, magnesium intake was inversely associated with metabolic biomarkers of insulin resistance (P < 0.01). Magnesium 31-40 insulin Homo sapiens 102-109 24084051-11 2013 These findings indicate that dietary magnesium intake is inadequate among non-diabetic individuals with MetS and suggest that increasing dietary magnesium to meet the RDA has a protective effect on insulin resistance. Magnesium 145-154 insulin Homo sapiens 198-205 23343670-5 2013 After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. Magnesium 80-89 insulin Homo sapiens 227-234 23472169-0 2013 High dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. Magnesium 13-22 insulin Homo sapiens 53-60 23472169-1 2013 BACKGROUND: Magnesium plays a role in glucose and insulin homeostasis and evidence suggests that magnesium intake is associated with insulin resistance (IR). Magnesium 12-21 insulin Homo sapiens 50-57 23472169-7 2013 Multiple regression analyses were used to test adiposity-specific associations of dietary magnesium intake on insulin resistance adjusting for caloric intake, physical activity, medication use and menopausal status. Magnesium 90-99 insulin Homo sapiens 110-117 23472169-8 2013 RESULTS: Subjects with the highest intakes of dietary magnesium had the lowest levels of circulating insulin, HOMA-IR, and HOMA-ss and subjects with the lowest intake of dietary magnesium had the highest levels of these measures, suggesting a dose effect. Magnesium 54-63 insulin Homo sapiens 101-108 23472169-11 2013 CONCLUSION: The results of this study indicate that higher dietary magnesium intake is strongly associated with the attenuation of insulin resistance and is more beneficial for overweight and obese individuals in the general population and pre-menopausal women. Magnesium 67-76 insulin Homo sapiens 131-138 23472169-12 2013 Moreover, the inverse correlation between insulin resistance and dietary magnesium intake is stronger when adjusting for %BF than BMI. Magnesium 73-82 insulin Homo sapiens 42-49 23226651-1 2012 INTRODUCTION: Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function. Magnesium 61-70 insulin Homo sapiens 156-163 22777676-1 2012 Calcium and magnesium that are associated with insulin resistance play an antagonistic role with each other in cells. Magnesium 12-21 insulin Homo sapiens 47-54 22777676-4 2012 The ratio of calcium/magnesium in hair showed a significantly positive correlation with the HOMA-IR (r = 0.191, P = 0.038) and insulin (r = 0.198, P = 0.031). Magnesium 21-30 insulin Homo sapiens 127-134 22777676-7 2012 The result of this study showed that insulin resistance increased as the ratio of Ca/Mg increased, or as the chromium concentration in hair decreased. Magnesium 85-87 insulin Homo sapiens 37-44 22854408-1 2012 BACKGROUND: Dietary magnesium might be related to colorectal tumor risk through the pivotal roles of magnesium in cellular metabolism, insulin resistance, and systemic inflammation. Magnesium 20-29 insulin Homo sapiens 135-142 23199535-11 2012 Low Mg levels, high TG levels in association with enhanced HbA1c levels could thus serve as a reliable biochemical indicator of insulin status and action without resorting to the usage of criteria for insulin sensitivity and resistance. Magnesium 4-6 insulin Homo sapiens 128-135 21696337-0 2012 Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance. Magnesium 6-15 insulin Homo sapiens 85-92 22415230-6 2012 Similarly, magnesium intakes were significantly inversely associated with concentrations of plasma C-peptide in age-adjusted model (P(trend)=0.002) but not in multivariate-adjusted model (P(trend)=0.61). Magnesium 11-20 insulin Homo sapiens 99-108 21719932-7 2012 Serum magnesium levels were inversely correlated with body mass index, systolic blood pressure, diastolic blood pressure, waist circumference and fasting insulin levels. Magnesium 6-15 insulin Homo sapiens 154-161 22379366-4 2012 Mg is an antioxidant and calcium blocker and in space there is oxidative stress, insulin resistance, and inflammatory conditions with evidence in experimental animals of significant endothelial injuries and damage to mitochondria. Magnesium 0-2 insulin Homo sapiens 81-88 22846360-2 2012 In addition, magnesium replacement therapy improves insulin resistance and glycemic control. Magnesium 13-22 insulin Homo sapiens 52-59 22846360-3 2012 Low levels of magnesium in the venous blood induce the disturbances of auto-phosphylation on the insulin receptor and deteriorate insulin resistance. Magnesium 14-23 insulin Homo sapiens 97-104 21696337-1 2012 OBJECTIVE: It has been revealed that low serum magnesium (Mg) is often associated with insulin resistance (IR), cardiovascular problems, diabetes mellitus, and hypertension. Magnesium 47-56 insulin Homo sapiens 87-94 22518291-4 2012 In addition, lower concentrations of magnesium are associated with oxidative stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia. Magnesium 37-46 insulin Homo sapiens 155-162 22051430-7 2011 Preliminary evidence suggests that insulin sensitivity, hyperglycemia, diabetes mellitus, left ventricular hypertrophy, and dyslipidemia may be improved with increased magnesium intake. Magnesium 168-177 insulin Homo sapiens 35-42 22068124-0 2011 Infusion of Mg in humans acutely reduces serum insulin levels: a pilot study. Magnesium 12-14 insulin Homo sapiens 47-54 20807870-0 2010 Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Magnesium 0-9 insulin Homo sapiens 55-62 21488144-1 2011 BACKGROUND: Magnesium modulates insulin-mediated glucose uptake but data regarding its role in insulin secretion are scarce; therefore, in this study we determined whether decreased serum magnesium levels are associated with the impairment of insulin secretion in non-diabetic individuals. Magnesium 12-21 insulin Homo sapiens 32-39 21241290-0 2011 Magnesium improves the beta-cell function to compensate variation of insulin sensitivity: double-blind, randomized clinical trial. Magnesium 0-9 insulin Homo sapiens 69-76 21159786-8 2011 RESULTS: We observed that magnesium treatment significantly decreased fasting C-peptide concentrations (change: -0.4 ng/mL after magnesium treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and appeared to decrease fasting insulin concentrations (change: -2.2 muU/mL after magnesium treatment compared with 0.0 muU/mL after placebo treatment; P = 0.25). Magnesium 26-35 insulin Homo sapiens 244-251 22145455-0 2011 The relationship between serum magnesium levels with childhood obesity and insulin resistance: a review of the literature. Magnesium 31-40 insulin Homo sapiens 75-82 22145455-1 2011 BACKGROUND: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. Magnesium 12-21 insulin Homo sapiens 103-110 22145455-1 2011 BACKGROUND: Magnesium, the second most abundant intracellular cation, plays a major role in regulating insulin effect and insulin mediated glucose uptake. Magnesium 12-21 insulin Homo sapiens 122-129 22145455-2 2011 It has been shown that serum magnesium levels were negatively correlated with HOMA-IR (homeostasis model of insulin resistance) index. Magnesium 29-38 insulin Homo sapiens 108-115 22145455-3 2011 AIM: To investigate the relationship between serum magnesium levels with obesity and insulin resistance in childhood. Magnesium 51-60 insulin Homo sapiens 85-92 22145455-9 2011 CONCLUSIONS: Low serum magnesium levels may contribute to the development of insulin resistance in obese children. Magnesium 23-32 insulin Homo sapiens 77-84 21821372-0 2011 The association of serum C-reactive protein, uric acid and magnesium with insulin resistance in Chinese postmenopausal women with prediabetes or early untreated diabetes. Magnesium 59-68 insulin Homo sapiens 74-81 21205110-0 2011 Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Magnesium 