PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18391018-2 2008 We show that exchange protein directly activated by cAMP (Epac), which functions as a guanine nucleotide exchange factor for the Ras-like GTPases Rap1 and Rap2, was required for cAMP-dependent stimulation of adipocyte differentiation. Guanine Nucleotides 86-104 Rap guanine nucleotide exchange factor 3 Homo sapiens 58-62 19307703-1 2009 The cyclic AMP (cAMP)-binding proteins, Epac, are guanine nucleotide exchange factors for the Ras-like small GTPases. Guanine Nucleotides 50-68 Rap guanine nucleotide exchange factor 3 Homo sapiens 40-44 18660803-1 2008 Epac proteins are activated by binding of the second messenger cAMP and then act as guanine nucleotide exchange factors for Rap proteins. Guanine Nucleotides 84-102 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 18604457-2 2008 In eukaryotic cells, the effects of cAMP are mediated by two ubiquitously expressed intracellular cAMP receptors, the classic protein kinase A (PKA)/cAMP-dependent protein kinase and the recently discovered exchange protein directly activated by camp (Epac)/cAMP-regulated guanine nucleotide exchange factors. Guanine Nucleotides 273-291 Rap guanine nucleotide exchange factor 3 Homo sapiens 252-256 18176800-1 2008 Epac1 (also known as cAMP-GEF-I) and Epac2 (also known as cAMP-GEF-II) are cyclic AMP-activated guanine nucleotide exchange factors for Ras-like GTPases. Guanine Nucleotides 96-114 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-5 18176800-1 2008 Epac1 (also known as cAMP-GEF-I) and Epac2 (also known as cAMP-GEF-II) are cyclic AMP-activated guanine nucleotide exchange factors for Ras-like GTPases. Guanine Nucleotides 96-114 Rap guanine nucleotide exchange factor 3 Homo sapiens 21-31 17716863-0 2008 Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors. Guanine Nucleotides 115-133 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 17716863-1 2008 The identification of 2"-O-methyl substituted adenosine-3",5"-cyclic monophosphate (cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs, also known as Epac1 and Epac2), has ushered in a new era of cyclic nucleotide research in which previously unrecognized signalling properties of the second messenger cAMP have been revealed. Guanine Nucleotides 146-164 Rap guanine nucleotide exchange factor 3 Homo sapiens 116-120 17716863-1 2008 The identification of 2"-O-methyl substituted adenosine-3",5"-cyclic monophosphate (cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs, also known as Epac1 and Epac2), has ushered in a new era of cyclic nucleotide research in which previously unrecognized signalling properties of the second messenger cAMP have been revealed. Guanine Nucleotides 146-164 Rap guanine nucleotide exchange factor 3 Homo sapiens 208-213 16973695-1 2006 Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein kinase A (PKA)-independent signal transduction properties of the second messenger cAMP. Guanine Nucleotides 106-124 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 17565009-8 2007 It was hypothesized that the A(2B)AR-mediated ERK1/2 activation may involve exchange protein activated by cAMP (Epac), a cAMP-activated guanine nucleotide exchange factor for Rap GTPases. Guanine Nucleotides 136-154 Rap guanine nucleotide exchange factor 3 Homo sapiens 112-116 17284589-1 2007 The exchange factor directly activated by cAMP (Epac) is a newly discovered direct target for cAMP and a guanine-nucleotide exchange factor for the small GTPase Rap. Guanine Nucleotides 105-123 Rap guanine nucleotide exchange factor 3 Homo sapiens 48-52 17725712-2 2007 Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1. Guanine Nucleotides 106-124 Rap guanine nucleotide exchange factor 3 Homo sapiens 153-159 17491018-5 2007 These effects are due to the action of a downstream cAMP effector, Epac, a guanine nucleotide exchange-activating protein for Rap1 (RAP1-GEF). Guanine Nucleotides 75-93 Rap guanine nucleotide exchange factor 3 Homo sapiens 67-71 16316996-1 2006 Epac-1 and -2 (exchange proteins directly activated by cyclic AMP) are