PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3372356-3 1988 Structure-cytotoxicity relationships studies have indicated that the C-3 and C-6 disubstituted piperazine-2,5-diones are structurally required for significant cytotoxicity, and the neihumicin-like C-3 and C-6 disubstituted unsymmetrical piperazine derivatives are, in general, more cytotoxic than the corresponding symmetrical piperazine-2,5-diones. Piperazine 95-105 complement C3 Homo sapiens 69-72