5-14 insulin Homo sapiens 39-46 21205110-1 2011 The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). Magnesium 95-104 insulin Homo sapiens 17-24 21205110-2 2011 We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic, overweight, insulin resistant, non-diabetic subjects. Magnesium 30-32 insulin Homo sapiens 52-59 21205110-5 2011 Mg supplementation resulted in a significant improvement of fasting plasma glucose and some insulin sensitivity indices (ISIs) compared to placebo. Magnesium 0-2 insulin Homo sapiens 92-99 21205110-7 2011 The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes. Magnesium 51-53 insulin Homo sapiens 79-86 21205110-7 2011 The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes. Magnesium 51-53 insulin Homo sapiens 229-236 21490788-5 2011 Taken together, intrauterine magnesium deficiency in the fetus may lead to or at least program insulin resistance after birth. Magnesium 29-38 insulin Homo sapiens 95-102 20807870-1 2010 OBJECTIVE: To investigate the long-term associations of magnesium intake with incidence of diabetes, systemic inflammation, and insulin resistance among young American adults. Magnesium 56-65 insulin Homo sapiens 128-135 20807870-9 2010 This inverse association may be explained, at least in part, by the inverse correlations of magnesium intake with systemic inflammation and insulin resistance. Magnesium 92-101 insulin Homo sapiens 140-147 18614418-0 2008 The effect of magnesium supplementation on glucose and insulin levels of tae-kwan-do sportsmen and sedentary subjects. Magnesium 14-23 insulin Homo sapiens 55-62 19629403-6 2010 Chronic magnesium deficiency has been associated with the development of insulin resistance. Magnesium 8-17 insulin Homo sapiens 73-80 20199997-4 2010 Through different mechanisms, some components of nuts such as magnesium, fiber, alpha-linolenic acid, L-arginine, antioxidants and MUFA may protect against inflammation and insulin resistance. Magnesium 62-71 insulin Homo sapiens 173-180 19359148-0 2009 Effects of oral magnesium supplementation on insulin sensitivity and blood pressure in normo-magnesemic nondiabetic overweight Korean adults. Magnesium 16-25 insulin Homo sapiens 45-52 19359148-1 2009 BACKGROUND AND AIM: Little is known about the effect of magnesium on insulin sensitivity and BP in healthy individuals. Magnesium 56-65 insulin Homo sapiens 69-76 19359148-2 2009 Therefore, we investigated whether magnesium could improve insulin sensitivity and blood pressure (BP) in normo-magnesemic nondiabetic overweight adults. Magnesium 35-44 insulin Homo sapiens 59-66 19124169-0 2009 Serum and intracellular magnesium deficiency in patients with metabolic syndrome--evidences for its relation to insulin resistance. Magnesium 24-33 insulin Homo sapiens 112-119 19124169-10 2009 In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. Magnesium 15-24 insulin Homo sapiens 165-172 20531272-0 2010 Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile. Magnesium 27-36 insulin Homo sapiens 56-63 19675375-11 2009 Among micronutrients, high magnesium and calcium intake have been reported to decrease insulin resistance. Magnesium 27-36 insulin Homo sapiens 87-94 18614418-1 2008 This study was performed to determine how the magnesium supplementation for a 4-week period affects the glucose and insulin levels at rest and at exhaustion in sportsmen. Magnesium 46-55 insulin Homo sapiens 116-123 18274977-2 2008 Some research has indicated that lower intakes of magnesium and lower serum magnesium concentrations may lead to and are associated with the metabolic syndrome, insulin resistance, and/or type 2 diabetes mellitus. Magnesium 50-59 insulin Homo sapiens 161-168 18274977-2 2008 Some research has indicated that lower intakes of magnesium and lower serum magnesium concentrations may lead to and are associated with the metabolic syndrome, insulin resistance, and/or type 2 diabetes mellitus. Magnesium 76-85 insulin Homo sapiens 161-168 17667214-1 2007 The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. Magnesium 62-71 insulin Homo sapiens 104-111 18196987-5 2008 Magnesium acts as a mild calcium antagonist on vascular smooth muscle tone, and on postreceptor insulin signaling; it is critically involved in energy metabolism, fatty acid synthesis, glucose utilization, ATPase functions, release of neurotransmitters, and endothelial cell function and secretion. Magnesium 0-9 insulin Homo sapiens 96-103 17972463-2 2007 Basic science research has implicated magnesium deficiency as a cause of insulin resistance which is related to hypertension, diabetes, hyperlipidemia and increased cardiovascular risk. Magnesium 38-47 insulin Homo sapiens 73-80 17667214-1 2007 The increasing evidence for the clinical relevance of altered magnesium metabolism to states of altered insulin resistance confirms the role of magnesium deficit as a possible underlying common mechanism of the "insulin resistance" of hypertension and altered glucose tolerance. Magnesium 144-153 insulin Homo sapiens 212-219 17197162-3 2007 Subjects with lower magnesium intake showed significantly higher fasting glucose, insulin and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) levels. Magnesium 20-29 insulin Homo sapiens 82-141 17197162-5 2007 Fasting insulin and HOMA-IR values were inversely associated with intakes of magnesium and fibres, and directly with Body Mass Index (BMI) and CUG. Magnesium 77-86 insulin Homo sapiens 8-15 17372382-2 2007 Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown. Magnesium 97-106 insulin Homo sapiens 56-63 17372382-2 2007 Also their application for the determination of zinc in insulin to control injection quality and magnesium in human urine for the diagnosis and treatment of magnesium deficiency was shown. Magnesium 157-166 insulin Homo sapiens 56-63 17285123-3 2007 Although an overall protective effect was not afforded, our results suggest an effect of magnesium in overweight subjects, possibly through decreasing insulin resistance. Magnesium 89-98 insulin Homo sapiens 151-158 17229895-3 2006 METHODS: We examined cross-sectional associations between magnesium intake and fasting glucose and insulin, 2-hour post-challenge plasma glucose and insulin, and insulin resistance assessed by the homeostasis model (HOMA-IR) in 1223 men and 1485 women without diabetes from the Framingham Offspring cohort. Magnesium 58-67 insulin Homo sapiens 99-106 16808892-0 2007 Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Magnesium 0-9 insulin Homo sapiens 73-80 16808892-3 2007 Insulin and glucose are important regulators of Mg metabolism. Magnesium 48-50 insulin Homo sapiens 0-7 16808892-4 2007 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 48-55 16808892-4 2007 Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose uptake and vascular tone. Magnesium 14-16 insulin Homo sapiens 64-71 16808892-5 2007 Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, post-receptorial impairment in insulin action, and worsening of insulin resistance in diabetic patients. Magnesium 22-24 insulin Homo sapiens 119-126 16808892-5 2007 Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, post-receptorial impairment in insulin action, and worsening of insulin resistance in diabetic patients. Magnesium 22-24 insulin Homo sapiens 152-159 16808892-6 2007 Mg deficit has been proposed as a possible underlying common mechanism of the "insulin resistance" of different metabolic conditions. Magnesium 0-2 insulin Homo sapiens 79-86 17229895-6 2006 RESULTS: After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 microU/mL in the lowest vs highest quintiles of magnesium intake; P trend <0.001), post-glucose challenge plasma insulin (86.4 vs 72 microU/mL; P trend <0.001), and HOMA-IR (7.0 vs 6.2; P trend <0.001). Magnesium 61-70 insulin Homo sapiens 116-123 17229895-6 2006 RESULTS: After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 microU/mL in the lowest vs highest quintiles of magnesium intake; P trend <0.001), post-glucose challenge plasma insulin (86.4 vs 72 microU/mL; P trend <0.001), and HOMA-IR (7.0 vs 6.2; P trend <0.001). Magnesium 61-70 insulin Homo sapiens 260-267 17229895-8 2006 CONCLUSIONS: Improved insulin sensitivity may be one mechanism by which higher dietary magnesium intake may reduce the risk of developing type 2 DM. Magnesium 87-96 insulin Homo sapiens 22-29 17125532-6 2006 A high intake of calcium, magnesium and potassium, together with a low sodium intake, is associated with protection against bone demineralisation, arterial hypertension, insulin resistance, and overall cardiovascular risk. Magnesium 26-35 insulin Homo sapiens 170-177 16846102-5 2006 Taken together, intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. Magnesium 29-38 insulin Homo sapiens 90-97 16861328-1 2006 Dairy intake has been inversely associated with insulin resistance, which may be partly due to the specific effects of calcium and magnesium. Magnesium 131-140 insulin Homo sapiens 48-55 16861328-7 2006 Furthermore, magnesium intake was associated with insulin sensitivity in a threshold fashion, with a Bayesian method-estimated threshold (325 mg) (beta=0.0607/100 mg, p=0.0008 for <325 mg of magnesium/day; and beta=-0.001/100 mg, p=0.82 for >or=325 mg of magnesium/day). Magnesium 13-22 insulin Homo sapiens 50-57 16861328-8 2006 This study suggests that magnesium and calcium intake specifically, but not dairy intake, is associated with insulin sensitivity. Magnesium 25-34 insulin Homo sapiens 109-116 17003272-0 2006 Insulin and glucose mediate opposite intracellular ionized magnesium variations in human lymphocytes. Magnesium 59-68 insulin Homo sapiens 0-7 17003272-1 2006 Insulin is capable of increasing intracellular magnesium, although very little is known about the effect of insulin on the biologically active fraction of magnesium, i.e. the ionized quota (Mg(i)(2+)), its interactions with glucose, and the cellular mechanisms involved in these processes. Magnesium 47-56 insulin Homo sapiens 0-7 17003272-2 2006 We studied the interactions of the effects of insulin and glucose on intracellular ionized magnesium in human lymphocytes. Magnesium 91-100 insulin Homo sapiens 46-53 16567569-10 2006 Magnesium intake was also inversely related to individual component of the metabolic syndrome and fasting insulin levels. Magnesium 0-9 insulin Homo sapiens 106-113 16544020-7 2005 Despite the small number of patients, this study shows that magnesium deficiency is frequent in patients with diabetes and its correlation with insulin resistance should be more studied. Magnesium 60-69 insulin Homo sapiens 144-151 15925015-3 2005 Chromium, magnesium, and antioxidants are essential elements involved in the action of insulin and energetic metabolism, without serious adverse effects. Magnesium 10-19 insulin Homo sapiens 87-94 15950075-1 2005 BACKGROUND: Epidemiological evidence shows a strong relationship between decreased serum magnesium levels (DSML) and insulin resistance. Magnesium 89-98 insulin Homo sapiens 117-124 16272620-5 2005 Taken together, chronic intrauterine magnesium deficiency in the fetus may lead to or program the insulin resistance after birth. Magnesium 37-46 insulin Homo sapiens 98-105 15855585-0 2005 Magnesium deficiency is associated with insulin resistance in obese children. Magnesium 0-9 insulin Homo sapiens 40-47 15855585-1 2005 OBJECTIVE: Magnesium deficiency has been associated with insulin resistance (IR) and increased risk for type 2 diabetes in adults. Magnesium 11-20 insulin Homo sapiens 57-64 15855585-6 2005 Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Magnesium 6-15 insulin Homo sapiens 54-61 15855585-6 2005 Serum magnesium was inversely correlated with fasting insulin (r(s) = -0.36 [95% CI -0.59 to -0.08]; P = 0.011) and positively correlated with quantitative insulin sensitivity check index (QUICKI) (0.35 [0.06-0.58]; P = 0.015). Magnesium 6-15 insulin Homo sapiens 156-163 15855585-8 2005 Dietary magnesium intake was inversely associated with fasting insulin (-0.43 [-0.64 to -0.16]; P = 0.002) and directly correlated with QUICKI (0.43 [0.16-0.64]; P = 0.002). Magnesium 8-17 insulin Homo sapiens 63-70 14747211-4 2004 It is abundant in nutrients such as magnesium, calcium, and protein, which have been associated with improved insulin sensitivity. Magnesium 36-45 insulin Homo sapiens 110-117 15692160-2 2005 Accumulating findings have revealed that magnesium deficiency relates cardiovascular risk factors including elevated blood pressure, insulin resistance, dyslipidemia, platelet aggregation, and inflammatory reaction, and leads to atherosclerosis. Magnesium 41-50 insulin Homo sapiens 133-140 15692165-1 2005 Recently, there are some reports about correlations between insulin resistance and deficiency of magnesium. Magnesium 97-106 insulin Homo sapiens 60-67 15692165-3 2005 It is expected that the exact mechanisms between insulin resistance, metabolic syndrome and magnesium metabolism. Magnesium 92-101 insulin Homo sapiens 49-56 15797443-7 2005 Almost 10(5) externally bound divalent cations are displaced from membranes for every attached insulin molecule, implying a conformational membrane change that releases enough Mg(2+) from the internal surface of the plasma membrane to account for the increase in free cytosolic Mg(2+). Magnesium 176-178 insulin Homo sapiens 95-102 15797443-7 2005 Almost 10(5) externally bound divalent cations are displaced from membranes for every attached insulin molecule, implying a conformational membrane change that releases enough Mg(2+) from the internal surface of the plasma membrane to account for the increase in free cytosolic Mg(2+). Magnesium 278-280 insulin Homo sapiens 95-102 15797443-8 2005 It is proposed that mTOR, the central control point for protein synthesis of the PI 3-K kinase cascade stimulated by insulin, is regulated by MgATP(2-) which varies directly with cytosolic Mg(2+). Magnesium 142-144 insulin Homo sapiens 117-124 15617878-0 2005 Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Magnesium 0-9 insulin Homo sapiens 62-69 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 0-9 insulin Homo sapiens 78-85 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 0-9 insulin Homo sapiens 250-257 15617878-4 2005 Magnesium is a likely candidate in this regard; magnesium deficiency promotes insulin resistance in rodents and in humans, whereas supplemental magnesium has been found to prevent type 2 diabetes in rodent models of this syndrome, and to improve the insulin sensitivity of elderly or diabetic humans. Magnesium 144-153 insulin Homo sapiens 250-257 15617878-5 2005 Magnesium-rich diets as well as above-average serum magnesium are associated with reduced diabetes risk in prospective epidemiology, and with greater insulin sensitivity in cross-sectional studies; moreover, other types of magnesium-rich foods--dairy products, legumes, and nuts--have been linked to decreased diabetes risk in prospective studies. Magnesium 0-9 insulin Homo sapiens 150-157 15617878-6 2005 The biochemical role of magnesium in support of insulin function is still poorly understood. Magnesium 24-33 insulin Homo sapiens 48-55 15617878-7 2005 In light of evidence that magnesium can function as a mild natural calcium antagonist, it is interesting to note suggestive evidence that increases in intracellular free calcium may compromise the insulin responsiveness of adipocytes and skeletal muscle, and may indeed play a pathogenic role in the insulin resistance syndrome. Magnesium 