guanine-nucleotide exchange factors for the GTPases Rap1 and -2. Guanine Nucleotides 71-89 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-13 16507992-3 2006 PKA-independent activation of Rap1 by cAMP is mediated by direct binding of cAMP to Rap1-guanine nucleotide exchange factors (Rap1-GEFs) Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (Epac1 and Epac2 are also called cAMP-GEFI and -GEFII). Guanine Nucleotides 89-107 Rap guanine nucleotide exchange factor 3 Homo sapiens 137-142 16507992-3 2006 PKA-independent activation of Rap1 by cAMP is mediated by direct binding of cAMP to Rap1-guanine nucleotide exchange factors (Rap1-GEFs) Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (Epac1 and Epac2 are also called cAMP-GEFI and -GEFII). Guanine Nucleotides 89-107 Rap guanine nucleotide exchange factor 3 Homo sapiens 144-189 16507992-3 2006 PKA-independent activation of Rap1 by cAMP is mediated by direct binding of cAMP to Rap1-guanine nucleotide exchange factors (Rap1-GEFs) Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (Epac1 and Epac2 are also called cAMP-GEFI and -GEFII). Guanine Nucleotides 89-107 Rap guanine nucleotide exchange factor 3 Homo sapiens 202-207 15655710-2 2004 GLP-1 utilizes this receptor to activate two distinct classes of cAMP-binding proteins: protein kinase A (PKA) and the Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs). Guanine Nucleotides 149-167 Rap guanine nucleotide exchange factor 3 Homo sapiens 119-123 15634783-3 2005 Here, we show that a new target for cAMP, exchange protein activated by cAMP (Epac) or cAMP-regulated guanine nucleotide exchange protein, is involved in the hormonal enhancement of synaptic transmission by serotonin. Guanine Nucleotides 102-120 Rap guanine nucleotide exchange factor 3 Homo sapiens 42-76 12578910-2 2003 However, more recently PKA-independent pathways have been established through the exchange protein directly activated by cAMP (Epac), a guanine nucleotide exchange factor for the small GTPases Rap1 and Rap2. Guanine Nucleotides 136-154 Rap guanine nucleotide exchange factor 3 Homo sapiens 127-131 12496249-3 2003 However, it is now apparent that cAMP also exerts its effects by binding to cAMP-regulated guanine nucleotide exchange factors (Epac). Guanine Nucleotides 91-109 Rap guanine nucleotide exchange factor 3 Homo sapiens 128-132 10486569-1 1999 Three groups of Rap1-specific guanine nucleotide exchange factors including C3G, CalDAG-GEFI, and Epac/cAMP-GEFI/II have been identified to date. Guanine Nucleotides 30-48 Rap guanine nucleotide exchange factor 3 Homo sapiens 98-102 10935551-5 2000 In addition, we analyzed the expression of the recently described, cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFI and GEFII) that impact Ras-related GTPases and Raf kinases, known regulators of various protein kinase cascades. Guanine Nucleotides 82-100 Rap guanine nucleotide exchange factor 3 Homo sapiens 119-138 10486569-1 1999 Three groups of Rap1-specific guanine nucleotide exchange factors including C3G, CalDAG-GEFI, and Epac/cAMP-GEFI/II have been identified to date. Guanine Nucleotides 30-48 Rap guanine nucleotide exchange factor 3 Homo sapiens 103-115 34685730-6 2021 Phylogenetic analyses of the individual cAMP binding domain (CBD) and guanine nucleotide exchange (GEF) domain of EPACs, two most conserved regions between the two isoforms, further reveal that EPAC1 and EPAC2 are closely clustered together within both the larger cyclic nucleotide receptor and RAPGEF families. Guanine Nucleotides 70-88 Rap guanine nucleotide exchange factor 3 Homo sapiens 194-199 34979574-7 2022 Epac is a cAMP-dependent guanine nucleotide exchange factor for the small G proteins including Rap1. Guanine Nucleotides 25-43 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 33298248-2 2021 The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on protein kinase A (PKA)-independent functions of cAMP signaling in neural tissues. Guanine Nucleotides 64-82 Rap guanine nucleotide exchange factor 3 Homo sapiens 53-57 33872697-10 2021 EPAC acts as the guanine nucleotide exchange factor for