PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34865947-3 2021 Expression levels of the magnesium transporters-SLC41A1, CNNM2, MAGT1, TRPM6, and TRPM7-were assessed in the peripheral leukocytes, while total calcium and magnesium were assessed in the serum between 10 and 13 weeks gestation. Magnesium 25-34 solute carrier family 41 member 1 Homo sapiens 48-55 33203509-0 2021 Gating-related Structural Dynamics of the MgtE Magnesium Channel in Membrane-Mimetics Utilizing Site-Directed Tryptophan Fluorescence. Magnesium 47-56 solute carrier family 41 member 1 Homo sapiens 42-46 30791470-0 2019 A Magnesium Transport Protein Related to Mammalian SLC41 and Bacterial MgtE Contributes to Circadian Timekeeping in a Unicellular Green Alga. Magnesium 2-11 solute carrier family 41 member 1 Homo sapiens 71-75 31076559-0 2019 Magnesium transporter protein solute carrier family 41 member 1 suppresses human pancreatic ductal adenocarcinoma through magnesium-dependent Akt/mTOR inhibition and bax-associated mitochondrial apoptosis. Magnesium 122-131 solute carrier family 41 member 1 Homo sapiens 30-63 30791470-6 2019 OtMgtE shares homology with the mammalian SLC41A1 magnesium/sodium antiporter, which has previously been implicated in maintaining clock period. Magnesium 50-59 solute carrier family 41 member 1 Homo sapiens 42-49 31187092-0 2016 SLC41A1 and TRPM7 in magnesium homeostasis and genetic risk for Parkinson"s disease. Magnesium 21-30 solute carrier family 41 member 1 Homo sapiens 0-7 30172737-1 2018 OBJECTIVES: The aim of this study was to investigate the expression of the mammalian Mg2+ transporter solute carrier family 41, member 1 (SLC41A1) in the striatum (STR) of a 6-hydroxydopamine (6-OHDA)-induced rat model, and its response to magnesium before the degenerative process commenced. Magnesium 240-249 solute carrier family 41 member 1 Homo sapiens 138-145 29256407-0 2017 Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. Magnesium 15-24 solute carrier family 41 member 1 Homo sapiens 83-90 29256407-3 2017 With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN). Magnesium 49-58 solute carrier family 41 member 1 Homo sapiens 117-124 28509138-12 2017 Furthermore, loss of function mutation in SLC41A1 gene that leads to magnesium depletion must be noted in patients with suspected to nephronophthisis. Magnesium 69-78 solute carrier family 41 member 1 Homo sapiens 42-49 29435164-1 2018 The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular. Magnesium 8-10 solute carrier family 41 member 1 Homo sapiens 23-30 25726166-8 2015 SLC41A1 expression level was positively correlated with serum magnesium whereas TRPM6 expression level was negatively correlated with serum magnesium. Magnesium 62-71 solute carrier family 41 member 1 Homo sapiens 0-7 26453619-4 2015 SLC41A1 (solute carrier family 41 member 1), the gene encoding a ubiquitous cellular Mg(2+)E (Mg(2+)efflux) system, has been shown to be regulated by activated AR. Magnesium 85-87 solute carrier family 41 member 1 Homo sapiens 0-7 26453619-4 2015 SLC41A1 (solute carrier family 41 member 1), the gene encoding a ubiquitous cellular Mg(2+)E (Mg(2+)efflux) system, has been shown to be regulated by activated AR. Magnesium 85-87 solute carrier family 41 member 1 Homo sapiens 9-42 26453619-4 2015 SLC41A1 (solute carrier family 41 member 1), the gene encoding a ubiquitous cellular Mg(2+)E (Mg(2+)efflux) system, has been shown to be regulated by activated AR. Magnesium 94-96 solute carrier family 41 member 1 Homo sapiens 0-7 26453619-4 2015 SLC41A1 (solute carrier family 41 member 1), the gene encoding a ubiquitous cellular Mg(2+)E (Mg(2+)efflux) system, has been shown to be regulated by activated AR. Magnesium 94-96 solute carrier family 41 member 1 Homo sapiens 9-42 26453619-5 2015 We hypothesize that overexpression/up-regulation of PARK7/DJ-1, attributable to OS and related activation of AR, is an important event regulating the expression of SLC41A1 and consequently, modulating the Mg(2+)E capacity. Magnesium 205-207 solute carrier family 41 member 1 Homo sapiens 164-171 26453619-7 2015 Imipramine, in use as an antidepressant, has been shown to reduce the Mg(2+)E activity of SLC41A1 and OS. Magnesium 70-72 solute carrier family 41 member 1 Homo sapiens 90-97 24661466-8 2014 Fluorescent probe mag-fluo-4 