26-35 insulin Homo sapiens 197-204 15617878-8 2005 Thus, it is proposed that some or all of the favorable impact of good magnesium status on insulin function may reflect antagonism of the induction or effects of increased intracellular free calcium. Magnesium 70-79 insulin Homo sapiens 90-97 15671919-7 2004 Preserving cellular potassium and magnesium pools by blocking the aldosterone effects could also improve both cellular insulin action and insulin secretion. Magnesium 34-43 insulin Homo sapiens 119-126 15466953-11 2004 CONCLUSIONS: Both Mg deficit and obesity may independently lead to a higher risk for insulin resistance and cardiovascular disease. Magnesium 18-20 insulin Homo sapiens 85-92 15384920-2 2004 The improved insulin sensitivity may be mediated in part by magnesium and dietary fiber, two nutrients found in whole-grain foods. Magnesium 60-69 insulin Homo sapiens 13-20 15095290-10 2004 WT significantly blocked the insulin-stimulated Na(+)/Mg(2+) activity (n = 6, P = 0.048), with an IC(50) of 0.5 nmol/L. Magnesium 54-56 insulin Homo sapiens 29-36 15562397-1 2004 Magnesium (Mg(2+)) has an important role in insulin action, and insulin stimulates Mg(2+) uptake in insulin-sensitive tissues. Magnesium 0-9 insulin Homo sapiens 44-51 15223977-0 2004 Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. Magnesium 5-14 insulin Homo sapiens 40-47 15223977-0 2004 Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. Magnesium 5-14 insulin Homo sapiens 90-97 15223977-3 2004 Our purpose was to determine whether oral magnesium supplementation with magnesium chloride (MgCl2) 2.5 g daily modify insulin sensitivity in non-diabetic subjects. Magnesium 42-51 insulin Homo sapiens 119-126 15223977-9 2004 CONCLUSIONS: Oral magnesium supplementation improves insulin sensitivity in hypomagnesemic non-diabetic subjects. Magnesium 18-27 insulin Homo sapiens 53-60 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 0-9 insulin Homo sapiens 35-42 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 74-83 insulin Homo sapiens 55-62 15319146-2 2004 Magnesium has an important role in insulin action, and insulin stimulates magnesium uptake in insulin-sensitive tissues. Magnesium 74-83 insulin Homo sapiens 55-62 15319146-4 2004 This review was designed to reach a better understanding of the mechanism involved in the correlation between magnesium and insulin resistance. Magnesium 110-119 insulin Homo sapiens 124-131 15319146-6 2004 In patients with type 2 diabetes an inverse association exists between the plasma magnesium and insulin resistance due to intracellular changes. Magnesium 82-91 insulin Homo sapiens 96-103 15319146-7 2004 The suppressed intracellular magnesium concentration may result in defective tyrosine kinase activity and modify insulin sensitivity by influencing receptor activity after binding or by influencing intracellular signaling and processing. Magnesium 29-38 insulin Homo sapiens 113-120 15319146-8 2004 Intracellular magnesium deficiency may affect the development of insulin resistance and alter the glucose entry into the cell. Magnesium 14-23 insulin Homo sapiens 65-72 15319146-9 2004 CONCLUSIONS: Magnesium is required for both proper glucose utilization and insulin signaling. Magnesium 13-22 insulin Homo sapiens 75-82 15319146-10 2004 Metabolic alterations in cellular magnesium, which may play the role of a second messenger for insulin action, contribute to insulin resistance. Magnesium 34-43 insulin Homo sapiens 95-102 15319146-10 2004 Metabolic alterations in cellular magnesium, which may play the role of a second messenger for insulin action, contribute to insulin resistance. Magnesium 34-43 insulin Homo sapiens 125-132 14693967-0 2004 Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Magnesium 8-17 insulin Homo sapiens 47-54 14693967-4 2004 In a sample of 349 apparently healthy women from this study, we measured plasma fasting insulin levels to examine their relation to magnesium intake. Magnesium 132-141 insulin Homo sapiens 88-95 14693967-9 2004 Multivariate-adjusted geometric mean insulin levels for overweight women in the lowest quartile of magnesium intake was 53.5 compared with 41.5 pmol/l among those at the highest quartile (P = 0.03 for trend). Magnesium 99-108 insulin Homo sapiens 37-44 12749615-2 2003 Lower levels of dietary and serum magnesium have been associated with an increased prevalence of hypertension, insulin resistance, and diabetes. Magnesium 34-43 insulin Homo sapiens 111-118 14684759-0 2003 The association between magnesium intake and fasting insulin concentration in healthy middle-aged women. Magnesium 24-33 insulin Homo sapiens 53-60 14684759-1 2003 OBJECTIVE: We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women. Magnesium 47-56 insulin Homo sapiens 76-83 14684759-6 2003 RESULTS: After adjustment for age, body mass index (BMI), total energy, physical activity, hours per week spent sitting outside work, alcohol intake, smoking, and family history of diabetes, magnesium intake was inversely associated with fasting insulin concentration. Magnesium 191-200 insulin Homo sapiens 246-253 14684759-9 2003 CONCLUSION: Higher magnesium intake is associated with lower fasting insulin concentrations among women without diabetes. Magnesium 19-28 insulin Homo sapiens 69-76 14684759-10 2003 Because lower fasting insulin concentrations generally reflect greater insulin sensitivity, these findings provide a mechanism through which higher dietary magnesium intake may reduce the risk of developing type 2 diabetes mellitus. Magnesium 156-165 insulin Homo sapiens 22-29 14684759-10 2003 Because lower fasting insulin concentrations generally reflect greater insulin sensitivity, these findings provide a mechanism through which higher dietary magnesium intake may reduce the risk of developing type 2 diabetes mellitus. Magnesium 156-165 insulin Homo sapiens 71-78 12663588-0 2003 Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Magnesium 5-14 insulin Homo sapiens 40-47 12663588-1 2003 OBJECTIVE: To determine whether oral magnesium supplementation (as magnesium chloride [MgCl(2)] solution) improves both insulin sensitivity and metabolic control in type 2 diabetic subjects with decreased serum magnesium levels. Magnesium 37-46 insulin Homo sapiens 120-127 12679171-6 2003 Treating HepG2 cells with other minerals known to have insulin-sensitizing effects such as magnesium (1 mM), zinc (0.2 mM), and vanadyl sulfate (0.1 mM) significantly reduced apoA-I promoter activity in the presence and absence of 100 microU/mL of insulin. Magnesium 91-100 insulin Homo sapiens 55-62 12679171-6 2003 Treating HepG2 cells with other minerals known to have insulin-sensitizing effects such as magnesium (1 mM), zinc (0.2 mM), and vanadyl sulfate (0.1 mM) significantly reduced apoA-I promoter activity in the presence and absence of 100 microU/mL of insulin. Magnesium 91-100 insulin Homo sapiens 248-255 12001011-1 2002 BACKGROUND: Magnesium deficiency is common in type 2 diabetes and may have a negative impact on glucose homeostasis and insulin resistance, as well as on the evolution of complications such as retinopathy, thrombosis and hypertension. Magnesium 12-21 insulin Homo sapiens 120-127 12537988-10 2003 In conclusion, a growing body of studies suggest that intracellular Mg may play a key role in modulating insulin-mediated glucose uptake and vascular tone. Magnesium 68-70 insulin Homo sapiens 105-112 12537988-0 2003 Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Magnesium 8-17 insulin Homo sapiens 21-28 12537988-4 2003 In vitro and in vivo studies have demonstrated that insulin may modulate the shift of Mg from extracellular to intracellular space. Magnesium 86-88 insulin Homo sapiens 52-59 12537988-5 2003 Intracellular Mg concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. Magnesium 14-16 insulin Homo sapiens 81-88 12537988-8 2003 By contrast, in NIDDM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 37-39 insulin Homo sapiens 140-147 12537988-8 2003 By contrast, in NIDDM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 99-101 insulin Homo sapiens 140-147 12145012-7 2002 The association between whole-grain intake and fasting insulin was attenuated after adjustment for dietary fiber and magnesium. Magnesium 117-126 insulin Homo sapiens 55-62 11735085-0 2001 Magnesium reduces insulin-stimulated glucose uptake and serum lipid concentrations in type 1 diabetes. Magnesium 0-9 insulin Homo sapiens 18-25 12511185-0 2002 Does magnesium dysbalance participate in the development of insulin resistance in early stages of renal disease? Magnesium 5-14 insulin Homo sapiens 60-67 11735085-10 2001 Mg repletion was associated with a decrease in atherogenic lipid fractions and a reduced insulin-stimulated glucose uptake. Magnesium 0-2 insulin Homo sapiens 89-96 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 63-70 11566960-0 2001 Insulin-mimetic action of vanadate: role of intracellular magnesium. Magnesium 58-67 insulin Homo sapiens 0-7 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 130-137 11566960-2 2001 Although the exact mechanism(s) remain undefined, we have previously demonstrated a direct relation of intracellular free magnesium (Mg(i)) levels to glucose disposal, to insulinemic responses following glucose loading, and to insulin-induced ionic effects. Magnesium 122-131 insulin Homo sapiens 171-178 11566941-1 2001 Previous studies by our group have identified ionic aspects of insulin resistance in hypertension, in which cellular responses to insulin were influenced by the basal intracellular ionic environment-the lower the cytosolic free magnesium (Mg(i)), the less Mg(i) increased following insulin stimulation. Magnesium 228-237 insulin Homo sapiens 130-137 10859688-3 2000 High-magnesium diets have preventive (though not curative) activity in certain rodent models of diabetes; conversely, magnesium depletion provokes insulin resistance. Magnesium 118-127 insulin Homo sapiens 147-154 11447731-2 2001 It has been repeatedly shown that a low serum ionized magnesium (Mg2+) and a high ionized calcium to magnesium (Ca2+/Mg2+) ratio is often associated with insulin resistance, cardiovascular problems, diabetes mellitus and hypertension. Magnesium 54-63 insulin Homo sapiens 154-161 11447731-2 2001 It has been repeatedly shown that a low serum ionized magnesium (Mg2+) and a high ionized calcium to magnesium (Ca2+/Mg2+) ratio is often associated with insulin resistance, cardiovascular problems, diabetes mellitus and hypertension. Magnesium 101-110 insulin Homo sapiens 154-161 11204289-4 2001 The changes in serum potassium and magnesium were both inversely related to the insulin-mediated glucose uptake (r= -0.62, P< 0.0001; r= -0.31, P< 0.05, respectively). Magnesium 35-44 insulin Homo sapiens 80-87 11462780-13 2001 There is potential interaction with insulin, in that magnesium causes hyperglycemia, which requires insulin to counteract it. Magnesium 53-62 insulin Homo sapiens 36-43 11462780-13 2001 There is potential interaction with insulin, in that magnesium causes hyperglycemia, which requires insulin to counteract it. Magnesium 53-62 insulin Homo sapiens 100-107 10726809-7 1999 No special fraction clearly indicates magnesium deficiency leading to insulin resistance. Magnesium 38-47 insulin Homo sapiens 70-77 10726923-0 2000 Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Magnesium 93-102 insulin Homo sapiens 0-7 10726923-1 2000 The relationship between the plasma magnesium (Mg) concentration and steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations at the end of a 180-minute infusion of octreotide, insulin, and glucose was determined in 98 healthy nondiabetic subjects. Magnesium 36-45 insulin Homo sapiens 89-96 10726923-6 2000 These results indicate that variations in the plasma Mg concentration have a relatively modest but significant effect on insulin-mediated glucose disposal in healthy subjects, with lower plasma Mg concentrations associated with increased insulin resistance. Magnesium 53-55 insulin Homo sapiens 121-128 10726923-6 2000 These results indicate that variations in the plasma Mg concentration have a relatively modest but significant effect on insulin-mediated glucose disposal in healthy subjects, with lower plasma Mg concentrations associated with increased insulin resistance. Magnesium 194-196 insulin Homo sapiens 238-245 10674850-4 2000 The serum phosphorus and magnesium concentrations decreased to nadirs of 1.6 mg/dl and 1.6 mg/dl respectively 7 hours after insulin injection. Magnesium 25-34 insulin Homo sapiens 124-131 10767668-5 2000 Minerals such as magnesium, calcium, potassium, zinc, chromium, and vanadium appear to have associations with insulin resistance or its management. Magnesium 17-26 insulin Homo sapiens 110-117 10488473-1 1999 It has been postulated that parathormone, calcitonine, insulin and catecholamines are involved in extracellular magnesium homeostasis. Magnesium 112-121 insulin Homo sapiens 55-62 10480466-0 1999 Low dietary magnesium is associated with insulin resistance in a sample of young, nondiabetic Black Americans. Magnesium 12-21 insulin Homo sapiens 41-48 10480466-1 1999 In both humans and experimental animals, dietary induced magnesium deficiency is correlated with insulin resistance. Magnesium 57-66 insulin Homo sapiens 97-104 10480466-2 1999 The purpose of this study was to determine whether dietary magnesium intake is associated with insulin sensitivity or blood pressure in a sample of nondiabetic, young adult black Americans. Magnesium 59-68 insulin Homo sapiens 95-102 10480466-9 1999 There was a significant negative correlation of total dietary magnesium intake with the sum of insulin levels measured during an oral glucose tolerance test (OGTT) (r = -0.13, P < .05). Magnesium 62-71 insulin Homo sapiens 95-102 10480466-10 1999 When corrected for body fat, in men there was also a significant correlation of dietary magnesium intake, measured in mg/kg of fat-free mass, with the sum of insulin concentrations on the OGTT (r = -0.22, P < .05). Magnesium 88-97 insulin Homo sapiens 158-165 10480466-12 1999 These results suggest a possible role for dietary magnesium in insulin resistance. Magnesium 50-59 insulin Homo sapiens 63-70 9589224-2 1998 Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Magnesium 54-63 insulin Homo sapiens 83-90 10218382-3 1999 The plasma magnesium level has been shown to be inversely related to insulin sensitivity. Magnesium 11-20 insulin Homo sapiens 69-76 10218382-4 1999 Magnesium supplementation improves insulin sensitivity as well as insulin secretion in patients with type 2 diabetes. Magnesium 0-9 insulin Homo sapiens 35-42 10090339-6 1999 Our results seem to indicate that the insulin resistance status, the hyperglycemia, and the disregulation of the adrenergic system in obese subjects could be involved in the pathogenesis of the magnesium homeostasis impairment observed in the obese subjects. Magnesium 194-203 insulin Homo sapiens 38-45 9828151-0 1998 Effects of insulin and insulin-like growth factor-1 on intracellular magnesium of platelets. Magnesium 69-78 insulin Homo sapiens 11-18 9851785-0 1998 Magnesium responsiveness to insulin and insulin-like growth factor I in erythrocytes from normotensive and hypertensive subjects. Magnesium 0-9 insulin Homo sapiens 28-35 9851785-10 1998 Together, these data support a role for IGF-I in cellular magnesium metabolism and emphasize the importance of magnesium as a determinant of insulin action. Magnesium 111-120 