the small GTPase Rap1. Guanine Nucleotides 17-35 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 31817822-1 2019 Signalling by cyclic adenosine monophosphate (cAMP) occurs via various effector proteins, notably protein kinase A and the guanine nucleotide exchange factors Epac1 and Epac2. Guanine Nucleotides 123-141 Rap guanine nucleotide exchange factor 3 Homo sapiens 159-164 33000885-9 2020 Finally, small G protein Rap1 and its guanine nucleotide exchange factor Epac1 were found to be involved in cAMP-induced PP2A activation. Guanine Nucleotides 38-56 Rap guanine nucleotide exchange factor 3 Homo sapiens 73-78 32340447-3 2020 Several potent EPAC1 binders were identified including 25g, 25q, 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro. Guanine Nucleotides 109-127 Rap guanine nucleotide exchange factor 3 Homo sapiens 15-20 32340447-3 2020 Several potent EPAC1 binders were identified including 25g, 25q, 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro. Guanine Nucleotides 109-127 Rap guanine nucleotide exchange factor 3 Homo sapiens 103-108 27900608-1 2017 Epac1 and Epac2 are cyclic nucleotide-binding (CNB) domain containing proteins, which were originally identified as cAMP-regulated guanine nucleotide exchange factors (GEFs) for the small G-protein Rap. Guanine Nucleotides 131-149 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-5 29111327-2 2018 EPAC has two isoforms (EPAC1 and EPAC2) and is a cAMP-dependent guanine nucleotide exchange factor for the small GTPases, Rap1 and Rap2. Guanine Nucleotides 64-82 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 27649969-1 2017 AIMS: In the heart, beta1-adrenergic signaling involves cyclic adenosine monophosphate (cAMP) acting via both protein kinase-A (PKA) and exchange protein directly activated by cAMP (Epac): a guanine nucleotide exchange factor for the small GTPase Rap1. Guanine Nucleotides 191-209 Rap guanine nucleotide exchange factor 3 Homo sapiens 182-186 31695683-3 2019 cAMP is able to trigger various downstream pathways, mainly the canonical PKA pathway and the non-canonical cAMP-activated guanine nucleotide exchange factor (EPAC) pathway. Guanine Nucleotides 123-141 Rap guanine nucleotide exchange factor 3 Homo sapiens 159-163 26151319-1 2015 Exchange proteins directly activated by cAMP (EPAC) as guanine nucleotide exchange factors mediate the effects of the pivotal second messenger cAMP, thereby regulating a wide variety of intracellular physiological and pathophysiological processes. Guanine Nucleotides 55-73 Rap guanine nucleotide exchange factor 3 Homo sapiens 46-50 26119090-1 2015 Mammalian exchange protein directly activated by cAMP isoform 1 (EPAC1), encoded by the RAPGEF3 gene, is one of the two-membered family of cAMP sensors that mediate the intracellular functions of cAMP by acting as guanine nucleotide exchange factors for the Ras-like Rap small GTPases. Guanine Nucleotides 214-232 Rap guanine nucleotide exchange factor 3 Homo sapiens 65-70 26119090-1 2015 Mammalian exchange protein directly activated by cAMP isoform 1 (EPAC1), encoded by the RAPGEF3 gene, is one of the two-membered family of cAMP sensors that mediate the intracellular functions of cAMP by acting as guanine nucleotide exchange factors for the Ras-like Rap small GTPases. Guanine Nucleotides 214-232 Rap guanine nucleotide exchange factor 3 Homo sapiens 88-95 26061564-7 2015 Novel effects of Rp-8-Br-cAMPS-pAB to block the activation of cAMP-regulated guanine nucleotide exchange factors (Epac1, Epac2) are also validated using genetically encoded Epac biosensors, and are independently confirmed in an in vitro Rap1 activation assay using Rp-cAMPS and Rp-8-Br-cAMPS. Guanine Nucleotides 77-95 Rap guanine nucleotide exchange factor 3 Homo sapiens 114-119 26061564-7 2015 Novel effects of Rp-8-Br-cAMPS-pAB to block the activation of cAMP-regulated guanine nucleotide exchange factors (Epac1, Epac2) are also validated using genetically encoded Epac biosensors, and are independently confirmed in an in vitro Rap1 activation assay using Rp-cAMPS and Rp-8-Br-cAMPS. Guanine Nucleotides 77-95 