PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11118199-2 2000 The therapeutically important K(+) channel openers (e.g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform. Cromakalim 68-78 ATP binding cassette subfamily C member 9 Homo sapiens 116-120 10625598-7 2000 The SUR2 segment containing the 12th through 17th predicted transmembrane domains, TMD12-17, confers sensitivity to the benzopyran, cromakalim, and the pyridine, pinacidil, whereas an SUR1 segment which includes TMD6-11 and the first nucleotide-binding fold, NBF1, controls responsiveness to the benzothiadiazine, diazoxide. Cromakalim 132-142 ATP binding cassette subfamily C member 9 Homo sapiens 4-8 35562524-5 2022 Here, we present cryo-EM structures of SUR2A and SUR2B subunits in complex with Mg-nucleotides and P1075 or levcromakalim, two chemically distinct KATP openers that are specific to SUR2. Cromakalim 108-121 ATP binding cassette subfamily C member 9 Homo sapiens 181-185