PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Carbamates 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 16256966-7 2005 To investigate this point, we have measured the reaction of carbamoyl esters (carbamates) with AChE. Carbamates 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Carbamates 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 15792266-8 2005 These include combinations of carbamates (reversible AChE inhibitors) and central anticholinergics or NMDA receptor antagonists, benzodiazepines or partial agonists for benzodiazepine receptor, and other central AChE inhibitors approved for Alzheimer"s disease. Carbamates 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 15974596-9 2005 The new carbamates were tested in vitro for the inhibition of both cholinesterases and also for the ability to prevent the AChE-induced Abeta aggregation. Carbamates 8-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16076434-4 2005 Carbamate pesticides inhibited acetylcholinesterase and the decrease in the enzyme activity was used to determine these pesticides. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Carbamates 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Carbamates 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 15241943-1 2004 The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. Carbamates 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. Carbamates 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Carbamates 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Carbamates 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 15494248-7 2004 Acetylcholinesterase is used to detect organophosphorous and carbamate insecticide residues but several molecules (reversible inhibitors, pH and ionic strength modifiers) generate matrix effects in free conditions. Carbamates 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15362815-10 2004 Carbamate poisoning was indicated on the basis of reactivation of brain AChE activity in two additional incidents. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 15715468-4 2005 Because the two series of carbamates (7-12) differ in their phenolic moieties, their respective potency and selectivity for AChE versus BChE was governed by their N-substituted groups. Carbamates 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 23902387-3 1999 AChE activity is highly sensitive to organophosphorus and carbamate insecticides but also to heavy metals. Carbamates 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 11370299-2 2001 Disposable biosensors, based on acetylcholinesterase inhibition activity, were exploited for testing the presence of organophosphorus and carbamate pesticides in water, fruit, and vegetable samples. Carbamates 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Carbamates 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 11888271-1 2002 Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer"s disease under the trade name of Exelon. Carbamates 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 10998265-1 2000 Acetylcholinesterase is the primary target of organophosphorous and carbamate insecticides. Carbamates 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 216-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 216-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 18966870-1 1997 A fibre-optic based on immobilized acetylcholinesterase is described and its application in the detection of carbamate and organophosphate pesticides through enzyme inhibition measurements is discussed. Carbamates 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Carbamates 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 9427520-6 1997 In vivo suppression of the acetylcholine hydrolyzing activity of AChE and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. Carbamates 227-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 8828163-5 1996 This approach to biosensor design has been extended to the determination of organophosphorus and carbamate pesticides by their inhibition of AChE enzymatic activity. Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Carbamates 122-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 35408132-3 2022 It is worth mentioning that organophosphates and carbamates inhibit AChE. Carbamates 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Carbamates 221-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 2400840-0 1990 In vitro inhibition of acetylcholinesterase from four marine species by organophosphates and carbamates. Carbamates 93-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Carbamates 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Carbamates 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 1906943-6 1991 Assays were also done with psychotropic drugs by employing the procedure of in vitro AChE inhibition kinetics, and it was found that psychotropic drugs are less potent than organophosphate and carbamate compounds. Carbamates 193-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 1906943-7 1991 Results indicate that pure and commercial organophosphates and carbamates and psychotropic drugs are all able to significantly alter the AChE activity. Carbamates 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 2180181-2 1990 Organophosphorus and carbamate insecticides produce acute toxicosis via a common mechanism--the inhibition of acetylcholinesterase--and, therefore, these categories of insecticides are considered together. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. Carbamates 193-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 2573709-3 1989 An apparent rate constant (ke) was derived for the reaction sequence in which carbamate is released from AChE inhibited by pyridostigmine. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 2667712-4 1989 Organophosphorus and carbamate insecticides generate their toxic effects by bonding to and inhibiting ChE enzymes (most importantly, AChE), which are responsible for breaking down the neurotransmitter ACh. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 3603322-3 1987 Carbamates also inhibit AChE but for a much shorter duration and they do not cause the same degree of central nervous system effects as OP. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 990993-1 1976 The reversible binding constant (Ki) for tetramethylammonium ion (TMA) was determined from the decrease in the bimolecular rate constant (ki) observed with each of 21 organophosphate or carbamate inhibitors of acetylcholinesterase (EC 3.1.1.7). Carbamates 186-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 588302-0 1977 The role of hydrophobic and electron donor properties in acetylcholinesterase inhibition by carbamates. Carbamates 92-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 564313-0 1977 Inhibition of acetylcholinesterase from different species by organophosphorus compounds, carbamates and methylsulphonyfluoride. Carbamates 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 5443532-0 1970 The effect of fluoride on the reaction of acetylcholinesterase with carbamates. Carbamates 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 5002755-0 1971 Affinity of human brain acetylcholinesterase to some organophosphates and carbamates in vitro. Carbamates 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 5103905-0 1971 Methods for the estimation of acetylcholinesterase activity in the plasma and brain of laboratory animals given carbamates or organophosphorus compounds. Carbamates 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 4826866-0 1974 Methods of the estimation of acetylcholinesterase activity in the erythrocytes of laboratory animals given carbamates or organophosphorus compounds. Carbamates 107-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 5167215-0 1971 Acceleration by free carbamate of the spontaneous reactivation of carbamylated acetylcholinesterase. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 5315358-1 1971 Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 5315358-1 1971 Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 5315358-2 1971 Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal action of AChE so that acetylcholine accumulates at synaptic junctions. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 5315358-3 1971 The necessary properties for a suitable insecticidal carbamate are lipid solubility, suitable structural complementarity to AChE, and sufficient stability to multifunction-oxidase detoxification. Carbamates 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 5378376-17 1969 These equations are applicable to reactions of acetylcholinesterase with organophosphorus compounds, carbamates etc. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 5971773-0 1966 Substrate and dilution effects on the inhibition of acetylcholinesterase by carbamates. Carbamates 76-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 6070126-0 1967 Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Carbamates 127-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 6070126-2 1967 The second-order rate constants of inhibition, k(a), of acetylcholinesterase were measured at pH values between 5.5 and 10.5 for two esters of phosphorus acids and five esters of carbamic acids. Carbamates 179-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. Carbamates 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. Carbamates 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Carbamates 194-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33479045-4 2021 Exposure to carbamate and organophosphate insecticides was assessed using haemoglobin-adjusted erythrocyte acetylcholinesterase (AChE/Hb). Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Carbamates 194-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31370232-5 2019 Indeed, inhibiting central AChE with brain-penetrating designed carbamates which are able to covalently bind to the enzyme and to concomitantly liberate active metabolites in the brain could constitute a clinically more efficient approach which, additionally, is less likely to cause peripheral side effects. Carbamates 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 32891393-9 2020 The sensitive HPTLC-S9-AChE assay allowed the detection of neurotoxic chemicals with and without metabolic activation, at levels consistent with the threshold of toxicological concern of organophosphates and carbamates. Carbamates 208-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Carbamates 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Carbamates 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Carbamates 89-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32086265-10 2020 As inhibition of AChE or BChE activity is determined, the CE-certified device is a global diagnostic tool for all ChE inhibitors including carbamates which might also be misused as chemical weapon. Carbamates 139-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32632029-6 2020 Exposure to organophosphate and carbamate insecticides was quantified using erythrocyte acetylcholinesterase normalised by haemoglobin (AChE/Hb). Carbamates 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Carbamates 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-3 2019 Therefore, carbamates are effective AChE inhibitors that have been developed as insecticides and as therapeutic agents. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 31035318-1 2019 New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. Carbamates 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. Carbamates 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. Carbamates 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30192517-7 2018 It is also versatile for the detection of other organophosphate or carbamate pesticides, which have the inhibition ability toward AChE. Carbamates 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30934674-0 2019 Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 30563111-2 2018 Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Carbamates 183-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 26985691-1 2016 A series of carbamate derivatives were synthesized and their carbonic anhydrase I and II isoenzymes and acetylcholinesterase enzyme (AChE) inhibitory effects were investigated. Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-131 30524149-2 2018 With the goal of developing new species-selective and resistance-breaking acetylcholinesterase (AChE)-inhibiting mosquitocides, in this report we revisit the effects of carbamate substitution on aryl carbamates, and variation of the 1-alkyl group on pyrazol-4-yl methylcarbamates. Carbamates 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30524149-2 2018 With the goal of developing new species-selective and resistance-breaking acetylcholinesterase (AChE)-inhibiting mosquitocides, in this report we revisit the effects of carbamate substitution on aryl carbamates, and variation of the 1-alkyl group on pyrazol-4-yl methylcarbamates. Carbamates 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Carbamates 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Carbamates 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29886321-7 2018 These preliminary results constitute one of the few examples of carbamate-based dual binding site AChE inhibitors. Carbamates 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Carbamates 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Carbamates 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 28274151-1 2017 Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer"s disease (AD). Carbamates 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-3 2018 Therefore, carbamates are effective AChE inhibitors that have been developed as insecticides and as therapeutic agents. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 29797194-4 2018 Here, a review on erythrocyte AChE characteristics and use as biomarker for organophosphorus and carbamate insecticides is presented since it is the first specific target/barrier of the action of these pesticides, besides plasma butyrylcholinesterase (BChE). Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29026987-4 2018 AChE is a physiological marker of organophosphate/carbamate pesticide exposures that may take up to 3 months to normalize after its inhibition. Carbamates 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. Carbamates 332-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. Carbamates 332-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 28338634-5 2017 The prepared nanoparticles were modified by pure AChE and they were used for the measurement anti-Alzheimer"s drug galantamine and carbamate pesticide carbofuran with limit of detection 1.5 microM and 20 nM, respectively. Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 26985691-1 2016 A series of carbamate derivatives were synthesized and their carbonic anhydrase I and II isoenzymes and acetylcholinesterase enzyme (AChE) inhibitory effects were investigated. Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 26985691-3 2016 The carbamates were determined to be very good inhibitors against for AChE and hCA I, and II isoenzymes. Carbamates 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26985691-8 2016 The results clearly showed that AChE and both CA isoenzymes were effectively inhibited by carbamates at the low nanomolar levels. Carbamates 90-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 27055524-0 2016 A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs. Carbamates 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Carbamates 140-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Carbamates 140-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 26547618-6 2016 Based on the inhibition of carbamate pesticides on the activity of AChE, the pesticide could be quantitatively determined at a very low potential. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 26492468-2 2016 A highly sensitive fluorescent biosensor for the detection of carbamate pesticide has been developed based on acetylcholinesterase (AChE)-catalyzed hydrolysis product triggered Hg(2+) release coupled with subsequent nicking enzyme-induced cleavage of a duplex DNA for cycling amplification. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 26492468-2 2016 A highly sensitive fluorescent biosensor for the detection of carbamate pesticide has been developed based on acetylcholinesterase (AChE)-catalyzed hydrolysis product triggered Hg(2+) release coupled with subsequent nicking enzyme-induced cleavage of a duplex DNA for cycling amplification. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 26492468-6 2016 In the presence of carbamate pesticide, the activity of AChE is inhibited, and the amount of the product containing the thiol group generated by the hydrolysis reaction of acetylthiocholine chloride (ACh) decreases, resulting in the release of a low concentration of Hg(2+). Carbamates 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26886849-2 2016 A set of pseudo-irreversible BChE inhibitors with high selectivity over hAChE was synthesized based on carbamates attached to tetrahydroquinazoline scaffolds with the 2-thiophenyl compound 2p as the most potent inhibitor of eqBChE (KC = 14.3 nM) and also of hBChE (KC = 19.7 nM). Carbamates 103-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 26646154-10 2016 Commonly prescribed carbamates have many severe side effects related to AChE carbamylation. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26646154-12 2016 Unlike carbamates, these new compounds target AChE via apparent pi-pi or pi-cationic interaction aside at the AChE catalytic site. Carbamates 7-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 26646154-12 2016 Unlike carbamates, these new compounds target AChE via apparent pi-pi or pi-cationic interaction aside at the AChE catalytic site. Carbamates 7-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 24964347-0 2015 Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. Carbamates 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27476673-4 2016 The AChE/BChE selectivity for each carbamate was calculated. Carbamates 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27476673-5 2016 These values varied from 0.50 to 9.46, two carbamate derivatives inhibited only AChE selectively. Carbamates 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 26520174-3 2015 The non-target toxicity and resistance problem of organophosphate and carbamate have become of growing concern, which may be due to the fact that they target the ubiquitous catalytic serine residue of acetylcholinesterase (AChE) in mammals, birds, and beneficial insects. Carbamates 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 24964347-2 2015 In this study, a series of carbamate derivative was synthesized, and their inhibition effects on hCA I, hCA II and acetylcholinesterase (AChE) enzymes were investigated. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-135 24964347-2 2015 In this study, a series of carbamate derivative was synthesized, and their inhibition effects on hCA I, hCA II and acetylcholinesterase (AChE) enzymes were investigated. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 24964347-6 2015 The results clearly showed that both CA isoenzymes and AChE were inhibited by carbamate derivatives at the nM levels. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 26563788-1 2015 Both organophosphorus (OP) and carbamate insecticides inhibit acetylcholinesterase (AChE), which results in accumulation of acetylcholine (ACh) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Carbamates 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Carbamates 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 26417364-0 2015 Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection. Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 25484901-0 2014 Bioactive paper sensor based on the acetylcholinesterase for the rapid detection of organophosphate and carbamate pesticides. Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 24344993-0 2014 Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Carbamates 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 24344993-2 2014 Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23936791-3 2013 As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning. Carbamates 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23962483-1 2013 Carbamates are widely used for pest control and act primarily by inhibition of insect and mammalian acetylcholinesterase (AChE). Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 23962483-1 2013 Carbamates are widely used for pest control and act primarily by inhibition of insect and mammalian acetylcholinesterase (AChE). Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 22989775-2 2013 New carbamates that are highly selective for inhibition of Anopheles gambiae acetylcholinesterase (AChE) over the human enzyme might be useful in continuing efforts to limit malaria transmission. Carbamates 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. Carbamates 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. Carbamates 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 23936791-4 2013 Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine. Carbamates 167-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23169765-0 2012 Carbamate protection of AChE against inhibition by agricultural chemicals. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 22990946-2 2013 Like other carbamates, it inhibits AChE activity, resulting in nerve and/or tissue failure and possibly death. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Carbamates 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22738634-2 2012 Compounds bearing a beta-branched 2-alkoxy or 2-thioalkyl group were found to possess good selectivity for inhibition of Anopheles gambiae AChE over human AChE; up to 530-fold selectivity was achieved with carbamate 11d. Carbamates 206-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22738634-2 2012 Compounds bearing a beta-branched 2-alkoxy or 2-thioalkyl group were found to possess good selectivity for inhibition of Anopheles gambiae AChE over human AChE; up to 530-fold selectivity was achieved with carbamate 11d. Carbamates 206-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 23256657-5 2012 Such an appropriate system for the detection of carbamates and highly toxic organophosphates is detection tubes with microcrystalline cellulose pellets containing immobilized acetylcholinesterase, by which analyzed air is sucked through. Carbamates 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Carbamates 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20684567-2 2010 The predictive pharmacophore model (correlation = 0.955) with one H-bond donor and three hydrophobic features was developed using HypoGen on a training set of 24 carbamates as AChE inhibitors. Carbamates 162-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 21432054-3 2011 Because of its physiological role, Ache has long been considered a highly specific biomarker for organisms exposed to anticholinesterasic agents, primarily agro-chemicals (organophosphate and carbamate pesticides). Carbamates 192-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 21414391-6 2011 It was possible to show that with erythrocyte and muscle AChE a similar level of protection by carbamates and reactivation after discontinuation of the carbamates and soman could be observed. Carbamates 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 21414391-6 2011 It was possible to show that with erythrocyte and muscle AChE a similar level of protection by carbamates and reactivation after discontinuation of the carbamates and soman could be observed. Carbamates 152-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 21414391-7 2011 Thus, these data indicate that carbamate pre-treatment is expected to protect a critical level of muscle AChE and confirm the presumption that erythrocyte AChE may serve as a surrogate for synaptic AChE. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 21144749-3 2011 However, carbamate inhibitors are known for many undesirable side-effects related to the carbamylation of AChE. Carbamates 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 20138030-5 2010 Many organophosphates and carbamates serve as potent insecticides, by selectively inhibiting insect acetylcholinesterase. Carbamates 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20684567-4 2010 The pharmacophore-based VS of virtual library led to the identification of novel carbamates as potent AChE inhibitors. Carbamates 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 18602908-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex and proceed to an acylated enzyme intermediate which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Carbamates 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Carbamates 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 20138518-2 2010 Carbamate inhibitors are known for many undesirable side effects related to the reversible inhibition of AChE. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. Carbamates 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. Carbamates 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 19441865-1 2009 In view of the nonavailability of complete X-ray structure of carbamates cocrystallized with AChE enzyme, the 3D-QSAR model development based on cocrystallized conformer (CCBA) as well as docked conformer-based alignment (DCBA) is not feasible. Carbamates 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 20890554-2 2010 OBJECTIVE: The acetylcholinesterase activity was determined in study participants with a history of organophosphate and carbamate exposure and the most commonly used pesticides were identified in each study area. Carbamates 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 19269469-1 2009 The article presents a novel strategy for a sensitive investigation of the interaction between acetylcholinesterase (AChE) and its small molecular carbamate inhibitors. Carbamates 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 19269469-1 2009 The article presents a novel strategy for a sensitive investigation of the interaction between acetylcholinesterase (AChE) and its small molecular carbamate inhibitors. Carbamates 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 19269469-3 2009 With the signal amplification of AuNPs, the specific interactions between the AuNPs labeled carbamate inhibitors (ALC1 and ALC2) and the immobilized AChE on sensor chip surface were readily examined. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 19269469-5 2009 The association/dissociation constants for the binding interaction between carbamate inhibitors and AChE were reported for the first time. Carbamates 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 19371631-2 2009 In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and methomyl (a carbamate) was examined in vitro. Carbamates 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Carbamates 108-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 19689278-2 2009 It can be reached using simple chemicals such as reversible inhibitors (preferably carbamates), which are able to inhibit AChE reversibly. Carbamates 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19689278-3 2009 AChE inhibited by carbamates is resistant to OP/nerve agent inhibition. Carbamates 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. Carbamates 132-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. Carbamates 132-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19006330-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex with free AChE (E) and proceed to an acylated enzyme intermediate (EC), which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 19006330-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex with free AChE (E) and proceed to an acylated enzyme intermediate (EC), which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 18281016-5 2008 One means of protecting against soman poisoning is the prophylactic use of certain reversible inhibitors (carbamates) of AChE. Carbamates 106-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 18515163-0 2008 An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis. Carbamates 41-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 18515163-0 2008 An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis. Carbamates 41-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 18515163-1 2008 In order to identify the essential structural features and physicochemical properties for acetylcholinesterase (AChE) inhibitory activity in some carbamate derivatives, the systematic QSAR (Quantitative Structure Activity Relationship) studies (CoMFA, advance CoMFA and CoMSIA) have been carried out on a series of (total 78 molecules) taking 52 and 26 molecules in training and test set, respectively. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 18515163-1 2008 In order to identify the essential structural features and physicochemical properties for acetylcholinesterase (AChE) inhibitory activity in some carbamate derivatives, the systematic QSAR (Quantitative Structure Activity Relationship) studies (CoMFA, advance CoMFA and CoMSIA) have been carried out on a series of (total 78 molecules) taking 52 and 26 molecules in training and test set, respectively. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 18631301-1 2008 This article demonstrates statistical models to quantify the interaction between a carbamate insecticide and acetylcholinesterase. Carbamates 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 18631301-2 2008 Carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 18304715-4 2008 The purpose of the present study was to compare the effect of carbamate pre-treatment and soman challenge with human erythrocyte and muscle homogenate AChE. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 18281016-6 2008 The question whether there is a possibility of an interaction between pre-treating carbamates and oximes at AChE arises. Carbamates 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18320105-2 2007 OBJECTIVE: Exposure to organophosphorus and carbamate pesticides and carbamates was established in the agricultural population of Putumayo by determining acetylcholinesterase levels. Carbamates 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 16904807-9 2007 The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment. Carbamates 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 17097792-0 2007 Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. Carbamates 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17097792-6 2007 In previous experiments with carbamate pre-treatment and paraoxon challenge we noticed an increased residual activity of erythrocyte acetylcholinesterase compared to non-pre-treatment. Carbamates 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 16905305-2 2007 When an inhibition study with the developed sensor was undertaken at the optimized AChE immobilization with varying concentrations of a model organophosphorus pesticide EPN and carbamate one carbofuran, a sensitive detection for them was possible with the limit of detection corresponding to 1.55 x 10(-8) and 1.30 x 10(-9)M, respectively. Carbamates 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). Carbamates 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17134713-10 2007 Furthermore, after inactivation by carbamates, activity could be fully recovered and the AChE-CIM-IMER could be reused for further studies. Carbamates 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213