PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32017603-0 2020 Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients. Magnesium 55-64 transient receptor potential cation channel subfamily M member 6 Homo sapiens 20-25 35060008-10 2022 Magnesium may also regulate TRPM6/7, promote the secretion of klotho protein and improve renal fibrosis. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-35 33114586-0 2020 Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 81-86 33114586-5 2020 Our findings demonstrate that TRPM6 is the key channel that mediates Mg influx in intestinal cells and that EGF stimulates such influx; consequently, CTX downregulates TRPM6-mediated Mg influx by interfering with EGF signaling. Magnesium 69-71 transient receptor potential cation channel subfamily M member 6 Homo sapiens 30-35 33114586-5 2020 Our findings demonstrate that TRPM6 is the key channel that mediates Mg influx in intestinal cells and that EGF stimulates such influx; consequently, CTX downregulates TRPM6-mediated Mg influx by interfering with EGF signaling. Magnesium 183-185 transient receptor potential cation channel subfamily M member 6 Homo sapiens 168-173 34012148-7 2021 The molecular genetic analysis revealed two novel mutations within the TRPM6 gene c.3308dupC (p.Pro1104Thrfs*28) (p.P1104Tfs*28) and c.3958C>T (p.Gln1302*) (p.Q1302*) and the patient was successfully treated with Mg supplementation. Magnesium 213-215 transient receptor potential cation channel subfamily M member 6 Homo sapiens 71-76 33565749-1 2021 Objective: Familial hypomagnesemia with secondary hypocalcemia (HSH) is an autosomal recessive disease caused by mutation on transient receptor potential melastatin 6 (TRPM6) gene and characterized by selective magnesium malabsorption. Magnesium 211-220 transient receptor potential cation channel subfamily M member 6 Homo sapiens 125-166 33565749-1 2021 Objective: Familial hypomagnesemia with secondary hypocalcemia (HSH) is an autosomal recessive disease caused by mutation on transient receptor potential melastatin 6 (TRPM6) gene and characterized by selective magnesium malabsorption. Magnesium 211-220 transient receptor potential cation channel subfamily M member 6 Homo sapiens 168-173 33440155-1 2021 Magnesium (Mg2+) homeostasis depends on active transcellular Mg2+ reuptake from urine in distal convoluted tubules (DCTs) via the Mg2+ channel TRPM6, whose activity has been proposed to be regulated by EGF. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 143-148 32017603-2 2020 The TRPM6 channel determines the fine-tuning of Mg2+ (re)absorption in intestine and kidney. Magnesium 48-52 transient receptor potential cation channel subfamily M member 6 Homo sapiens 4-9 30903373-10 2019 Considering the consanguinity of the parents and clinical features of the patients, genetic testing of the TRPM6 gene was performed and a novel homozygous mutation was detected as c.3178A>T. He was started on magnesium and calcium supplementation and he is symptom-free for 1 year. Magnesium 212-221 transient receptor potential cation channel subfamily M member 6 Homo sapiens 107-112 29093028-4 2018 We identified two loci associated with urinary magnesium (uMg), rs3824347 (P=4.4x10-13) near TRPM6, which encodes an epithelial Mg2+ channel, and rs35929 (P=2.1x10-11), a variant of ARL15, which encodes a GTP-binding protein. Magnesium 47-56 transient receptor potential cation channel subfamily M member 6 Homo sapiens 93-98 29912157-0 2018 TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon. Magnesium 23-32 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 29912157-5 2018 Exposure to the specific TRPM6/7 inhibitor NS8593 reduced Mg2+ influx, and consequently cell proliferation and migration, but Mg supplementation rescued the inhibition. Magnesium 58-60 transient receptor potential cation channel subfamily M member 6 Homo sapiens 25-30 29256407-0 2017 Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. Magnesium 15-24 transient receptor potential cation channel subfamily M member 6 Homo sapiens 65-70 29256407-3 2017 With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN). Magnesium 49-58 transient receptor potential cation channel subfamily M member 6 Homo sapiens 99-104 29256407-8 2017 Oral magnesium