PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9486113-5	1997	It was found that like anti-TNF-alpha, anti-IL-1 beta administered systemically to mice (by intraperitoneal injection), prior to skin sensitization with the contact allergen oxazolone, resulted in a marked inhibition of DC accumulation in draining lymph nodes.	Oxazolone	174-183	interleukin 1 beta	Mus musculus	44-53	
11133345-3	2000	The present study investigated the kinetics and in situ localization of induced IL-1 beta expression in mouse skin following topical exposure to the contact allergen oxazolone.	Oxazolone	166-175	interleukin 1 beta	Mus musculus	80-89	
11133345-6	2000	Following topical exposure of mice to oxazolone for 5-15 min, upregulation of IL-1 beta mRNA was observed in the epidermis, dermis, hair follicles, and sebaceous glands; at 90 min and beyond the pattern of IL-1 beta mRNA expression declined toward control.	Oxazolone	38-47	interleukin 1 beta	Mus musculus	78-87	
11133345-6	2000	Following topical exposure of mice to oxazolone for 5-15 min, upregulation of IL-1 beta mRNA was observed in the epidermis, dermis, hair follicles, and sebaceous glands; at 90 min and beyond the pattern of IL-1 beta mRNA expression declined toward control.	Oxazolone	38-47	interleukin 1 beta	Mus musculus	206-215	
11133345-8	2000	Following exposure to oxazolone, cutaneous IL-1 beta protein expression was elevated at 30 min, decreased at 1 h, and fell below the limit of detection of the assay at 2 h before returning to constitutive levels at 4 and 24 h. IL-1 beta protein levels in vehicle-treated mice, naive mice, and mice treated with the respiratory allergen trimellitic anhydride were unchanged over this time period.	Oxazolone	22-31	interleukin 1 beta	Mus musculus	43-52	
11133345-8	2000	Following exposure to oxazolone, cutaneous IL-1 beta protein expression was elevated at 30 min, decreased at 1 h, and fell below the limit of detection of the assay at 2 h before returning to constitutive levels at 4 and 24 h. IL-1 beta protein levels in vehicle-treated mice, naive mice, and mice treated with the respiratory allergen trimellitic anhydride were unchanged over this time period.	Oxazolone	22-31	interleukin 1 beta	Mus musculus	227-236	
31775224-7	2019	OIR3 was able to reduce oxazolone-induced skin inflammation in allergic dermatitis mouse model via the inhibition of TNF-alpha, IL-1beta and IL-6 mRNA expression.	Oxazolone	24-33	interleukin 1 beta	Mus musculus	128-136	
27966619-6	2016	Oxazolone treatment stimulated maturation of pro-caspase-1 and pro-IL-1beta, while it reduced IL-18 expression.	Oxazolone	0-9	interleukin 1 beta	Mus musculus	67-75	
27966619-9	2016	Compared to wild-type mice, NLRP3-/- mice exhibited higher sensitivity to oxazolone treatment with enhancement of Th2 cytokine expression and reduction of mature IL-1beta and IL-18 production; this phenotype was rescued by exogenous IL-1beta or IL-18.	Oxazolone	74-83	interleukin 1 beta	Mus musculus	233-241	
16116312-6	2005	RESULTS: Intracolonic administration of oxazolone increased myeloperoxidase activity, damage score, and interleukin (IL)-4, IL-10, tumor necrosis factor alpha, and IL-1beta mRNA expression but lowered interferon-gamma mRNA expression, indicating colonic inflammation of a TH2 profile.	Oxazolone	40-49	interleukin 1 beta	Mus musculus	164-172	
20147964-5	2010	Striking increases in DsRed signal were observed after topical application of a contact sensitizer, oxazolone, which also induced markedly elevated IL-1beta mRNA and protein expression.	Oxazolone	100-109	interleukin 1 beta	Mus musculus	148-156	
25959240-6	2015	Furthermore, neutrophil depletion during the elicitation phase of OXA-induced contact dermatitis also caused significant decreases in ear swelling and CD8(+) T-cell infiltration accompanied by significantly decreased LTB4 synthesis and gene expression of CXCL2, interferon-gamma and interleukin-1beta.	Oxazolone	66-69	interleukin 1 beta	Mus musculus	283-300	
17984289-2	2008	In this study, we have explored the role of IL-18, a cytokine with structural similarities to IL-1 beta, in murine LC migration and contact hypersensitivity (CHS), which to oxazolone (OX) and 2-4,dinitrofluorobenzene (DNFB) was suppressed significantly in IL-18 knockout (IL-18-/-) mice and could be rescued by local intradermal administration of IL-18 prior to sensitization, suggesting that the defect in these mice was in the afferent phase of CHS.	Oxazolone	173-182	interleukin 1 beta	Mus musculus	94-103	
15914323-4	2005	The compound K also significantly reduced the levels of mRNA of cyclooxygenase (COX)-2, IL-1beta, TNF-alpha, IFN-gamma and IL-4 increased in oxazolone-applied mouse ears.	Oxazolone	141-150	interleukin 1 beta	Mus musculus	88-96