insulin Homo sapiens 141-148 30636864-8 1998 Potentially mediating nutrients explaining part of the relationship between whole grain intake and fasting insulin were dietary magnesium and fiber. Magnesium 128-137 insulin Homo sapiens 107-114 9632126-0 1998 Oral magnesium supplementation in insulin-requiring Type 2 diabetic patients. Magnesium 5-14 insulin Homo sapiens 34-41 9632126-1 1998 Oral magnesium (Mg) supplementation can improve insulin sensitivity and secretion in patients with Type 2 diabetes mellitus (DM). Magnesium 5-14 insulin Homo sapiens 48-55 9632126-1 1998 Oral magnesium (Mg) supplementation can improve insulin sensitivity and secretion in patients with Type 2 diabetes mellitus (DM). Magnesium 16-18 insulin Homo sapiens 48-55 9632126-2 1998 We studied the effect of Mg supplementation on glycaemic control, blood pressure, and plasma lipids in insulin-requiring patients with Type 2 DM. Magnesium 25-27 insulin Homo sapiens 103-110 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 19-21 insulin Homo sapiens 41-48 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 100-102 insulin Homo sapiens 41-48 9632126-9 1998 Three months" oral Mg supplementation of insulin-requiring patients with Type 2 DM increased plasma Mg concentration and urinary Mg excretion but had no effect on glycaemic control or plasma lipid concentrations. Magnesium 100-102 insulin Homo sapiens 41-48 9589224-2 1998 Several studies have suggested an association between magnesium (Mg) depletion and insulin resistance and/or reduction of insulin secretion in these cases. Magnesium 65-67 insulin Homo sapiens 83-90 9360541-0 1997 Effect of variations in plasma magnesium concentration on resistance to insulin-mediated glucose disposal in nondiabetic subjects. Magnesium 31-40 insulin Homo sapiens 72-79 9790249-0 1998 Effects of insulin on intracellular magnesium of platelets. Magnesium 36-45 insulin Homo sapiens 11-18 9595547-6 1998 Primary magnesium depletion is due to dysregulation of factors controlling magnesium status: intestinal magnesium hypoabsorption, reduced magnesium bone uptake and mobilisation, sometimes urinary leakage, hyperadrenoglucocorticism by decreased adaptability to stress, insulin-resistance and adrenergic hyporeceptivity. Magnesium 8-17 insulin Homo sapiens 268-275 9952286-1 1998 In order to assess the links which are claimed to exist between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT) in a group of 16 normotensive control subjects (NC) and 34 essential hypertensive subjects (EH). Magnesium 112-121 insulin Homo sapiens 75-82 9952286-7 1998 In a first attempt to study the relationships between insulin resistance, Mg(i) and Ca(i) in nucleated cells, the chosen index of peripheral resistance seems to be linked to intracellular free magnesium. Magnesium 193-202 insulin Homo sapiens 54-61 9360541-7 1997 Thus, a low Mg concentration in nondiabetic subjects was associated with relative insulin resistance, glucose intolerance, and hyperinsulinemia. Magnesium 12-14 insulin Homo sapiens 82-89 9322186-9 1997 Ingestion of sugars, fats, and sodium have been linked to decreased insulin sensitivity, while caloric restriction, exercise, ingestion of chromium, vanadium, soluble fibers, magnesium, and certain antioxidants are associated with greater insulin sensitivity. Magnesium 175-184 insulin Homo sapiens 239-246 9403322-4 1997 Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Magnesium 262-271 insulin Homo sapiens 0-7 9056694-8 1997 By contrast, in NIDDM patients daily magnesium administration, restoring a more appropriate intracellular magnesium concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 106-115 insulin Homo sapiens 154-161 9342541-3 1997 Insulin-resistant states, such as essential hypertension and NIDDM, as well as "normal" ageing, are characterised by similar intracellular ionic defects, i.e. accumulation of cytosolic free calcium and depletion of free magnesium. Magnesium 220-229 insulin Homo sapiens 0-7 9342541-5 1997 A rise in cellular free calcium and a depletion in cellular magnesium may induce cellular insulin resistance and vasoconstriction. Magnesium 60-69 insulin Homo sapiens 90-97 9404425-1 1997 To ascertain the claimed links between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations, as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT), in a group of 15 normotensive control subjects (NC) and 29 essential hypertensive subjects (EH). Magnesium 87-96 insulin Homo sapiens 50-57 9278926-3 1997 Peripheral insulin resistance, which usually responds to a very-low-fat diet, aerobic exercise training, and appropriate weight loss, can also treated with high-dose chromium picolinate, high-dose vitamin E, magnesium, soluble fiber, and possibly taurine; these measures appear likely to correct the diabetes-associated metabolic derangements of vascular smooth muscle, and thus lessen risk for macrovascular disease. Magnesium 208-217 insulin Homo sapiens 11-18 9177378-6 1997 Furthermore, a blunting of Mg(i) responses to insulin could be reproduced in normal cells that were magnesium depleted by prior treatment either with A23187 in a calcium-free medium or with high glucose concentrations (15 mmol/L). Magnesium 100-109 insulin Homo sapiens 46-53 9056694-4 1997 In fact, in vitro and in vivo studies have demonstrated that insulin may modulate the shift of magnesium from extracellular to intracellular space. Magnesium 95-104 insulin Homo sapiens 61-68 9056694-5 1997 Intracellular magnesium concentration has also been shown to be effective on modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli, by stimulating Ca2+-dependent K+ channels. Magnesium 14-23 insulin Homo sapiens 88-95 9056694-8 1997 By contrast, in NIDDM patients daily magnesium administration, restoring a more appropriate intracellular magnesium concentration, contributes to improve insulin-mediated glucose uptake. Magnesium 37-46 insulin Homo sapiens 154-161 9056694-9 1997 Similarly, in HP patients magnesium administration may be useful in decreasing arterial blood pressure and improving insulin-mediated glucose uptake. Magnesium 26-35 insulin Homo sapiens 117-124 9056694-11 1997 In conclusion, a growing body of studies suggest that intracellular magnesium may play a key role on modulating insulin-mediated glucose uptake and vascular tone. Magnesium 68-77 insulin Homo sapiens 112-119 8861135-0 1995 Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Magnesium 0-9 insulin Homo sapiens 65-72 8914428-4 1996 Several mechanisms mediated by hyperinsulinemia can be entertained as follows: 1) sodium and water retention, 2) increased sympathetic nerve activity and reduced catecholamine clearance, 3) increased intracellular calcium concentration and reduced magnesium concentration, 4) increased coagulant activity and impaired fibrinolytic activity, 5) impaired endothelium-dependent NO synthesis and release, 6) increased vascular responsiveness for the vasoactive substrates, 7) increased proliferation of vascular smooth muscle cell by activation of protein kinase C or mediated by insulin and IGF-1 action. Magnesium 248-257 insulin Homo sapiens 36-43 8861135-3 1995 Magnesium deficiency per se has also been reported to result in insulin resistance. Magnesium 0-9 insulin Homo sapiens 64-71 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 32-34 insulin Homo sapiens 8-15 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 66-75 insulin Homo sapiens 8-15 8861135-11 1995 and the insulin-induced rise in Mg(2+) fell from 27.2 percent pre-magnesium depletion to 12.7 percent post-magnesium depletion. Magnesium 107-116 insulin Homo sapiens 8-15 8861135-12 1995 These data suggest that insulin resistance and magnesium depletion may