staining indicated that R244H SLC41A1 is dysfunctional in Mg(2+) efflux. Magnesium 87-89 solute carrier family 41 member 1 Homo sapiens 59-66 24968120-3 2014 Three families of transport proteins were previously identified for magnesium import: CorA, MgtE, and MgtA/MgtB P-type ATPases. Magnesium 68-77 solute carrier family 41 member 1 Homo sapiens 92-96 24661466-9 2014 CONCLUSIONS: This study has shown loss of Mg(2+) efflux function consequent to SLC41A1 R244H variant and SLC41A1 coding variants seem to be rare in Taiwanese PD. Magnesium 42-44 solute carrier family 41 member 1 Homo sapiens 79-86 23844728-0 2013 SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women. Magnesium 20-29 solute carrier family 41 member 1 Homo sapiens 0-7 23976986-4 2013 Interestingly, gene SLC41A1 located in the novel PD locus PARK16 has recently been identified as being a Na+/Mg2+ exchanger (NME, Mg2+ efflux system), a key component of cellular magnesium homeostasis. Magnesium 179-188 solute carrier family 41 member 1 Homo sapiens 20-27 21696366-4 2011 Consistent with this conclusion, structure-function analyses of heterologous SLC41A1 transporter expression demonstrate that SLC41A1 transporters exhibit the same plasma membrane orientation as homologous bacterial MgtE proteins, are capable of complementing growth of TRPM7-deficient cells only when the Mg(2+) transporting pore is intact, and require an N-terminal cytoplasmic domain for Mg(2+)-dependent regulation of lysosomal degradation and surface expression. Magnesium 215-217 solute carrier family 41 member 1 Homo sapiens 125-132 18367447-3 2008 Here, we demonstrate that human SLC41A1 overexpressed in HEK293 cells forms protein complexes and locates to the plasma membrane without, however, giving rise to any detectable magnesium currents during whole cell patch clamp experiments. Magnesium 177-186 solute carrier family 41 member 1 Homo sapiens 32-39 18367447-4 2008 Nevertheless, in a strain of Salmonella enterica exhibiting disruption of all three distinct magnesium transport systems (CorA, MgtA, and MgtB), overexpression of human SLC41A1 functionally substitutes these transporters and restores the growth of the mutant bacteria at magnesium concentrations otherwise non-permissive for growth. Magnesium 93-102 solute carrier family 41 member 1 Homo sapiens 169-176 18367447-4 2008 Nevertheless, in a strain of Salmonella enterica exhibiting disruption of all three distinct magnesium transport systems (CorA, MgtA, and MgtB), overexpression of human SLC41A1 functionally substitutes these transporters and restores the growth of the mutant bacteria at magnesium concentrations otherwise non-permissive for growth. Magnesium 271-280 solute carrier family 41 member 1 Homo sapiens 169-176 18367447-6 2008 Most importantly, overexpressed SLC41A1 provide HEK293 cells with an increased magnesium efflux capacity. Magnesium 79-88 solute carrier family 41 member 1 Homo sapiens 32-39 18367447-7 2008 With outwardly directed Mg(2+) gradients, a SLC41A1-dependent reduction of the free intracellular magnesium concentration accompanied by a significant net decrease of the total cellular magnesium concentration could be observed in such cells. Magnesium 98-107 solute carrier family 41 member 1 Homo sapiens 44-51 18367447-7 2008 With outwardly directed Mg(2+) gradients, a SLC41A1-dependent reduction of the free intracellular magnesium concentration accompanied by a significant net decrease of the total cellular magnesium concentration could be observed in such cells. Magnesium 186-195 solute carrier family 41 member 1 Homo sapiens 44-51 18367447-9 2008 Taken together, these data functionally identify SLC41A1 as a mammalian carrier mediating magnesium efflux. Magnesium 90-99 solute carrier family 41 member 1 Homo sapiens 49-56 17700703-5 2007 The MgtE family of Mg2+ transporters is ubiquitously distributed in all phylogenetic domains, and human homologues have been functionally characterized and suggested to be involved in magnesium homeostasis. Magnesium 184-193 solute carrier family 41 member 1 Homo sapiens 4-8 15809054-1 2005 We have recently demonstrated that the human solute carrier, SLC41A1, is a Mg 2+ transporter that is regulated by extracellular magnesium. Magnesium 128-137 solute carrier family 41 member 1 Homo sapiens 61-68