supplementation increases the leukocyte TRPM6 mRNA relative expression, in subjects with new diagnosis of preHTN. Magnesium 5-14 transient receptor potential cation channel subfamily M member 6 Homo sapiens 55-60 28124936-3 2016 Hypomagnesemia is caused by the impairment of magnesium reabsorption through TRPM6 channel which is located just by NCCT. Magnesium 46-55 transient receptor potential cation channel subfamily M member 6 Homo sapiens 77-82 27546733-2 2017 Acutely, it stimulates the shift of magnesium from plasma into red blood cells and platelets, and in vitro, it stimulates the activity of the TRPM6 channel, a key regulator of renal magnesium reabsorption. Magnesium 182-191 transient receptor potential cation channel subfamily M member 6 Homo sapiens 142-147 27757375-0 2016 Magnesium-permeable TRPM6 polymorphisms in patients with meningomyelocele. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 20-25 27757375-1 2016 BACKGROUND: To evaluate whether there is an association between single nucleotide polymorphisms in magnesium-permeable TRPM6 ion channel and development of meningomyelocele (MMC). Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 119-124 26563869-5 2015 Accordingly, resistant cells express lower amounts of the TRPM6 and 7, both involved in magnesium transport. Magnesium 88-97 transient receptor potential cation channel subfamily M member 6 Homo sapiens 58-63 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 251-260 transient receptor potential cation channel subfamily M member 6 Homo sapiens 128-133 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 251-260 transient receptor potential cation channel subfamily M member 6 Homo sapiens 178-183 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 251-260 transient receptor potential cation channel subfamily M member 6 Homo sapiens 178-183 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 326-335 transient receptor potential cation channel subfamily M member 6 Homo sapiens 128-133 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 326-335 transient receptor potential cation channel subfamily M member 6 Homo sapiens 178-183 26705539-1 2015 The homo- and hetero-tetrameric channel complexes formed by transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) (collectively referred to as TRPM6/TRPM7 channels in this study) are the major regulators of cellular magnesium uptake, yet the exact roles of TRPM6/TRPM7 channels and cellular magnesium homeostasis during development are poorly understood. Magnesium 326-335 transient receptor potential cation channel subfamily M member 6 Homo sapiens 178-183 26705539-4 2015 We demonstrated that MEG functions by inhibiting TRPM6/TRPM7 magnesium channel activity, as MEG reduced intracellular magnesium level, while TRPM6/TRPM7 channel modulation and magnesium-withdrawal phenocopied MEG at enhancing mesoderm and DE differentiations. Magnesium 61-70 transient receptor potential cation channel subfamily M member 6 Homo sapiens 49-54 25138239-2 2015 The PPIs may inhibit active magnesium (Mg) absorption by interfering with transcellular transient receptor potential melastatin-6 and -7 (TRPM 6 and 7) channels. Magnesium 28-37 transient receptor potential cation channel subfamily M member 6 Homo sapiens 138-144 25726166-8 2015 SLC41A1 expression level was positively correlated with serum magnesium whereas TRPM6 expression level was negatively correlated with serum magnesium. Magnesium 140-149 transient receptor potential cation channel subfamily M member 6 Homo sapiens 80-85 25138239-2 2015 The PPIs may inhibit active magnesium (Mg) absorption by interfering with transcellular transient receptor potential melastatin-6 and -7 (TRPM 6 and 7) channels. Magnesium 39-41 transient receptor potential cation channel subfamily M member 6 Homo sapiens 138-144 26130997-4 2015 The cellular mechanisms of magnesium homeostasis are increasingly being understood, including both passive paracellular absorption through claudins and active transcellular transporters, including the transient receptor potential channels (TRPM6) identified in the intestine and nephron. Magnesium 27-36 transient receptor potential cation channel subfamily M member 6 Homo sapiens 240-245 22113391-6 2011 Inhibition of the EGFR induces a mutated-like