PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17034141-5 2006 The 3-position on the piperazine ring was also found to play an appreciable role, as substitutions in that position exerted a significant and stereospecific beneficial effect on the alpha(2C)-adrenoceptor affinity and potency. Piperazine 22-32 adrenoceptor alpha 2C Homo sapiens 182-204