PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12837533-4	2003	Of the carbamates, 4-benzyl-piperazine-1-carboxylic acid 2-nitrophenol showed preferential hydrolysis by rCE compared to hCE1 with a V(max) of 54.4 micromoles/min/mg, and a K(m) value of 1071 microM.	Carbamates	7-17	carboxylesterase 1	Homo sapiens	121-125	
24461291-2	2014	The anticipated pathway of carboxylesterase-1-mediated carbamate cleavage followed by lactamization and drug release was frustrated by unexpectedly high sensitivity of the ester linkage toward hydrolysis by carboxylesterase-2 and other microsomal components.	Carbamates	55-64	carboxylesterase 1	Homo sapiens	27-45	
29407485-2	2018	Carboxylesterases (CESs) are enzymes catalyzing the hydrolysis of many structurally different ester, amide and carbamate chemicals, including prodrugs.	Carbamates	111-120	carboxylesterase 1	Homo sapiens	0-17	
1920540-2	1991	In this study, we showed that egasyn is identical to one of the carboxylesterase isozymes and organophosphorus and carbamate insecticides, acetanilide which is a specific substrate of egasyn and halothane caused a rapid dissociation of the egasyn-microsomal beta-glucuronidase complex when administered in vivo or when added in vitro to isolated hepatocytes.	Carbamates	115-124	carboxylesterase 1	Homo sapiens	30-36	
19062296-4	2009	Several different scaffolds capable of inhibiting carboxylesterases have been reported, including organophosphates, carbamates, trifluoromethyl ketone-containing structures (TFKs), and aromatic ethane-1,2-diones.	Carbamates	116-126	carboxylesterase 1	Homo sapiens	50-67	
23123248-4	2013	We observed inhibition of hCE1 and hiCE by carbamate-containing small molecules, including those used for the treatment of Alzheimer"s disease.	Carbamates	43-52	carboxylesterase 1	Homo sapiens	26-30	
23647544-1	2013	Human carboxylesterase I (hCES 1) plays an important role in the metabolism and activation of prodrugs, such as, the hydrolysis of a variety of drugs of prodrugs featuring an ester, amide or carbamate function.	Carbamates	191-200	carboxylesterase 1	Homo sapiens	26-32	
23386599-1	2013	Carboxylesterases are a multigene family of mammalian enzymes widely distributed throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and carbamates.	Carbamates	165-175	carboxylesterase 1	Homo sapiens	0-17	
17125253-2	2006	The carbamates were designed for selective hydrolysis by one or more human carboxylesterases to release doxazolidine (Doxaz), the formaldehyde-oxazolidine of doxorubicin that cross-links DNA to trigger cell death.	Carbamates	4-14	carboxylesterase 1	Homo sapiens	75-92	
17125253-3	2006	Simple butyl and pentyl, but not ethyl, carbamate prodrugs inhibited the growth of cancer cells that overexpress carboxylesterase CES1 (hCE1) and CES2 (hiCE).	Carbamates	40-49	carboxylesterase 1	Homo sapiens	113-129	
16223870-1	2006	Carboxylesterases are among the best characterized prodrug-hydrolyzing enzymes involved in the activation of several therapeutic carbamate and ester prodrugs.	Carbamates	129-138	carboxylesterase 1	Homo sapiens	0-17