result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which may limit the role of magnesium in vital cellular processes. Magnesium 47-56 insulin Homo sapiens 110-117 8861135-12 1995 These data suggest that insulin resistance and magnesium depletion may result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which may limit the role of magnesium in vital cellular processes. Magnesium 194-203 insulin Homo sapiens 24-31 7587003-0 1995 Insulin increases renal magnesium excretion: a possible cause of magnesium depletion in hyperinsulinaemic states. Magnesium 24-33 insulin Homo sapiens 0-7 8549022-2 1995 Insulin sensitivity can be improved by reduction of excessive body weight, regular physical activity and, possibly, by correcting a subclinical magnesium deficiency. Magnesium 144-153 insulin Homo sapiens 0-7 7587003-0 1995 Insulin increases renal magnesium excretion: a possible cause of magnesium depletion in hyperinsulinaemic states. Magnesium 65-74 insulin Homo sapiens 0-7 7587003-4 1995 Compared to baseline, the renal magnesium excretion increased 30% during the infusion of insulin at a rate of 120 pmol m-2 min-1. Magnesium 32-41 insulin Homo sapiens 89-96 7587003-5 1995 During infusion of insulin, 240 pmol m-2 min-1, renal magnesium excretion increased 50% compared to baseline. Magnesium 54-63 insulin Homo sapiens 19-26 7587003-8 1995 Thus, physiological concentrations of insulin induce a specific increase in the renal excretion of magnesium. Magnesium 99-108 insulin Homo sapiens 38-45 7812848-5 1994 The increase of free Ca and decrease of free Mg concentrations participate both in insulin resistance and hemodynamic changes in diseases of the Reaven"s syndrome. Magnesium 45-47 insulin Homo sapiens 83-90 7782801-9 1995 In participants without CVD, serum Mg levels were also inversely associated with fasting serum insulin, glucose, systolic blood pressure and smoking. Magnesium 35-37 insulin Homo sapiens 95-102 7782801-10 1995 Dietary Mg intake was inversely associated with fasting serum insulin, plasma high density lipoprotein-cholesterol, systolic and diastolic blood pressure. Magnesium 8-10 insulin Homo sapiens 62-69 7714113-0 1995 Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. Magnesium 29-38 insulin Homo sapiens 11-18 7714113-1 1995 Insulin influences both glucose metabolism and magnesium homeostasis in humans. Magnesium 47-56 insulin Homo sapiens 0-7 7714113-2 1995 The present studies sought to determine whether insulin-induced stimulation of magnesium uptake is impaired in noninsulin-dependent diabetes mellitus (NIDDM) and enhanced by acute hyperglycemia. Magnesium 79-88 insulin Homo sapiens 48-55 7714113-5 1995 During the prandial insulin infusion, the decrement in the plasma magnesium concentration was lower (P < 0.05) in the diabetic patients than that in the nondiabetic subjects during both the euglycemic (4.1 +/- 0.9 vs. 7.8 +/- 1.3 mmol/L.4 h) and hyperglycemic (1.7 +/- 1.1 vs. 6.6 +/- 1.4 mmol/L.4 h) studies. Magnesium 66-75 insulin Homo sapiens 20-27 7714113-6 1995 Glucose disappearance also was lower (P < 0.05) in the diabetic patients than that in the nondiabetic subjects, and the insulin-induced decrement in plasma magnesium was correlated (P < 0.01) with glucose disappearance. Magnesium 159-168 insulin Homo sapiens 123-130 7714113-8 1995 We conclude that insulin resistance in subjects with NIDDM impairs the ability of insulin to stimulate magnesium as well as glucose uptake. Magnesium 103-112 insulin Homo sapiens 17-24 7714113-8 1995 We conclude that insulin resistance in subjects with NIDDM impairs the ability of insulin to stimulate magnesium as well as glucose uptake. Magnesium 103-112 insulin Homo sapiens 82-89 7714114-2 1995 Magnesium accumulation is dependent upon insulin action and correlates with insulin-mediated glucose uptake. Magnesium 0-9 insulin Homo sapiens 41-48 7714114-2 1995 Magnesium accumulation is dependent upon insulin action and correlates with insulin-mediated glucose uptake. Magnesium 0-9 insulin Homo sapiens 76-83 7714114-3 1995 As Pima Indians are known to be insulin resistant, we investigated whether, in response to insulin infusion, they have lower erythrocyte magnesium accumulation than Caucasians. Magnesium 137-146 insulin Homo sapiens 91-98 7714114-8 1995 In response to insulin infusion, erythrocyte magnesium content increased less in Pima Indians than in Caucasians (0.15 +/- 0.07 vs. 0.28 +/- 0.21 mmol/L; P < 0.03). Magnesium 45-54 insulin Homo sapiens 15-22 7714114-10 1995 In conclusion, nondiabetic Pima Indians have a lower erythrocyte magnesium accumulation in response to insulin infusion; this is probably due to their high degree of insulin resistance. Magnesium 65-74 insulin Homo sapiens 103-110 7783102-0 1995 Low fasting and insulin-mediated intracellular magnesium accumulation in hypertensive patients with left ventricular hypertrophy: role of insulin resistance. Magnesium 47-56 insulin Homo sapiens 16-23 7783102-8 1995 In conclusion, hypertensive patients with LVH compared with those without LVH have a lower intracellular magnesium content due a higher degree of insulin resistance. Magnesium 105-114 insulin Homo sapiens 146-153 8206589-0 1994 Dietary magnesium prevents fructose-induced insulin insensitivity in rats. Magnesium 8-17 insulin Homo sapiens 44-51 8206564-8 1994 After treatment, intracellular potassium and magnesium were both associated with higher serum insulin (P < .001 for each), and serum potassium was associated with higher and serum magnesium with lower serum glucose (P < .01 for each). Magnesium 45-54 insulin Homo sapiens 94-101 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 32-41 insulin Homo sapiens 205-212 8206589-2 1994 It is possible that the reduced magnesium content of the high-fructose commercial diet used in some studies may play a role in these abnormalities because it is known that magnesium deficiency can produce insulin insensitivity and increased angiotensin II action in humans. Magnesium 172-181 insulin Homo sapiens 205-212 8206589-9 1994 Blood pressure and fasting insulin levels were also lower in the magnesium-supplemented group. Magnesium 65-74 insulin Homo sapiens 27-34 8206589-10 1994 These results suggest that magnesium deficiency and not fructose ingestion per se leads to insulin insensitivity in skeletal muscle and changes in blood pressure. Magnesium 27-36 insulin Homo sapiens 91-98 8405745-0 1993 Intracellular and extracellular magnesium depletion in type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 32-41 insulin Homo sapiens 67-74 8200955-8 1994 In conclusion, a 4-week magnesium supplementation improves insulin sensitivity and glucose oxidation in the course of a euglycemic-hyperinsulinemic glucose clamp in noninsulin-dependent diabetic patients. Magnesium 24-33 insulin Homo sapiens 59-66 8054257-2 1994 It is known that magnesium deficiency or hypomagnesaemia induces hyperinsulinism, while hypermagnesaemia inhibits insulin secretion: however, the mechanism controlling the intracellular level of free magnesium and its role in the insulin-secretory mechanism of pancreatic beta cells (RIN m5F cells) are still unclear. Magnesium 17-26 insulin Homo sapiens 70-77 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 44-51 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 113-120 8054257-7 1994 Elucidation of the role of magnesium in the insulin secretory mechanism will be beneficial for understanding the insulin secretory mechanism of pancreatic beta cells and may be helpful in treating insulin-related abnormalities in patients with hypo- or hypermagnesaemia. Magnesium 27-36 insulin Homo sapiens 113-120 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 27-36 insulin Homo sapiens 0-7 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 