PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32199135-8 2020 Methanone 16 and its carbamate derivative 17b inhibit FLT3-ITD at least as potently as the TKi AC220 (quizartinib). Carbamates 21-30 fms related receptor tyrosine kinase 3 Homo sapiens 54-58 23618709-4 2013 Structure-activity relationships led to the discovery of sulfonamide, carbamate and urea series of FLT3 inhibitors. Carbamates 70-79 fms related receptor tyrosine kinase 3 Homo sapiens 99-103 23618709-5 2013 Previous studies showed that the sulfonamide 4 and carbamate 5 series were potent and selective FLT3 inhibitors with good in vivo efficacy. Carbamates 51-60 fms related receptor tyrosine kinase 3 Homo sapiens 96-100 22726931-2 2012 The structure-activity relationships led to the discovery of two carbamate series, and some potent compounds within these two series exhibited better growth inhibition of FLT3-mutated MOLM-13 cells than FLT3 inhibitors sorafenib (2) and ABT-869 (3). Carbamates 65-74 fms related receptor tyrosine kinase 3 Homo sapiens 171-175 22726931-2 2012 The structure-activity relationships led to the discovery of two carbamate series, and some potent compounds within these two series exhibited better growth inhibition of FLT3-mutated MOLM-13 cells than FLT3 inhibitors sorafenib (2) and ABT-869 (3). Carbamates 65-74 fms related receptor tyrosine kinase 3 Homo sapiens 203-207