PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6465832-4 1984 Visualization of ALP activity is accomplished by the use of buffered p-toluidinium 5-bromo-4-chloro-indolyl phosphate and magnesium ions. Magnesium 122-131 alkaline phosphatase, placental Homo sapiens 17-20 35631664-8 2022 An in vitro study showed that metal ions released from Mg-Zn-Ca BMG promoted cell proliferation and migration and elevated alkaline phosphatase (ALP) activity and mineralization. Magnesium 55-57 alkaline phosphatase, placental Homo sapiens 123-143 35631664-8 2022 An in vitro study showed that metal ions released from Mg-Zn-Ca BMG promoted cell proliferation and migration and elevated alkaline phosphatase (ALP) activity and mineralization. Magnesium 55-57 alkaline phosphatase, placental Homo sapiens 145-148 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 13-15 alkaline phosphatase, placental Homo sapiens 0-3 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 67-69 alkaline phosphatase, placental Homo sapiens 114-117 2702751-6 1989 ALP requires Mg ion in vitro for optimal activity, but addition of Mg in the appropriate amounts to sera with low ALP activity did not restore ALP activity. Magnesium 67-69 alkaline phosphatase, placental Homo sapiens 114-117 32814632-4 2020 In addition, it was confirmed that the junctional site localization of Zona-occludens 1 (ZO-1), a representative tight junction protein, was destroyed by magnesium treatment; furthermore, it was determined that cytoplasmic localization increased, and alkaline phosphatase (ALP) activity increased. Magnesium 154-163 alkaline phosphatase, placental Homo sapiens 251-271 13416568-0 1957 The alkaline phosphomonoesterase activity of cell nuclei; activation by 0.16M magnesium. Magnesium 78-87 alkaline phosphatase, placental Homo sapiens 4-32 33313164-7 2020 These results were consistent with those of in vitro experiments, in which high levels of magnesium inhibited mineral deposition by mesenchymal stem cells (MSCs) but increased alkaline phosphatase (ALP) expression. Magnesium 90-99 alkaline phosphatase, placental Homo sapiens 176-196 33313164-7 2020 These results were consistent with those of in vitro experiments, in which high levels of magnesium inhibited mineral deposition by mesenchymal stem cells (MSCs) but increased alkaline phosphatase (ALP) expression. Magnesium 90-99 alkaline phosphatase, placental Homo sapiens 198-201 32814632-4 2020 In addition, it was confirmed that the junctional site localization of Zona-occludens 1 (ZO-1), a representative tight junction protein, was destroyed by magnesium treatment; furthermore, it was determined that cytoplasmic localization increased, and alkaline phosphatase (ALP) activity increased. Magnesium 154-163 alkaline phosphatase, placental Homo sapiens 273-276 30581701-4 2018 Magnesium ions released from the hydrogels promote osteogenic differentiation of the encapsulated human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). Magnesium 0-9 alkaline phosphatase, placental Homo sapiens 153-173 31931298-5 2020 For this purpose, ALP is introduced in Ca2+/Mg2+-containing solution (pH = 7.4; 37 C), and its activity modulated by the concentration of its substrate. Magnesium 44-47 alkaline phosphatase, placental Homo sapiens 18-21 30581701-4 2018 Magnesium ions released from the hydrogels promote osteogenic differentiation of the encapsulated human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). Magnesium 0-9 alkaline phosphatase, placental Homo sapiens 175-178 26928781-6 2016 Accordingly, experimental studies with MG-63 osteoblast-like cells show a more efficient in vitro secretion of alkaline phosphatase (ALP) and collagen I and a more copious in vivo formation of new bone trabeculae, thus suggesting a relevant role of dHA to support the main mechanisms involved in bone regeneration. Magnesium 39-41 alkaline phosphatase, placental Homo sapiens 111-131 29257215-3 2018 PPLF significantly increased ALP release from MG-63 cells and mineralization in a dose-dependent manner. Magnesium 46-48 alkaline phosphatase, placental Homo sapiens 29-32 28882757-3 2017 Results indicate that Mg ions up-regulated the expression of Runx2 and alkaline phosphatase (ALP) through TRPM7/PI3K signalling pathway, which could significantly enhance the osteogenic activity of human osteoblasts. Magnesium 22-24 alkaline phosphatase, placental Homo sapiens 71-91 28882757-3 2017 Results indicate that Mg ions up-regulated the expression of Runx2 and alkaline phosphatase (ALP) through TRPM7/PI3K signalling pathway, which could significantly enhance the osteogenic activity of human osteoblasts. Magnesium 22-24 alkaline