Rap guanine nucleotide exchange factor 3 Homo sapiens 114-118 23139415-4 2012 We identified an Epac1 inhibitor compound named CE3F4 that blocked Epac1 guanine nucleotide exchange activity toward its effector Rap1 both in cell-free systems and in intact cells. Guanine Nucleotides 73-91 Rap guanine nucleotide exchange factor 3 Homo sapiens 17-22 24605759-6 2014 While 7-CH-cAMP is a general activator for cAMP- and cGMP-dependent protein kinases as well as for the guanine nucleotide exchange factors Epac1 and Epac2, it displays the highest affinity to HCN channels. Guanine Nucleotides 103-121 Rap guanine nucleotide exchange factor 3 Homo sapiens 139-144 23364803-2 2013 The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A. Guanine Nucleotides 56-74 Rap guanine nucleotide exchange factor 3 Homo sapiens 4-8 23364803-2 2013 The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A. Guanine Nucleotides 56-74 Rap guanine nucleotide exchange factor 3 Homo sapiens 35-40 23143065-1 2013 Adenosine 3",5"-cyclic adenosine monophosphate (cAMP) activates intracellular signaling by regulating protein kinase A, calcium influx, and cAMP-binging guanine nucleotide exchange factors (Epac [exchange protein directly activated by cAMP] or cAMP-GEF). Guanine Nucleotides 153-171 Rap guanine nucleotide exchange factor 3 Homo sapiens 190-194 23139415-4 2012 We identified an Epac1 inhibitor compound named CE3F4 that blocked Epac1 guanine nucleotide exchange activity toward its effector Rap1 both in cell-free systems and in intact cells. Guanine Nucleotides 73-91 Rap guanine nucleotide exchange factor 3 Homo sapiens 67-72 21670213-2 2011 In this paper, we demonstrate that the nuclear pore component RanBP2 acts as a negative regulator of cAMP signaling through Epac1, a cAMP-regulated guanine nucleotide exchange factor for Rap. Guanine Nucleotides 148-166 Rap guanine nucleotide exchange factor 3 Homo sapiens 124-129 22607683-1 2012 Exchange proteins directly activated by cAMP (Epac) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. Guanine Nucleotides 68-86 Rap guanine nucleotide exchange factor 3 Homo sapiens 46-50 19855995-2 2010 Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2 and function independently of protein kinase A. Guanine Nucleotides 44-62 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-4 20009023-1 2010 Potential insulin secretagogue properties of an acetoxymethyl ester of a cAMP analog (8-pCPT-2"-O-Me-cAMP-AM) that activates the guanine nucleotide exchange factors Epac1 and Epac2 were assessed using isolated human islets of Langerhans. Guanine Nucleotides 129-147 Rap guanine nucleotide exchange factor 3 Homo sapiens 165-170 19855995-2 2010 Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2 and function independently of protein kinase A. Guanine Nucleotides 44-62 Rap guanine nucleotide exchange factor 3 Homo sapiens 23-28 19912228-4 2010 The identification of the cAMP-activated guanine nucleotide exchange factors for Ras-like GTPases, Epac1 (also known as cAMP-GEF-I) and Epac2 (also known as cAMP-GEF-II), profoundly altered the prevailing assumptions concerning cAMP signalling, which until then had been solely associated with protein kinase A (PKA). Guanine Nucleotides 41-59 Rap guanine nucleotide exchange factor 3 Homo sapiens 99-104 20055708-3 2010 Epac1 and Epac2 function as guanine nucleotide exchange factors for the small G protein Rap. Guanine Nucleotides 28-46 Rap guanine nucleotide exchange factor 3 Homo sapiens 0-5 19912228-4 2010 The identification of the cAMP-activated guanine nucleotide exchange factors for Ras-like GTPases, Epac1 (also known as cAMP-GEF-I) and Epac2 (also known as cAMP-GEF-II), profoundly altered the prevailing assumptions concerning cAMP signalling, which until then had been solely associated with protein kinase A (PKA). Guanine Nucleotides 41-59 Rap guanine nucleotide exchange factor 3 Homo sapiens 120-130 19546222-3 2009 The relevant cAMP target is Epac, a guanine nucleotide exchange factor for the small GTPase Rap. Guanine Nucleotides 36-54 Rap guanine nucleotide exchange factor 3 Homo sapiens 28-32