PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23802687-1 2013 We examined the effects of six furocoumarins with alkoxy groups at the C-5 or C-8 position isolated from Umbelliferae medicinal plants on cell proliferation, and their mechanisms of action against B16F10 melanoma cells or in melanin-possessing hairless mice implanted with B16F10 cells, under UVA irradiation. Furocoumarins 31-44 cell division cycle associated 3 Mus musculus 78-81 23802687-6 2013 We suggest that the antitumor actions of UVA plus furocoumarins with an alkoxy group at C-5 or C-8 were due to G2/M arrest of the cell cycle by an increase in phosphor-Chk1 and decrease in phospho-cdc2. Furocoumarins 50-63 cell division cycle associated 3 Mus musculus 95-98 23802687-3 2013 Furthermore, three furocoumarins with an alkoxy group at C-8, imperatorin (4), heraclenin (5) and heraclenol (6), inhibited the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 mum. Furocoumarins 19-32 cell division cycle associated 3 Mus musculus 57-60