PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29059157-3 2018 Here, we show that a Rho family GTPase regulator, Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1), can interact with ephrinB1, and this interaction is enhanced upon binding the extracellular domain of the cognate EphB2 receptor. Guanine Nucleotides 54-72 Rho GDP dissociation inhibitor alpha Homo sapiens 99-106 24598074-4 2014 The participation of Rac is expressed in the following sequence: (1) Translocation of the RacGDP-RhoGDI complex to the membrane; (2) Dissociation of RacGDP from RhoGDI; (3) GDP to GTP exchange on Rac, mediated by a guanine nucleotide exchange factor; (4) Binding of RacGTP to p67(phox); (5) Induction of a conformational change in p67(phox), promoting interaction with Nox2. Guanine Nucleotides 215-233 Rho GDP dissociation inhibitor alpha Homo sapiens 97-103 28148498-2 2017 Here we investigate roles for Rho-specific guanine nucleotide dissociation inhibitor proteins (RhoGDIs) in platelet function. Guanine Nucleotides 43-61 Rho GDP dissociation inhibitor alpha Homo sapiens 95-102 25503727-2 2015 We recently reported two siblings with heritable nephrotic syndrome caused by a loss of function mutation in the gene ARHGDIA, which encodes for Rho guanine nucleotide dissociation inhibitor-alpha (GDIalpha). Guanine Nucleotides 149-167 Rho GDP dissociation inhibitor alpha Homo sapiens 118-125 18178769-6 2008 When introduced into guard cells together with CA-ROP2, At RhoGDI1, which encodes a guanine nucleotide dissociation inhibitor, inhibited plasma membrane localization of CA-ROP2 and abolished the inhibitory effect of CA-ROP2 on light-induced stomatal opening, supporting the negative effect of active ROP2 on stomatal opening. Guanine Nucleotides 84-102 Rho GDP dissociation inhibitor alpha Homo sapiens 59-66 23776598-2 2013 In all cell types studied to date, inactive Rho GTPases are present in the cytosol bound to the guanine nucleotide dissociation inhibitor RhoGDI. Guanine Nucleotides 96-114 Rho GDP dissociation inhibitor alpha Homo sapiens 138-144 20696765-3 2010 A search for the underlying mechanism revealed direct interaction of plexin-B3 with RhoGDP dissociation inhibitor alpha (RhoGDIalpha), a negative regulator of RhoGTPases that blocks guanine nucleotide exchange and sequesters them away from the plasma membrane. Guanine Nucleotides 182-200 Rho GDP dissociation inhibitor alpha Homo sapiens 84-119 20400958-1 2010 At steady state, most Rho GTPases are bound in the cytosol to Rho guanine nucleotide dissociation inhibitors (RhoGDIs). Guanine Nucleotides 66-84 Rho GDP dissociation inhibitor alpha Homo sapiens 110-117 18190708-2 2008 They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), RHOGTPase-activating proteins (RHOGAPs) and RHO guanine nucleotide inhibitors (RHOGDIs). Guanine Nucleotides 63-81 Rho GDP dissociation inhibitor alpha Homo sapiens 189-196 18190708-2 2008 They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), RHOGTPase-activating proteins (RHOGAPs) and RHO guanine nucleotide inhibitors (RHOGDIs). Guanine Nucleotides 158-176 Rho GDP dissociation inhibitor alpha Homo sapiens 189-196 16085653-7 2005 Statin treatment disrupted the interaction of Rac with its negative regulator the Rho guanine nucleotide dissociation inhibitor (RhoGDI), an interaction that is dependent on protein isoprenylation. Guanine Nucleotides 86-104 Rho GDP dissociation inhibitor alpha Homo sapiens 129-135 11060289-2 2001 To identify novel components that affect the ER transcriptional response, we performed a genetic screen in yeast and identified RDI1, a Rho guanine nucleotide dissociation inhibitor (Rho GDI), as a positive regulator of ER transactivation. Guanine Nucleotides 140-158 Rho GDP dissociation inhibitor alpha Homo sapiens 183-190 15292224-3 2004 The present study investigated the roles of Rho GTPase guanine nucleotide disassociation inhibitor (RhoGDI) in the reorganization of actin cytoskeleton mediated by ExoS RhoGAP. Guanine Nucleotides 55-73 Rho GDP dissociation inhibitor alpha Homo sapiens 100-106 12454455-2 2002 In a previous study using a model system of Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI), it was shown that mutating Lys residues to Ala results in enhanced crystallizability, particularly when clusters of lysines are targeted. Guanine Nucleotides 57-75 Rho GDP dissociation inhibitor alpha Homo sapiens 100-106 15530857-8 2004 Taken together, the results presented herein indicate that although RhoGDI is a critical regulator of guanine nucleotide binding, cycling of Cdc42 between membranes and the cytosol and cellular transformation, it is not essential for Cdc42-mediated organization of the actin cytoskeleton. Guanine Nucleotides 102-120 Rho GDP dissociation inhibitor alpha Homo sapiens 68-74 9195882-3 1997 Guanine nucleotide dissociation inhibitors (GDIs) of the rhoGDI family bind to these G proteins and regulate their activity by preventing nucleotide dissociation and by controlling their interaction with membranes. Guanine Nucleotides 0-18 Rho GDP dissociation inhibitor alpha Homo sapiens 57-63 10655614-1 2000 Rho family-specific guanine nucleotide dissociation inhibitors (RhoGDIs) decrease the rate of nucleotide dissociation and release Rho proteins such as RhoA, Rac and Cdc42 from membranes, forming tight complexes that shuttle between cytosol and membrane compartments. Guanine Nucleotides 20-38 Rho GDP dissociation inhibitor alpha Homo sapiens 64-71 10673424-4 2000 The cytosolic guanine nucleotide dissociation inhibitors, RhoGDIs, regulate both the GDP/GTP exchange cycle and the membrane association/dissociation cycle. Guanine Nucleotides 14-32 Rho GDP dissociation inhibitor alpha Homo sapiens 58-65 8504089-5 1993 Direct binding of rho-GDI to the GTP gamma S-bound forms of these G-proteins was demonstrated by gel filtration following exchange with radiolabeled guanine nucleotide. Guanine Nucleotides 149-167 Rho GDP dissociation inhibitor alpha Homo sapiens 18-25 8491184-1 1993 RhoGDI inhibits guanine nucleotide dissociation from post-translationally processed Rho and Rac proteins but its biochemical role in vivo is unknown. Guanine Nucleotides 16-34 Rho GDP dissociation inhibitor alpha Homo sapiens 0-6 32876072-1 2020 Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays important roles in numerous cellular processes, including cell motility, adhesion, and proliferation, by regulating the activity of Rho GTPases. Guanine Nucleotides 4-22 Rho GDP dissociation inhibitor alpha Homo sapiens 49-56