PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23440520-1 2013 The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non-selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg(2+) homeostasis in mammals. Magnesium 214-216 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 4-50 23765921-3 2014 We found that a TRPM7-like current was recorded with Mg(2+) -free pipette solution in 3T3-L1 preadipocytes, and the current was inhibited by intercellular free Mg(2+) . Magnesium 53-55 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 16-21 23440520-1 2013 The transient receptor potential melastatin type 7 (TRPM7) channel is a widely expressed non-selective cation channel with fusion to the C-terminal alpha kinase domain and regarded as a key regulator of whole body Mg(2+) homeostasis in mammals. Magnesium 214-216 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 52-57 21045827-6 2010 Cells derived from heterozygous TRPM7(Deltakinase) mice demonstrated reduced TRPM7 currents that had increased sensitivity to the inhibition by Mg(2+). Magnesium 144-146 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 32-37 21207015-5 2011 Gene expression of TRPM7 increased with osteoblastic differentiation, suggesting the importance of intracellular Ca/Mg homeostasis to cell differentiation. Magnesium 116-118 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 19-24 21207015-11 2011 Our results indicate that intracellular Ca and Mg homeostasis ensured by TRPM7 expression is important for the osteoblastic differentiation of MC3T3 cells. Magnesium 47-49 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 73-78 21290295-2 2011 TRPM7 current is typically small at physiological magnesium concentrations, but large outwardly rectifying currents develop in low-magnesium extracellular solution when cells are dialyzed with magnesium free solutions during whole-cell patch clamp recordings. Magnesium 50-59 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-5 21290295-3 2011 In addition to regulation by magnesium, TRPM7 current is potentiated by low extracellular pH and inhibited by depletion of phosphatidylinositol 4,5-bisphosphate (PIP(2)) during phospholipase C mediated signaling events. Magnesium 29-38 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 40-45 21290295-4 2011 A diverse body of literature has implicated TRPM7 in fundamental cellular processes including death, survival, proliferation, cell cycle progression, magnesium homeostasis and responses to shear stress and oxidative stress. Magnesium 150-159 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 44-49 21045827-6 2010 Cells derived from heterozygous TRPM7(Deltakinase) mice demonstrated reduced TRPM7 currents that had increased sensitivity to the inhibition by Mg(2+). Magnesium 144-146 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 77-82 28821869-8 2017 Consequently, the association of mTRPM6 with mTRPM7 allows for high constitutive activity of mTRPM6/7 in the presence of physiological levels of Mg2+ and Mg ATP, thus laying the mechanistic foundation for constant vectorial Mg2+ transport specifically into epithelial cells. Magnesium 145-147 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 45-51 35389104-0 2022 Structural mechanism of TRPM7 channel regulation by intracellular magnesium. Magnesium 66-75 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 24-29 35163580-0 2022 Magnesium Homeostasis in Myogenic Differentiation-A Focus on the Regulation of TRPM7, MagT1 and SLC41A1 Transporters. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 79-84 31650715-5 2019 Consistent with known properties of TRPM7 current, the current in adipocytes was activated by the elimination of extracellular divalent cations and the reduction of intracellular free Mg2+ concentrations, and was inhibited by the TRPM7 inhibitors, 2-aminoethyl diphenylborinate (2-APB), hydrogen peroxide (H2 O2 ), N-methyl maleimide (NMM), NS8593, and 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (FTY720). Magnesium 184-188 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 36-41 31650715-5 2019 Consistent with known properties of TRPM7 current, the current in adipocytes was activated by the elimination of extracellular divalent cations and the reduction of intracellular free Mg2+ concentrations, and was inhibited by the TRPM7 inhibitors, 2-aminoethyl diphenylborinate (2-APB), hydrogen peroxide (H2 O2 ), N-methyl maleimide (NMM), NS8593, and 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol (FTY720). Magnesium 184-188 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 230-235 31559137-0 2019 Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 58-63 31559137-3 2019 Data show that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Magnesium 29-32 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 72-77 20696983-0 2010 Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Magnesium 100-109 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 80-85 20696983-10 2010 TRPM 7 activation was decreased by calcification medium, an effect reversed by magnesium. Magnesium 79-88 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-6 20696983-13 2010 Magnesium negatively regulates vascular calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein. Magnesium 0-9 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 112-117 19103997-2 2009 The novel magnesium transporter TRPM7 is a critical regulator of magnesium homeostasis in vascular cells, but its role in pathophysiology is unclear. Magnesium 10-19 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 32-37 33210606-8 2020 MgD (with Ca:Mg ratios >1) elevated intracellular Ca levels, calpain activity and TRPM7 expression, as well as oxidative stress and cell migration, consistent with observed degradation of full-length E-cadherin, beta-catenin, and N-terminal FAK. Magnesium 0-2 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 82-87 31650715-2 2019 TRPM7 is a Ca2+ /Mg2+ -permeable non-selective cation channel. Magnesium 17-21 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-5 27458382-10 2016 Supplemented magnesium successfully rescued the activities of ALPase in ameloblasts, odontoblasts and osteoblasts of Trpm7 (Deltakinase/+) mice. Magnesium 13-22 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 117-122 26504086-1 2015 Trpm7 is a divalent cation-permeable channel that has been reported to be involved in magnesium homeostasis as well as cellular adhesion and migration. Magnesium 86-95 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-5 26928801-1 2016 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg(2+))/cation channel and a kinase domain. Magnesium 89-98 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-41 26928801-1 2016 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg(2+))/cation channel and a kinase domain. Magnesium 89-98 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 43-48 25534891-0 2014 Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice. Magnesium 83-92 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 28-33 25534891-0 2014 Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice. Magnesium 83-92 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 48-53 25534891-2 2014 TRPM7 is implicated in regulating cellular and systemic magnesium homeostasis. Magnesium 56-65 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 0-5 25534891-7 2014 Furthermore, mouse embryonic fibroblasts isolated from TRPM7 kinase-dead animals exhibited increased resistance to magnesium deprivation and oxidative stress. Magnesium 115-124 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 55-60 25534891-9 2014 Together, our results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation. Magnesium 63-72 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 35-40 25534891-9 2014 Together, our results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation. Magnesium 144-153 transient receptor potential cation channel, subfamily M, member 7 Mus musculus 35-40