transient receptor potential cation channel, subfamily M, member 6 (TRPM6) syndrome, characterized by urinary magnesium and calcium wasting. Magnesium 156-165 transient receptor potential cation channel subfamily M member 6 Homo sapiens 114-119 26058915-14 2015 Following-up on functional studies of gene expression identified gene-environment interactions between progestin use and MUC1 and between insulin and TRPM6 on serum magnesium concentration in ARIC European-American participants. Magnesium 165-174 transient receptor potential cation channel subfamily M member 6 Homo sapiens 150-155 26218331-4 2015 Among the known 8 TRPM channels only TRPM6 and TRPM7 channels are highly permeable to both Ca(2+) and Mg(2+); however here we will only focus on TRPM7 as unlike TRPM6, TRPM7 channels are abundantly expressed in neuronal cells. Magnesium 102-104 transient receptor potential cation channel subfamily M member 6 Homo sapiens 37-42 26218331-4 2015 Among the known 8 TRPM channels only TRPM6 and TRPM7 channels are highly permeable to both Ca(2+) and Mg(2+); however here we will only focus on TRPM7 as unlike TRPM6, TRPM7 channels are abundantly expressed in neuronal cells. Magnesium 102-104 transient receptor potential cation channel subfamily M member 6 Homo sapiens 161-166 26598820-10 2015 Specifically, TRPM6 channels in Mg absorption, ZIP4 and ZnT1 transporters for Zn absorption, and CTR1 and ATP7A for Cu absorption are overviewed. Magnesium 32-34 transient receptor potential cation channel subfamily M member 6 Homo sapiens 14-19 24353324-3 2014 We hypothesize that CsA-induced hypomagnesaemia is due to a renal magnesium leak, also in patients, resulting from a downregulation of the renal EGF production, thereby inhibiting the activation of TRPM6. Magnesium 66-75 transient receptor potential cation channel subfamily M member 6 Homo sapiens 198-203 24385424-3 2014 We show that homomeric TRPM6 is highly sensitive to intracellular free Mg(2+) and therefore unlikely to be active at physiological levels of [Mg(2+)]i. Co-expression of TRPM7 and TRPM6 produces heteromeric TRPM7/M6 channels with altered pharmacology and sensitivity to intracellular Mg ATP compared with homomeric TRPM7. Magnesium 71-73 transient receptor potential cation channel subfamily M member 6 Homo sapiens 23-28 22974787-2 2012 TRPM6, TRPM7 and MagT1 are involved in the active transcellular Mg transport processes in intestine and kidney. Magnesium 64-66 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 25589264-6 2015 These cells also play a key role in magnesium reabsorption, which occurs predominantly, via a transient receptor potential channel (TRPM6). Magnesium 36-45 transient receptor potential cation channel subfamily M member 6 Homo sapiens 132-137 26632157-8 2015 Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 27-78 26632157-8 2015 Magnesium is reabsorbed by transient receptor potential subfamily melastatin 6 (TRPM6) in the distal convoluted tubule. Magnesium 0-9 transient receptor potential cation channel subfamily M member 6 Homo sapiens 80-85 24385424-1 2014 The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are divalent cation channel kinases essential for magnesium (Mg(2+)) homeostasis in vertebrates. Magnesium 132-141 transient receptor potential cation channel subfamily M member 6 Homo sapiens 75-80 26104253-11 2014 Furthermore, the expression of TRPM6 was related to the urinary excretion of magnesium and the change in diastolic blood pressure weeks 12-37 was inversely related to the change in magnesium excretion. Magnesium 77-86 transient receptor potential cation channel subfamily M member 6 Homo sapiens 31-36 26104253-11 2014 Furthermore, the expression of TRPM6 was related to the urinary excretion of magnesium and the change in diastolic blood pressure weeks 12-37 was inversely related to the change in magnesium excretion. Magnesium 181-190 transient receptor potential cation channel subfamily M member 6 Homo sapiens 31-36 23142866-4 2013 Our understanding of the molecular physiology of calcium and magnesium balance has grown considerably following the discovery of the calcium-sensing receptor (CaSR) and the main intestinal and renal transporters for calcium and magnesium, namely, the transient receptor potential