38-47 insulin Homo sapiens 0-7 8091358-2 1994 Insulin secretion requires magnesium: magnesium deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Magnesium 38-47 insulin Homo sapiens 0-7 8091358-3 1994 Furthermore, experimental magnesium deficiency reduces the tissues sensitivity to insulin. Magnesium 26-35 insulin Homo sapiens 82-89 8091358-6 1994 In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance. Magnesium 56-65 insulin Homo sapiens 18-25 8091358-6 1994 In type 2, or non-insulin-dependent, diabetes mellitus, magnesium deficiency seems to be associated with insulin resistance. Magnesium 56-65 insulin Homo sapiens 105-112 8155490-8 1993 Primary magnesium depletion is due to dysregulation of factors controlling magnesium status: intestinal magnesium hypoabsorption, reduced magnesium bone uptake and mobilization, sometimes urinary leakage, hyperadrenoglucocorticism by decreased adaptability to stress, insulin resistance and adrenergic hyporeceptivity. Magnesium 8-17 insulin Homo sapiens 268-275 8155490-13 1993 The importance of magnesium deficit in the aetiologies of insulin resistance, and the adrenergic, osseous, oncogenic, immune and oxidant disturbances of ageing is still uncertain. Magnesium 18-27 insulin Homo sapiens 58-65 8305165-4 1993 Insulin infusion per se stimulated erythrocyte magnesium (1.83 +/- 0.04 v 1.98 +/- 0.03 mmol/L, P < .03) and calcium (4.7 +/- 0.3 v 6.2 +/- 0.4 mumol/L, P < .02) accumulation, and enhanced total body glucose disposal oxidative and nonoxidative glucose metabolisms. Magnesium 47-56 insulin Homo sapiens 0-7 7692419-6 1993 The sequence of changes suggests that the decrease of potassium and magnesium after ventricular tachycardia was due to a shift of the electrolytes into cells, related to the insulin-mediated movement of glucose from the blood into cells. Magnesium 68-77 insulin Homo sapiens 174-181 8505087-0 1993 Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Magnesium 0-9 insulin Homo sapiens 30-37 8243023-2 1993 It was found that a diabetic condition is apt to bring about marked changes in body magnesium content and its compartmental distribution, and that the administration of dietary magnesium supplements can have a favorable influence on metabolic control, thus reducing insulin requirement and counteracting the progression of late diabetic complications. Magnesium 177-186 insulin Homo sapiens 266-273 8505087-8 1993 Analysis showed that all subjects studied had a decrease in insulin sensitivity after magnesium deficiency (3.69 +/- 0.6 to 2.75 +/- 0.5 min-1 per microunit per milliliter x 10(-4), p < 0.03). Magnesium 86-95 insulin Homo sapiens 60-67 8505087-10 1993 These effects are associated with a decrease in insulin action, suggesting that magnesium deficiency may be a common factor associated with insulin resistance and vascular disease. Magnesium 80-89 insulin Homo sapiens 48-55 8505087-10 1993 These effects are associated with a decrease in insulin action, suggesting that magnesium deficiency may be a common factor associated with insulin resistance and vascular disease. Magnesium 80-89 insulin Homo sapiens 140-147 8264520-1 1993 Abnormal dietary deficiency in Mg as well as abnormalities in Mg metabolism appear to play important roles as risk factors for ischemic heart disease and acute myocardial infarction, namely in hypertensive vascular disease, diabetic vascular disease, insulin resistance, atherosclerosis and vasospasm. Magnesium 62-64 insulin Homo sapiens 251-258 8225454-4 1993 The hyperglycemia in these cases was inversely related to hypomagnesemia and its restoration towards normal by insulin therapy restored the normal serum magnesium concentration. Magnesium 153-162 insulin Homo sapiens 111-118 8458528-1 1993 Elevated erythrocyte cytosolic free calcium, and suppressed free magnesium and pH values are associated with the hyperinsulinaemia and insulin resistance of hypertension, obesity, and Type 2 (non-insulin-dependent) diabetes mellitus. Magnesium 65-74 insulin Homo sapiens 118-125 8458528-6 1993 Similarly, insulin also increased intracellular free magnesium at all time points (basal: 177 +/- 11 mumol/l; 60 min: 209 +/- 19 mumol/l; 120 min: 206 +/- 22 mumol/l; and 180 min: 202 +/- 12 mumol/l; p < 0.05 vs basal at all times). Magnesium 53-62 insulin Homo sapiens 11-18 8445010-0 1993 Insulin increases intracellular magnesium transport in human platelets. Magnesium 32-41 insulin Homo sapiens 0-7 8445010-9 1993 Furthermore, the insulin-stimulated Mg transport was inhibited by the addition of chelating agent ethylenediaminete-traacetate while the receptor binding was not altered. Magnesium 36-38 insulin Homo sapiens 17-24 8445010-10 1993 These findings suggest that insulin can translocate Mg from the extracellular space. Magnesium 52-54 insulin Homo sapiens 28-35 1418829-9 1992 In the multiple linear regression analysis of the pooled basal data (n = 42), erythrocyte magnesium content displayed an independent correlation with basal plasma insulin levels (t = -2.08, P < .05). Magnesium 90-99 insulin Homo sapiens 163-170 1418832-3 1992 These Mg-mediated activities were further enhanced when platelets were preincubated with insulin (100 microU/mL). Magnesium 6-8 insulin Homo sapiens 89-96 1418832-10 1992 Furthermore, insulin can potentiate the inhibitory effects of Mg on platelet activation. Magnesium 62-64 insulin Homo sapiens 13-20 1591145-7 1992 It is not known to what extent suboptimal intakes may affect the aging process; however, magnesium-deficient conditions have been associated with neuromuscular and cardiovascular disorders, endocrine disturbances, insulin resistance and Alzheimer"s disease. Magnesium 89-98 insulin Homo sapiens 214-221 1457764-5 1992 Furthermore, for all subjects, free calcium and free magnesium levels were closely related both to the left ventricular mass and to the degree of insulin resistance present. Magnesium 53-62 insulin Homo sapiens 146-153 1511567-0 1992 Conventional and sprinkler needle injection of magnesium insulin. Magnesium 47-56 insulin Homo sapiens 57-64 1511567-3 1992 Magnesium insulin (50 U ml-1) given by sprinkler needle was compared with unmodified human insulin (100 U ml-1) given by conventional needle and unmodified human insulin (50 U ml-1) given by sprinkler needle in normal volunteers using a euglycaemic clamp. Magnesium 0-9 insulin Homo sapiens 10-17 1511567-4 1992 Magnesium insulin had a significantly faster onset of action resulting in a higher exogenous insulin level by 15 min, peak level was reached after 60 min compared with 75 min for the unmodified insulins, and duration of action was significantly shorter than both unmodified insulins. Magnesium 0-9 insulin Homo sapiens 10-17 1511567-4 1992 Magnesium insulin had a significantly faster onset of action resulting in a higher exogenous insulin level by 15 min, peak level was reached after 60 min compared with 75 min for the unmodified insulins, and duration of action was significantly shorter than both unmodified insulins. Magnesium 0-9 insulin Homo sapiens 93-100 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 23-30 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1511567-6 1992 Injection of magnesium insulin prior to a test breakfast in people with Type 2 diabetes resulted in significantly lower total and 0 to 120 min areas under the glucose curve, an earlier rise in exogenous insulin levels and a higher area under the insulin curve from 0 to 120 min compared with unmodified 100 U ml-1 human insulin. Magnesium 13-22 insulin Homo sapiens 203-210 1541384-1 1992 Low levels of magnesium have frequently been reported in diabetes mellitus especially in poorly controlled Type 1 (insulin-dependent) diabetic patients. Magnesium 14-23 insulin Homo sapiens 115-122