phosphatase, placental Homo sapiens 93-96 27694822-6 2016 Following optimization of immobilized materials-such as MG, PTH, and alkaline phosphatase (ALP)-the performance of the MG sensor was investigated via cyclic voltammetry, to assess its linearity, repeatability, and reproducibility. Magnesium 119-121 alkaline phosphatase, placental Homo sapiens 69-89 27694822-6 2016 Following optimization of immobilized materials-such as MG, PTH, and alkaline phosphatase (ALP)-the performance of the MG sensor was investigated via cyclic voltammetry, to assess its linearity, repeatability, and reproducibility. Magnesium 119-121 alkaline phosphatase, placental Homo sapiens 91-94 24616281-0 2016 Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs. Magnesium 0-9 alkaline phosphatase, placental Homo sapiens 91-111 24616281-6 2016 Magnesium exposure profoundly enhanced alkaline phosphatase (ALP) gene expression and activity even at a relatively low magnesium concentration (2.5 mm). Magnesium 0-9 alkaline phosphatase, placental Homo sapiens 39-59 24616281-6 2016 Magnesium exposure profoundly enhanced alkaline phosphatase (ALP) gene expression and activity even at a relatively low magnesium concentration (2.5 mm). Magnesium 0-9 alkaline phosphatase, placental Homo sapiens 61-64 24616281-6 2016 Magnesium exposure profoundly enhanced alkaline phosphatase (ALP) gene expression and activity even at a relatively low magnesium concentration (2.5 mm). Magnesium 120-129 alkaline phosphatase, placental Homo sapiens 61-64 24616281-7 2016 Exposure to magnesium ions facilitated hBMSC proliferation via integrin alpha2 and alpha3 expression and partly promoted differentiation into osteoblasts via the alteration of ALP expression and activity. Magnesium 12-21 alkaline phosphatase, placental Homo sapiens 176-179 26928781-6 2016 Accordingly, experimental studies with MG-63 osteoblast-like cells show a more efficient in vitro secretion of alkaline phosphatase (ALP) and collagen I and a more copious in vivo formation of new bone trabeculae, thus suggesting a relevant role of dHA to support the main mechanisms involved in bone regeneration. Magnesium 39-41 alkaline phosphatase, placental Homo sapiens 133-136 24737106-0 2014 Strontium ranelate stimulates the activity of bone-specific alkaline phosphatase: interaction with Zn(2+) and Mg (2+). Magnesium 110-112 alkaline phosphatase, placental Homo sapiens 60-80 24737106-3 2014 In this study we investigated the direct effect of strontium (SR and SrCl2) on the activity of ALP obtained from UMR106 osteosarcoma cells, as well as its possible interactions with the divalent cations Zn(2+) and Mg(2+). Magnesium 214-216 alkaline phosphatase, placental Homo sapiens 95-98 11937510-4 2002 We found that mutations at Zn2 or Mg sites had similar effects in PLAP and ECAP but that the environment of the Zn1 ion in PLAP is less affected by substitutions than that in ECAP. Magnesium 34-36 alkaline phosphatase, placental Homo sapiens 66-70 22696393-8 2012 The results showed that the Sr, Zn, and Si (or Sr, Mg, and Si)-containing ionic products from SZS and SMS powders enhanced ALP activity of BMSCs, compared to those from beta-TCP. Magnesium 51-53 alkaline phosphatase, placental Homo sapiens 123-126 23827608-11 2013 In particular, Mg ion implantation increased the initial cell adhesion, and in an osteoblast differentiation assay, ALP activity and calcium accumulation. Magnesium 15-17 alkaline phosphatase, placental Homo sapiens 116-119 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 11-20 alkaline phosphatase, placental Homo sapiens 4-7 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 11-20 alkaline phosphatase, placental Homo sapiens 96-99 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 126-135 alkaline phosphatase, placental Homo sapiens 4-7 10469152-9 1999 The ALP is magnesium-dependent for its catalytic activity and was inhibited after incubation of ALP-containing liposomes in a magnesium-free buffer. Magnesium 126-135 alkaline phosphatase, placental Homo sapiens 96-99 10469152-10 1999 The ALP activity was restored by the addition of detergent to the liposomes, due to the release of the luminal magnesium ions. Magnesium 111-120 alkaline phosphatase, placental Homo sapiens 4-7 1424126-6 1992 The addition of the metal ion buffer N-hydroxyethylethylenediaminetriacetic acid, along with low concentrations of Zn and Mg, as used in the IFCC/RM/ALP, reduced the slow loss in activity over time, as did decreasing the reaction temperature to 30 degrees C, but had no effect on the early rapid decay in activity seen in the first minute. Magnesium 122-124 alkaline phosphatase, placental Homo sapiens 149-152