PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30139743-0 2018 Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6). Magnesium 27-36 uromodulin Mus musculus 0-10 30139743-4 2018 Umod-knockout (Umod -/-) mice excreted more urinary magnesium than WT mice and displayed up-regulation of genes promoting magnesium absorption. Magnesium 52-61 uromodulin Mus musculus 0-4 30139743-4 2018 Umod-knockout (Umod -/-) mice excreted more urinary magnesium than WT mice and displayed up-regulation of genes promoting magnesium absorption. Magnesium 52-61 uromodulin Mus musculus 15-19 30139743-4 2018 Umod-knockout (Umod -/-) mice excreted more urinary magnesium than WT mice and displayed up-regulation of genes promoting magnesium absorption. Magnesium 122-131 uromodulin Mus musculus 0-4 30139743-4 2018 Umod-knockout (Umod -/-) mice excreted more urinary magnesium than WT mice and displayed up-regulation of genes promoting magnesium absorption. Magnesium 122-131 uromodulin Mus musculus 15-19 30139743-11 2018 WT mice fed a low-magnesium diet had an increased urinary UMOD secretion compared with the same mice on a regular diet. Magnesium 18-27 uromodulin Mus musculus 58-62 30139743-12 2018 Our results suggest that increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magnesium losses. Magnesium 65-74 uromodulin Mus musculus 43-47 30139743-12 2018 Our results suggest that increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magnesium losses. Magnesium 196-205 uromodulin Mus musculus 43-47