PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16153839-1	2005	An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over the 5-HT1A and 5-HT1D receptors and low intrinsic activity.	Piperazine	135-145	5-hydroxytryptamine receptor 1A	Homo sapiens	30-36	
17763374-5	2007	Docking analysis indicated that the binding to D(2) and 5-HT(1A) receptors is based on (i) interaction between protonated N1 of the piperazine ring and various aspartate residues, (ii) hydrogen bonds between various moieties of the ligand and the residues of threonine, serine, histidine or tryptophane, and (iii) edge-to-face interactions of the aromatic ring of the arylpiperazine moiety with phenylalanine or tyrosine residues.	Piperazine	132-142	5-hydroxytryptamine receptor 1A	Homo sapiens	56-63	
33543794-3	2021	The combination of structural elements (heterocyclic nucleus, hydroxyalkyl chain, and 4-substituted piperazine), known to be critical for the affinity to 5-HT1A receptors, and the proper selection of substituents resulted in compounds with high specificity and affinity toward serotoninergic receptors.	Piperazine	100-110	5-hydroxytryptamine receptor 1A	Homo sapiens	154-160	
10881999-4	2000	The results pointed out the critical role of the group linked in the N-1 position of the piperazine in terms of 5-HT1A binding affinity.	Piperazine	89-99	5-hydroxytryptamine receptor 1A	Homo sapiens	112-118	
35611784-0	2022	Molecular Modelling and Virtual Screening to Identify New Piperazine Derivatives as Potent Human 5-HT1A Antagonists and Reuptake Inhibitors.	Piperazine	58-68	5-hydroxytryptamine receptor 1A	Homo sapiens	97-103	
33668396-1	2021	We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT1A and 5-HT2A receptors.	Piperazine	101-111	5-hydroxytryptamine receptor 1A	Homo sapiens	148-154	
20022748-3	2010	However, the replacement of the piperazine moiety by a 1,2,3,6-tetrahydropyridine ring in 4-arylpiperazine-ethyl carboxamide derivatives was recently shown to be highly favourable for 5-HT(1A) affinity.	Piperazine	32-42	5-hydroxytryptamine receptor 1A	Homo sapiens	184-191