channels TRPV5, TRPV6 and TRPM6. Magnesium 228-237 transient receptor potential cation channel subfamily M member 6 Homo sapiens 306-311 23343670-7 2013 However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Magnesium 22-31 transient receptor potential cation channel subfamily M member 6 Homo sapiens 53-58 22846351-6 2012 In the DCT, the transcellular pathway via transient receptor potential melastatin 6 (TRPM6) plays a fundamental role in the final 5%-10% magnesium reabsorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 42-83 22846351-6 2012 In the DCT, the transcellular pathway via transient receptor potential melastatin 6 (TRPM6) plays a fundamental role in the final 5%-10% magnesium reabsorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 85-90 22364157-7 2012 Cellular magnesium deficit, perhaps involving TRPM6/7 channels, elicits calcium-activated inflammatory cascades independent of injury or pathogens. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 46-51 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 17-58 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 60-65 22876566-2 2012 Mutations of the transient receptor potential melastatin 6 (TRPM6) gene, which codes for TRPM6, the basic channel for intestinal Mg absorption and a new member of the transient receptor potential (TRP) family of cation channels, result in primary hypomagnesemia. Magnesium 129-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 89-94 22180838-0 2011 Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Magnesium 56-65 transient receptor potential cation channel subfamily M member 6 Homo sapiens 77-82 19581665-7 2009 In the past decade our understanding of transcellular magnesium transport was enhanced by the discovery of several gene mutations i.e. transient receptor potential melastin (TR PM) 6 and 7. Magnesium 54-63 transient receptor potential cation channel subfamily M member 6 Homo sapiens 135-188 19890837-0 2010 Modulation of TRPM6 and Na(+)/Mg(2+) exchange in mammary epithelial cells in response to variations of magnesium availability. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 14-19 19890837-6 2010 Surprisingly, we found that cells grown in low magnesium upregulated mRNA for the magnesium channel TRPM6, but not for other channels like TRPM7 or MagT1. Magnesium 47-56 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 83-92 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 103-112 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-9 2010 We propose that mammary epithelial cells adapt to decreased magnesium availability by upregulating magnesium influx via TRPM6, and counteract increased magnesium availability by increasing magnesium efflux primarily via Na(+)/Mg(2+) exchange. Magnesium 99-108 transient receptor potential cation channel subfamily M member 6 Homo sapiens 120-125 19890837-10 2010 These results show, for the first time, that TRPM6 contributes to regulating magnesium influx in mammary epithelial cells, similar to what is known for intestine and kidney. Magnesium 77-86 transient receptor potential cation channel subfamily M member 6 Homo sapiens 45-50 20700443-5 2010 The association of common variants at six genomic regions (in or near MUC1, ATP2B1, DCDC5, TRPM6, SHROOM3, and MDS1) with serum magnesium levels was genome-wide significant when meta-analyzed with the replication dataset. Magnesium 128-137 transient receptor potential cation channel subfamily M member 6 Homo sapiens 91-96 19937979-1 2010 Transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of magnesium in the kidney. Magnesium 93-102 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-41 19937979-1 2010 Transient receptor potential melastatin 6 (TRPM6) channel is involved in the reabsorption of magnesium in the kidney. Magnesium 93-102 transient receptor potential cation channel subfamily M member 6 Homo sapiens 43-48 19203841-5 2009 The latter was shown to cause hypomagnesaemia by impeding EGF-dependent activation of TRPM6, the main cation channel responsible for Mg transcellular absorption in the intestine and kidney. Magnesium 133-135 transient receptor potential cation channel subfamily M member 6 Homo sapiens 86-91 18949482-2 2009 Here, several transport proteins, like the thiazide-sensitive NaCl cotransporter (NCC) and the epithelial magnesium (Mg(2+)) channel (TRPM6), are exclusively expressed. Magnesium 106-115 transient receptor potential cation channel subfamily M member 6 Homo sapiens 134-139 24459527-7 2008 The active transcellular transport of magnesium in the DCT was similarly enhanced by the realization that defects in transient receptor potential melastatin 6 (TRPM6) cause hypomagnesemia with secondary hypocalcemia. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 117-158 19149903-1 2009 BACKGROUND: Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism. Magnesium 122-131 transient receptor potential cation channel subfamily M member 6 Homo sapiens 82-87 19149903-8 2009 Our haplotype analyses suggested a significant risk of type 2 diabetes among carriers of both the rare alleles from two non-synomous SNPs in TRPM6 (Val1393Ile in exon 26 [rs3750425] and Lys1584Glu in exon 27 [rs2274924]) when their magnesium intake was lower than 250 mg per day. Magnesium 232-241 transient receptor potential cation channel subfamily M member 6 Homo sapiens 141-146 19149903-10 2009 CONCLUSION: Our results provide suggestive evidence that two common non-synonymous TRPM6 coding region variants, Ile1393Val and Lys1584Glu polymorphisms, might confer susceptibility to type 2 diabetes in women with low magnesium intake. Magnesium 219-228 transient receptor potential cation channel subfamily M member 6 Homo sapiens 83-88 24459527-7 2008 The active transcellular transport of magnesium in the DCT was similarly enhanced by the realization that defects in transient receptor potential melastatin 6 (TRPM6) cause hypomagnesemia with secondary hypocalcemia. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 160-165 18021175-4 2007 RESULTS: Genetic expression of TRPM6 and TRPM7 was shown in human osteoblast-like MG-63, SaOS and U2-OS cells, and reduction of extracellular Mg2+ or Ca2+ led to a decrease of cell proliferation. Magnesium 82-84 transient receptor potential cation channel subfamily M member 6 Homo sapiens 31-36 18192217-9 2008 This review discusses the importance of magnesium in vascular biology and implications in hypertension and highlights the transport systems, particularly TRPM6 and TRPM7, which may play a role in the control of vascular magnesium homeostasis. Magnesium 220-229 transient receptor potential cation channel subfamily M member 6 Homo sapiens 154-159 18562569-10 2008 We anticipate that the next decade will provide further detail into the control of the gatekeeper TRPM6 and, therefore, overall whole-body Mg(2+) balance. Magnesium 139-141 transient receptor potential cation channel subfamily M member 6 Homo sapiens 98-103 17481860-0 2007 TRPM6 and TRPM7--Gatekeepers of human magnesium metabolism. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 0-5 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 198-207 transient receptor potential cation channel subfamily M member 6 Homo sapiens 191-196 17918133-5 2007 Mutations in the claudin 16 (paracellin) paracellular protein in the thick ascending limb (TAL) of Henle"s loop and in the transient receptor potential cation channel, subfamily 6, member 6 (TRPM6) magnesium channel expressed in distal tubules found in patients with renal magnesium wasting and hypomagnesemia underscore the importance of these transport proteins. Magnesium 273-282 transient receptor potential cation channel subfamily M member 6 Homo sapiens 191-196 17481860-4 2007 Patients with Hypomagnesemia with Secondary Hypocalcemia (HSH), a primary defect in intestinal magnesium absorption, were found to carry mutations in TRPM6, a member of the melastatin-related subfamily of transient receptor potential (TRP) ion channels. Magnesium 95-104 transient receptor potential cation channel subfamily M member 6 Homo sapiens 150-155 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 71-80 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 17481860-5 2007 Before, a close homologue of TRPM6, TRPM7, had been characterized as a magnesium and calcium permeable ion channel vital for cellular magnesium homeostasis. Magnesium 134-143 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 17660622-3 2007 Investigation of hypomagnesemia-exhibiting inherited diseases revealed molecular mechanisms of Mg transport pathways; paracellin-1 as a passive paracellular transport and TRPM6 as an active transcellular transport. Magnesium 95-97 transient receptor potential cation channel subfamily M member 6 Homo sapiens 171-176 15843919-4 2005 On the other hand, TRPM8 and TRPA1 have been described as cold receptors, TRPM4 and TRPM5 as calcium-activated nonselective cation channels, TRPM6 and TRPM7 as magnesium-permeable and magnesium-modulated cation channels, TRPM2 as an ADP-ribose-activated channel of macrophages, and TRPM3 as a hypo-osmolarity- and sphingosine-activated channel. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 141-146 16075242-0 2005 Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Magnesium 39-48 transient receptor potential cation channel subfamily M member 6 Homo sapiens 19-24 16075242-0 2005 Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Magnesium 68-77 transient receptor potential cation channel subfamily M member 6 Homo sapiens 19-24 15845589-6 2005 Whereas electrophysiological and biochemical analyses identified TRPM7 as an important player in cellular magnesium homeostasis, the critical role of TRPM6 for epithelial magnesium transport emerged from the discovery of loss-of-function mutations in patients with a severe form of hereditary hypomagnesaemia called primary hypomagnesaemia with secondary hypocalcaemia or HSH. Magnesium 171-180 transient receptor potential cation channel subfamily M member 6 Homo sapiens 150-155 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Magnesium 146-155 transient receptor potential cation channel subfamily M member 6 Homo sapiens 66-71 17197439-10 2007 We conclude that a functional defect in the putative pore of TRPM6/7 channel complexes is sufficient to impair body magnesium homeostasis. Magnesium 116-125 transient receptor potential cation channel subfamily M member 6 Homo sapiens 61-66 15001450-5 2004 In this review, we focus on TRPM6, an ion channel of the "transient receptor potential (TRP) gene family, which, when mutated, causes a combined defect of intestinal magnesium absorption and renal magnesium conservation as observed in primary hypomagnesemia with secondary hypocalcemia. Magnesium 166-175 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-33 15001450-5 2004 In this review, we focus on TRPM6, an ion channel of the "transient receptor potential (TRP) gene family, which, when mutated, causes a combined defect of intestinal magnesium absorption and renal magnesium conservation as observed in primary hypomagnesemia with secondary hypocalcemia. Magnesium 197-206 transient receptor potential cation channel subfamily M member 6 Homo sapiens 28-33 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 49-54 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 9-18 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 49-54 14976260-1 2004 Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial magnesium transport. Magnesium 160-169 transient receptor potential cation channel subfamily M member 6 Homo sapiens 100-105 14976260-6 2004 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 56-61 14976260-6 2004 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium 137-146 transient receptor potential cation channel subfamily M member 6 Homo sapiens 117-122 12032568-6 2002 The TRPM6 protein is a new member of the long transient receptor potential channel (TRPM) family and is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity. Magnesium 204-213 transient receptor potential cation channel subfamily M member 6 Homo sapiens 4-9 12032568-8 2002 These findings indicate that TRPM6 is crucial for magnesium homeostasis and implicate a TRPM family member in human disease. Magnesium 50-59 transient receptor potential cation channel subfamily M member 6 Homo sapiens 29-34 34836340-10 2021 Dapagliflozin increased intracellular magnesium concentration, and this effect was inhibited by TRPM6 blockade and the EGFR antagonist. Magnesium 38-47 transient receptor potential cation channel subfamily M member 6 Homo sapiens 96-101 34836340-14 2021 Dapagliflozin enhances TRPM6-mediated trans-epithelial magnesium transport in renal tubule cells. Magnesium 55-64 transient receptor potential cation channel subfamily M member 6 Homo sapiens 23-28